254 results about "Mangiferin" patented technology

The invention relates to a process for preparing high purity mango glycosides by using mango leaf or amygdale leaf as the raw material through resin method decolorization. The extracted mango glycosides has a purity higher than 90%.

The invention provides a Tibetan virgate wormwood herb extract containing swertiamain, gentiopicroside, sweroside, mangiferin and isoorientin, and the weight ratio of the five ingredients is (0.04-0.71): (20-40): (1-15): (1.6-26): (0.01-0.16). The invention further provides a preparation method of the Tibetan virgate wormwood herb extract, a pharmaceutical composition containing the Tibetan virgate wormwood herb extract and a medical use of the Tibetan virgate wormwood herb extract. The Tibetan virgate wormwood herb extract can improve various indicators caused by liver injury, promote the reversal of the liver fibrosis process and better prevent liver cirrhosis.

The invention relates to a method for extracting mangiferin, which uses a mango leaf or an almond leaf as a raw material to sufficiently extract the mangiferin in the mango leaf or the almond leaf by using water or alcohol-water mixed solution as menstruum through adopting a high-temperature and high-pressure method. The method has the advantages that the method has a simple process, saves energy and time, and is easy to realize industrialized production.

The present invention relates to one kind of mangiferin-berberine composition with relatively high water solubility and its preparation process and medicinal application. The mangiferin-berberine composition has water solubility up to 25 mg / ml. Animal test shows that the mangiferin-berberine composition has functions of inhibiting bacteria, lowering blood sugar, diminishing inflammation, protecting liver, etc. The mangiferin-berberine composition may be used in preparing eye drops, medicine for women's vaginal diseases, medicine for lowering blood sugar and medicine for treating hepatitis.

The invention discloses a full chemical synthesis method for mangiferin aglycones. In a process of full chemical synthesis, the mangiferin aglycones are prepared from 3,4-methyl dihydroxybenzoate serving as an initiative raw material through six chemical reactions and steps. The synthetic process of the full chemical synthesis of the mangiferin aglycones has the advantages of short synthetic routes, mild condition of a synthetic reaction and high yield, and can be used for large-scale production.

The invention relates to an action of ferulic acid on enhancing the drug effect of some medicaments and a purpose thereof, wherein the medicaments mainly comprise alkaloid medicaments including matrine, kushenin, sophocarpine, hyoscyamine, narceine, hanfangchin A, jamaicin, morphine, codeine, evodiamine, strychnine, catharanthine, vincristine, taxol, verticine, peimine, peiminine, ephedrine, pseudoephedrine, wilfordine, triptolide, tripdiolide and the like, and flavonoid medicaments including puerarin, ginsenoside, ginsengenin, mangiferin, scutelloside, alkannin, meletin, rutin, hesperidin, daidzin, soybean isoflavone, daidzein, carthamin, catechin and the like. The ferulic acid and the medicaments can form a compound or a medicament compound, or the ferulic acid and the medicaments can generate a chemical reaction (including salification, esterification, amidation, ketonization, etherification and the like), and / or the ferulic acid and the medicaments can generate a synergistic effect and an additive effect.

The invention relates to a preparation method of mangiferin. The preparation method adopts the process steps of saturated limewater solution soaking and extraction, macroporous resin adsorption, stepwise elution of water and ethanol solution of different concentration, concentration and crystallization under reduced pressure, and recrystallization by adjusting acidity through methanol. The obtained product has the advantages of high purity, high yield and low cost. The process is easy to popularize and industrialize.

The invention relates to the field of pharmaceutical chemistry and discloses a preparation method of mangiferin. The preparation method of the mangiferin comprises the following steps: extracting mango fruits, mango leaves, mango skin and rhizoma anemarrhenae rootstock which are utilized as raw materials by utilizing a mixed solution of alcohol and water; filtering, condensing the filtered solution and extracting the obtained concentrated solution with an organic solvent; then crystallizing the extracted water phase; and recrystallizing with a mixed solution of acetone and water, thus obtaining the mangiferin. According to the preparation method of the mangiferin, macroporous resin is not used for purification, so that the resin pretreatment, adsorption and elution process can be avoided, the production period is shortened, the transfer rate is improved, the usage amount of the organic solvent is reduced, the production cost is reduced, and the environmental pollution is reduced. The mangiferin prepared by the preparation method of the mangiferin disclosed by the invention is high in purity, does not contain benzene organic solvents and is high in safety.

