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1675 results about "Coumarin" patented technology

Coumarin (/ˈkuːmərɪn/) or 2H-chromen-2-one is an aromatic organic chemical compound with formula C9H6O2. Its molecule can be described as a benzene molecule, with two adjacent hydrogen atoms replaced by a lactone-like chain –(CH)=(CH)–(C=O)–O–, forming a second six-membered heterocycle that shares two carbons with the benzene ring. It can be placed in the benzopyrone chemical class, and as a lactone.

Novobiocin analogues as anticancer agents

Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
Owner:UNIVERSITY OF KANSAS +1

Novobiocin analogues as anticancer agents

Novel analogues and derivatives of novobiocin are provided, including compounds having modifications to the amide side chain, coumarin ring, and sugar moieties. The compounds of the present invention are useful as heat shock protein 90 inhibitors, and may be used as anticancer and neuroprotective agents.
Owner:UNIVERSITY OF KANSAS +1

Electroluminescent devices

This invention relates to compositions and electroluminescent (EL) devices that have enhanced performance as a result of a novel class of anthracene derivatives used as host materials for a full range of color dopands. When using coumarin derivatives as color dopands in the anthracene derivatives in an EL device, the device performs a desirable light emitting efficiency and durability. The performance of the EL device can be further improved by using benazole derivatives as the electron transporting layer. The organic EL device of the present invention is useful in preparing display devices.
Owner:ELIGHT

Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.
Owner:PACIFIC ARROW

Photo-induced reversible self-repair polyurethane film and repair method

The invention relates to a photo-induced reversible self-repair polyurethane film and a preparation method and a repair method thereof. The polyurethane film mainly comprises 10 to 40 parts of phenolic hydroxyl coumarin derivative, 10 to 50 parts of alkyl bromal compound, 10 to 40 parts of polyisocyanate, and 10 to 30 parts of polyether polyol or polyester polyol. The preparation method comprises the following steps of: generating phenolic hydroxyl coumarin by using the phenolic hydroxyl coumarin derivative and the alkyl bromal compound under the action of absolute potassium carbonate; and reacting the phenolic hydroxyl coumarin, the polyisocyanate and the polyether polyol or the polyester polyol to obtain polyurethane solution, and performing cross linking under the irradiation of ultraviolet with wavelength of 350 nanometers after the film is formed to obtain the polyurethane film. The damaged surface is irradiated through the ultraviolet with wavelength of 254 to 350 nanometers, so that the reduced coumarin monomers are subjected to dimer cross linking reaction again and the purpose of repairing cracks is fulfilled. Compared with the prior art, the polyurethane film has the characteristics of good film forming property and high transparency; and the repair process is simple and has low cost.
Owner:SUN YAT SEN UNIV

Organic semiconductor lasers

Lasers comprising a substrate and a layer of organic material over the substrate. The organic material includes host and dopant materials that result in the laser emission of a desired color when pumped by optical pump energy. Host materials include CBP and tris-(8-hydroxyquinoline) aluminum, which when combined with dopant materials such as coumarin-47, coumarin-30, perylene, rhodamine-6G, DCM, DCM2, and pyrromethane-546 result in the efficient lasing of colors such as blue, green and yellow.
Owner:SOUTHERN CALIFORNIA UNIV OF THE +2

Skin lightening agents, compositions and methods

InactiveUS6852310B2Effective skin lightening propertyLess irritatingCosmetic preparationsHair cosmeticsHydrogen atomAlkoxy group
Cosmetic methods of skin lightening using coumarin derivatives of formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle: Where each or both R1 and / or R2 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, cycloalkyl, cycloalkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups;Each or both R3 and / or R4, which may be connected by a single or double carbon-carbon bond (shown as a dotted line), represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, alkoxy, cycloalkyl, or cycloalkenyl group; andEach or both R5 and / or R6 represents a hydrogen atom, OH, C1-C4 acyl group, C1-C4 alkyl group, O—CO—R7, O—COO—R8 group, mesyl group or tosyl group, where each or both R7 and / or R8 represents hydrogen; linear or branched C1-C18 alkyl, alkenyl, hydroxyalkyl, hydroxyalkenyl, acyl, cycloacyl, or alkoxy groups.
Owner:UNILEVER HOME & PERSONAL CARE USA DIV OF CONOPCO IN C

