45 results about "Trimetazidine" patented technology

This invention relates to a pharmaceutical composition for preventing and curing myocardium ischemia and reducing area of myocardial infarction, its pharmaceutical preparation and applications. The composition includes (a) levocarnitine or its derivatives, and (b) trimetazidine or its medicative salts. The quantity of levocarnitine or its derivatives, and trimetazidine or its medicative salts in the composition is effective amount for treating myocardial ischemia and reducing the area of myocardial infarction.

The pharmaceutical compositions for treating abnormal energy metabolism, comprising a) medicines for promoting oxidation of fatty acid or derivatives thereof, particularly levocarnitine, and b) medicines for promoting oxidation of glucose or pharmaceutically acceptable salts thereof, particularly trimetazidine, are provided in the present invention. The said pharmaceutical composition can also auxiliarily treat many kinds of diseases such as acute or chronic ischemia, trauma, severe infection, diabetes and tumor etc.

The invention relates to a preparation method of trimetazidine, belonging to the preparation field of medicine compound. The method comprises the steps of: by taking 2, 3, 4-trimethoxy benzaldehyde and piperazine as raw materials and formic acid as a catalyst; adding a solvent and formic acid in the 2, 3, 4-trimethoxy benzaldehyde and the piperazine for reaction; removing the solvent by steaming, and adjusting the pH value of reaction liquid to be 11-13; and then, carrying out reflux, acidification and rotary steaming to obtain the trimetazidine. In the method, the reductive amination reaction is adopted and the trimetazidine is synthesized in one step under the condition that the formic acid is taken as the catalyst, and the yield reaches up to 83-92%; meanwhile, precious metal palladium catalyst is not used, so that the synthesis cost is reduced. The LiAlH4 and NaBH4 which are high in danger are not used, so that the experimental safety is improved; and the method is beneficial to the large-scale production of the trimetazidine.

The present invention discloses an antihypoxic pharmaceutical composition and application thereof. The pharmaceutical composition contains vinpocetine and L-carnitine or a derivative thereof and a pharmaceutically acceptable salt thereof, and also can contain trimetazidine or a pharmaceutically acceptable salt thereof.

The invention discloses trimetazidine and a production method of hydrochloride thereof, which belongs to the technical field of chemical synthesis and is characterized by adopting 2,3,4-3-methoxybenzaldehyde and piperazine as raw materials. The method comprises the following steps of: adding a solvent, 2,3,4-3-methoxybenzaldehyde and anhydrous piperazine with the molar ratio of 1:1 to 1:3, and a nickel-based catalyst accounting for 3 to 10% of the mass percentage of the 2,3,4-3-methoxybenzaldehyde and the anhydrous piperazine to a pressure kettle; using nitrogen for purging before hydrogen isled in, with hydrogen pressure maintained within the range of 0.7MPa to 2.0MPa, reaction temperature within the range of 50 DEG C to 95 DEG C, reaction time within the range of 4 hours to 10 hours, and pH value regulated to 3 to 4; separating out organic phase; and recovering the solvent. The water phase is washed with chlorinated hydrocarbon extraction, and the pH value is regulated to 12, then the water phase is extracted with aromatic hydrocarbon, and the aromatic hydrocarbon in the aromatic hydrocarbon extraction liquid is steamed out, thus obtaining the trimetazidine. The invention has the advantages of low production cost, high yield, and good environmental protection.

The invention relates to a slow-release micro drop whose active component is Humeitashen or other salt, wherein it is formed by element and film layer that controlling the drug release, whose weight ratio is 20:1-5:1; the Humeitashen content of element is 10-60%. The invention mainly uses protrusion method to prepare drop, and uses fluidize bed to pack.