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552 results about "Energy metabolism" patented technology

Energy metabolism is generally defined as the entirety of an organism's chemical processes. These chemical processes typically take the form of complex metabolic pathways within the cell, generally categorized as being either catabolic or anabolic.

Inhibitors of glutaminyl cyclase

The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Owner:VIVORYON THERAPEUTICS NV

Method for establishing obese rat animal model based on CRISPR (clustered regularly interspaced short palindromic repeat) gene knockout technology

InactiveCN103614415AImprove the level ofDeepen understanding of gene regulationVector-based foreign material introductionAnimal husbandryDiseaseLepr gene
The invention provides a method for establishing an obese rat animal model based on a CRISPR (clustered regularly interspaced short palindromic repeat) gene knockout technology. The method comprises the following steps: (1) establishing an Lep / Lepr gene knockout rat model; (2) carrying out the authentication and related analysis on the obese rat animal model; (3) evaluating the energy metabolism and the body fat rate of the obese rat animal model. According to the method, a CRISPR / Cas system is used for respectively or simultaneously knocking out Lep and LepR genes so as to obtain the rat model modified by a corresponding target gene, so that the understanding of gene regulation in the obesity morbidity process can be deepened, and the high-level animal model can be provided for the translational medicine and the new medicine research and development.
Owner:SUZHOU TONGSHAN BIO TECH

Mitochondria-targeted antioxidants

ActiveUS20080031862A1Protect mitochondrionHigh energyCosmetic preparationsBiocideDiseasePersonal care
The present invention relates to a pharmaceutical or veterinary or nutritional or personal care composition comprising coenzyme Q10 (CoQ10), reduced CoQ10, or mixtures thereof and oxygenated dibenzo-α-pyrone or an amino acyl ester thereof. The composition of the present invention is able to support and / or provide therapy to individuals at risk and / or under treatment for dysfunctions of energy metabolism, and specifically, for mitochondrial diseases.
Owner:NATREON INC +1

Cest MRI methods for imaging of metabolites and the use of same as biomarkers

The CEST effect for various neurotransmitters and energy metabolites in the brain and muscles and various endogenous metabolites in the liver, brain, and myocardium are imaged using MR imaging to illustrate a unique CEST effect that may be used to monitor the concentration of the metabolite and hence to characterize and monitor various disease states in the body correlated to the concentration of that metabolite. By adjusting the timing, amplitude, and length of the RF pulse as well as other parameters of the CEST pulse sequence to address the unique chemical shifts and exchange rates of the target, new targets with unique characteristics may be acquired using CEST MR imaging.
Owner:THE TRUSTEES OF THE UNIV OF PENNSYLVANIA

Instant pu'er tea and its preparation method

ActiveCN1907060ATransparent red colorStrong teaTea extractionInstant teaAdditive ingredient
The invention discloses a rapid-soluble Pu'er tea and preparing method to accelerate body to release energy, which comprises the following steps: blending Pu'er tea and ripe tea ( or black tea and green tea) according to certain proportion; grinding roughly; extracting through water; condensing; drying; adding beta-cyclodextrin; recycling aged perfume benzine ingredient through steam distilling method or super-critical extracting method; packing the benzine and rapid-soluble tea powder together; adding isomaltose hypgather, degrading factor and flavoring factor.
Owner:YUNNAN LONGRUN TEA TECH

Methods for enhancing energy metabolism

The invention provides methods for one or more of enhancing energy metabolism, promoting healthy energy metabolism, maintaining healthy energy metabolism, preventing conditions that result in a decline or deficiency in energy metabolism, treating conditions that result in a decline or deficiency in energy metabolism, and preventing the accumulation of excess body fat in animals without reducing energy intake by the animals. The methods comprise administering isoflavones to the animals, preferably in amounts of from about 0.001 to about 10 g / kg / day.
Owner:SOC DES PROD NESTLE SA

