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396 results about "Mast cell" patented technology
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A mast cell (also known as a mastocyte or a labrocyte) is a migrant cell of connective tissue that contains many granules rich in histamine and heparin. Specifically, it is a type of granulocyte derived from the myeloid stem cell that is a part of the immune and neuroimmune systems. Mast cells were discovered by Paul Ehrlich in 1877. Although best known for their role in allergy and anaphylaxis, mast cells play an important protective role as well, being intimately involved in wound healing, angiogenesis, immune tolerance, defense against pathogens, and blood–brain barrier function.
Purinone derivative
ActiveUS20130079327A1Good metabolic stabilityAvoid liver toxicityBiocideOrganic chemistryMast cellMetabolic stability
Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.
Owner:ONO PHARMA CO LTD
Purinone derivative
ActiveUS20130217880A1Good metabolic stabilityAvoid liver toxicityOrganic active ingredientsOrganic chemistryDiseaseMast cell
Compounds represented by general formula (I) (all of the symbols in the formula conform to the definitions in the Description) are compounds that, in addition to having a Btk-selective inhibitory activity, exhibit an excellent metabolic stability and can avoid hepatotoxicity or the like, and as a consequence can provide safe therapeutic agents for diseases in which B cells or mast cells participate.
Owner:ONO PHARMA CO LTD
Purinone derivative hydrochloride
ActiveUS20140330015A1Good metabolic stabilityImprove solubilityOrganic active ingredientsAntipyreticMast cellSolubility
The purinone derivative 6-amino-9-[(3R)-1-(2-butynoyl)-3-pyrrolidinyl]-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one hydrochloride has Btk-selective inhibitory activity and, in addition to having excellent metabolic stability, it is a compound that exhibits a high level of solubility and absorption with respect to the free base and can be crystallized, hence it can serve as a therapeutic agent for diseases involving B cells and mast cells.
Owner:ONO PHARMA CO LTD
7-Substituted Purine Derivatives for Immunosuppression
The present invention provides novel purinone and related derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula III:
Owner:WYETH LLC
8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression
The present invention provides novel purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formula I:
Owner:WYETH LLC
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II:
Owner:WYETH LLC
6-substituted 2-(benzimidazolyl)purine and purinone derivatives for immunosuppression
The present invention provides novel purinones and purines useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulae I and II:
Owner:WYETH LLC
Composition comprising the extract of Actinidia arguta and related species for the prevention and treatment of allergic disease and non-allergic inflammatory disease
ActiveUS9131722B2Reduce actionTreat and prevent allergic diseaseBiocideSenses disorderFood additiveDisease
The present invention provides a pharmaceutical composition comprising the extract of hardy kiwifruit as an active ingredient in an effective amount to treat and prevent allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum and reducing the level of Th2 cytokines and IgE in serum. The present invention also provides a use of above extract for the preparation of pharmaceutical composition. The present invention also provides a health food or food additives, a cosmetic composition, a feed or feed additives comprising above extract for prevention or alleviation of allergic disease and non-allergic inflammatory disease by reducing inflammation action, by inhibiting histamine release from mast cell, and by increasing the level of Th1 cytokines, IgG2a in serum, and reducing the level of Th2 cytokines and IgE in serum.
Owner:VIROMED CO LTD
Concentrated mast cell stabilizing pharmaceutical formulations
ActiveUS20120118991A1Favourable aerosolisation propertyEasy to solveBiocideDispersion deliveryMast cellActive agent
Liquid aqueous pharmaceutical solutions, containing a mast cell stabilizing active agent for application to the upper and lower respiratory tract or in the eye are provided. The solutions comprise both a non-ionic and an ionic tonicity-adjusting excipient. They are particularly useful for the aerosol treatment of respiratory diseases such as asthma. Furthermore, methods for nebulization of these solutions and methods of packaging the solutions are provided.
