1050 results about "Click chemistry" patented technology

Compositions, systems and methods of sequencing are disclosed, where the compositions and systems include polymerase enzymes that have been genetically modified to more efficiently incorporate nucleotides including labels having a detectable properties that are released during incorporation, to augment a rate of labeled nucleotide incorporation, to augment a rate of pyrophosphate release, or to augment two or more of these properties and rates. Also disclosed are terminally labeled and dual labeled nucleotides, and click-chemistry based methods of synthesizing the same.

A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.

The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.

The process of the present invention is directed toward conducting highly selective, high yield post polymerization reactions on polymers to prepare functionalized polymers. An embodiment of the present invention comprises conducting click chemistry reactions on polymers. Preferably, the polymers were prepared by controlled polymerization processes. Therefore, embodiments of the present invention comprise processes for the preparation of polymers comprising conducting a click chemistry reaction on a functional group attached to a polymer, wherein the polymer has a molecular weight distribution of less than 2.0. The functional polymers may be prepared by converting an attached functional unit on the polymer thereby providing site specific functional materials, site specific functional materials comprising additional functionality, or chain extended functional materials. Embodiments of the process of the present invention include functionalization reactions, chain extensions reactions, to form mock copolymer linking reactions, and attaching side chains to form graft copolymers, for example.

The invention relates to a preparation method of a functional textile, and belongs to the field of textile surface grafting modification. The method for preparing a super-hydrophobic textile from a thiol-ene click chemistry-modified fiber is characterized by comprising the steps that alkali liquor steaming treatment is performed on a polyester fiber, then mercaptosilane is fixed to the surface of the polyester fiber, finally a methacrylate monomer is grafted to the surface of the polyester through a thiol-ene click chemistry reaction to reduce the surface tension of the fiber, and then the super-hydrophobic polyester textile is obtained. The contact angle between the polyester textile prepared through the method and water drops is larger than 150 degrees, and the polyester textile is stable to acid, alkali, salt and solvent and capable of resisting friction and washing and has the very good hydrophobic stability.

The invention provides a tetrazole-containing polymer of intrinsic microporosity comprising (10) or more subunits, wherein one or more of the subunits comprise one or more tetrazolyl moieties. In one embodiment, a polymer of intrinsic microporosity (PIM-1) was modified using a “click chemistry” [2+3] cycloaddition reaction with sodium azide and zinc chloride to yield new PIMs containing tetrazole units. Polymers of the present invention are useful as high-performance materials for membrane-based gas separation, materials for ion exchange resins, materials for chelating resins, materials for superabsorbents, materials for ion conductive matrixes, materials for catalyst supports or materials for nanoparticle stabilizers.

A copper catalyzed click chemistry ligation process is employed to bind azides and terminal acetylenes to provide 1,4-disubstituted 1,2,3-triazole triazoles. The process comprises contacting an organic azide and a terminal alkyne with a source of reactive Cu(I) ion for a time sufficient to form by cycloaddition a 1,4-disubstituted 1,2,3-triazole. The source of reactive Cu(I) ion can be, for example, a Cu(I) salt or copper metal. The process is preferably carried out in a solvent, such as an aqueous alcohol. Optionally, the process can be performed in a solvent that comprises a ligand for Cu(I) and an amine.

The invention relates to novel hybrid compounds comprising at least one polyon entity (Po)—for example oligomer or polymer—in which at least one of the hydroxyl functions of Po is substituted by at least one entity A that can be of a variable nature, for example polymer (e.g. polyorganosiloxane-POS), hydrocarbonated or mineral. The bond Ro between the entity Po and the entity A is obtained by means of “click chemistry” and corresponds to formula (II.1) or (II.2), Z representing —CH— or —N—. A is an entity selected from the group comprising the various polyols of Po, polyorganosiloxanes (POS), polyalkylene glycols, polyamides, polyesters, polystyrenes, alkyls, alkenyls, alkynyls, aryls, and combinations thereof, in addition to mineral materials such as silica and the combinations thereof. Said hybrid components can be used as emulsifiers, especially for cosmetics.

The invention provides a light emitting diode. The light emitting diode comprises a substrate, positive pole, hole transfer layer, emitting layer, electron transport layer and negative pole. The emitting layer comprises quantum dots and energy transfer molecules. The energy transfer molecules crosslink with the quantum dots by click chemistry. The energy transfer molecules, as dispersion medium of the quantum dots, have high electron / hole carrier injection ability, which can promote the production of excitons in energy transfer molecules and realize effective energy transfer from energy transfer molecules to fluorescent quantum dots. At certain voltage, the device can emit within the wavelength range of 380-900nm, with the maximum emitting peak covering ultraviolet to dark red light range. The invention further discloses the fabrication method and electronic display equipment of a light emitting diode.