Novel inhibitors of glutaminyl cyclase

The present invention relates to novel inhibitors of glutaminyl cyclase and combinations thereof for the treatment of neuronal disorders, especially Alzheimer's disease, Down Syndrome, Parkinson disease, Chorea Huntington, pathogenic psychotic conditions, schizophrenia, impaired food intake, sleep-wakefulness, impaired homeostatic regulation of energy metabolism, impaired autonomic function, impaired hormonal balance, impaired regulation, body fluids, hypertension, fever, sleep dysregulation, anorexia, anxiety related disorders including depression, seizures including epilepsy, drug withdrawal and alcoholism, neurodegenerative disorders including cognitive dysfunction and dementia.
Owner:VIVORYON THERAPEUTICS NV

System for recognizing human gait, real-time monitoring energy consumption thereof and instructing exercise training thereof

The invention relates to a system for recognizing human gait, real-time monitoring energy consumption thereof and guiding exercise training thereof, comprising a functional innersole, a data storage display system and a health auxiliary guidance system. The system is characterized in that the functional innersole comprises an amorphous wire pressure sensor measuring human pressure and a data acquisition processing system which are embedded; the data storage display system sets system initial parameters and individual parameters through the input of keys and sends the parameters to the data acquisition processing system in the functional innersole through a wireless communication module; the data of the data acquisition processing system are wirelessly sent to the data storage display system, and a display interface on the data storage display system displays the information such as gait, step number, step frequency, energy consumption, time for exercise, and the like; and the data stored in the data storage display system are uploaded to a personal computer, and energy metabolism analysis for an exerciser is carried out and training guidance and training reference are provided under the help of the health auxiliary guidance system in the personal computer. The invention has low energy consumption, high sensitivity, quick response time, high anti-interference ability and low cost.
Owner:北京国浩微磁电子智能传感器技术研究所

Plant drug for treatment of liver disease

The present invention related to safe plant drug for treatment of liver disease, specifically, this invention proves a safe plant drug Schisandrin and its preparation. Schisandrin has the following pharmaceutical functions: increasing tumor suppresson genes express activity, decreasing activity of oncogenes, increasing immune function, increasing liver DNA synthesis, decreasing serum alamine aminotransferase activity, increasing glutathione level, increasing glutathione reductase activity, decreasing lipid peroxidation of liver, increasing hepatic microsomal monooxygenases activity, increasing ATP content in liver, increasing energy metabolism activity, decreasing density lipoprotein oxidation, protecting gastrointestinal function, increasing killer cell activity, increasing complement activity, decreasing induced liver cancer activity and decreasing grown of cancer cells.
Owner:ZHAO XINXIAN

Heteroaryl-substituted spirocyclic diamine urea modulators of fatty acid amide hydrolase

Certain heteroaryl-substituted spirocyclic diamine urea compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis).
Owner:JANSSEN PHARMA NV

Cryopreservation media and molecules

The cryopreservation media utilizes naturally occurring endogenous molecules and their chemical derivatives which act as osmotically active cryopreservative agents as well as molecules which insert into and protect specific regions of cellular membranes, lead to membrane repair, maintain normal cellular levels of energy metabolites, and act as antioxidants. Cryoperserved cells can be returned to a pre- cryopreservation state without damaging the cells resulting in a very high survival rate.
Owner:PETTEGREW JAY W +3

Novel compounds and their effects on feeding behaviour

Peptide containing sequence from both the GLP-1 peptide and glucagon peptide, compositions comprising said peptides and methods of using said peptides for the treatment and prevention of metabolic disorders, for example disorders of energy metabolism such as obesity or diabetes, are provided
Owner:IP2IPO INNOVATIONS LTD

Compositions, methods, and kits for regulating energy metabolism

The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and / or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.
Owner:NUSIRT SCI

