573 results about "Acetoxy group" patented technology

A method for depositing a silicon-containing film, the method comprising: placing a substrate comprising at least one surface feature into a flowable CVD reactor which is at a temperature of from about −20° C. to about 400° C.; introducing into the reactor at least one silicon-containing compound having at least one acetoxy group to at least partially react the at least one silicon-containing compound to form a flowable liquid oligomer wherein the flowable liquid oligomer forms a silicon oxide coating on the substrate and at least partially fills at least a portion of the at least one surface feature. Once cured, the silicon oxide coating has a low k and excellent mechanical properties.

The present invention relates, inter alia, to compounds having the general formula: in which: R1 is a member selected from the group consisting of —OCH3, —SCH3, —N(CH3)2, —NHCH3, —NC4H8, —NC5H10, —NC4H8O, —CHO, —CH(OH)CH3, —C(O)CH3, —O(CH2)2N(CH3)2, and —O(CH2)2NC5H10; R2 is a member selected from the group consisting of hydrogen, halogen, alkyl, acyl, hydroxy, alkoxy (e.g., methoxy, ethoxy, vinyloxy, ethynyloxy, cyclopropyloxy, etc.), acyloxy (e.g., acetoxy, glycinate, etc.), alkylcarbonate, cypionyloxy, S-alkyl, —SCN, S-acyl and —OC(O)R6, wherein R6 is a functional group including, but not limited to, alkyl (e.g., methyl, ethyl, etc.), alkoxy ester (e.g., —CH2OCH3) and alkoxy (—OCH3); R3 is a member selected from the group consisting of alkyl, hydroxy, alkoxy and acyloxy; R4 is a member selected from the group consisting of hydrogen and alkyl; and X is a member selected from the group consisting of ═O and ═N—OR5, wherein R5 is a member selected from the group consisting of hydrogen and alkyl.In addition to providing the compounds of Formula I, the present invention provides methods wherein the compounds of Formula I are advantageously used, inter alia, to antagonize endogenous progesterone; to induce menses; to treat endometriosis; to treat dysmenorrhea; to treat endocrine hormone-dependent tumors; to treat meningiomas; to treat uterine leiomyomas; to treat uterine fibroids; to inhibit uterine endometrial proliferation; to induce cervical ripening; to induce labor; and for contraception.

An element of an absorbent article is provided. The element has a bio-based content of at least about 50% based on the total weight of the element, and comprises a synthetic polymer derived from a renewable resource via a first intermediate compound selected from the group consisting of crotonic acid, propiolactone, ethylene oxide, i-propanol, butanol, butyric acid, propionic acid, 2-acetoxypropanoic acid, methyl 2-acetoxypropanoate, methyl lactate, ethyl lactate, polyhydroxybutyrate, and a polyhydroxyalkanoate comprising 3-hydroxypropionate monomers. An absorbent article comprising the element and a method of making an element for an absorbent article also are provided.

The present invention relates to a new industrial process for the synthesis of solvate- free 17a-acetoxy-11ss-[4-(N,N-dimethyl-amino)-phenyl]-19-norpregna-4,9-diene-3,20-dione [CDB -2914] of formula (I) which is a strong antiprogestogene and antiglucocorticoid agent. The invention also relates to compounds of formula (VII) and (VIII) used as intermediates in the process. The process according to the invention is the following: i) 3-(ethylene-dioxy)-estra-5(10),9(11)-diene-17-one of formula (X) is reacted with potassium acetilyde formed in situ in dry tetrahydrofuran by known method, ii) the obtained 3-(ethylene-dioxy)-17a-ethynyl-17ss-hydroxy-estra-5(10),9(11)-diene of formula (IX) is reacted with phenylsulfenyl chloride in dichloromethane in the presence of triethylamine and acetic acid, iii) the obtained isomeric mixture of 3-(ethylene-dioxy)-21-(phenyl-sulfinyl)-19-norpregna-5(10),9(11),17(20),20-tetraene of formula (VIII) is reacted first with sodium methoxide in methanol, then with trimethyl phosphite, iv) the obtained 3-(ethylene-dioxy)-17a-hydroxy-20-methoxy-19-norpregna-5(10),9(11),20-triene of formula (VII) is reacted with hydrogen chloride in methanol, then v) the obtained 3-(ethylene-dioxy)-17a-hydroxy-19-norpregna-5(10),9(11l); -diene-20- one of formula (VI) is reacted with ethylene glycol hi dichloromethane in the presence of trimethyl orthoformate and p-toluenesulfonic acid by known method, vi) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-19-norpregna- 5(10),9(11)-diene of formula (V) is reacted with hydrogen peroxide in a mixture of pyridine and dichloromethane in the presence of hexachloroacetone by known method, vii) the obtained 3,3,20,20-bis(ethylene-dioxy)-17a-hydroxy-5,10-epoxy-19-norpregn-9(11)-ene of formula (IV), containing approximately a 1:1 mixture of 5a,10a- and 5ss,10ss-epoxides, is isolated from the solution and reacted with a Grignard reagent obtained from 4-bromo-N,N-dimethyl-aniline in tetrahydrofuran.