The present disclosure provides compositions which may be utilized as adhesives or sealants in medical and surgical applications. The compositions may, in embodiments, be formed from the cycloaddition reaction of a first component possessing at least one azide group with a second component possessing at least one alkyne group.

The invention discloses a method for preparing surface carboxylic group functional polystyrene / nano-silicon dioxide hybrid material by effectively combining click chemistry and ATRP; in the method, a silane coupling agent is adopted for linking an ATRP evocating agent to a SiO2 particle surface, and polystyrene (PSt) is grafted on the SiO2 particle surface by adopting the ATRP; then, carboxyl is led into a nano-silicon dioxide particle surface modified by the polystyrene by means of the click reaction, thus obtaining the surface carboxylic group functional polystyrene / nano-silicon dioxide hybrid material. After the infrared, nuclear magnetism and thermogravimetry mapping analysis, the surface carboxylic group functional polystyrene / nano-silicon dioxide hybrid material prepared by the invention has good thermal stability and dispersivity; in addition, as the carboxyl has wide reaction range and the characteristic of easy ionization, nano-particles has high reactive behavior so as to be widely applied to the fields such as high polymer material modifying agents, water treatment agents, catalysts, sensing agents and protein carriers.

The present disclosure provides a method for preparing a radioactive ligand or radioactive substrate having affinity for a target biomacromolecule, the method comprising: (a) reacting a first compound comprising a first functional group capable of participating in a click chemistry reaction, with a radioactive reagent under conditions sufficient to displace the leaving group with a radioactive component of the radioactive reagent to form a first radioactive compound; (b) providing a second compound comprising a second complementary functional group capable of participating in a click chemistry reaction with the first functional group; (c) reacting the first functional group of the first radioactive compound with the complementary functional group of the second compound via a click chemistry reaction to form the radioactive ligand or substrate; and (d) isolating the radioactive ligand or substrate.

The invention relates to a preparation method for a hyperbranched polymer grafted carbon nanotube based on click chemistry. The preparation method comprises the following steps: 1) subjecting the carbon nanotube to treatment by utilizing concentrated nitric acid so as to obtain an acid-treated carbon nanotube; 2) subjecting the acid-treated carbon nanotube to reaction with a mercapto contained silane coupling agent so as to obtain a mercapto contained silane coupling agent grafted carbon nanotube; 3) subjecting alkyne butanol and mercaptopropionic acid to esterification reaction so as to obtain a hyperbranched monomer; and 4) with a mercapto group on the mercapto contained silane coupling agent grafted carbon nanotube and an alkynyl group contained in the hyperbranched monomer as reactive groups, initiating mercapto-alkynyl click reaction by utilizing ultraviolet light so as to eventually obtain the hyperbranched polymer grafted carbon nanotube. The invention has the following advantages: through light-initiated click reaction, the preparation method reduces the usage amount of a solvent, simplifies post-processing steps, facilitates to large-scale production, and enables active functional groups on the surface layer of the carbon nanotube to be increased through grafting of a hyperbranched polymer coating layer formed on the surface of the carbon nanotube, thereby facilitating to further use of the carbon nanotube.

The invention discloses an amphipathic chitosan derivative PAMAM-Cs-DCA (Poly(amido amine)-chitosan-deoxycholic acid). The PAMAM-Cs-DCA is prepared by sequentially grafting a PAMAM unit and a deoxycholic acid unit on a main chain of chitosan by click chemical reaction and amidation reaction. The preparation method has mild reaction conditions, high efficiency and selectivity. The invention also discloses an application of the amphipathic chitosan derivative in preparing an anticancer drug carrier: the amphipathic chitosan derivative forms nanomicelle which takes the PAMAM unit and chitosan asa hydrophilic shell and takes the DCA unit as a hydrophobic core by self assembly in a water solution, wherein hydrophobic anticancer drugs can be coated in the core, and the shell can be compounded with pDNA (plasmid deoxyribonucleic acid) to realize co-transmission of the drugs and genes. Due to the unique molecular structure, the amphipathic chitosan derivative has potential application valuesin the fields of gene therapy, controlled release of drugs, tissue engineering and the like.