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122 results about "Fatty acid metabolism" patented technology

Fatty acid metabolism consists of catabolic processes that generate energy, and anabolic processes that create biologically important molecules (triglycerides, phospholipids, second messengers, local hormones and ketone bodies). Fatty acids are a family of molecules classified within the lipid macronutrient class. One role of fatty acids in animal metabolism is energy production, captured in the form of adenosine triphosphate (ATP). When compared to other macronutrient classes (carbohydrates and protein), fatty acids yield the most ATP on an energy per gram basis, when they are completely oxidized to CO₂ and water by beta oxidation and the citric acid cycle. Fatty acids (mainly in the form of triglycerides) are therefore the foremost storage form of fuel in most animals, and to a lesser extent in plants. In addition, fatty acids are important components of the phospholipids that form the phospholipid bilayers out of which all the membranes of the cell are constructed (the cell wall, and the membranes that enclose all the organelles within the cells, such as the nucleus, the mitochondria, endoplasmic reticulum, and the Golgi apparatus). Fatty acids can also be cleaved, or partially cleaved, from their chemical attachments in the cell membrane to form second messengers within the cell, and local hormones in the immediate vicinity of the cell. The prostaglandins made from arachidonic acid stored in the cell membrane, are probably the most well known group of these local hormones.

Fatty acid epoxygenase genes from plants and uses therefor in modifying fatty acid metabolism

The present invention relates generally to novel genetic sequences that encode fatty acid epoxygenase enzymes, in particular fatty acid Δ12-epoxygenase enzymes from plants that are mixed function monooxygenase enzymes. More particularly, the present invention exemplifies cDNA sequences from Crepis spp. and Vernonia galamensis that encode fatty acid Δ12-epoxygenases. The genetic sequences of the present invention provide the means by which fatty acid metabolism may be altered or manipulated in organisms, such as, for example, yeasts, moulds, bacteria, insects, birds, mammals and plants, and more particularly in plants. The invention also extends to genetically modified oil-accumulating organisms transformed with the subject genetic sequences and to the oils derived therefrom. The oils thus produced provide the means for the cost-effective raw materials for use in the efficient production of coatings, resins, glues, plastics, surfactants and lubricants.
Owner:COMMONWEALTH SCI & IND RES ORG

Systems and methods for treating human inflammatory and proliferative diseases and wounds, with fatty acid metabolism inhibitors and/or glycolytic inhibitors

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a fatty acid metabolism inhibitor, a glycolytic inhibitor, and / or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an oxirane carboxylic acid, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and / or an antibody against UCP and / or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

Compositions for Enhancing the Production of PPAR and/or PPAR-Associated Factors

The present inventors focused on certain nutritional compositions known to have activity of controlling blood glucose levels. These foods were administered to rats for long periods, and real-time PCR was used to analyze the expression of genes associated with lipid metabolism in the liver and adipose tissues. As a result, the present inventors found that the expression of the PPARα gene is enhanced by these foods, and that this is accompanied by suppressed expression of fatty acid synthase and enhanced expression of a group of PPARα target genes associated with fatty acid metabolism. The present inventors also confirmed the effect of these foods in enhancing the expression of PPARγ and adiponectin, and discovered that these foods have the activity of enhancing the production of PPAR and PPAR-associated factors.
Owner:MEIJI CO LTD

Systems and methods for treating human inflammatory and proliferative diseases and wounds, with UCP and/or FAS antibody or other inhibitor, optionally with a fatty acid metabolism inhibitor and/or a glucose metabolism inhibitor

Systems and methods for treating inflammatory and proliferative diseases, and wounds, using as a pharmacon a UCP and / or Fas antibody or other inhibitor, or combination thereof, and a therapeutically acceptable amount of a fatty acid metabolism inhibitor and / or a therapeutically acceptable amount of a glucose metabolism inhibitor, optionally in combination with one or more chemotherpeutic agents. In preferred embodiments, the invention combines an antibody against UCP and / or Fas antigen with an oxirane carboxylic acid, represented by etomoxir, and / or with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers.
Owner:UNIV OF COLORADO THE REGENTS OF