Owner:PARI PHARMA GMBH
Purine and imidazopyridine derivatives for immunosuppression
The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas:
Owner:WYETH LLC +1
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
InactiveUS20130150559A1Strong upregulationImmunoglobulin superfamilyImmunoglobulins against cell receptors/antigens/surface-determinantsAutoimmune conditionDc maturation
Novel activating receptors of the lg super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
Owner:NOVO NORDISK AS
Surgical and examination gloves
InactiveUS6684405B2Avoid stimulationEasy to donPeptide/protein ingredientsSynthetic resin layered productsHuman typeEnzyme inhibitor
An examination or surgical glove having an inner coating of a compound which prevents the degranulation of mast cells which releases medicators of inflammation. The coating includes anti-mast cell and anti-inflammatory agents such cromolyn compounds and human type protease inhibitors.
Owner:LEZDEY JOHN
Methods of treating asthma
InactiveUS20050164323A1Increase kinase activityDecrease kinase activityCompound screeningApoptosis detectionMast cellKinase activity
Methods for agents useful for treating asthma are disclosed. The methods include screening for agents that inhibit the production of a PKC-θ protein, as well as for agents that inhibit the kinase activity of a PKC-θ protein, or a functional fragment thereof, wherein such agents are useful for treating asthma. The methods also include screening for agents that inhibit the production of a reporter gene product encoded by a nucleic acid sequence operably linked to a PKC-θ promoter. Also disclosed are methods of treating asthma that include administering an agent that inhibits the production of a functional PKC-θ protein or the kinase activity of a PKC-θ protein or a functional fragment thereof. An isolated mast cell lacking expression of endogenous PKC-θ is also disclosed.
Owner:WYETH LLC
Purine and imidazopyridine derivatives for immunosuppression
The present invention provides novel purine and imidazopyridine derivatives useful for the prevention and treatment of autoimmune diseases, inflammatory disease, mast cell mediated disease and transplant rejection. The compounds are of the general formulas:
Owner:PHARMACOPEIA INC CO LIGAND PHARM INC +1
Anti-inflammatory compositions for treating multiple sclerosis
Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biochemicals from the activated mast cells, the compositions containg one or more of a flavone or flavonoid glycoside a heavily sulfated, non-bovine proteoglycan, an unrefined olive kernel extract that increases absorption of these compositions in various routes of administration, a hexosamine sulfate such as D-glucosamine sulfate, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, a long-chain unsaturated fatty acid, a phospholipid, Krill oil, a polyamine, glutiramer acetate and interferon. Certain of the present compositions are useful in protecting against the neuropathological components of multiple sclerosis and similar inflammatory neurological diseases.
Owner:THETA BIOMEDICAL CONSULTING & DEVMENT
Methods for the Treatment of Systemic Disorders Treatable with Mast Cell Stabilizers, including Mast Cell Related Disorders
Owner:RESPIVANT SCI GMBH
Co-Administration of an Agent Linked to an Internalization Peptide with an Anti-Inflammatory
ActiveUS20090176713A1Reduce capacityInhibit the inflammatory responseOrganic active ingredientsNervous disorderCo administrationBiotin
The invention provides methods of delivering pharmacologic agents linked to an internalization peptide, in which an inflammatory response inducible by the internalization peptide is inhibited by co-administration of an anti-inflammatory or by linking the internalization peptide to biotin or similar molecule. Such methods are premised in part on the results described in the examples whereby administration of a pharmacological agent linked to tat high dosages is closely followed by an inflammatory response, which includes mast cell degranulation, histamine release and the typical sequelae of histamine release, such as redness, heat, swelling, and hypotension.
Owner:NONO INC
Bi-Aryl Meta-Pyrimidine Inhibitors of Kinases
The invention provides methods of treating a disease selected from systemic sclerosis, rheumatoid arthritis, mastocytosis, and chronic eosinophilic leukemia comprising administering biaryl meta-pyrimidine compounds having the general structure (A) to a subject in need thereof. The pyrimidine compounds of the invention are capable of inhibiting kinases, such as members of the JAK kinase family, and various other specific receptor and non-receptor kinases.
