478 results about "Positron" patented technology

A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and / or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.

A cardiovascular imaging and functional analysis system and method is disclosed, wherein a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis is employed. The cardiovascular imaging and functional analysis system of the present invention can be used as a dedicated nuclear cardiology small field of view imaging camera. The disclosed cardiovascular imaging system and method has the advantages of being able to image physiology, while offering an inexpensive and portable hardware, unlike MRI, CT, and echocardiography systems.The cardiovascular imaging system of the invention employs a basic modular design suitable for cardiac imaging with one of several radionucleide tracers. The detector can be positioned in close proximity to the chest and heart from several different projections, making it possible rapidly to accumulate data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood (MUGA) tests..In a preferred embodiment, the Cardiovascular Non-Invasive Screening Probe system can perform a novel diagnostic screening test for potential victims of coronary artery disease. The system provides a rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer. Ratios of this activity with the time progression of the injected bolus of radioactive tracer are used to perform diagnosis of the coronary patency (artery disease).

A Cardiovascular imaging and functional analysis system and method employing a dedicated fast, sensitive, compact and economical imaging gamma camera system that is especially suited for heart imaging and functional analysis. The system uses a dedicated nuclear cardiology small field of view imaging camera, allowing image physiology, while offering inexpensive and portable hardware. In some variations, a basic modular design suitable for cardiac imaging with one of several radionucleide tracers is used. The detector is positioned in close proximity to the chest and heart from several different projections, allowing rapid accumulation of data for first-pass analysis, positron imaging, quantitative stress perfusion, and multi-gated equilibrium pooled blood tests. In one variation, a Cardiovascular Non-Invasive Screening Probe system provides rapid, inexpensive preliminary indication of coronary occlusive disease by measuring the activity of emitted particles from an injected bolus of radioactive tracer.

A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and / or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.

Apparatus and methods are provided that enable the interaction of low-energy electrons and positrons with sample ions to facilitate electron capture dissociation (ECD) and positron capture dissociation (PCD), respectively, within multipole ion guide structures. It has recently been discovered that fragmentation of protonated ions of many biomolecules via ECD often proceeds along fragmentation pathways not accessed by other dissociation methods, leading to molecular structure information not otherwise easily obtainable. However, such analyses have been limited to expensive Fourier transform ion cyclotron resonance (FTICR) mass spectrometers; the implementation of ECD within commonly-used multipole ion guide structures is problematic due to the disturbing effects of RF fields within such devices. The apparatus and methods described herein successfully overcome such difficulties, and allow ECD (and PCD) to be performed within multipole ion guides, either alone, or in combination with conventional ion fragmentation methods. Therefore, improved analytical performance and functionality of mass spectrometers that utilize multipole ion guides are provided.

An improved method of, and apparatus for, nuclear imaging takes advantage of the ability to determine the depth of gamma ray / electron interaction within a semiconducting gamma ray detector to determine the (most highly probable) location of the first gamma ray / electron interaction within the detector. Lines of interaction constructed between opposing detector arrays, extending between the location of the first gamma ray / electron interaction in each detector associated with the coincident detection of gamma radiation, permits a positron-emitting object of interest to be imaged according to protocols known in the art, but with better spatial resolution than previously believed to have been known.

Positron emitting compounds and methods of their production are provided. The compounds have the formula: (F)m G (R)n wherein each R is a group comprising at least one carbon, nitrogen, phosphorus or sulfur atom and G is joined to R through said carbon, nitrogen, phosphorus or sulfur atom; G is silicon or boron; m is 2 to 5 and n is 1 to 3 with m+n=3 to 6 when G is silicon; m is 1 to 3 and n is 1 to 3 with m+n=3 to 4 when G is boron; and wherein the compound further comprises one or more counterions when the above formula is charged; and wherein at least one F is 18 F.

Inventions relates to scintillation substances and they may be utilized in nuclear physics, medicine and oil industry for recording and measurements of X-ray, gamma-ray and alpha-ray, nondestructive testing of solid states structure, three-dimensional positron-emission tomography and X-ray tomography and fluorography. Substances based on silicate comprising lutetium and cerium characterized in that compositions of substances are represented by chemical formulae CexLu2+2y−xSi1−yO5+y, CexLiq+pLu2−p+2−y−x−zAzSi1−yO5+y−p, CexLiq+pLu9.33−x−p−z□0.67AzSi6O26−p, where A is at least one element selected from group consisting of Gd, Sc, Y, La, Eu, Tb, x is value between 1×10−4 f.units and 0.02 f.units., y is value between 0.024 f.units and 0.09 f.units, z is value does not exceeding 0.05 f.units, q is value does not exceeding 0.2 f.units, p is value does not exceeding 0.05 f.units. Achievable technical result is the scintillating substance having high density, high light yield, low afterglow, and low percentage loss during fabrication of scintillating elements.

The invention addresses possible fault scenarios including exposure to electromagnetic interference (EMI) which can include radio frequency (RF) electromagnetic radiation due to one or more security and / or communication regimens as well as various imaging modalities such as magnetic resonance imaging (MRI), positron electron transmission (PET) imaging or the like. In one aspect, an active implantable medical device (AIMD) is configured to sense a physiologic parameter of a patient and provide a therapy such as cardiac pacing, high-energy cardioversion / defibrillation therapy and / or a drug or substance delivery regimen. An implantable physiologic sensor (IPS) couples to the AIMD with coaxial conductors with the inner conductor carrying the IPS output signals thus avoiding output signal degradation due to EMI. That is, the outer conductor couples to ground providing electromagnetic protection (e.g., like a Faraday cage) to the inner conductive and the output signals.

A camera sub-module is provided for providing tomographic imaging of radiation emissions generated internally by a body. The camera sub-module includes a radiation-emitting layer having a radioactive source for emitting transmission emissions, and at least one radiation-detection layer for contemporaneously detecting and permitting differentiation between the transmission emissions and emissions generated internal to an imaged body administered with a positron-emitting radiotracer. Also provided herein are imaging systems, scanners, and other apparatus and methods.

Detector crystals in a positron emission tomography (PET) apparatus gantry are cooled by directing cooling gas flow into a cooling duct bounded by the crystals and a cover defining the patient scanning field within the gantry. The cooling gas cools the crystals. Cooling gas may also be directed radially outwardly from the cooling duct into spatial gaps defined between detector enclosures that include the crystals, further isolating heat generated by other components within gantry from the detector crystals. Cooling gas is provided by a cooling system that may be incorporated within the gantry, external the gantry or a combination of both. Cooling gas can be provided by directing air within the gantry in contact with internal gantry cooling tubes and routing cooled air directly into the cooling duct with a powered fan.