8930 results about "Saponin" patented technology

Rebaudioside M compositions with improved aqueous solubility and methods for preparing the same are provided herein. The rebaudioside M compositions include (i) disordered crystalline compositions comprising rebaudioside M and rebaudioside D, (ii) spray-dried compositions comprising rebaudioside M, rebaudioside D and steviol glycoside mixtures and / or rebaudioside B and / or NSF-02, (iii) spray-dried compositions comprising rebaudioside M, rebaudioside D and at least one surfactant, polymer, saponin, carbohydrate, polyol, preservative or a combination thereof. Sweetened compositions, such a beverages, containing the rebaudioside M compositions with improved water solubility are also provided herein.

The present invention relates generally to functional sweetener compositions comprising non-caloric or low-caloric natural and / or synthetic high-potency sweeteners and methods for making and using them. In particular, the present invention relates to different functional sweetener compositions comprising at least one non-caloric or low-caloric natural and / or synthetic high potency sweetener, at least one sweet taste improving composition, and at least one functional ingredient, such as saponin. The present invention also relates to functional sweetener compositions and methods that can improve the tastes of non-caloric or low-caloric high-potency sweeteners by imparting a more sugar-like taste or characteristic. In particular, the functional sweetener compositions and methods provide a more sugar-like temporal profile, including sweetness onset and sweetness linger, and / or a more sugar-like flavor profile.

It is intended to easily separate saponins from isoflavones extracted from starting soybeans thereby giving highly pure saponins at a high yield on an industrial scale. Saponins can be highly efficiently separated from isoflavones by performing multistage extraction under mild conditions such that malonyl isoflavone glycoside, from among isoflavones contained in the starting soybeans, is not converted into isoflavone glycoside, acetyl isoflavone glycoside or isoflavone aglycon. Thus, highly pure saponins can be obtained at a high yield on an industrial scale.

This invention provides compositions, methods and process of producing extracts and pure compounds from Xanthoceras sorbifolia. The extract comprises saponins and other constituents including alkaloids, coumarins, saccharides, proteins, polysaccharides, glycosides, tannins, acid, flavonoids and others. The composition can be used for treating cancer and other conditions, such as arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, coronary heart disease, headache, kidney disorder, and impotence; for improving cerebral functions; or for curing enuresis, frequent micturition, urinary incontinence, dementia, weak intelligence and Alzheimer's disease, autism, brain trauma, Parkinson's, cerebral dysfunctions, and treating arthritis, rheumatism, poor circulation, arteriosclerosis, Raynaud's syndrome, angina pectoris, cardiac disorder, headache, dizziness, kidney disorder. This invention provides compounds of oleanene triterpenoidal saponin in nature with the characteristics that at least one angeloyl group attache to Carbon 21 or / and 22, or / and linked to the sugar. The compounds of the present invention have various pharmaceutical and therapeutic applications.

Nanoparticles formed by emulsion of one or more core polymers, one or more surface altering materials, and one or more low molecular weight emulsifiers have been developed. The particles are made by dissolving the one or more core polymers in an organic solvent, adding the solution of the one or more core polymers to an aqueous solution or suspension of the emulsifier to form an emulsion, and then adding the emulsion to a second solution or suspension of the emulsifier to effect formation of the nanoparticles. In the preferred embodiment, the molecular weight of the emulsifiers is less than 1500, 1300, 1200, 1000, 800, 600, or 500 amu. Preferred emulsifiers include cholic acid sodium salt, dioctyl sulfosuccinate sodium, hexadecyltrimethyl ammonium bromide, saponin, TWEEN® 20, TWEEN® 80, and sugar esters. The surface altering materials are present in an amount effective to make the surface charge of the particles neutral or essentially neutral when the one or more emulsifiers are charged. The emulsifiers have an emulsification capacity of at least about 50%, preferably at least 55, 60, 65, 70, 75, 80, 85, 90, or 95%.