Methods for treating human proliferative diseases, with a combination of fatty acid metabolism inhibitors and glycolytic inhibitors

The present invention generally relates to systems and methods for treating inflammatory and proliferative diseases, and wounds, using a combination of (1) fatty acid metabolism inhibitors and (2) glycolytic inhibitors and / or UCP and / or Fas inhibitors or antibodies. More particularly, the invention combines an oxirane carboxylic acid compound, represented by etomoxir, with a 2-deoxyglucose compound, represented by 2-deoxy-D-glucose, and / or an antibody against UCP and / or Fas antigen. The systems and methods of the invention can be used to treat drug-resistant or multi-drug resistant cancers (i.e., cancers resistant to conventional cancer drug therapies).
Owner:UNIV OF COLORADO THE REGENTS OF

Methods for determining the metabolism of sugars and fats in an individual

Provided herein are methods for determining the metabolism of one or more sugars and / or fatty acids, and applications thereof. Such applications include determining the rate of glycogen synthesis and glycolysis, which are believed to be early markers for predicting elevated risk of diabetes and cardiovascular disease. Other applications include methods for screening drugs that effect sugar and / or fatty acid metabolism. The methods are useful for at least partially characterizing drugs for desirable or undesirable (toxic) characteristics. Drugs that are at least partially characterized using the methods of the invention can then be further developed in pre-clinical testing and clinical trials. Such drugs may be found to be useful in treating obesity, diabetes, cardiovascular disease, and other disorders of metabolism.
Owner:RGT UNIV OF CALIFORNIA

Methods, compounds, and compositions for reducing body fat and modulating fatty acid metabolism

Methods, pharmaceutical compositions, and compounds for reducing body weight, modulating body lipid metabolism, and reducing food intake in mammals are provided. The compounds of the invention include fatty acid ethanolamide compounds, homologues and analogs of which the prototype is the endogenous fatty acid ethanolamide, oleoylethanolamide.
Owner:RGT UNIV OF CALIFORNIA

Methods of using krill oil to treat risk factors for cardiovascular, metabolic, and inflammatory disorders

This invention discloses methods of using krill oil and compositions comprising krill oil to treat risk factors for metabolic, cardiovascular, and inflammatory disorders. The present invention also relates to methods of using compositions comprising krill oil to modulate biological processes selected from the group consisting of glucose metabolism, lipid biosynthesis, fatty acid metabolism, cholesterol biosynthesis, and the mitochondrial respiratory chain. The present invention further includes pharmaceutical and / or nutraceutical formulations made from krill oil, methods of making such formulations, and methods of administering them to treat risk factors for metabolic, cardiovascular, and inflammatory disorders.
Owner:AKER BIOMARINE ANTARCTIC

Method for the preparation of diols

ActiveUS20110294178A1Increasing endogenous expressionHigh expressionFungiBacteriaMicroorganismMetabolite
The present invention concerns a new method for the biological preparation of a diol comprising culturing a microorganism genetically modified for the bioproduction of an aliphatic diol, wherein the microorganism comprises a metabolic pathway for the decarboxylation of a hydroxy-2-keto-aliphatic acid metabolite with an enzyme having a 2-keto acid decarboxylase activity, the product obtained from said decarboxylation step being further reduced into the corresponding aliphatic diol, and wherein the microorganism is genetically modified for the improved production of said hydroxy-2-keto-aliphatic acid metabolite.The invention also concerns a modified microorganism for the production of an aliphatic diol.
Owner:METABOLIC EXPLORER

Dietary and other compositions, compounds, and methods for reducing body fat, controlling appetite, and modulating fatty acid metabolism