Multi-nuclide multi-frequency resonance synchronous imaging system

The invention provides a multi-nuclide multi-frequency resonance synchronous imaging system which is used for detecting the tumor ion dynamic balance, the energy metabolism, the molecular target change and the tumor microenvironment change. The system can simultaneously transmit radio frequency pulse signals corresponding to four nuclides of 1H, 23Na, 31P and 19F and synchronously receive the nuclear magnetic resonance load signals of the four nuclides. The multi-nuclide multi-frequency resonance synchronous imaging system comprises a signal excitation system, a multi-nuclide multi-frequency signal excitation and acquisition system, a magnetization system and an imaging system. The multi-nuclide multi-frequency signal excitation and acquisition system comprises four nuclide channel modules of 1H, 23Na, 31P and 19F, and each nuclide channel module comprises a signal excitation power amplifier submodule and a signal acquisition submodule. The magnetization system comprises magnets and radio frequency transmitting coils. The imaging system comprises a signal preamplifier, a signal acquisition command module, an image reconstruction module, an image post-processing and display module and an image database.
Owner:HARBIN MEDICAL UNIVERSITY

Plant drug for treatment of liver disease

InactiveUS6605305B2BiocideEther/acetal active ingredientsAtp contentAminotransferase activity
The present invention related to safe plant drug for treatment of liver disease, specifically, this invention proves a safe plant drug Schisandrin and its preparation. Schisandrin has the following pharmaceutical functions: increasing tumor suppresson genes express activity, decreasing activity of oncogenes, increasing immune function, increasing liver DNA synthesis, decreasing serum alamine aminotransferase activity, increasing glutathione level, increasing glutathione reductase activity, decreasing lipid peroxidation of liver, increasing hepatic microsomal monooxygenases activity, increasing ATP content in liver, increasing energy metabolism activity, decreasing density lipoprotein oxidation, protecting gastrointestinal function, increasing killer cell activity, increasing complement activity, decreasing induced liver cancer activity and decreasing grown of cancer cells.
Owner:ZHAO XINXIAN

Treatment of benign prostatic hyperplasia using energolytic agents

InactiveUS20060172953A1PSA level is decreasedDegradation is usually manifestedBiocideCarbohydrate active ingredientsProstatic epitheliumProstate hyperplasia
The invention provides a method for treatment or prophylaxis of benign prostatic hyperplasia by administration of an agent that interferes with energy metabolism, particularly the production of ATP and NADH / NADPH, in prostate epithelial cells.
Owner:THRESHOLD PHARM INC

Use of Rhodiola crenulata extract via the topical route

The invention relates to the use of a Rhodiola crenulata extract, via the topical route, for increasing the energy metabolism of the cutaneous tissues of a subject. The invention relates notably to topical compositions which comprise an active agent for increasing the energy metabolism of the cutaneous tissues of a subject, said active agent being a Rhodiola crenulata extract. The present invention enables making a cosmetic care such as fighting against, or slowing down or preventing the loosening of the cutaneous tissue, increasing the plasticity of the cutaneous tissue, exerting an anti-wrinkle effect or slowing down or preventing the appearance of wrinkles, fighting against, slowing down or preventing the appearance of acne, exerting a depigmenting effect of the cutaneous tissue, in particular of the skin, and promoting desquamation of the cutaneous tissue (or “peeling”).
Owner:BASF BEAUTY CARE SOLUTIONS FRANCE SAS

Perfect compound feed with low nitrogen and phosphorus emissions for feeding culter alburnus and preparation method of perfect compound