The invention discloses a comprehensive extraction method for extracting tea seed oil, tea saponin and tea seed polysaccharide from tea seeds or camellia seeds, belonging to the process fields of grain and oil processing and byproduct extraction. The method comprises the following steps of: with shelled tea seeds as a raw material, firstly, cooking to produce oil; then, adding an exogenous enzyme to obtain a boiled oil layer of a first level an emulsified oil layer, a water layer and a slag layer through zymolysis, blanching and still standing; demulsifying the emulsified oil layer to take boiled oil of a second level; mixing the oil layers of the two levels; centrifugalizing to obtain the tea seed oil; depositing the water layer in alcohol to separate the tea saponin and the tea seed polysaccharide; leaching the slag layer with water or monohydric alcohol to further separate the tea saponin and the tea seed polysaccharide; and purifying a clear solution which is leached with the water or the alcohol with a macroporous absorption resin chromatography column, eluting a resin adsorbate with a base and then an ethanol and collecting an ethanol eluant to obtain high-purity tea saponin. The tea seed oil, the tea saponin and the tea seed polysaccharide are synchronously prepared, thus the invention realizes that a tea seed or camellia seed resource is comprehensively extracted and utilized and has the advantages of simple process, less needed equipment and low cost.

The invention discloses multi-herb antibacterial liquid, relates to an external medicament for treating skin diseases and a preparation method thereof, and belongs to a medical external medicament. The external liquid medicine for treating various skin diseases comprises the following medicinal components by weight: 10-20 g of folium artemisiae argyi, 10-15 g of white mulberry branch, 10-15 g of angelica root, 10-15 g of galanga, 5-20 g of isatis root, 10-15 g of mint, 10-15 g of schizonepeta, 10-15 g of lithospermum, 5-15 g of fructus forsythiaev, 10-20 g of cortex dictamni, 10-15 g of rhizoma atractylodis, 10-15 g of tuber of stemona, 10-15 g of corktree, 10-20 g of cicada slough, 10-20 g of honeysuckle, 10-15 g of divaricate saposhnikovia root, 10-15 g of scutellaria baicalensis, 10-20 g of sophora flower, 5-15 g of pepper, 10-15 g of root-bark of Chinese wolfberry, 10-15 g of seed of Job's tears, 10-15 g of cinnamon, 10-15 g of coptis, 10-20 g of astragalus root, 10-15 g of golden larch bark, 10-15 g of rhubarb, 10-20 g of safflower, 10-20 g of radix sophorae flavescentis, 10-15 g of ephedra, 5-15 g of black snake, 10-20 g of angelica, 10-15 g of asarum, 10-15 g of vermilion, 5-10 g of borneol, 5-15 g of long-noded pit viper, 10-15 g of saponin, 5-10 g of cantharis, 10-15 g of fructus cnidii and 3,200 ml of 60-degree spirit brewed from store-up grains. A product provided by the invention is dark brown liquid and has the smell of Chinese herbal medicines and mild fragrance of wine. The 39 raw material medicaments included in the product are processed through seven operation processes.

The present invention relates to pharmaceutical compositions and methods for the prevention and treatment of autoimmune diseases, infectious diseases, neurodegenerative diseases, and primary and metastatic neoplastic diseases. In the practice of the invention, the compositions are employed comprising: (a) a heat shock protein (hsp) or an alpha(2)macroglobulin (alpha2M); (b) a saponin; and, optionally, (c) an antigenic molecule. The antigenic molecule displays the antigenicity of an antigen of: (a) a cell that elicits an autoimmune response; (b) an agent of an infectious disease; (c) a cancerous cell; or (d) a cell or structure associated with a neurodegenerative or amyloid disease. The hsps that can be used in the practice of the invention include but are not limited to hsp70, hsp90, gp96, calreticulin, hsp 110, grp 170, and PDI, alone or in combination with each other. The antigenic molecule can be covalently or noncovalently bound to the hsp or alpha2M, free in solution, and / or covalently bound to the saponin. The compositions of the invention can be administered alone or in combination with the administration of antigen presenting cells sensitized with an hsp- or alpha2M-antigenic molecule complex.

The present invention discloses a balanced nutrient tea and beverage. Its raw material composition includes (by weight portion) 0.5-3 portions of American ginseng, 1-3 portions of sterculia, 2-5 portions of dried longan flesh, 2-5 portions of dried jujube, 2-5 portions of dried apricot flesh, 1-3 portions of spiny jujube kernel, 1-4 portions of lyceum berry, 2-5 portions of raisins, 1-3 portions of tea, 0.5-3 portions of lonicera flower, 0.5-2 portions of notoginseng flower and 1-15 portions of honey. Said invention contains several nutrient components of vitamins, amino acids, saponin, mineral and organic acid, etc. and has several health-care functions of raising immunity of human body, etc.

