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62 results about "Serum uric acid" patented technology

A uric acid blood test, also known as a serum uric acid measurement, determines how much uric acid is present in your blood. The test can help determine how well your body produces and removes uric acid.

Method for preparing bonito stick protein hydrolysate with effect of reducing uric acid

The invention relates to a method for preparing bonito stick protein hydrolysate with an effect of reducing uric acid. The method comprises the following main steps of raw material heat treatment, restriction digestion, membrane separation-anion exchange chromatography-gel filtration chromatography separation, concentration and spray drying so as to obtain the bonito stick protein hydrolysate with an effect of reducing uric acid. The amino acid analysis indicates that the zymolyte peptide fragment primary amino acid sequence contains four amino acids, namely histidine, arginine, lysine and threonine, the total mass content of the four amino acids is 70 percent of the total amino acid content of zymolyte. MALDI-TOF-MS mass spectrum determines that the molecular weight of the main peptide effective ingredient is less than 700Da. In-vitro uric acid reduction experiments prove that the bonito stick protein hydrolysate has a remarkable effect of inhibiting generation of uric acid, and has an inhibition rate over 50 percent; an oteracil potassium molded hyperuricemic rat animal model indicates that the bonito stick protein hydrolysate can be used for remarkably reducing the level of serum uric acid and serum creatinine of rats, and shows a relatively good kidney protecting effect.
Owner:SOUTH CHINA UNIV OF TECH

Enteric coated preparation for preventing and treating hyperuricemia and gout

Provided is an enteric preparation for preventing and curing hyperuricemia and gout. The employing essential component of the preparation is enteric capsules of uricase. The causes of the hyperuricemia and the gout are that uric acid is over generated and / or the uric acid is diminished in discharging, and metabolic diseases increasing the density of serum uric acid. About one third of the uric acid of the human body is defecated from intestinal canals, and the uric acid entering the canals still can be reabsorbed. When the hyperuricemia and the gout happen, the proportion of the uric acid defecated from the intestinal canals is increased. The uricase is capable of rapidly effectively dissociating the uric acid. The uricase of the enteric preparation after being orally taken is disintegrated in the intestinal canals and is diffused from blood into the uric acid of the intestinal canals, preventing the uric acid from reabsorbing, thereby reducing the density of the serum uric acid, achieving the purposes of preventing and curing the hyperuricemia and the gout. The oral uricase has the characteristics of non-absorbent property by the intestinal canals, keeping out of blood circulation, no producing of antibodies of organisms and allergic response, providing a new method for preventing and curing the hyperuricemia and the gout.
Owner:XI AN JIAOTONG UNIV

Mango leaf extract and application thereof

The invention belongs to the field of medicines and discloses a mango leaf extract and application thereof. Mango leaves are subjected to refluxing extraction and concentration via aliphatic alcohol with 1-4 carbon atoms, and the obtained product is extracted and purified via low-polarity organic solvent and is refined to obtain the mango leaf extract. The mango leaf extract disclosed by the invention contains mangiferin and homomangiferin which are at specific proportion, and is better than a mangiferin monomer in the solubility. Pharmacological research proves that the mango leaf extract has the effects of lowering the level of serum uric acid of a hyperuricemia mice and reducing blood sugar, and is better than the mangiferin. Therefore, the invention provides application of the mango leaf extract provided by the invention to the medicine for preventing or treating the metabolic syndrome.
Owner:KPC PHARM INC

Application of 3-methoxy xanthone compound in preparation of medicament for preventing and treating hyperuricemia

The invention discloses application of high mangiferin and aglycon thereof in preparation of a medicament for preventing and treating hyperuricemia and in particular relates to application of high mangiferin and aglycon thereof in preparation of a medicament for preventing and treating hyperuricemia as well as gout and lithangiuria brought by the hyperuricemia, and a medicine application way. The high mangiferin and aglycon thereof provided by the invention can be used for obviously reducing the concentration of serum uric acid in an animal for experiment and have the serum uric acid inhibition effect similar to that of a xanthine oxidase inhibition medicament allopurinol; and simultaneously, the high mangiferin and aglycon thereof provided by the invention can be used for obviously improving the concentration of uric acid in urine and have the uric acid excretion promoting function similar to that of a uric acid excretion promoting medicament probenecid. The high mangiferin and aglycon thereof provided by the invention are efficient, low in toxicity and high in safety, thus the high mangiferin and aglycon thereof are wide in application prospect.
Owner:KPC PHARM INC

Application of cassia ketoside in preparation of xanthine oxidase inhibitor

The invention provides an application of cassia ketoside in preparation of a xanthine oxidase inhibitor. In vitro tests prove that cassia ketoside has an obvious inhibitory effect on the activity of xanthine oxidase; a test by an experimental hyperuricemia mouse model proves that the cassia ketoside greatly reduces the level of serum uric acid in the model mouse; therefore, the cassia ketoside can be used for preparing the xanthine oxidase inhibitor and used for preparing products for inhibiting the activity of the xanthine oxidase to treat hyperuricemia.
Owner:QINGDAO UNIV

Medicaments assembly for clearing heat and removing dampness, dispelling wind evil and relaxing vein and preparation thereof

The invention discloses a Chinese herbal medicine composition that clears heat and humidity, dispels wind and activates collaterals and the preparation method. The active ingredients of the invention are extracted from atractylodes, phellodendron bark, anemarrhena, cassia twig, honeysuckle stem, prepared rhizome of rehmanniae, gardenia, cassia twig, olibanum, clematis root, eupolyphaa sinensis, Chinese rhubarb, Oriental Waterplantain Rhizome, angelica, safflower and radix glycyrrhizae. The special medical active components in the invention have the functions of clearing heat and humidity, dispelling wind and activating collaterals. The medicine composition has obvious reducing function for serum uric acid abnormal rising caused by gout and has good pain easing and repercussion effects for various rheumatic complaints.
Owner:BEIJING ZHONGTAI TIANHE SCI & TECH

Plant extract composition capable of regulating human uric acid and preparation method thereof

The invention discloses a plant extract composition capable of regulating human uric acid and a preparation method thereof. In mass ratio, the plant extract comprises 35-45% of coconut milk powder, 11-21% of green papaya powder, 10-20% of carrot powder and 20-25% of tea polyphenol. The composition has the effect of remarkably reducing the uric acid. A bio-engineering technology is utilized to extract a variety of raw materials, so that the advantages of being high in extraction rate, free of toxic and side effects and environment-friendly are provided. The tea polyphenol is a natural antioxidant which has no toxic or side effect and no odor, consists of flavonol, anthocyanin, catechin, phenolic acid and depside; and the main component epigallocatechin gallate (EGCG) has the function of inhibiting xanthine oxidase and is suitable for the case of excessive production of uric acid.
Owner:GUANGZHOU TRACE ELEMENTS BIOLOGICAL TECH CO LTD
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