A method and composition for treating a subterranean formation with a fluid, including forming a fluid including a particulate and an organosilane with the chemical formula RnSiX4-n, wherein n is equal to 1, 2, or 3, R is an organic functional group, and X is a halogen, alkoxy, or acetoxy group, introducing the fluid into a subterranean formation with exposed surfaces, and modifying the wettability of a surface of the particulate or subterranean formation or both. A method and composition for treating a subterranean formation with a fluid including forming a fluid comprising a particulate and an organosilane, introducing the fluid into a subterranean formation with exposed surfaces, and modifying the wettability of the proppant or surfaces or both, wherein the wettability modification degrades.

A method and composition for treating a subterranean formation with a fluid, including forming a fluid including a particulate and an organosilane with the chemical formula RnSiX4-n, wherein n is equal to 1, 2, or 3, R is an organic functional group, and X is a halogen, alkoxy, or acetoxy group, introducing the fluid into a subterranean formation with exposed surfaces, and modifying the wettability of a surface of the particulate or subterranean formation or both. A method and composition for treating a subterranean formation with a fluid including forming a fluid comprising a particulate and an organosilane, introducing the fluid into a subterranean formation with exposed surfaces, and modifying the wettability of the proppant or surfaces or both, wherein the wettability modification degrades. A method and composition for producing hydrocarbon from a subterranean formation, including providing a wellbore in a subterranean formation, forming a fluid including a particulate and an organosilane with the chemical formula RnSiX4-x, wherein n is equal to 1, 2, or 3, R is an organic functional group, and X is a halogen, alkoxy, or acetoxy group, introducing the fluid into the subterranean formation with exposed surfaces, modifying the wettability of a surface of the particulate or the subterranean formation or both, and producing hydrocarbon from the wellbore in the subterranean formation.

An object of the present invention is to provide a curable resin having a silyl group at the terminal that is also moisture-hardening resin which has lower in viscosity when it is used and provides superior adhesiveness when it is utilized for adhesive, sealant, and paint. The object of the invention could be achieved by a curable resin that has silicon atom-containing groups having a silicon atom bound to one or more hydrolysable groups such as alkoxy groups, acetoxy groups and oxim groups at the ends of the molecule, thioether and hydroxyl groups in the molecule, and a polymer having a polyoxyalkylene, (meth)acrylic ester, or hydrocarbon polymer as the main chain skeleton.

Novel acetyloxymethyl esters are disclosed. Methods of treating an illness, including cancer, hemological disorders and inherited metabolic disorders, and treating or ameliorating other conditions using these compounds are also disclosed. The compounds are effective in the inhibition of histone deacetylase.

The present invention provides a radiation curable coating composition for forming a polymeric coating on a glass optical fiber, the composition comprising a mixture of: a base radiation curable liquid composition capable of forming a polymeric coating; at least one adhesion promoter selected from the group consisting of bis-silyl amines, diacrylated silane tertiary amine, acetoxy functional silanes, trifunctional isocyanurates and mixtures thereof, and 0 to about 10 percent by weight of one or more photoinitiators. The present invention also includes a coated optical fiber, a method for making an optical fiber and compositions containing adhesion promoters that do not undergo free radical reaction with base radiation curable pre-polymer of the composition.

Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17a-hydroxylase / C17, 20-lyase inhibitor, such as abiraterone acetate (i.e., 3beta-acetoxy-17-(3-pyridyl) androsta-5, 16-diene), in combination with at least one additional therapeutic agent such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising a 17a- hydroxylase / C17, 20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid.