A biodegradable lubricating grease comprises (overall composition weight as benchmark) (1) 70-94% vegetable oil whose kinetic viscosity is 100-250 square mm per second, (2) 6-30% thickening agent, wherein the thickening agent is alta-mud, or single saponin or composite saponin produced through the reaction of C1-C20 organic acid with calcium hydroxide, calcium oxide, lithium hydroxide or lithium oxide, (3) 0-2% amine antioxidant or phenol and amine mixed anti-oxidant. The lubricating grease possesses both fine normal physical chemical properties and good bio-ecological characteristics.

The invention discloses an external skin care product capable of adjusting skin immunity and delaying skin aging. The external skin care product is characterized by comprising powder, an aqueous solution and emulsion, wherein the powder comprises oligopeptide-1 and ginsenoside; the aqueous solution comprises glycyrrhiza glabra root extract, artemisia capillaris flower extract, mulberry root extract, jujube fruit extract, scutellaria root extract, hydrolyzed rice protein and nicotinamide; and the emulsion comprises hgytantriol bifida ferment lysate, creatine, carnosine, alpha glucosyl hesperidin, hexapeptide-3, centella asiatica extract, coenzyme Q10 inclusion complex, opuntia ficus-indica stem extract, rhodiola rosea extract, saussurea involucrate extract, pseudo-ginseng root extract and Chinese angelica extract inclusion complex. According to the external skin care product, the powder, the aqueous solution and the emulsion are jointly used, and the external skin care product can reduce wrinkle and pachulosis, even skin tone and improve skin elasticity and skin firmness, so that the skin is finer and smoother and looks young.

This invention provides virosome preparations from an enveloped virus, in particular from influenza virus, containing from said virus, and a saponin adjuvant. In particular the invention provides a virosome preparation from influenza virus an influenza antigen a QS21, optionally with a sterol. The invention also provides vaccine compositions containing said virosome preparations, methods of preparing said virosome preparations and vaccine containing them.

The present invention provides for a novel oil-in-water (O / W) emulsion, with increased stability in the presence of bacterial or viral suspensions, especially those concentrated and non-purified (crude extracts) or minimally purified. The emulsion of the present invention can act as vehicle for the delivery of a pharmaceutical composition comprising at least one immunogen and, in particular, an immunogen selected from the group consisting of an inactivated pathogen, an attenuated pathogen, a subunit, a recombinant expression vector, and a plasmid or combinations thereof.

This invention relates to a combination therapy that finds utility in the treatment or prophylaxis of infectious diseases, cancers, autoimmune diseases and related conditions. In particular, the combination therapy comprises the administration of a TH-1 cytokine, in particular, IL-18, and an immunogenic composition, in particular, a vaccine, comprising an antigen and a saponin adjuvant. In particular, the invention relates to the use of IL-18 or bioactive fragment or variant thereof and an immunogenic composition comprising a tumour-associated antigen and a saponin adjuvant, for the treatment of preneoplasic lesions or cancer.

The preparation method to extract tea saponin from oil meal, which comprises smashing, removing enzyme, leaching with hot mixing to boost infiltration capacity, centrifugal solid-liquid separating to add flocculant, deposition separating, disc centrifugal separating for cleaning solution, prefiltration separating for flocculation deposition, nano-membrane concentrating, and spray drying. Wherein, using chemical treatment to inhibit and eliminate hydrolase activity before leaching. This invention is simple and low cost with yield more than 70% and 80% purity.

The invention provides a method for simply, conveniently and quickly preparing notoginsenoside R1 and ginsenoside Rg1, Re, Rb1 and / or Rd, which can meet the requirement of industrial production and is environment-friendly. In the method, notoginseng extract and arasaponin or notoginsenoside intermediates are used as original materials, a preparative scale reversed phase high-performance liquid chromatography is adopted, and an ethanol-water system is used as a flow phase to carry out isocratic elution or gradient elution, wherein the ethanol-water system is an ethanol-water solution of 30 percent to 80 percent (V / V). The method has the advantages of simple process, no pollution, low cost and high purity, wherein the purity of products produced by the method is more than 97 percent.