The invention provides a mangiferin salt, in particular to a salt formed in the basic amino acid, organic amine and inorganic alkaline matter capable of being accepted by the mangiferin and medicine. The salt can solve the dissolubility, improve the pharmacological activity and be used for curing or curing auxiliary the diseases related closely to the oxidative damage. The general formula of the structure refers to the drawing, wherein, R is the basic amino acid, organic amine or inorganic alkaline metallic ion.

The invention relates to the field of medicinal chemistry, and discloses a method for preparing mangiferin aglycone. The method comprises that: step 1, 2-halogenate-4,5-dimethoxy benzoic acid and 1,3,5-trimethoxy benzene are subjected to Friedel-Crafts reaction, so a compound which has a structure in a formula IV is generated; step 2, the compound in the formula IV is selectively demethylated, and a compound which has the structure in the formula V is generated; step 3, the compound in the formula V is cyclized, and a compound which has the structure in the formula VI is generated; and step 4, the compound in the formula VI is completely demethylated, and mangiferin aglycone is generated. The method for preparing mangiferin aglycone improves the synthetic yield of the mangiferin aglycone, has the characteristics of cheap and easily-obtained raw materials, less synthetic steps, convenience in operation, easiness in control and high product purity, and can be widely applied in industrial production.

The invention relates to a freshwater fish feed additive, in particular to a complex immunity reinforcing agent for a black carp. The immunity reinforcing agent for improving the stress resistance of a black carp comprises the following components in percent by weight: 10-20 percent of dangshen polysaccharide, 10-15 percent of isatis root, 15-20 percent of astragalus root polysaccharide, 5-10 percent of mangiferin, 5-10 percent of rose roxburghii tratt polysaccharide, 0.5-5 percent of vitamin C, 1-6 percent of vitamin E and 20-40 percent of wheat-middlings. The complex immunity reinforcing agent can be used as a feed additive for making up the defects presented by the black carp in the stress state, improving the stress resisting capacity of the black carp and the utilization rate of the feed, lowering the feed coefficients, reducing the damage caused by the stress, reinforcing the immunity of the black carp and increasing the survival rate.

The present invention relates to a novel purpose of mangiferin compound for preventing and remedying hyperuricemia and gout. A study shows that the mangiferin compound has very strong anti-gout effect; 0.002mmol / kg (0.78mg / kg) of the dosage can reduce the serum uric acid level of a mouse with the hyperuricemia obviously; the mangiferin compound has higher activity than allopurinol and has little toxic and side effect; the maximum gastric infusion tolerance dose of the mouse is 47.4mmol / kg (20g / kg), which is lower than that of current clinical applied anti-gout medicines, such as colchicines, the allopurinol, sulphinpyrazone, etc.; the present invention can be applied to prepare for oral anti-gout medicines and health care products.

The invention provides a method for effectively separating and purifying mangiferin from mango pericarp. According to the method, the liquid-liquid extraction, a macroporous resin and HSCCC (High-Speed Counter Current Chromatography) coupling technique is adopted, and dried mango pericarp powder is used as the raw material, extracted with ethyl acetate, and separated and purified by HPD100 macroporous resin and HSCCC to obtain high-purity mangiferin. According to the invention, the method is reasonable in design, simple in operation, safe in production flow, easy in operation, short in production period, low in sample consumption and low in equipment investment; the whole purifying process is accurately quantified by HPLC (High-Performance Liquid Chromatography), so that the accuracy is high, and the conditions are stable and easy to control; the solvent used by HSCCC can be recycled, so that the cost is lower; the purified product is high in recovery rate and purity, and the purity of the finally purified mangiferin is not less than 98%; and the method is suitable for industrial production.

This invention discloses compounds with natural product mangiferin as the frame. The general chemical structure of the compounds is shown in formula I, wherein, R1 and R2 are C1-20 linear or branched alkyl, benzyl, or substituted benzyl. The substituent is halogen, alkyl, etc. The compounds have strong inhibitive activity on protein tyrosine phosphatase 1B (PTP1B). This invention also discloses a method for preparing the compounds. The compounds can be used to treat diseases related to PTP1B inhibition, including diabetes type 2.

An orally applied chimonin preparation for relieving cough and dispelling phlegm is prepared from mango leaf or almond leaf through extracting. Its advantage is high curative effect.

The present invention relates to one kind of mangiferin clathrate with high water solubility and it preparation process. Normally mangiferin is water insoluble, and the present invention solves the problem by means of clathrating technology to form mangiferin clathrate with water solubility as high as 35.99 mg / ml.