The invention relates to a coating flatting agent, in particular to a preparation of polyether terminal modified polydimethylsiloxane and an application of the polyether terminal modified polydimethylsiloxane serving as the flatting agent in coatings. The structural formula of a terminal modified organic silicone coating flatting agent is shown as follows, wherein m is equal to 0-100; and R is equal to - (CH2) 3-O-(C2H4O) x (C3H6O) y-R', wherein the x is equal to 0-100, the y is equal to 0-100, and R' is hydrogen (H) or alkyl, acetoxy group and epoxy group with one to ten carbon atoms. The flatting agent has the advantages that the surface tension of the coatings is reduced, the wettability of substrates is improved, the flowing and flatting of the coatings are increased, the surface defects are eliminated, the smoothness is improved, the surface friction coefficient of the coatings is lowered, and the scrath resistance and anti-blocking are improved.

A room temperature crosslinking, one component (RTV 1C) silicone rubber formulation with hydrophobic, silica featuring extremely low water absorption, a high level of whiteness, and fine-tunable, storage-stable rheological properties with a high reinforcing action in the silicone rubber vulcanizate contains A) from 0.5 to 60% by weight of a hydrophobic silica having the following properties: a carbon content of >3.1%; a methanol wettability of >60%; a reflectance of >94%; a BET / CTAB ratio of from >1 to <3; a DBP absorption of <230 g / 100 g; a BET surface area of from 50 to 110 m2 / g; a CTAB surface area of >30 m2 / g; a water vapor absorption at 30° C. at an ambient humidity of 30 of <1.3; a water vapor absorption at 30° C. at an ambient humidity of 70 of <1.7; and B) 40-99.5% by weight of an organopolysiloxane of the formulaZnSiR3-n—O—[SiR2O]x—SiR3-n—Z′nwherein each R represents independently alkyl, acetoxy, oxime, alkoxy, amido, aryl or alkenyl radicals, each having from 1 to 50 carbon atoms, each unsubstituted or substituted identically or differently by O, S, F, Cl, Br or I; or R represents independently polystyrene, polyvinyl acetate, polyacrylate, polymethacrylate, or polyacrylonitrile radicals, each having 50-10 000 repeating units; wherein each Z represents independently OH, Cl, Br, acetoxy, amino, amido, amineoxy, oxime, alkoxy, alkenyloxy, acyloxy or phosphate radicals, wherein said acetoxy, amino, amido, amineoxy, oxime, alkoxy, alkenyloxy and acyloxy radicals each have up to 20 carbon atoms; wherein each Z′ represents independently oxime, alkoxy, amido or acetoxy radicals; wherein n is 1-3; and wherein x is 100-15 000.

A rubber component containing at least one a diene-based rubber in an amount of 100 parts by weight and a surface-treated silica treated, on the surface thereof, with at least one silane coupling agent X represented by formula (I): wherein Y independently indicate a methoxy, ethoxy, propoxy, isopropoxy, butoxy, isobutoxy or acetoxy group, R indicates a C1 to C18 hydrocarbon group selected from a linear, cyclic or branched alkyl group, alkenyl group, aryl group, and aralkyl group and a rubber composition containing the same.

A hydrophilic modification method comprising a step of forming a coat having a solid coat amount of 0.02 to 3 g / m2 on a heat exchanger with a modifier for hydrophilicity after treatment for rust prevention thereof wherein said modifier for hydrophilicity comprises a modified polyvinyl alcohol (A) having, on a side chain thereof, a group represented by the formula (I): in the formula, n represents an integer of 1 to 500, R1 represents a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, and R2 represents a hydrogen atom or a methyl group, and at least one member (B) selected from the group consisting of phosphorus compound salts and boron compound salts of Ca, Al, Mg, Fe and Zn, said group represented by the formula (I) accounting for 0.01 to 20 mole percent relative to hydroxyl and acetoxy groups contained in said modified polyvinyl alcohol.