The invention discloses a perfect compound feed with low nitrogen and phosphorus emissions for feeding culter alburnus and a preparation method of the perfect compound feed. The perfect compound feed comprises the following raw materials: fish meal, puffed bean pulp, puffed beans, shrimp shell meal, DDGS, vegetable cake, cottonseed meal, wheat, monocalcium phosphate, multi-vitamin premix, polymineral premix, fish oil, lard oil, vegetable oil, compound amino acid, granulesten, glycine betaine, choline chloride, phytase, purple perilla and the like. The prepared perfect compound feed has the characteristics that the protein utilization efficiency is high; the decomposition of protein into amino acid for energy metabolism is alleviated by amino acid balance; the energy utilization of lipid is improved by adjusting lipid metabolism and hepatoprotective effect; the utilization rate of phosphorus in the feed is high; phytate phosphorus is degraded by mainly selecting special phytase and is changed into effective phosphorus for use; the properties of the feed are ensured by a production process of puffing and pelletizing at high temperature and spraying at low temperature; the feed is reasonable in formula; the processing process of the feed is scientific; the nitrogen and phosphorus emissions are reduced; the requirements on healthful aquaculture of the culter alburnus can be met.
Owner:JIANGXI AGRICULTURAL UNIVERSITY

Creatine-containing vitamin and mineral composition

A composition and method is provided for supporting multiple aspects of mammalian energy producing systems. Creatine, a key substance for energy production, is provided along with a substance to enhance the uptake of creatine and vitamins and minerals involved in energy metabolism. The compositions may further comprise additional components with anabolic and antioxidant activity. The compositions are suitable for supplementing the diet of individuals engaging in physical activity, particularly intense physical activity.
Owner:NORTHERN INNOVATIONS HLDG

Pharmaceutical composition for treatment of abnormal energy metabolism and application thereof

The invention relates to a pharmaceutical composition for the treatment of abnormal energy metabolism, which is the pharmaceutical composition containing a) a medicine for promoting fatty acid oxidation or derivatives thereof and b) a medicine for promoting glucose oxidation or pharmaceutical salts thereof. The pharmaceutical composition can comprehensively balance the metabolisms of fatty acid and glucose, optimize the productivity of fatty acid and glucose, reduce the jeopardy of abnormal aggregation of acidic metabolites, including free fatty acid or lactic acid and the like on organism, treat mitochondrial dysfunction, improve the defect that trimetazidine and the like are likely to create the accumulation of free fatty acid owing to the suppression on the fatty acid oxidation, and can be used for the auxiliary treatment for a plurality of diseases featured by imbalanced energy metabolism, such as acute and chronic ischemia, traumas, serious infection, diabetes, tumors, etc.
Owner:CHANGZHOU HI TECH DISTRICT MULTIPLE DIMENSION IND TECH INST

Application of nicotinamide mononucleotide containing composition to ageing resisting drugs/health-care products

InactiveCN110237118AActivate energy metabolismImproves oxidative stress responseOrganic active ingredientsAntinoxious agentsOxidative stressAgeing
The invention belongs to the fields of research and development of drugs and health-care products, particularly relates to an application of a nicotinamide mononucleotide containing composition to ageing resisting drugs / health-care products, provides a composition, further provides a preparation method of the composition, and further provides the composition or the application of the product prepared by the preparation method to ageing resisting drugs / health-care products. NMN can achieve the effects of activating organism energy metabolism and improving an organism oxidation stress reaction, and besides, through cooperation with synergism of other components, favorable effect of resisting ageing can be achieved; and the components in the composition are stable in structure. The prepared product is not liable to deteriorate or damage, and besides, the components are safe. The product basically has no poor reaction on human bodies. The composition solves the technical problems that in the prior art, the ageing resisting products do not have favorable ageing resisting effect, are free from damage to human bodies, and are stable in product quality.
Owner:HOBOOMLIFE BIO TECH SHENZHEN CO LTD

