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Application of BMP4 protein for preparation of drugs for autoimmune diseases

An autoimmune and autoimmune technology, which is applied in the application field of BMP4 protein as a drug for the preparation of autoimmune diseases, can solve the problems of uncontrollable condition of patients, high risk of transplantation treatment, and restriction of wide application, so as to reduce myocardial damage, Achieve functional recovery and improve cardiac function

Pending Publication Date: 2019-09-17
SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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AI Technical Summary

Problems solved by technology

Due to autoimmune diseases, there are still some patients whose condition cannot be controlled after autologous HSCT, and some cases relapse after operation. In addition, the risk of transplantation treatment is high, and the relevant mortality rate is about 7%, which is higher than that of non-autoimmune diseases (3%). wide application of the technology

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  • Application of BMP4 protein for preparation of drugs for autoimmune diseases
  • Application of BMP4 protein for preparation of drugs for autoimmune diseases

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Embodiment Construction

[0022] The following describes several preferred embodiments of the present invention with reference to the accompanying drawings, so as to make the technical content clearer and easier to understand. The present invention can be embodied in many different forms of embodiments, and the protection scope of the present invention is not limited to the embodiments mentioned herein.

[0023] The present invention is based on the discovery that BMP4 protein can promote the proliferation of Treg cells, further increase the inhibitory effect of Treg cells, and regulate the occurrence of autoimmunity by playing the role of suppressive T cells. Consistent with the present invention, it has also been found that BMP4 protein has a positive therapeutic effect in animal models of myocardial infarction.

[0024] The "BMP4 protein" mentioned herein refers to the human BMP4 protein, which is a non-glycosylated polypeptide chain in the form of a monomer, containing 116 amino acids in a specific...

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Abstract

The present invention discloses an application of BMP4 protein for preparation of drugs for autoimmune diseases. The BMP4 protein can be used as a protein preparation for regulating autoimmune responses after myocardial infarction after dredging blocked coronary artery, can reduce myocardial damage after the myocardial infarction, improves cardiac function after healing, and realizes myocardial regeneration and functional recovery after the myocardial infarction.

Description

technical field [0001] The invention relates to a new application field of the BMP4 protein, in particular to the application of the BMP4 protein as a medicine for the preparation of autoimmune diseases. Background technique [0002] Myocardial infarction is an acute and severe heart disease. Its main pathological mechanism is: sudden interruption of blood circulation in part of the myocardium, myocardial damage caused by hypoxia, and insufficient blood supply to the whole body. The vast majority of myocardial infarctions are caused by blockage / thrombosis in the coronary arteries of the heart. At present, for the treatment of myocardial infarction, the main principles are to restore the blood supply as soon as possible to reduce the infarct size, protect the heart function, save the dying myocardium and deal with various complications. The current mainstream treatment plan is thrombolysis through percutaneous coronary intervention, followed by anticoagulant drugs to inhibit...

Claims

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Application Information

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IPC IPC(8): A61K38/18A61P37/02A61P9/10
CPCA61K38/1875A61P37/02A61P9/10
Inventor 张臻王文峰张敏王晔宋鹤杰魏璐
Owner SHANGHAI CHILDRENS MEDICAL CENT AFFILIATED TO SHANGHAI JIAOTONG UNIV SCHOOL OF MEDICINE
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