Skin lightening agents, compositions and methods

Cosmetic compositions and methods, particularly for skin lightening, using 7-hydroxy-2-phenyl coumarin and derivatives of general formula I as skin lightening agents alone or in combination with other skin benefit agents and together with a cosmetic vehicle:Where R1 and / or R2 may be positioned at the 1-, 2-, 3-, 5-, and / or 6-positions on the phenyl ring. Each or both R1 and / or R2 represents a hydrogen atom, OH, C1–C4 acyl group, or C1–C4 alkyl group; andR represents a hydrogen atom, C1–C4 acyl group, or C1–C4 alkyl group.
Owner:CONOPCO INC D B A UNILEVER

Coumarin-based cyanine dyes for non-specific protein binding

Protein dyes whose molecular structure is that of a coumarin moiety coupled to a quaternary ammonium heterocycle through a vinyl or polyvinyl linkage demonstrate the ability to associate with proteins in a non-covalent, non-specific manner at low pH, where the associated form displays a significantly higher fluorescence emission than the unassociated form. This makes the dyes useful as selective labels for proteins at the low pH and eliminates the need for the removal of extraneous components from the medium in which the proteins reside prior to detection.
Owner:BIO RAD LAB INC

3,4-Disubstituted coumarin and quinolone compounds

InactiveUS20060223783A1High substituent toleranceBiocideOrganic chemistryQuinoloneMedicine
The present invention relates to 3,4-disubstituted coumarin and quinolone derivatives and processes for their preparation. The invention also related to methods for treating infection of Hepatitis C virus by administering a 3,4-disubstituted coumarin or quinolone derivative.
Owner:XTL BIOPHARMLS

SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors

Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
Owner:CERCACOR LAB INC

Application of flavonoids of celery seed and coumarins in preparation of drug for preventing and treating gout

The invention disclosed the application of celery seed coumarins and flavanoid in preparing arthrifuge, anti-inflammatory agent or health food, which belongs to the natural occurring drugs and medical technology domain. The coumarins and flavanoid is the extract from acetic ether. The preparing method includes the following steps: selecting 10kg celery dry seed, adding 15-20 times of 75-95%(V / V) as the seed or extracting with 4-5 times of 75-95%(V / V) alcohol at higher temperature, heating for 1-1.5h every time; vacuum condensing the extracts until nearly all the alcohol is away; adding 1-2 times of water, extracting with 1 / 3 volume of the diluted solution sherwood oil (60-90DEG C) for 2-3 times; reclaiming the sherwood oil; extracting the water layer with 1 / 3 volume of acetic ether for 4 times; reclaiming the acetic ether to get the extracts. The invention has very simple preparing technologies; the product in the invention has obvious anti-inflammatory function; it can also decrease the amount of serum uric acid of rats.
Owner:BEIJING HUMANWELL JUNWEI PHARM TECH CO LTD

Phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe for iron ion detection and synthesis and use methods thereof

The invention provides a phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe for iron ion detection and synthesis and use methods thereof, relates to fluorescent molecular probes and synthesis and application thereof and aims to solve the problem that an existing Fe<3+> fluorescent probe is prone to being interfered by pH, concentration and other metal ions. The fluorescent molecular probe is 4-methyl-7-hydroxide radical-8-[2-(1- phenyl group-1H-phenanthrene and [9, 10-d] imidazole-2-)benzene ammonia methylene]-2H-pyran-2-ketone. The phenanthrene and imidazole-coumarin double-fluorescent group ratio fluorescent molecular probe is formed by conducting condensation on 1-N-phenyl group-2-(2-aminophenyl)-1H-phenanthrene and [9, 10-d] imidazole and 4-methyl-7-hydroxide radical-8- formyl group coumarin, and the yield is 75-85%. The fluorescent molecular probe is dissolved in mixed liquid of N, N- dimethylformamide and an HEPES buffering solution, existence of iron ions is judged through the absorbance value or fluorescence intensity change before and after adding of test samples, and the fluorescent molecular probe can be used for detection of Fe<3+> pollution in water.
Owner:QIQIHAR UNIVERSITY