Provided is a ceramide emulsion containing the following components (A), (B) and (C) and not containing an acrylic acid polymer or a phospholipid: (A) sphingosines represented by Formula (1): (wherein R1 represents a hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group and the like; Y represents CH2, CH or O; X1, X2 and X3 represent H, a hydroxyl group or an acetoxy group; X4 represents H, an acetyl group or a glyceryl group or, together with an adjacent O atom, forms an oxo group; R2 and R3 represent H, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; groups “R”s are H or an amidino group or represent a hydrocarbon group having 1 to 8 carbon atoms which may have a substituent such as a hydroxyl group and the like; and “a” is 2 or 3), (B) an acidic compound selected from inorganic acids and organic acids having a molecular weight of 200 or less, and (C) ceramides represented by Formula (2): (wherein R7 represents a hydrocarbon group having 4 to 30 carbon atoms which is optionally substituted with a hydroxyl group and the like; Z represents CH2, CH or O; X5, X6 and X7 represent H, a hydroxyl group or an acetoxy group, X4 represents H, an acetyl group or a glyceryl group or, together with an adjacent O atom, forms an oxo group; R8 and R9 represent H, a hydroxyl group, a hydroxymethyl group or an acetoxymethyl group; R10 represents a hydrocarbon group having 5 to 60 carbon atoms which is optionally substituted with a hydroxyl group and the like; and R11 represents H or a hydrocarbon group having 1 to 8 carbon atoms which optionally have a substituent such as a hydroxyl group and the like).

The present invention relates to a production method capable of producing an optically active α-hydroxyphosphonic acid and its derivatives with sufficiently high enantioselectivity not only for aromatic aldehydes but also for aliphatic aldehydes, and more specifically to a method of producing an optically active α-hydroxyphosphonic acid and its derivatives, characterized in that an optically active aluminum(salalen) complex represented by any one of the following formulae (I), (I′), (II) and (II′):[wherein R1s are each alkyl group or aryl group independently; R2s are each alkyl group or aryl group independently; R3s are each alkyl group or aryl group independently, and two R3s may bond with each other to form a ring; R4s are each hydrogen atom, halogen atom, alkyl group, alkoxy group, nitro group, or cyano group independently; R5 is alkyl group; and X1 is halogen atom, alkyl group, alkoxy group, acetoxy group or toluenesulfonyloxy group] is used as a catalyst to asymmetrically hydrophosphonylate an aldehyde with phosphonic acid or its derivatives.

The invention discloses a room temperature crosslinkable and curable styrene-acrylate emulsion, and its preparation method. The styrene-acrylate emulsion adopts a non-APEO emulsifier to emulsify, proper amounts of phosphate groups, hydroxy groups, siloxane groups, epoxide groups and acetylacetoxy groups are introduced to a system to make the adhesion of a film of a styrene-acrylate emulsion anti-corrosion coating reach first order, and the coating cures at 25DEG C for 6 days to form the film, so the salt mist resistance is not less than 240h, the impact resistance is 50Kg / cm, and excellent anti-corrosion performance and mechanical performances are possessed; and the substitution of traditional organic solvents by a water solvent reduces the VOC discharge, accords with a 8E' principle, and reaches environmental protection and energy saving purposes.

Provided is a toner comprising a toner particle including a toner base particle and fine particles present on a surface of the toner base particle, wherein each of the fine particles includes a core fine particle and a condensate of at least one organosilicon compound selected from the group consisting of organosilicon compounds represented by specific structural formulas, the condensate coating the surface of the core fine particle, and in a wettability test of the toner with respect to a methanol / water mixed solvent, a methanol concentration, when a transmittance of light having a wavelength of 780 nm is 50%, is 5.0 to 20.0% by volume:in above Formulas, each of Ra, Rb and Rc independently represents an alkyl group, an alkenyl group, an acetoxy group, an acyl group, an aryl group, or a methacryloxyalkyl group, R1 to R5 each independently represents a halogen atom or an alkoxy group.

The invention discloses a preparation method for imipenem medicine intermediate 4AA. The preparation method comprises making 4-substituted aniline into an intermediate A, perform epoxidation on L-threonine to produce (2R, 3R)-epoxy butyric acid; enabling (2R, 3R)-epoxy butyric acid and the intermediate A to undergo a coupling reaction, obtaining an intermediate B, enabling the intermediate B to undergo a cyclization reaction, obtaining an intermediate C, enabling the intermediate C to undergo a hydroxyl protection reaction, obtaining an intermediate D, enabling the intermediate D to be oxidized to form an acetoxy group, and enabling an oxidized product to undergo an ozonation reaction, wherein G is H, F, Cl, Br, a methoxy group, oxethyl or an amino group; and R is H, straight chain alkyl of C1-C6, cyclopropyl, isopropyl, tert-butyl, a phenyl group, p-chlorophenyl, o-chlorophenyl, p-bromophenyl, o-bromophenyl, p-methoxyphenyl, o-methoxyphenyl or m-methoxyphenyl. According to the preparation method, raw materials are cheap and easy to obtain, reaction conditions are mild, the conversion rate and the yield rate are high, and the preparation method is suitable for industrial production.