The invention relates to a down jacket cleaning agent which comprises the following components in parts by mass: 1-30 parts of anion surface active agent, 1-15 parts of nonionic surface active agent, 1-10 parts of DP-3000, 0.1-10 parts of tea saponin, 0.1-10 parts of soybean ethyl sulfate morpholine, 0.1-10 parts of ColtideHSi, 0.1-1 part of essence, 0.1-1 part of sodium citrate and 13-97.4 parts of deionized water. The cleaning agent provided by the invention can integrate sterilization, flavor removal and conditioning into a whole and has the advantages of high detergency, high stability, adaptability in cold and hot water and neutrality without damaging hands.

The invention provides an aquatic animal preparation capable of protecting liver. The aquatic animal preparation capable of protecting liver is composed of an A preparation and a B preparation. The A preparation is composed of 70 to 100% of a Chinese herbal medicine mixture, 0 to 15% of a flavonoid compound, 0 to 15% of a saponin compound, 0 to 15% of an alkaloid, 0 to 15% of trace element, and 0 to 15% of a polysaccharide; and the B preparation is one or a mixture of a plurality of ingredients selected from a feed additive, a photosynthesis accelerant, and a vitamin. In vivo, the aquatic animal preparation is capable of increasing the activity of liver cells, repairing cell damage, removing a plurality of toxins in aquatic animals, relieving liver burden, improving immunity, resisting free radical injury, reducing lipid peroxide, protecting liver, nourishing gallbladder, and preventing tumor; beneficial substances of living bacteria agents and Chinese herbal particles dissolved in water are capable of inhibiting planting of pathogenic bacteria in water bodies, and killing virokine.

The invention discloses a method for preparing total saponins and polysaccharides from Apios americana flowers simultaneously and relates to the technical field of plant extraction. The method comprises the following steps: (1) harvesting raw materials, cleaning and drying; (2) reflux-extracting with ethanol, and filtering to obtain a supernatant and filter residues; (3) defatting the supernatant with petroleum ether, extracting with n-butanol, performing adsorption and elution, concentrating, and drying to obtain powdery Apios americana flower saponins; (4) removing the solvent from the filter residues, reflux-extracting with water, filtering, collecting and mixing the filtrates; and (5) decolorizing the filtrate, performing deproteinization, concentrating, precipitating with alcohols, dialyzing and concentrating, and drying to obtain Apios americana flower polysaccharides. The method has the advantages of simple process, high yield and low cost. Besides, the total saponins and polysaccharides of Apios americana flowers are prepared simultaneously, have high purity and strong activity, and can be widely used in pharmaceuticals or functional foods with antioxidant and blood sugar regulating effects.

The present invention provides a pharmaceutical composition containing steroidal saponins. The pharmaceutical composition comprises 5˜25 parts by weight of furostanal saponins represented by general formula A or general formula B and 1˜10 parts by weight of spirostanol saponin represented by general formula C. The present invention further provides a method for preparing the pharmaceutical composition. After determination of the three steroidal saponin components in the pharmaceutical composition of the present invention, it is proved that it has high stability and liability in its therapeutic effect. Meanwhile, the method to identify the three steroidal saponins is provided with reliable controllability. Besides, with its daily dosage of 300˜600 mg, which is less dosage, the drug of this invention provides a new choice in clinics.

A process for preparing high-purity momordicoside from fructus momordicae includes such steps as pulverizing, reflux extracting in alcohol, filtering to obtain extract A, suspending it in water, extracting in ethyl acetate 1-3 times, recovering ethyl acetate mother liquid, extracting in n-butanol 1-3 times, recovering n-butanol to obtain extract B, passing it through polyamide column, water washing, concentrating to obtain coarse saponin, chromatography by silica gel column, eluting with chloroform-methanol-water, collecting coarse momordicoside V, chromatography, water washing, eluting with alcohol, and collecting product.