Composition comprising xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

InactiveUS20050220910A1Preventing cerebral agingEnhance memoryBiocideSugar derivativesRheumatismHeadaches
This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating cancer, arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder, impotence and premature ejaculation; for preventing cerebral aging; for improving memory, cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's disease or other diseases caused by cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, dizziness, kidney disorder. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications.
Owner:PACIFIC ARROW

Agents for treatment of glaucomatous retinopathy and optic neuropathy

InactiveUS20050137146A1Delaying and preventing lossImprove availabilityBiocideSenses disorderQuinoneThiocarbamate
Agents that stimulate nuclear translocation of Nrf2 protein and the subsequent increases in gene products that detoxify and eliminate cytotoxic metabolites are provided in a method for treating glaucomatous retinopathy or optic neuropathy. The structurally diverse agents that act on the Nrf2 / ARE pathway induce the expression of enzymes and proteins that possess chemically versatile cytoprotective properties and are a defense against toxic metabolites and xenobiotics. Agents include certain electrophiles and oxidants such as a Michael Addition acceptor, diphenol, thiocarbamate, quinone, 1,2-dithiole-3-thione, butylated hydroxyanisole, flavonoid, an isothiocyanate, 3,5-di-tert-butyl-4-hydroxytoluene, ethoxyquin, a coumarin, combinations thereof, or a pharmacologically active derivative or analog thereof.
Owner:ALCON INC

Composition comprising Xanthoceras sorbifolia extracts, compounds isolated from same, methods for preparing same and uses thereof

InactiveUS7524824B2Preventing cerebral agingEnhance memoryBiocideSugar derivativesSide chainProstate cancer
This invention provides compositions, methods and process of producing extracts from Xanthoceras sorbifolia. The extract comprises alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, saponins, tannins, acid, flavonoids and others. The composition can be used for treating breast, leukocyte, liver, ovarian, bladder, prostate, bone or brain cancer. This invention provides compounds comprising at least one sugar, a triterpene, such as Sapogenin, and at least one side chains at Carbon 21 and 22, such as Angeloyl groups. The compounds of the present have various pharmaceutical and therapeutic applications, including treating breast, leukocyte, liver, ovarian, bladder, prostate, bone or brain cancer.
Owner:PACIFIC ARROW

Light emitting device containing phosphorescent complex

An OLED device comprises a cathode, an anode, and has therebetween a light emitting layer comprising a phosphorescent emitter represented by Formula (I):LnM   (I)wherein each L is a cyclometallated ligand with at least one containing a coumarin group, M is Ir or Pt, and n is 3 when M is Ir and 2 when M is Pt. The invention also comprised the compound of formula (I).
Owner:GLOBAL OLED TECH

Photocurable polymeric dielectrics and methods of preparation and use thereof

Disclosed are polymer-based dielectric compositions (e.g., formulations) and materials (e.g. films) and associated devices. The polymers generally include photocrosslinkable pendant groups; for example, the polymers can include one or more coumarin-containing pendant groups.
Owner:FLEXTERRA INC

Coumarin-oxacalix[3]arene fluorescent reagents as well as preparation method and application thereof

The invention discloses coumarin-oxacalix[3]arene fluorescent reagents as well as a preparation method and application thereof, and belongs to the fields of organic synthesis and analytical chemistry. The invention respectively synthesizes two coumarin-oxacalix[3]arene fluorescent reagents: chemical name a: 7,15,23-tertiary butyl-25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene; b: 7,15,23-triethoxycarbonyl -25,26,27-tri{1-[N-(7-coumarin oxyethyl)-1,2,3-triazole]-4-methoxy}-3,11,19-trioxacalix[3]arene. Meanwhile, the invention discloses a synthesis method and process conditions. According to the invention, the two coumarin-oxacalix[3]arene fluorescent reagents, in detecting ferric ions, have characteristics of high selectivity and high sensitivity; the fluorescent reagents are applicable to qualitative and quantitative analysis.
Owner:GUIZHOU UNIV