The invention includes a method of forming an alpha, beta-unsaturated compound. A carboxylic acid is mixed with an alpha-hydroxy acid or an alpha-hydroxy ester and is esterified to form an alpha-acyloxy derivative. The alpha-acyloxy derivative is transformed into an alpha, beta-unsaturated derivative. The invention additionally includes a process of forming an acrylate. Lactic acid or a lactic acid ester is reacted with a first portion of acetic acid in the presence of a first catalyst to produce the corresponding 2-acetoxy propionic acid or ester. A non-reacted portion of the acetic acid is recycled. The 2-acetoxy propionic acid or ester is transferred to a second vessel containing a second catalyst, and acetic acid is liberated from the 2-acetoxy propionic acid or ester to produce a corresponding acrylic acid or acrylate ester. The acid or ester is subsequently esterified by reaction with an alcohol to form a desired acrylate ester.

The invention discloses a method of acquiring high-purity 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione, comprising the following steps: a) putting the acquired crude 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione in a proper solvent system to generate a pure 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione solid; b) separating the 17 alpha-acetoxy-11 beta-(4-N, N-dimethylaminophenyl)-19-norpregna-4,9-diene-3,20-dione solid; and c) carrying out recrystallization on the acquired solid. The compound used as a new oral emergency contraception can be taken in 120 h after unprotected sexual intercourse of women without a reduction of emergency contraception effect with the delay of the time of using drugs, and has good safety and survivability simultaneously.

The invention discloses a quinaldine derivative b fluorescent and colorimetric reagent as well as a preparation method and an application thereof and belongs to the field of organic synthesis and analytical chemistry. 8-hydroxyquinaldine serving as a raw material has a Knoevenagel condensation reaction with 2,4-dihydroxy benzaldehyde to obtain an intermediate a, wherein the chemical name of the intermediate a is (E)-2-(2,4-didiacetoxylphenyl)ethenyl-8-acetoxyquinoline; the intermediate a is hydrolyzed in a mixed medium of pyridine and water to obtain a derivative b, wherein the chemical name of the derivative b is (E)-2-(2,4-dihydroxylphenyl)ethenyl-8-hydroxyquinoline. The reaction materials are easily available; the synthesis method is simple; a target product can be obtained by two-step reaction. In a special solvent medium, the derivative b can act as fluorescent and colorimetric reagent for detecting Al<3+> and F-. The structural formula of the derivative is shown in the specification.

The emulsion composition of the present invention contains(A) 0.001 to 10 wt. % of an organic compound having two or more hydroxyl groups, an inorganic value of 220 to 450, and an organic value of 300 to 1,000;(B) 0.001 to 10 wt. % of an organic compound having one hydroxyl group, an inorganic value of 100 to 200, and an organic value of 280 to 700;(C) 0.001 to 10 wt. % of a compound represented by formula (2):wherein R1 is a C4 to C30 hydrocarbon group; Z is a methylene group, a methine group, or an oxygen atom; X1, X2, X3 is a hydrogen atom, a hydroxyl group, or an acetoxy group; X4 is a hydrogen atom, an acetyl group, or a glyceryl group; each of R2 and R3 a hydrogen atom, a hydroxyl group, a hydroxymethyl group, or an acetoxymethyl group; R4 is a C5 to C60 hydrocarbon group; and R5 is a hydrogen atom or a hydrocarbon group containing 1 to 30 carbon atoms in total;(D) 0.00012 to 10 wt. % of at least one compound selected from the group consisting of a nonionic surfactant having a polyoxyethylene group and an HLB of 10 or higher, an ionic surfactant, and a sphingosine salt;(E) 0.003 to 15 wt. % of at least one compound selected from the group consisting of a sugar alcohol selected from the group consisting of erythritol, threitol, xylitol, and mannitol, a disaccharide, and a trisaccharide; and(F) water.