The invention relates to a method for extracting tea saponin directly from tea seeds. The method comprises the following steps: firstly, the oil-tea camellia seeds are hulled, tea kernels are crushed into 200-300 meshes of particles; then, the leaching is carried out, the PH value of the leaching solution is controlled between 5 and 9, the leaching solution is added with organic solution, the amount of the organic solution is determined according to the weight-to-volume ratio (3-8 times) between the oil-tea camellia seeds and the organic solution, the temperature is controlled between 60-80 DEG C, the extraction time is 1-4 hours, and the lixiviation is repeatedly performed for 1-2 times; then, the separation and the solvent recovery are carried out, the filtering or the centrifugal separation is performed to the leaching solution, and meanwhile, the reduced pressure evaporation and the recovery are performed to the organic solvent in the leaching solution to obtain aqueous solution of the tea saponin; and finally, the water is removed from the liquid tea saponin to obtain the crude tea saponin product. The invention has the advantages that the oil-tea camellia seeds are directly taken as the raw materials for extracting the tea saponin, the extract of the obtained tea saponin has high purity and good quality, and the method is suitable for the industrial large-scale production.

A process for preparing the common saponin of Chinese paris rhizome includes such steps as extracting, separating and purifying, and features that the extracting in alcohol, membrane filtering, resin adsorbing, resin decoloring, decoloring with activated carbon and defatting with acetone are combined. Its advantages are high extracting rate and low cost.

The invention relates to a method for extracting tea saponin from oil tea cakes. The method includes the following steps: (1) grinding; (2) dezymotization; (3) adding water with the temperature of 35 DEG C to 45 DEG C to extract the dezymotized oil tea cake for 4 to 6 hours; (4) using a microstainer to finely filter the extract obtained in step 3; (5) using a hyperfiltration membrane made of polyethersulfone resin to purify the filtrate obtained in step 4, and using a nanofiltration membrane made of polyethersulfone resin for dehydration and concentration; and (6) decolorization and spray drying. The method has the advantages of simple and safe operation, less equipment investment, low production cost and little energy consumption, the yield is more than 75 percent, the purity of the obtained tea saponin product is larger than or equal to 90 percent, and the method is suitable for industrialized production.

The invention discloses a method for preparing antibiotic substituent for feed by probiotic asynchronous fermentation of Chinese herbal medicine, belonging to the field of food nutrition and the technical fields of microorganisms and feed. The method comprises the following steps: extracting Chinese herbal medicine by adopting asynchronous fermentation and enzymolysis technologies, namely adding water and nutritive salt in proportion to prepare a Chinese herbal medicine fermentation liquid after a plurality of Chinese herbal medicines are subjected to impurity removal and super-micro smashing; firstly inoculating Aspergillus niger for aerobic fermentation, thus cellulose and pectinase are prepared; and then inoculating enterococcus faecium and lactobacillus plantarum for anaerobic fermentation; and then carrying out enzymolysis on damage cell walls, and dissolving out active substances of saponin, alkaloid, phytosterol, enzymic preparations, organic acid and the like. A plate-and-frame filter press is adopted to filter the fermentation liquid, the filtration liquid is directly subjected to low-temperature spray drying to prepare antibiotic substituent powder A; a filtration cake is dried by adopting a roller drier to prepare antibiotic substituent powder B, and the power A and the powder B are mixed and formulated in proportion to replace fermented enzymolysis Chinese herbal medicine extracts of antibiotic for feed.

The invention discloses a method for sequentially extracting tea saponin and tea seed oil from oil-tea camellia seeds. A biological enzymatic hydrolysis method is firstly adopted for extracting tea saponin from shelled oil-tea camellia seed powder, and a water extraction method is further adopted for extracting the tea seed oil from desaponification residues. The process for extracting the tea saponin through the biological enzymatic hydrolysis method comprises the steps of cleaning, husking, crushing, fixing, homogenizing, performing enzymatic hydrolysis, performing coarse filtration through plate-frame filter cloth, and performing fine filtration through a miccroporous membrane. The process for extracting the tea seed oil through the water extraction method comprises the steps of ultrasonic vibration extraction and centrifugal separation. According to the method, the extraction efficiency of the tea saponin can be more than 90%, and the extraction efficiency of the tea seed oil can be more than 90%. The whole process flow is performed at low temperature, so that natural activity of the tea saponin, as well as vitamin E, phytosterol, squalene, natural flavor ingredients and the like in the tea seed oil are effectively protected. The foaming property and foam stability of the tea saponin prepared by the process are better in comparison with a traditional extraction method, the prepared tea seed oil has excellent quality, and the national pressed first-class tea seed oil standard can be achieved only by simple refining.

Saponins from plant materials are alkaline modified and used as molluscicides.