59 results about "Autoimmune Reactions" patented technology

Based upon a strong correlation between regulator T cells (Treg cells) and suppressing or preventing a cytotoxic T cell response, provided are methods for the production of ex vivo activated and culture-expanded isolated CD4+CD25+ suppressor Treg cells for the prevention or suppression of immune reactions in a host, particularly in a human host, and including autoimmune responses. The resulting ex vivo culture-expanded Treg cells provide a sufficient amount of otherwise low numbers of such cells, having long term suppressor capability to permit therapeutic uses, including the preventing, suppressing, blocking or inhibiting the rejection of transplanted tissue in a human or other animal host, or protecting against graft vs host disease. Also provided are therapeutic and immunosuppressive methods utilizing the ex vivo culture-expanded Treg cells for human treatment, and high efficiency methods for research use.

The invention relates to a traditional Chinese medicine external patch for treating rheumatism and rheumatoid diseases. In traditional Chinese medical science, limb pain or numbness caused by wind, cold and humidity is considered as rheumatism, and the rheumatism is mainly caused by the wind, the cold and the humidity that enter human bodies in weak states, flow and fill in channels and collaterals and joints to obstruct the qi and blood operation. The rheumatoid diseases are arthropathy on the basis of synovitis resulted from autoimmune response caused by infectious diseases. The traditional Chinese medicine external patch comprises the follow ingredients in parts by weight: 1 to 5 parts of radix aconiti kusenzoffii, 1 to 5 parts of unprocessed radix aconiti kusnezoffii, 1 to 5 parts of ma-huang, 1 to 5 parts of aconite, 1 to 5 parts of cinnamon, 1 to 5 parts of rhizoma zingiberis, 1 to 5 parts of frankincense, 1 to 5 parts of myrrh, 1 to 4 parts of asarum and 14 parts of rhizoma arisaematis. The traditional Chinese medicine external patch is applied to the treatment of the rheumatism and the rheumatoid diseases.

The present invention is related to a process for obtaining a composition comprising peptides bound to one or more heat shock protein(s) and for possibly recovering from said composition the bound peptides, wherein the peptides resulting from a previously in-vitro hydrolysis of at least one immunogenic and antigenic macromolecular structure, are mixed in-vitro with one or more heat shock protein(s).The present invention is also related to the compositions obtained by said process.

The present invention relates to a multifunctional cosmetic composition containing pieces or an extract from fish eyes as an active ingredient, which has good skin whitening effects and good skin resiliency improving effects, and has good skin moisturizing effects and cell activation effects, so as to exhibit excellent skin-regenerating and wound healing effects as well as excellent irritation relief effects. Also, the present invention relates to a composition for preventing and treating arthritis, which includes pieces or an extract from fish eyes as an active ingredient. The composition of the present invention promotes immune tolerance in the intestinal immune system without having any side effects so as to prevent and treat arthritis by effectively controlling autoimmune reactions and infections which particularly occur in joints. In addition, the present invention relates to a pharmaceutical composition for treating dry eye, which includes an extract from fish eyes as an active ingredient. The present invention uses fish eye extract to effectively treat eye disorders, such as conjunctival epithelium disorder, without the traditional side effects from the repeated administration of anti-inflammatory drugs.

The invention comprises a composition of matter and method of its use for the treatment of multiple sclerosis in humans. The composition is a modified anticholinergic alpha-neurotoxin. Alpha-neurotoxin solution, such as cobratoxin, is filter sterilized to remove bacteria. It is modified using H2O2. Any suitable preservative for parenteral administration can be employed such as methyl paraben, benzalkonium chloride or metacreosol. It is preferred that the composition is administered every other day or daily. The composition may be administered orally, subcutaneously, intramuscularly or intravenously. Parenterally, either subcutaneous or intramuscular injection is preferred.

Methods and apparatus are disclosed co-culturing stem cells with mononuclear cells and / or lymphocytes to modulate their function. The invention also discloses the use of stem cells to educate autoreactive immune cells as a mechanism to treat autoimmune diseases and immune disorder-related diseases, such as diabetes. In one aspect of the invention, bioreactors are disclosed for modulating lymphocytes and suppressing autoreactive T cells. The bioreactors can include a chamber having at least one positively charged and / or hydrophobic substrate surface, a population of stem cells attached to the substrate surface, an inlet conduit for introducing lymphocytes into the chamber, and an outlet conduit for extracting treated lymphocytes following co-culturing with the stem cells.

This invention relates to a method of producing an auto induced biological barrier against spermatozoids and / or other microorganisms including viruses and / or pre cancers or non invasive cancers involving the production of an autoimmune reaction in a host in need of such auto-inducement. The invention is characterized in that it comprises the steps of producing heat shock proteins inside vaginal and cervical mucosal cells and releasing said heat shock proteins into the vaginal cavity thus inducing an autoimmune response through a trigger and / or stimulation of both innate and adaptive systems and, as a consequence, the production of: a contraceptive effect through the elimination of the migration or free movement of individual or populations of spermatozoids and / or an inhibition of the maturation and / or capacitation process of the same and / or a neutralization or destruction of the same; a prophylactic effect through an elimination of the migration or free movement of individual or populations of other microorganisms including viruses and / or a neutralization or destruction of the same; a prophylactic effect against pre cancers; a therapeutic effect against non invasive cancers. The invention also relates to a device for using said method comprising a hollow body (1) provided with a heat source on the inside as well as with a means (13, 27) of removal of said hollow body from the vaginal or rectal cavity and a means (6, 8, 10) capable of exchanging heat originating from the hollow body.

The present invention is related to a process for obtaining a composition comprising peptides bound to one or more heat shock protein(s) and for possibly recovering from said composition the bound peptides, wherein the peptides resulting from a previously in-vitro hydrolysis of at least one immunogenic and antigenic macromolecular structure, are mixed in-vitro with one or more heat shock protein(s). The present invention is also related to the compositions obtained by said process.

The invention belongs to the field of traditional Chinese medicine, relating to the usage of cyrtomium rhizome total polysaccharides for preparing a drug preventing and curing systemic lupus erythematosus. In the invention, total polysaccharide extracts are separated and extracted from the traditional Chinese medicine cyrtomium rhizome, product yield thereof averages 5.72% and polysaccharide content thereof exceeds 50%; An integral animal model test result shows that the total polysaccharides have an obvious protection effect on autoimmune response hyper-function and renal injury of mice with systemic lupus erythematous syndrome. The test demonstrates that the total polysaccharides can prevent and cure systemic lupus erythematous syndrome and be applicable for preparing the drug preventing and curing systemic lupus erythematosus and auto-immune diseases.

An application of N-acetylaminoglucose in preparing the medicines for treating the local injury or general sympton caused by autoimmune reaction is disclosed.

The invention provides a method and system for screening siRNA sequences to reduce off-target effect. The method comprises the following steps: S1, integrating siRNA candidate sequence data, and marking whether common SNP exists in a siRNA sequence target region genome interval or not; S2, analyzing the characteristics of the siRNA positive and negative chain sequences, and marking whether the positive and negative chains can be correctly recognized or not on the siRNA positive and negative chain sequences; S3, analyzing the negative strand characteristics of the siRNA sequence, and labeling whether the negative strand of the siRNA sequence can trigger an autoimmune reaction or not; S4, analyzing the specificity of the siRNA positive and negative chain sequences, and carrying out siRNA sequence specificity labeling on the siRNA positive and negative chain sequences; and S5, synthesizing all the labeling results, and screening the candidate siRNA sequences. The system comprises unit modules corresponding to the steps of the method.