Genetically encoded fluorescent coumarin amino acids

The invention relates to orthogonal pairs of tRNAs and aminoacyl-tRNA synthetases that can incorporate the coumarin unnatural amino acid L-(7-hydroxycoumarin-4-yl) ethylglycine into proteins produced in eubacterial host cells such as E. coli. The invention provides, for example but not limited to, novel orthogonal synthetases, methods for identifying and making the novel synthetases, methods for producing proteins containing the unnatural amino acid L-(7-hydroxycoumarin-4-yl)ethylglycine and related translation systems.
Owner:THE SCRIPPS RES INST

Four-color fluorescence labeling reversible terminal and use thereof in DNA (Deoxyribonucleic Acid) sequencing

The invention discloses a four-color fluorescence labeling reversible terminal and a use thereof in DNA (Deoxyribonucleic Acid) sequencing. The structural formula of the reversible terminal is as shown in a formula (I) in the specification, wherein R1 is triphosphate; R2 is H or OH; the basic group is U, C, A, G or derivatives thereof; the connecting unit is a bifunctional compound which is breakable under a mild condition; the fluorescence group is one selected from a combination of BODIPY, fluorescein, rhodamine, coumarin, xanthene, cyanin, pyrene, phthalocyanine, alexa, squarene dye and an energy transferring dye, and derivatives thereof. The reversible terminal provided by the invention can be used for DNA single-molecule sequencing; simultaneously, raw materials required by the synthesis of the reversible terminal provided by the invention are simple and easy to get and the synthesis process of the reversible terminal is completely involved with conventional chemical reactions, so that the four-color fluorescence labeling reversible terminal can be popularized and utilized to a large scale; biological evaluation results indicate that the reversible terminal is capable of completely meeting the biochemical reaction requirements of high-flux sequencing and has a good practical prospect.
Owner:SHANGHAI JIAO TONG UNIV

Fluorescent probe for selectively detecting zinc ions in cells, synthesizing method thereof and application thereof

The invention relates to a fluorescent probe for selectively detecting zinc ions in cells, a synthesizing method thereof and application thereof. The fluorescent probe has good selectivity for the zinc ions in vitro, and can be used for quick imaging of the zinc ions in the cells. The synthesizing method comprises the following steps: dissolving a coumarin-3-carbonyl compound with R1, R2, R3, R4 and R5 substituted groups into a drying organic solvent, slowing dropping 2-hydrazopyridine with R6 substituted group into the solution under refluxing and stirring, filtering the mixture after refluxing and stirring reaction, and removing the organic solvent to obtain the fluorescent probe (1) for selectively detecting the zinc ions in the cells. The fluorescent probe can be used for analysis detection and fluorescent imaging detection for the zinc ions in biological living cells and living tissues and detection for the zinc ions in pathological tissues in clinical medicine.
Owner:TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI

Organic Electroluminescent Device

The present invention relates to an organic electroluminescent device comprising an anthracene derivative represented by Formula (1) shown below as a host and at least one selected from a perylene derivative, a borane derivative, a coumarin derivative, a pyran derivative, an iridium complex and a platinum complex as a dopant. The organic electroluminescent device of the present invention has a high efficiency, a long life, a low driving voltage and a high durability in storing and driving. wherein R1 to R4 and R12 are independently hydrogen or alkyl having 1 to 12 carbon atoms; R5 to R11 are independently hydrogen, alkyl having 1 to 12 carbon atoms, cycloalkyl having 3 to 12 carbon atoms or aryl having 6 to 12 carbon atoms; and Ar is non-condensed aryl represented by Formula (3); and m is an integer of 1 to 3; wherein n is an integer of 0 to 5; R13 to R21 are independently hydrogen, alkyl having 1 to 12 carbon atoms or aryl having 6 to 12 carbon atoms.
Owner:CHISSO CORP

Coumarin-carbazole type oxime ester compound as well as preparation method and application thereof

The invention relates to the technical field of novel material organic chemicals, relates to a coumarin-carbazole type oxime ester compound as well as a preparation method and application thereof, and in particular relates to a novel compound of a structure of formula (I) or (II) as shown in the specification, a chemical preparation process technique of the novel compound, application of the novel compound as a radiation curing light-sensitive initiator, a radiation curing formula product of the novel compound, and particularly application of the novel compound in multiple places such as UV-Vis-LED excited light cured coatings or ink.
Owner:TONGJI UNIV

