Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Novel mangiferin calcium salts, the method for its preparation and its use

A technology of mangiferin calcium salt and mangiferin, which is applied in medical preparations containing active ingredients, pharmaceutical formulations, metabolic diseases, etc., can solve the problems of mangiferin solubility, bioavailability, absorption defects, etc., and achieves stable properties and yields. high effect

Inactive Publication Date: 2010-09-29
CHANGZHOU DEZE MEDICAL SCI CO LTD
View PDF1 Cites 10 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, mangiferin still has defects in solubility, bioavailability and absorption of the body.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Novel mangiferin calcium salts, the method for its preparation and its use
  • Novel mangiferin calcium salts, the method for its preparation and its use
  • Novel mangiferin calcium salts, the method for its preparation and its use

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0075] Preparation Example 1: Preparation of Mangiferin

[0076] 100kg Anemarrhena decoction pieces were extracted twice at 80°C with 80% ethanol, concentrated, adsorbed by macroporous resin, washed with water, eluted with 40% ethanol, and the eluate was concentrated under reduced pressure to obtain crude mangiferin. The crude mangiferin was purified by solvent-dioxane-water recrystallization to obtain pure mangiferin. The mangiferin sample was identified with the mangiferin reference substance, and the obtained sample was determined to be mangiferin. The purity was determined to be 98.5% by HPLC. .

[0077] Compound Identification:

[0078] 1 HNMR (DMSO-d 6 ) (δppm), 4.60 (1H, d, J=9.8Hz) is a glucose end group proton, and exists in the form of B-glycosidic bond; and 6.37 (1H, s), 6.86 (1H, s) and 7.39 (1H, s) Signal of 3 aromatic protons.

[0079] 13 CNMR (DMSO-d 6 )(δppm): 162.7(C-1), 108.4(C-2), 164.7(C-3), 94.2(C-4), 157.1(C-4a), 102.2(C-4b), 103.5(C -5), 154.9(C-...

Embodiment 1

[0084] Embodiment 1: the preparation of mangiferin monosodium salt

[0085]Add 42.2g (0.1mol) of mangiferin, 1800ml of water, and 600ml of ethanol into the reactor to fully suspend, add 8.4g (0.1mol) of sodium bicarbonate into water to make a 0.5% (w / v) solution, and slowly add the In the suspension, react until clarification, filter, add an appropriate amount of absolute ethanol-ethyl acetate (1:1.5v / v) to the solution, stir well, a large amount of precipitates precipitate, filter with suction, and dry the solid below 60°C , to obtain 31.2 g of mangiferin monosodium salt as light yellow solid, with a yield of 74.0%. The purity of the sample was determined to be 98.6% by HPLC.

Embodiment 2

[0086] Embodiment 2: the preparation of mangiferin monosodium salt

[0087] Add 42.2g (0.1mol) of mangiferin, 1800ml of water, and 900ml of ethanol into the reactor to fully suspend, add 5.30g (0.05mol) of sodium carbonate with water to make a 0.5% (w / v) solution, and slowly add the mixture in a stirring state. Suspension, react until clarification, filter, add a proper amount of acetone to the solution, stir well, a large amount of precipitate precipitates, filter with suction, dry the solid below 60°C, and obtain 31.4g of light yellow solid mangiferin monosodium salt, yield was 74.5%. The purity of the sample was determined to be 98.5% by HPLC.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
weightaaaaaaaaaa
purityaaaaaaaaaa
purityaaaaaaaaaa
Login to View More

Abstract

The present invention provides a mangiferin calcium and its preparation and use. The mangiferin calcium can lower plasma insulin, glucose, lipid, and also can improve the solubility and oral bioavailability of mangiferin and increase insulin sensitivity.

Description

technical field [0001] The invention relates to a mangiferin calcium salt, a preparation method thereof and an application as an insulin sensitizer for treating diabetes and its complications. Background technique [0002] Insulin resistance (IR) refers to a series of pathological and clinical manifestations caused by the decrease or loss of the responsiveness of the target organs and tissues of insulin to the biological effects of insulin. A large number of studies have shown that IR runs through the development of type 2 diabetes and is a prominent feature of type 2 diabetes. With IR at its core, it can lead to hyperglycemia, hypertension, microalbuminuria, inflammation, hyperfibrinolytic state, abnormal lipid metabolism, endothelial dysfunction, atherosclerosis, and cardiovascular disease. Therefore, by enhancing the action of insulin and improving the sensitivity of insulin receptors, develop insulin sensitizers to treat diabetes and its complications (diabetic complica...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04A61K31/7048A61P3/10
CPCC07H17/04
Inventor 滕厚雷吴巍徐广爱
Owner CHANGZHOU DEZE MEDICAL SCI CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com