Methods, pharmaceutical, dietary supplement, and nutraceutical compositions, and compounds for reducing body weight, modulating body lipid metabolism, and reducing food intake in mammals are provided. The compounds of the invention include fatty acid ethanolamide compounds, homologues and analogs of which the prototype is the endogenous fatty acid ethanolamide, oleoylethanolamide.
Owner:RGT UNIV OF CALIFORNIA

Alteration of oil traits in plants

InactiveUS20050160494A1Improving oil production and characteristicImprove yield rateOther foreign material introduction processesFermentationBiotechnologyPlant cell
Compositions and methods for modulating the production and characteristics of oil in a plant or plant part thereof are provided. Compositions of the invention are nucleotide constructs that provide for expression of transcriptional activators that increase lipid biosynthesis in a plant in combination with the inhibition or disruption of starch biosynthesis and / or starch storage, and optionally in combination with expression of another polynucleotide of interest. Compositions also include transformed plants, plant cells, plant tissues, and plant seeds comprising these nucleotide constructs. The methods of the invention comprise introducing a combination of polynucleotides into a plant, wherein the polynucleotides provide for increased lipid biosynthesis and disruption of starch biosynthesis and / or starch storage, and optionally alteration of fatty acid metabolism. The methods and constructs find use in alteration of oil phenotype in a plant or plant part thereof.
Owner:PIONEER HI BRED INT INC +1

Microbial Conversion of Oils and Fatty Acids to High-Value Chemicals

Microorganisms for the production of high-value chemicals from free fatty acids are provided. The microorganisms comprise genetic mutations that alter fatty acid metabolism. The genetic mutations include a mutation or deletion of a fadR gene in which the FadR enzyme activity is partially or substantially eliminated and a mutation in an atoC gene that provides overexpression of the microorganism's ato operon. Methods of using the microorganisms to produce high-value chemicals are also provided. The high-value chemicals include ethanol, methyl acetate, succinate, gamma-butyrolactone, 1,4-butanediol, acetone, iso-propanol, butyrate, butanol, mevalonate, propionate, ethanolamine and 1,2-propanediol.
Owner:GLYCOS BIOTECH

Transcription factor of regulating and controlling vegetable fatty acid metabolism and its coding gene and application

This invention discloses a transcription factor and its coding gene and its application which regulating plant fatty acid metabolism. The purpose is to provide a transcription factor and its coding gene and its application in regulating plant fatty acid metabolism. The transcription factor is one of the following amino acid residue series. 1) SEQ ID NO1 in series table. 2) One to ten amino acid residue of SEQ ID NO:1 is displaced, absence or added to protein that can control plant fatty acid metabolism.
Owner:INST OF GENETICS & DEVELOPMENTAL BIOLOGY CHINESE ACAD OF SCI

Glyceride oil composition from fish oil and preparation method thereof

Provided are a glyceride oil composition derived from a fish oil and a preparation method thereof. The composition includes docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA) with a content of 45 to 95% by weight and eicosapentaenoic acid (EPA) with a content of 0.001 to 13% by weight among constituent fatty acids, and a saturated fatty acid having 16 to 18 carbon atoms, which is bonded at 1- and 3-positions, with a content of 0.001 to 5% by weight among constituent fatty acids, in which a weight ratio of docosahexaenoic acid (DHA) / docosapentaenoic acid (DPA) is 0.5 to 8 and a weight ratio of docosahexaenoic acid (DHA) / eicosapentaenoic acid (EPA) is 3.5 to 15. The glyceride oil composition derived from fish oil has nutritional and physiological superiority due to containing a great amount of polyunsaturated fatty acids such as DHA and DPA in a form of glyceride, and can minimize disadvantages of EPA such as inhibition of ω-6 fatty acid metabolism by containing a low amount of EPA. The glyceride oil composition is excellent in digestion and absorption of polyunsaturated fatty acids into a human body by containing a low amount of saturated fatty acids at 1- and 3-positions and process characteristics such as an oxidation stability and water-dispersibility.
Owner:ILSHINWELLS