Treatment of pets with sirtuin activators

InactiveUS20160000737A1Regulating energy metabolismReduce weightBiocideLiquid surface applicatorsMetaboliteReady to use
The present invention provides for systems, compositions, methods and kits for regulating energy metabolism in pets. The systems, compositions, and kits can comprise, and methods can make use of, pet foods, pet treats, pet supplements, and pet drinks. In one aspect, the invention provides for pet food, treat, supplement, and drink compositions that comprise a combination of (a) leucine, and (b) a sirtuin activator, or any precursors or metabolites of (a) or (b). These combinations may be effective for reducing weight or adipose volume in the pet. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising leucine, a leucine metabolite, and / or a sirtuin activator. The invention also provides for kits comprising compositions of leucine, a leucine metabolite, and / or a sirtuin activator packaged in an oral dose form with usage instructions.
Owner:NUSIRT SCI

Compositions, methods, and kits for regulating energy metabolism

The present invention provides for compositions, methods and kits for regulating energy metabolism. In one aspect, the invention provides for compositions that comprise a combination of (a) branched chain amino acids, such as leucine, and (b) vitamin B6, or any precursors or metabolites of (a) or (b). These combinations may be synergistic and / or effective for reducing weight or adipose volume. In another aspect, the invention provides for methods of regulating energy metabolism by the administration of one or more compositions comprising branched chain amino acids and vitamin B6. The invention also provides for kits comprising compositions of branched chain amino acids and vitamin B6 packaged in an oral dose form with usage instructions.
Owner:NUSIRT SCI

Aryl - Hydroxyethylamino - Pyrimidines and Triazines as Modulators of Fatty Acid amide Hydrolase

Certain aryl-hydroxyethylamino-pyrimidine and triazine compounds are described, which are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity, such as anxiety, pain, inflammation, sleep disorders, eating disorders, energy metabolism disorders, and movement disorders (e.g., multiple sclerosis). Methods of synthesizing such compounds are also disclosed.
Owner:JANSSEN PHARMA NV

Non-invasive blood sugar measuring method and fingertip measuring probe

The present invention discloses a non-invasive blood glucose measurement method, applied to noninvasive blood glucose measuring instruments including measuring hosts and fingertip measuring probes, comprising pre-storing a random forest algorithm and a neural network prediction algorithm in the measuring host; measuring energy metabolism parameters of a fingertip of an individual to be measured and transmitting the parameters to the measuring host by the fingertip measuring probe; calling the random forest algorithm to predict the blood glucose type of the energy metabolism parameters of the fingertip of the individual to be measured and calling the corresponding neural network prediction algorithm to calculate the blood glucose value of the fingertip of the individual to be measured by the measuring host. The present invention also provides a fingertip-measuring probe. The non-invasive blood glucose measurement method disclosed in the present invention can be applied to non-invasive measurement of blood glucose, parameters related to energy metabolism of human body, healthy parameters of angiocarpy, etc.
Owner:GUILIN MEDICINE ELECTRONICS TECH CO LTD +1

Production method of bacillus amyloliquefaciens antimicrobial lipopeptide and application thereof in prawn feed

InactiveCN103478509AAntibacterial Broad Spectrum High EfficiencySolve bottlenecksAnimal feeding stuffAccessory food factorsBiotechnologyFeed additive
The invention relates to a production method of bacillus amyloliquefaciens antimicrobial lipopeptide and application thereof in prawn feeds and belongs to the technical fields of aquiculture and biology in the field of agriculture. The production method comprises the following steps that bacillus amyloliquefaciens fmb-50 with the collection number of CGMCC No.6249 is used as a strain and is sequentially subjected to seed culture, amplification culture and fermentation production to obtain fermentation liquor; the thalli of the fermentation liquor are removed through microfiltration or membrane filtration and nanofiltration; corn starch or porous starch is added for absorption and spray drying is carried out, thus obtaining an antibacterial substance feed additive with the antibacterial valence of 40000-50000 IU / g or 250000 IU / g. The antibacterial substance which is produced from the bacillus amyloliquefaciens fmb-50 through fermentation can be industrially produced in a large scale; the production period is short and production cost is greatly reduced; when used in the prawn feeds, the antibacterial substance can reduce the mortality rate, improve the utilization ratio of the prawn feeds, promote the nonspecific immunoreaction of prawns and enhance the energy metabolism level.
Owner:NANJING AGRICULTURAL UNIVERSITY +2