Owner:IMPACT BIOMEDICINES INC
Composition for protection against superficial vasodilator flush syndrome
InactiveUS20050220909A1Promote absorptionBiocideCosmetic preparationsChondroitin Sulfate CVascular dilatation
Compositions with synergistic anti-inflammatory effects in inflammatory diseases resulting from activation and consequent degranulation of mast cells and followed by secretion of inflammatory biomolecules from the activated mast cells, composed of a heavily sulfated, non-bovine proteoglycan such as shark cartilage chondroitin sulfate C, an unrefined olive kernel oil / extract that increases absorption of these compositions in various routes of administration, and one or more of a hexosamine sulfate such as D-glucosamine sulfate, a flavone such as quercetin, S-adenosylmethionine, a histamine-1 receptor antagonist, a histamine-3 receptor agonist, an antagonist of the actions of CRH, caffeine, and a polyamine.
Owner:THEOHARIDES THEOHARIS C
Hybrid protein for inhibiting the degranulation of mastocytes and the use thereof
InactiveUS6822076B2Avoid allergic reactionsAvoid symptomsHydrolasesPeptide/protein ingredientsTetanusBasophilia
A hybrid protein contains a protein that binds to a receptor of mastocytes and basophils and is endocyted by them. The protein can be IgE; IgE fragment; IgE Fc fragment; antibody against IgE receptor of mastocytes and basophils; fragment of the antibody against the IgE receptor of mastocytes and basophils; antibody against mastocyte specific potassium channel; and mast cell degranulating peptide. The hybrid protein also contains a protease cleaving proteins of the secretion process of the mastocytes and basophils so as to inhibit the secretion process without killing the mastocytes and basophils. The protease can be light chain Clostridium botulinum toxin; proteolytically active fragment of the light chain of a Clostridium botulinum toxin containing an amino acid sequence His-Xaa-Xaa-Xaa-His-Xaa-Xaa-His wherein Xaa is an amino acid; light chain of the tetanus toxin; proteolytically active fragment of the light chain of the tetanus toxin containing His-Asp-Leu-lIe-His-Val-Leu-His; IgA protease of Neisseria gonorrhoeae; and proteolytic domain of the IgA protease of Neisseria gonorrhoeae.
Owner:MERZ PHARMA GMBH & CO KGAA
Receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
InactiveUS8231878B2Strong upregulationImmunoglobulin superfamilyPeptide/protein ingredientsDc maturationAutoimmune disease
Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
Owner:COSMO TECH LTD
N-acyl ureas exhibiting anti-cancer and anti-proliferative activities
Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including, but not limited to, malignant melanomas, solid tumors, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, hepatic cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, chronic myelogenous leukemia, leukemias, papillary thyroid carcinoma, non-small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, diabetic retinopathy, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, and diseases caused by PDGFR-α kinase, PDGFR-β kinase, c-KIT kinase, cFMS kinase, c-MET kinase, and oncogenic forms, aberrant fusion proteins and polymorphs of any of the foregoing kinases.
Owner:DECIPHERA PHARMA LLC
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
InactiveUS20100310560A1Strong upregulationOrganic active ingredientsImmunoglobulin superfamilyAutoimmune responsesDc maturation
Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
Owner:COSMO TECH LTD
Purine and imidazopyridine derivatives for immunosuppression
Owner:WYETH LLC +1
Concentrated mast cell stabilizing pharmaceutical formulations
ActiveUS9198859B2Improve securityIncrease concentrationBiocideDispersion deliveryMast cellActive agent
Liquid aqueous pharmaceutical solutions, containing a mast cell stabilizing active agent for application to the upper and lower respiratory tract or in the eye are provided. The solutions comprise both a non-ionic and an ionic tonicity-adjusting excipient. They are particularly useful for the aerosol treatment of respiratory diseases such as asthma. Furthermore, methods for nebulization of these solutions and methods of packaging the solutions are provided.