Chromones As Therapeutic Agents

The present invention describes the identification and isolation of chromones and novel chromone compositions from plant sources that exhibit up-regulation of adiponectin production by adipocytes and the normalization of virtually hundreds of genes related to glucose and fatty acid metabolic and signaling pathways. The chromone compositions are effective in enhancing adiponectin production by adipocytes and regulating genes involved in fatty acid biosynthesis, mitochondrial β-oxidation of fatty acids, steroid biosynthesis, gluconeogenesis, fat transport, PPARα / RXRα liver signaling and xenobiotic metabolism. The chromone compositions can be used to increase insulin sensitivity, improve glucose tolerance, lower triglyceride levels and balance glucose levels in mammals. Included in the present invention are methods for the prevention and treatment of a variety of diseases and conditions including, but not limited to insulin resistance, glucose intolerance, hyperglycemia, metabolic syndromes, dyslipidemia, and hypertriglyceridemia.
Owner:UNIGEN

Full-nutrition formulated food for fatty acid metabolic disorder

The present invention provides a full-nutrition formulated food, a special full-nutrition formulated food or a non-full nutrition food for fatty acid metabolic disorder patients to eat. The formula is developed according to the requirement of "General principles of formulated food for special medical purposes", combining with the physical characteristics of patients with fatty acid metabolic disorder, and based on the essential theory (liver, spleen, kidney simultaneously regulating as the main principle) of "communicating while tonifying" and "balanced nursing". The present product adopts a plurality of medical and edible Chinese herbal extracts essence extracted by biologic enzymolysis or prehydrolysis SBE technology and adds a plurality of probiotics, oligopeptides, prebiotics, carbohydrates, amino acids, a plurality of vitamins and minerals, and mixes the materials to prepare the product. The full-nutrition formulated food not only can used as sole source of nutrition to meet the nutritional needs of patients with fatty acid metabolic disorder, but also has efficacy of promoting blood circulation to restore menstrual flow, detoxifying and draining pus, eliminating dampness and subsiding swelling, soothing liver and regulating qi, promoting fluid production to quench thirst, regulating lipid to lose weight and enhancing immunity.
Owner:胡安然

N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, pharmaceutical compositions thereof and methods for their therapeutic use

The present invention comprises N-[1,3,4]-thiadiazol-2-yl-benzene sulfonamides, their physiologically acceptable salts and functional derivatives that exhibit peroxisome proliferator activated receptor (PPAR) PPARdelta and PPARgamma agonist activity. The structure of the compounds of the invention are defined by Formula I below,And the isomers thereof wherein the various substituents are defined herein, including their physiologically acceptable salts. Processes for the compounds preparation are also disclosed. The compounds are suitable for the treatment of fatty acid metabolism and glucose utilization disorders, disorders relating to insulin resistance are involved as well as demyelinating and other neurodegenerative disorders of the central and peripheral nervous system.
Owner:SANOFI SA

Therapeutic Bifunctional Compounds

The invention generally relates to systems and methods for treating inflammatory and proliferative diseases, enabling treatment of MDR tumor cells by using a bifunctional compound that inhibits both fatty acid metabolism and glycolysis. Thus, the invention links a fatty acid metabolism inhibitor to a glycolysis inhibitor. More particularly, the invention provides novel bifunctional compounds that link a moiety having the functionality of an oxirane carboxylic acid compound to a moiety having the functionality a glucose derivative. In specific embodiments, the invention provides a bifunctional compound that links a moiety having the functionality of etomoxir to a moiety having the functionality of 2-deoxy-D-glucose.
Owner:UNIV OF COLORADO THE REGENTS OF

Spinosad high-yield gene engineering bacterium and construction method and application thereof