Medicine for treating male oligozoospermia and improving semen quality and preparation method of medicine

The invention relates to a medicine for treating male oligozoospermia and improving semen quality. Various natural edible plant medicines such as Rhizoma Polygonati, Fructus Lycii, Cordyceps militaris (L.) Link., Fructus Rubi, Fructus Mori, Fructus Hippophae, Semen Coicis, Radix Ginseng, and Concha Ostreae (calcined) serve as raw materials, are combined suitably, and jointly have effects of invigorating the spleen and replenishing Qi, and nourishing the kidney and replenishing essence, Lepidium Meyenii contains macaenes and macamides which are used as active substances has effects of promoting sexual function, increasing the number of sperms and improving activity of the sperms, selenium yeast, aminoacid, L-carnitine tartrate, calcium carbonate and fructose can strengthen and protect energy metabolism of the sperms, taurine and vitamin effectively remove reactive oxide species and protect activity of the sperms, and folacin can promote maturity of the sperms and improve functions of the sperms. The medicine is reasonable in composition, and the synergistic effect of various components is utilized, so that the medicine is remarkable and lasting in treatment effect, safe and reliable and convenient to take orally, and can effectively promote spermatogenesis, improve survival rate of the sperms and improve activity of the sperms.
Owner:梁晓会

Application of ginkgoic acid and ginkgol compounds to killing Ampullaria gigas

InactiveCN101911938AEfficient killingPlay a role in preventing its harmBiocideMolluscicidesAcute toxicity testingRespiratory chain
The invention belongs to the technical field of biopesticides, discloses application of ginkgoic acid and ginkgol compounds to killing agriculturally harmful mollusks, and discloses novel application of the ginkgoic acid and ginkgol to preparation of the biopesticides. The invention shows that the ginkgoic acid and ginkgol compounds can effectively inhibit the synthesis of glycogen and protein inmollusk ampullaria gigas, can simultaneously inhibit the activities of ChE, SDH and MDH in the cephalopodium and the liver of the ampullaria gigas, interfere a NADH respiratory chain and cause energymetabolic dysfunction so as to cause cell energy supply deficiency and unattainability of normal synthesis and secretion functions, and promote the lack of important proteins and enzymes in the body of the ampullaria gigas so as to cause the death of the ampullaria gigas. The ginkgoic acid and the ginkgol are readily degradable in the natural environment, and have small influence on the environment; and an acute toxicity test proves that the ginkgoic acid and the ginkgol are proved to be slightly toxic pesticides, can be developed into novel biopesticides, and can be used for preventing the ampullaria gigas for rice, vegetables and fruits.
Owner:JIANGSU UNIV

N1-cyclic amine-N5-substituted phenyl biguanide derivatives, methods of preparing the same and pharmaceutical composition comprising the same

An N1-cyclic amine-N5-substituted phenyl biguanide derivative of Formula 1 or a pharmaceutically acceptable salt thereof, a method of manufacturing the same, and a pharmaceutical composition including the biguanide derivative or the pharmaceutically acceptable salt thereof as an active ingredient are provided. The biguanide derivatives have an effect of inhibiting cancer cell proliferation and also exhibit anticancer activity including inhibition of cancer metastasis and cancer recurrence, because they are effective in activating AMPK, which is associated with the control of energy metabolism, even when administered in a small dose compared with conventional drugs.; Also, the biguanide derivatives are highly effective at lowering blood glucose and lipid concentration by AMPK activation, thus they may be effectively used to treat diabetes mellitus, obesity, hyperlipemia, hypercholesterolemia, fatty liver, coronary artery disease, osteoporosis, polycystic ovary syndrome and metabolic syndrome.
Owner:IMMUNOMET THERAPEUTICS
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