Fluorescent retroreflective sheet

This invention provides encapsulated type fluorescent retroreflective sheeting which is excellent in appearance and weatherability, and which comprises a surface-protective layer disposed on the side on which light is to strike, a binder layer connected to the surface-protective layer through network bonding parts, an air layer which is sealed-up by the network bonding parts between the surface-protective layer and the binder layer, and a retroreflective element layer disposed between the surface-protective layer and the air layer, or between the binder layer and the air layer, wherein at least one layer located on the light-incident side of sealed-up air layer contains at least one fluorescent dye selected from the group consisting of benzimidazole coumarin type-fluorescent dyes of formula (1) as follows: and benzopyran type-fluorescent dyes of formula (2) as follows:
Owner:NIPPON CARBIDE KOGYO KK

Environmentally friendly shell powder functional coating and preparation method therefor and uses thereof

The present invention relates to an environmentally friendly shell powder functional coating, a preparation method therefor and uses thereof. The coating comprises: bisphenol A-epon, modified shell powder, vegetable extract, propyl silicone emulsion, a nano additive, a modified organic micro powder agent, a surfactant, dioctylphthalate, 3, 3'-(4-trifluoromethyl methyl)-bi-4-hydroxy coumarin, 2,2,4-amino trimethyl-1,3-isoprene glycol mono iso-butyl methacrylate, butyl acetate, ethanol, trimethylol propane triacrylate, N-ammonia amino ethyl piperazine, polydimethylsiloxane and deionized water. In the present invention, by modification of a variety of components and materials, selection and collocation of specific components and a specific preparation method, the variety of components exert a synergistic effect, so as to make the prepared coating have significant antimicrobial, environmental-cleaning and wear-resisting properties. The coating has a huge application potential and extensive value in industrial production.
Owner:广西世家丽环保投资有限公司

Coumarin derivatives as well as preparation method and application thereof

InactiveCN103570701ANo significant fluorescence responseHigh fluorescence intensityOrganic chemistryBiological testingDiseaseFluorescence
The invention provides coumarin derivatives as well as a preparation method and application thereof. The coumarin derivatives have the molecular formula: Cl3H6N2O4. The preparation method comprises the steps: firstly, preparing 4-chloromethyl-7-hydroxycoumarin, 4-hydroxymethyl-7-hydroxycoumarin and 7-hydroxycoumarin-4-formaldehyde; and then, adding the 7-hydroxycoumarin-4-formaldehyde into water, next, adding malononitrile and 1-methylimidazole, stirring at the room temperature, and filtering to obtain 2, 2-dicyano-3-(7-hydroxyl-4-coumarinyl)oxacyclopropane. The 2, 2-dicyano-3-(7-hydroxyl-4-coumarinyl)oxacyclopropane prepared by the preparation method can be used as a fluorescent probe for selectively detecting cysteine in an organism and can also be used for fluorescently marking cysteine in a cell so as to provide help for the diagnosis of related diseases in clinical medicals.
Owner:SHANXI UNIV

Method for synthesizing coumarin and derivatives thereof under catalysis of choline ionic liquids

The invention discloses a method for synthesizing coumarin and derivatives thereof under catalysis of choline ionic liquids. According to the technical scheme, the method is characterized in that the coumarin and the derivatives thereof are prepared from a phenolic compound and beta-ketonic acid or keto ester under the catalytic action of choline ionic liquids and the choline ionic liquids include an ionic liquid of melted binary acid and choline chloride, a functionalized acidic choline ionic liquid and a protonized choline ionic liquid. According to the method disclosed by the invention, the synthesized choline ionic liquid is used for Pechmann condensation reaction; the negative and positive ions of the ionic liquids are adjusted according to the catalytic effect based on different acid-base properties of the ionic liquids, so that better catalytic effect can be achieved; the choline ionic liquids take the place of dangerous concentrated sulfuric acid when the choline ionic liquids are used for catalyzing the Pechmann reaction; the reaction conditions are simple, the product is easy to separate and no by-product is generated; more importantly, the catalyst can be reused.
Owner:HENAN NORMAL UNIV
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