Owner:PARI PHARMA GMBH
Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha
The invention relates to compounds of general formula (I); 1a, 1 b, 1 c and 1 d. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and / or physiologically compatible salts thereof which can be produced therefrom and / or solvates thereof, and to the pharmaceutical use of said compounds, salts or solvates thereof as inhibitors of phosphodiesterase 4. The compounds comprise active ingredients for the treatment of diseases which can have a positive influence by inhibiting the activity of phosphodiesterase 4 and / or TNFα-release, for example, in lymphocytes, eosinophile and basophile granulocytes, macrophages and mastocytes.
![Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/6b070c20-5975-4f0b-9ddd-c22a4a4e5553/US20080160028A1-20080703-D00000.png "Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha")
![Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/6b070c20-5975-4f0b-9ddd-c22a4a4e5553/US20080160028A1-20080703-D00001.png "Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha")
![Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha](https://images-eureka-patsnap-com.libproxy1.nus.edu.sg/patent_img/6b070c20-5975-4f0b-9ddd-c22a4a4e5553/US20080160028A1-20080703-C00001.png "Substituted pyrido [3', 2': 4, 5] thieno [3, 2-d] pyrimidines and pyrido [3', 2': 4, 5] furo [3, 2-d] pyrimidines used as inhibitors of the pde-4 and/or the release of tnf-alpha")
Owner:THE MEDICINES CO (LEIPZIG) GMBH
Receptor TREM (triggering receptor expressed on myeloid cells) and uses thereof
InactiveUS8981061B2Strong upregulationImmunoglobulin superfamilyImmunoglobulins against cell receptors/antigens/surface-determinantsDc maturationApoptosis
Owner:NOVO NORDISK AS
Compounds and methods for the treatment of asthma
Compounds and methods for the treatment of asthma are disclosed. The methods involve mast cell stabilization together with selective inhibition of iNOS. The compounds are combinations of a mast cell inhibiting moiety and an inhibitor of iNOS. An example is:
Owner:IRONWOOD PHARMA
Novel receptor trem (triggering receptor expressed on myeloid cells) and uses thereof
InactiveUS20090081199A1Strong upregulationOrganic active ingredientsCompound screeningApoptosisAutoimmune disease
Novel activating receptors of the Ig super-family expressed on human myeloid cells, called TREM(s) (triggering receptor expressed on myeloid cells) are provided. Specifically, two (2) members of TREMs, TREM-1 and TREM-2 are disclosed. TREM-1 is a transmembrane glycoprotein expressed selectively on blood neutrophils and a subset of monocytes but not on lymphocytes and other cell types and is upregulated by bacterial and fungal products. Use of TREM-1 in treatment and diagnosis of various inflammatory diseases is also provided. TREM-2 is also a transmembrane glycoprotein expressed selectively on mast cells and peripheral dendritic cells (DCs) but not on granulocytes or monocytes. DC stimulation via TREM-2 leads to DC maturation and resistance to apoptosis, and induces strong upregulation of CCR7 and subsequent chemotaxis toward macrophage inflammatory protein 3-β. TREM-2 has utility in modulating host immune responses in various immune disorders, including autoimmune diseases and allergic disorders.
Owner:BIOXELL
Methods for reducing allergies caused by environmental allergens
ActiveUS20100143266A1Reduce and minimize and prevent allergyReducing or preventing allergic responses to an environmental allergenAerosol deliveryImmunoglobulins against animals/humansMast cellEnvironmental health
Compositions suitable for reducing symptoms of an allergic response to environmental allergens comprising molecules that specifically inhibit the ability of the allergen to bind to mast cells in an animal predisposed to having an allergic response to the allergen and methods for reducing such symptoms comprising contacting a source of the environmental allergen with such compositions. Kits, packages, medicaments, and means of communicating about the compositions and methods are also provided.
Owner:SOC DES PROD NESTLE SA
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