The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I′)wherein R1 is a hydrogen atom, a hydroxyl group, a methoxy group or an ethoxy group, R2 is a hydroxyl group, a methoxy group or an acetoxy group, or R1 and R2 in combination optionally form a methylenedioxy group,R is represented by the following formulawherein Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=2 to 8, and R3 and R4 are each independently a hydrogen atom, a methyl group or an ethyl group,provided that,(1) when R1 is a methoxy group, then R2 is not a hydroxyl group; and(2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy group.According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided.

The invention relates to a method for hydroformylation of vinyl acetate. The method comprises the step of enabling the vinyl acetate to be in contact with carbon monoxide and hydrogen gas in the presence of a solvent and a catalyst system, wherein the catalyst system contains a rhodium complex and a phosphine ligand; the rhodium complex is one or more selected from rhodium(triphenylphosphine)carbonyl acetylacetonate, rhodium acetylacetone and chlorocarbonylbis(triphenylphosphine)rhodium; and the phosphine ligand is one or more selected from phosphine-containing organic matters represented by the following formulae shown in the description, wherein Ar in the formulae (1, 3 and 4) is substituted or unsubstituted aryl, M in the formula (2) is hydrogen, halogen element or substituted or unsubstituted alkyl, and t in the formula (3) is an integer from 2 to 10. According to the method, the selectivity to 3-acetoxypropanal in a hydroformylation reaction process of the vinyl acetate can be improved while a relatively high conversion ratio is guaranteed under the conditions of relatively low reaction temperature and reaction pressure.

The invention relates to a novel method for preparing rocuronium bromide 1-[17beta-acetoxyl-3alpha-hydroxyl-2beta-(4-morpholinyl)-androstane-16beta-yl]-1-(2-propenyl) pyrrole bromide, the problem of chemoselectivity of pyrrolidine open epoxy in an original line is solved, generation of byproducts is avoided, reaction yield is greatly improved, the production cost is reduced, column chromatography separation is avoided, and aftertreatment purification is implemented easily.

The invention discloses a method for preparing 4-acetoxy-2-methyl-2-butenal. The method comprises the following steps of: carrying out a methyl esterification reaction, an ester exchange reaction and an oxidizing reaction on 1-acetoxy-4-chloro-3-methyl-2-butene to obtain a product of 4-acetoxy-2-methyl-2-butene-1-ol. According to the method, the problems of raw material cost and environment friendliness are comprehensively considered, the 4-acetoxy-2-methyl-2-butenal is synthesized through chloride ester through a three-step reaction which is mild in conditions and high in yield, an easily recovered organic solvent is adopted in the reaction of each step, the pollutant discharge is greatly reduced, the pollution problem is effectively solved due to the improvement of a synthetic route, the yield is improved, the raw material cost is reduced, the effective resource treatment is realized, and the method is suitable for industrial production.

The present invention relates to acetamido glucose derivatives of indomethacin and their synthesis process and use. The kinds of acetamido glucose derivatives of indomethacin prepared with indomethacin and acetamido glucose are 1-O-[1-(4-chloro-benzoyl)-5 -methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose and 6-O-[1-(4-chloro-benzoyl)-5-methoxy-2-methyl-3-indolyl-acetoxy]-2-acetylamino-2-deoxy-alpha-D-glucose. The derivatives of the present invention has the activity of inhibiting mouse ear dropsy caused by croton oil and may be used in preparing antiphlogistic medicine.

The present invention relates to a pharmaceutical composition, a food composition or a cosmetic composition, containing one or more kinds of a compound represented by the following formula (I′)wherein R1 is a hydrogen atom, a hydroxyl group, a methoxy group or an ethoxy group, R2 is a hydroxyl group, a methoxy group or an acetoxy group, or R1 and R2 in combination optionally form a methylenedioxy group,R is represented by the following formulawherein Y is an ethylene group or a vinylene group, m and n are each an integer of 0 to 7, which satisfy m+n=2 to 8, and R3 and R4 are each independently a hydrogen atom, a methyl group or an ethyl group,provided that,(1) when R1 is a methoxy group, then R2 is not a hydroxyl group; and(2) when R1 is a hydroxyl group, then R2 is not a hydroxyl group and an acetoxy group.According to the present invention, a stable capsinoid derivative is provided, and a pharmaceutical composition, a food composition, a cosmetic composition and the like containing the derivative as an active ingredient can be provided.