39 results about "Lyase inhibitor" patented technology

Methods and compositions for treating cancer are described herein. More particularly, the methods for treating cancer comprise administering a 17a-hydroxylase / C17, 20-lyase inhibitor, such as abiraterone acetate (i.e., 3beta-acetoxy-17-(3-pyridyl) androsta-5, 16-diene), in combination with at least one additional therapeutic agent such as an anti-cancer agent or a steroid. Furthermore, disclosed are compositions comprising a 17a- hydroxylase / C17, 20-lyase inhibitor, and at least one additional therapeutic agent, such as an anti-cancer agent or a steroid.

The present invention provides methods and compositions for treating cancers using a combination of a CYP 1 7 inhibitor and an additional therapeutic agent which modulates the PBK / Akt / mTOR pathway. In one aspect, the invention provides methods for the treatment of a disorder in a human subject. In some embodiments, the disorder is a neoplastic disorder. In some embodiments, the neoplastic disorder is a cancer. In some embodiments, the method comprises administering to said subject a 17a-hydroxylase / C17,20-lyase inhibitor (CYP17 inhibitor) and an additional agent, wherein the additional agent is a PBK inhibitor and / or mTOR inhibitor.

The invention relates to microorganisms, in particular to a method for screening a trimethylamine lyase inhibitor by utilizing microorganisms. The method for screening the trimethylamine lyase inhibitor by utilizing microorganisms is characterized by comprising the following steps: inoculating a specific culture medium only containing cholineinoculator with Klebsiella pneumoniae ATCC 13883 servingas an indicator; adding a substance to be screened into the culture medium at a concentration lower than the minimum inhibitory concentration, and carrying out anaerobic culture for 12-48 hours at 37DEG C; and taking a culture solution, determining the content of trimethylamine, taking a culture solution without the to-be-detected substance as a contrast, and indicating that the substance can inhibit microorganisms from converting choline to generate trimethylamine and is a trimethylamine lyase inhibitor when the content of trimethylamine is lower than that of a control group; The method hasthe advantages of quickness, simplicity, convenience, easiness in operation, low reagent demand, capability of performing high-throughput screening and accurate result.