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Usage of mangiferin calcium salt taken as AMPK agonist

A technology of mangiferin calcium salt and activator, applied in medical preparations containing active ingredients, anti-inflammatory agents, non-central analgesics, etc.

Inactive Publication Date: 2010-12-22
HAINAN DEZE DRUG RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In summary, the research and development of AMPK activators has important clinical significance, but there is no AMPK activator on the market [Li Ji. AMPK: a new target for the treatment of diabetes and cardiovascular diseases. China Medical Tribune, 2009, (1149) ; Ren Junfang. AMPK and Cardiovascular Remodeling. International Journal of Pathological Sciences and Clinics, 2008, 28(1): 33-36; Ricardo Lage, Carlos Dieguez, Antonio Vidal-Puig.et al. AMPK: a metabolic gauge regulating whole- body energy homeostasis. Trends MolMed, 2008, 14(12): 539-49; Fu Qingying, Gao Yuqi. Research progress of protein kinase AMPK. Life Science, 17(2): 147-152; Chen Qi, Liang Houjie, Zou Lan, etc. .Adenosine monophosphate-activated protein kinase, the relationship between the expression of cyclooxygenase-2 and the sensitivity of 5-fluorouracil treatment of colon cancer. Practical Hospital Clinical Journal, 2008, 5(3): 56-58, etc.]

Method used

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  • Usage of mangiferin calcium salt taken as AMPK agonist
  • Usage of mangiferin calcium salt taken as AMPK agonist
  • Usage of mangiferin calcium salt taken as AMPK agonist

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Abstract

The invention provides a usage of mangiferin calcium salt for preparing AMPK agonist. The mangiferin calcium salt has the structure shown by the following formula.

Description

technical field The invention relates to the use of a mangiferin calcium salt as an AMPK activator. Background technique AMP-activated protein kinase (AMPK) is a protein kinase that regulates energy metabolism in cells. Numerous studies have confirmed that AMPK affects sugar, fat and protein metabolism, and AMPK plays a crucial role in the pathogenesis of human metabolic diseases such as diabetes and obesity. Recent studies have also found that AMPK gene mutations can lead to cardiac hypertrophy and arrhythmia. When myocardial and vascular smooth muscle are stimulated by ischemia / hypoxia or cardiovascular active substances, AMPK activation can also inhibit cell proliferation by affecting cell cycle and substance metabolism, and plays an important role in the prevention and treatment of hypertension and atherosclerosis. Therefore, AMPK is expected to become an important new target for the treatment of metabolic diseases and cardiovascular diseases. The researchers also be...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61P3/10A61P3/04A61P3/06A61P5/50A61P3/00A61P9/00A61P9/06A61P9/10A61P9/04A61P9/12A61P11/00A61P11/06A61P1/16A61P13/08A61P1/18A61P13/12A61P19/02A61P29/00A61P19/04A61P1/00A61P25/28A61P25/16A61P35/00
Inventor 吴巍滕厚雷
Owner HAINAN DEZE DRUG RES
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