The invention discloses a spinosad high-yield gene engineering bacterium. The preservation number of the gene engineering bacterium is CGMCC No. 14193. The invention further discloses a method by enhancing a fatty acid metabolism pathway to construct the spinosad high-yield gene engineering bacterium and application of the engineering bacterium to produce spinosad. According to the construction method, by conducting expression enhancement on the oxidation pathway of fatty acid Beta of saccharopolyspora spinosa, supply for the spinosad to biosynthesize the important precursor of acetyl coenzyme A is improved, and compared with original strains, the yield of the spinosad of obtained gene engineering strains is improved obviously.
Owner:ACAD OF NAT FOOD & STRATEGIC RESERVES ADMINISTRATION

Pet radiotracers for imaging fatty acid metabolism and storage

Fatty acid analogue (FAA) molecules comprising positron-emitting radionuclides, salts thereof, and FAA-triglycerides are disclosed. Also disclosed are methods of synthesis, and methods of imaging distribution and metabolism of fatty acids and fatty acid triglycerides.
Owner:WASHINGTON UNIV IN SAINT LOUIS

Compositions for enhancing the production of PPAR and/or PPAR-associated factors

The present inventors focused on certain nutritional compositions known to have activity of controlling blood glucose levels. These foods were administered to rats for long periods, and real-time PCR was used to analyze the expression of genes associated with lipid metabolism in the liver and adipose tissues. As a result, the present inventors found that the expression of the PPARα gene is enhanced by these foods, and that this is accompanied by suppressed expression of fatty acid synthase and enhanced expression of a group of PPARα target genes associated with fatty acid metabolism. The present inventors also confirmed the effect of these foods in enhancing the expression of PPARγ and adiponectin, and discovered that these foods have the activity of enhancing the production of PPAR and PPAR-associated factors.
Owner:UNIVERSITY OF TOKUSHIMA +1

Method for detecting special growth and development law of muscles of Jingning chicken

InactiveCN104542453AAnimal husbandryChick embryosPosterior limb bud
The invention provides a method for detecting a special growth and development law of muscles of Jingning chicken. The Jingning chicken are unique and peculiar local chicken of the Gansu province, are fresh and tender in texture and unique in flavor, and have good public praise, however, the Jingning chicken are endangered, and the prospect is grim. In the method for detecting the special growth and development law of the muscles of the Jingning chicken, chick embryos of the Jingning chicken are researched, and special meat quality trait controlling genes such as growth and development gap-associated proteins: CECR2 (cat eye syndrome chromosome region) and IGF-1 (insulinlike growth factor-1), fatty acid metabolism gap-associated proteins: Ex-FABP (fatty acid-binding protein) and LPL (lipoprotein lipase) and protein degradation gap-associated proteins: CAST and CAPN1 are selected. Protein expression distribution and change of expression level of proteins in posterior limb buds and body segments in a chick embryo development HH19-31 period are detected by using methods of immunohistochemistry and Western blotting and the like, and the Jingning chicken are compared to white feather broilers, yellow feather broilers and hyline brown chicken. By the method for detecting the special growth and development law of the muscles of the Jingning chicken, the relation of growth and development regulatory functional genes, growth performance and meat quality is discussed, and data are provided for establishing target genes of transgenic chicken. Moreover, the resource superiority can be widely developed and used, and new vitality is injected to development of local economy.
Owner:LANZHOU UNIVERSITY

Compositions and Methods for Treating Obesity and Diabetes

ActiveUS20110237505A1Preventing and minimizing obesityBiocidePeptide/protein ingredientsCell-Extracellular MatrixCholesterol
Disclosed are methods of modulating the expression of genes linked to adipocytokine signaling, carbohydrate metabolism, fatty acid metabolism, arachidonic acid metabolism, PPAR signaling, insulin signaling, lipid metabolism, extracellular matrix (ECM)-receptor interaction, or combinations thereof, methods of treating hyperlipidemia, obesity, excessive cholesterol, cardiovascular disease, liver disease, diabetes, or combinations thereof, and methods of stimulating glucose uptake in an animal in need thereof, comprising administering a composition comprising at least one isolated glyceollin to said animal.
Owner:MICROBIOME THERAPEUTICS LLC +1
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