The invention provides a photophobic medical soft polyvinyl chloride plastic and a preparation method thereof. The photophobic medical soft polyvinyl chloride plastic comprises the following compositions in part by weight: 100 parts of polyvinyl chloride resin, 10 to 90 parts of plasticizer, 1 to 10 parts of stabilizer, 1 to 10 parts of auxiliary stabilizer, 0.1 to 2.0 parts of ultraviolet absorber, 0.1 to 0.5 part of auxiliary antioxidant and 0.1 to 6 parts of surfactant. In the photophobic medical soft polyvinyl chloride plastic, a proper opacifier and the surfactant are selected, pohydrophilic and oleophilic property of the surfactant are utilized, the photophobic medical soft polyvinyl chloride plastic is dispersed more evenly and combined more firmly in a system containing a lipoid plasticizer, the use amount of the opacifier is reduced, and a pigment is difficult to separate out; and the photophobic medical soft polyvinyl chloride plastic has good dissolution resistance, and is suitable for producing special liquid bags, conduits, medical accessories, drip chambers and various disposable medical products. Various indexes of a reduction material and the like of a finished product meet the requirement of GB18458.3-2005 standard; and the photophobic range can meet the special requirement and is even expanded to all wave bands.