The invention discloses a preparation method of mangiferin, comprising the following steps: (1) taking raw material mango leaves, drying, pulverizing, using enzyme solution in an amount of 6 to 10 times the amount of the raw material by weight to soak for 0.1hr to 1.0hr, then carrying out water bath and enzymolysis in the case of the pH value ranging from 4.0-7.0 and the temperature ranging from 35 DEG C to 55 DEG C, and fully stirring; (2) filtering, taking dregs of a decoction, using petroleum ether in an amount of 6 to 10 times by weight respectively to 2 to 3 times; (3) using 60%-80% of ethanol water in an amount of 6 to 10 times of the raw material by weight to extract the degreased dregs of a decoction of step (2) 2-3 times, combining the extracting liquid, and recycling alcohol; (4)spraying and drying the extracting liquid of step(3) to obtain dry powder, using 10%-30% of ethanol water to dissolve the dry powder, and then centrifuging and filtering; and (5) taking the filter liquor after centrifugal filtration in (4), carrying out water bath and pressure reduction, concentrating and drying to obtain the mangiferin. In the invention, an enzymatic method is utilized to extract the mangiferin from mango leaves so as to utilize waste materials, thereby greatly lowering the cost.

The invention provides a usage of mangiferin calcium salt for preparing AMPK agonist. The mangiferin calcium salt has the structure shown by the following formula.

The invention relates to a mangiferin aglycon derivative which has the chemical structure shown as in the chemical structure general formula (I), wherein R1, R2, R3 and R4 are selected from a, b, c or H, and R1, R2, R3 and R4 can not be H simultaneously; a refers to propionyl, butyryl or valeryl, b reters to various substituted benzoyl groups, and c refers to various substituted phenylsulfonyl groups. The invention also provides a preparation method and an application of the mangiferin aglycon derivative. The advantages are as follows: the compound has good blood glucose lowering effect whichis obviously superior to that of mangiferin and mangiferin aglycon, and the compound has no influence to blood glucose and blood fat of a normal rat and no toxic-side effect exist. The preparation method of the compound is convenient and feasible and has good repeatability and high compound yield; and with good officinal effect, the compound can be used for preparing drugs for treating diabetes mellitus and has wonderful development and utilization values. Formula (I).

The invention provides use of a mangiferin calcium salt as a PPARs excitant. The structural formula of the mangiferin calcium salt is as shown on the right.

The invention discloses high-purity mangiferin prepared from leaves and twigs of aquilaria sinensis and a preparation method thereof. The method comprises the following steps: on the basis of utilizing leaves and / or twigs of aquilaria sinensis as raw materials, extracting with an alcohol solution; after recovering alcohol at reduced pressure, carrying out water precipitation, alcohol precipitation, devitrification and the like so as to obtain a mangiferin crude product; and then recrystallizing to prepare the high-purity mangiferin. The method has the advantages that the leaves and twigs of aquilaria sinensis are used as the raw materials; the content of the mangiferin is high, and the variety and quantity of impurities are both low; the obtained high-purity mangiferin dose not contain allergic components, and the final product is high in quality and can be widely applied to the industries such as medicine, health care products and cosmetics; and the method has the advantages of simple, stable, practicable preparation process step, short production period, less labor consumption and low cost.

The invention belongs to the field of plant extraction, and specifically relates to a method for extracting and separating mangiferin from mango leaves. The technical problem to be solved by the invention is to provide a brand-new method for extracting and separating the mangiferin from the mango leaves. The method is simple and easy to operate, and the mangiferin with relatively high purity can be obtained. The extraction method disclosed by the invention comprises the following steps: A, raw material preparation; B, ester extraction and impurity removal; C, methyl alcohol extraction; D, concentration washing, so that a mangiferin crude product with the purity of 60% to 70% can be obtained; the extraction method further comprises the step E of crystallization purification, so that a mangiferin pure product with the purity of 90% to 98% can be obtained. According to the extraction method disclosed by the invention, the relatively high mangiferin can be obtained just by using several simple extraction and separation means, so that the operation is simple and convenient, and the cost is greatly reduced. According to the extraction method disclosed by the invention, the mangiferin crude product with the purity of 60% to 70% and the mangiferin pure product with the purity of 90% to 98% can be obtained respectively, the yield of the mangiferin crude product is greater than or equal to 83%, and the yield of the pure product is greater than or equal to 65%.

The invention discloses a chimonin reserving method, which is characterized by the following: maintaining main frame; utilizing NaHCO3 to decorate structure of 3-position phenolic hydroxyl group with strong acid; generating single sodium salt of chimonin with structure formula as formula I.

The invention discloses a method for preparing mangiferin. The method comprises the following steps of: taking a natural plant as a raw material; and performing the processes of solvent extraction, concentration, separation and purification. The method is characterized in that: the solvent is the aqueous solution of an alkali; and the processes comprise the following steps of: adding the natural plant into the aqueous solution of the alkali in an amount of 8 to 10 times based on the weight part of the natural plant; heating for boiling for 30 to 50 minutes; filtering extracting solution for later use; adding the aqueous solution of the alkali in the amount of 8 to 10 times based on the weight part of the natural plant again; boiling for 10 to 30 minutes; merging the extracting solution obtained from twice filtering; adding the aqueous solution of an acid into the merged solution for precipitating; filtering for removing impurities; and obtaining the mangiferin with the purity of over 95 percent by performing the processes such as enriching, decoloring and refining on the filtrate. The method has a simple process and is suitable for industrial production.

The invention provides an application of a mangiferin compound with a structure shown as a formula I as a pancreatic lipase inhibitor, an application of a mango extract containing the mangiferin compound with the structure shown as the formula I as a pancreatic lipase inhibitor, and an application of the mangiferin compound with the structure shown as the formula I or the mango extract containing the mangiferin compound with the structure shown as the formula I to preparation of a medicament or a food for treating and / or preventing obesity, and provides an application of the mangiferin compound with the structure shown as the formula I or the mango extract containing the mangiferin compound with the structure shown as the formula I to preparation of a medicament or a food for treating and / or preventing obesity. The mangiferin compound has the function of inhibiting the activity of pancreatic lipase, so that the occurrence of obesity can be avoided by inhibiting the accumulation of in-vivo fat. Meanwhile, the mangiferin compound has wide physiological activity, so that side effects on human bodies caused by the conventional weight-losing product can be avoided.

The invention provides a detection method of cassia twig, peony and anemarrhena decoction, where detecting is achieved by means of high-performance liquid chromatography. The detection method includesthe steps of 1) preparing reference solutions, to be specific, collecting controls of gallic acid, mangiferin, paeoniflorin, prim-o-glucosylcimifugin, liquiritin, 5-O-methylvisammioside, cinnamic acid and ammonium glycyrrhetate, and adding methanol solution respectively to obtain the reference solutions; 2) preparing a test solution, to be specific, adding methanol to dissolve lyophilized powderof cassia twig, peony and anemarrhena decoction to obtain the test solution; 3) sucking the reference solutions and the test solution, and injecting them into a liquid chromatograph. The detection method is suitable for detecting gallic acid, mangiferin, paeoniflorin, prim-o-glucosylcimifugin, liquiritin, 5-O-methylvisammioside, cinnamic acid and ammonium glycyrrhetate, allows overall quality of the cassia twig, peony and anemarrhena decoction to be controlled, also helps provide methodological basis for the study on the material basis of the cassia twig, peony and anemarrhena decoction, and is worthy of popularization and application.

The invention discloses a mangiferin single-site derivative, which is as shown in a formula I-I, wherein definition of R6 is specified in the specification. In addition, the invention further discloses a preparation method of the derivative. The derivative is capable of inhibiting diabete-related enzymes such as PTP1B and alpha-glycosidase, so as to play a role of reducing blood sugar; meanwhile, a mangiferin compound has wide physiological activity; and side effects on a human body caused by traditional hypoglycemic drugs can be avoided.

The invention discloses a method for separating and purifying mangiferin from aquilaria sinensis leaves. The method is used for solving the problems such as low purity, low yield and complex operation of the mangiferin separated by virtue of the existing process. The method comprises the following step: quickly preparing the high-purity mangiferin by use of the aquilaria sinensis leaves used as raw materials by virtue of adopting a method of combining normal phase column chromatography with high-speed counter-current chromatography. The method has the advantages of great preparation amount, high efficiency, quickness, low cost, simplicity in operation, high product quality and no pollution; and moreover, a solvent can be recycled, the solvent cost and the solvent treatment cost can be lowered, and the method can be widely applied to industrial production.

The invention discloses a method for chemically synthesizing a mangiferin penta-esterified derivative and a pharmacological effect of resisting inflammation and reducing blood sugar of the derivative. The chemical structural formula of the derivative is shown in the specifications. The derivative has a remarkable effect of inhibiting mouse auricle tumefaction caused by dimethylbenzene; and the derivative has a remarkable effect of treating diabetic mice induced by alloxan.

The present invention provides a mangiferin calcium and its preparation and use. The mangiferin calcium can lower plasma insulin, glucose, lipid, and also can improve the solubility and oral bioavailability of mangiferin and increase insulin sensitivity.