209 results about "Chromone" patented technology

The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydroxychrome or a mixture of 7-hydroxychromones. The present invention includes methods that are effective in inhibiting free radical and oxidation caused damage through the simultaneous suppression of free radical generation and the suppression of the production of reactive oxygen species (ROS). The present invention also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. The method for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes is comprised of administering to a host in need thereof an effective amount of a composition comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones and a pharmaceutically acceptable carrier. Included in this invention is an improved method to isolate and purify 7-hydroxychromones from plant sources.

This invention provides compounds defined by Formula I or a pharmaceutically acceptable salt thereof,wherein R1, Q, Y2, Y3, Y4, U5, U6, U8, and R2 are as defined in the specification. The invention also provides pharmaceutical compositions comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, as defined in the specification, together with a pharmaceutically acceptable carrier, diluent, or excipient. The invention also provides methods of inhibiting an MMP-13 enzyme in an animal, comprising administering to the animal a compound of Formula I, or a pharmaceutically acceptable salt thereof. The invention also provides methods of treating a disease mediated by an MMP-13 enzyme in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides methods of treating diseases such as heart disease, multiple sclerosis, osteo- and rheumatoid arthritis, arthritis other than osteo- or rheumatoid arthritis, cardiac insufficiency, inflammatory bowel disease, heart failure, age-related macular degeneration, chronic obstructive pulmonary disease, asthma, periodontal diseases, psoriasis, atherosclerosis, and osteoporosis in a patient, comprising administering to the patient a compound of Formula I, or a pharmaceutically acceptable salt thereof, either alone or in a pharmaceutical composition. The invention also provides combinations, comprising a compound of Formula I, or a pharmaceutically acceptable salt thereof, together with another pharmaceutically active component as described in the specification.

The present invention describes the identification and purification of 7-hydroxychromes that exhibit potent antioxidant activity. In one embodiment the present invention includes a method for providing an antioxidant to a host in need thereof, comprising administering an effective amount of a 7-hydroxychrome or a mixture of 7-hydroxychromones. The present invention includes methods that are effective in inhibiting free radical and oxidation caused damage through the simultaneous suppression of free radical generation and the suppression of the production of reactive oxygen species (ROS). The present invention also includes methods for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes. The method for preventing and treating ROS mediated diseases and conditions and diseases and conditions associated with other oxidative processes is comprised of administering to a host in need thereof an effective amount of a composition comprised of a 7-hydroxychrome or a mixture of 7-hydroxychromones and a pharmaceutically acceptable carrier. Included in this invention is an improved method to isolate and purify 7-hydroxychromones from plant sources.

A general chromone extract of ledebouriella root includes proportionally cimifugin, 5-0-methylwestammiol, etc. It is prepared by solvent extracting method or macroreticular adsorption resin method.

The invention pertains to the technical field of medicaments, and relates to a new flavonoid compound extracted from Maackia amurensis. The invention uses various separation methods including silica gel column chromatography, macroporous adsorptive resins, sephadex LH-20 column chromatography, semi-preparation type high-efficiency liquid chromatography, and the like. 54 compounds and 14 flavonoid compounds are seperated from the maackia amurensis, wherein, 7 new chemical components are included, which are respectively Maackiaflavanone A, Maackiaflavanone B, Maackiapentone, Maackiapterocarpan A, Maackiapterocarpan B, Maackiaisoflavonoside and 8-3, 3-dimethylallyl-5-hydroxy-7-methoxy chromone. A preliminary activity study indicates that the compound has certain effect of inhibiting the proliferation of tumor cells, thereby providing a basis for the development and research in the future.

The present invention is directed to inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

The invention belongs to the technical field of agilawood quality detection, and particularly discloses detection method for detecting agilawood quality by using a high-performance liquid chromatography. The method comprises the operation steps of chromatographic condition setting, preparation of a mother liquor of a reference substance, sample analysis and calculation for the analysis result. Byadopting the detection method, five chromones including agarotetrol, 6-hydroxy-2-[2-(4'-methoxyl) phenethyl] chromone, 6-hydroxy-2-(2-phenethyl) chromone, 6,7-dimethoxy-2-[2-(4'-methoxyl) phenethyl] chromone and 6,7-dimethoxy-2-(2-phenethyl) chromone which are contained in agilawood can be detected at a time, the comprehensiveness of agilawood quality detection is effectively improved, the accuracy of detecting the agilawood quality is improved, and the method has the advantages that the operation is simple, and the detection efficiency is high.

The invention belongs to the field of medicaments, and relates to a 2-substituted chromone compound, as well as a preparation method and application thereof. In-vitro anti-HBV (hepatitis b virus) activity test results of the 2-substituted chromone compound prove that: the 2-substituted chromone compound has remarkable anti-HBV effect, low effective concentration and low cytotoxicity. A medicinal composition can be further prepared from the 2-substituted chromone compound to be used for treating or preventing infection of hepatitis b virus, and particularly for inhibiting replication of surface antigen and e-antigen of the hepatitis b virus. The medicinal composition provided by the invention can be given nasally, orally, transdermally, parenterally, or by venous or intramuscular injection.

The invention relates to a method to simply and efficiently prepare a 2-alkyl substituted chromanone compound and relates to the field of medicine, organic chemical industry and fine chemical industry. The method uses chromone compounds and fatty aldehyde compounds as materials, and the 2-alkyl substituted chromanone compound is synthesized in the presence of the free radical initiators. The reaction conditions include: heating to 100-150 DEG C for 10-15 hours; isopropanol, tertiary butanol, chlorobenzene, acetonitrile, dimethyl sulfoxide and acetone are used as reaction solvents; tert-butyl hydroperoxide, tert-butyl peroxybenzoate, hydrogen peroxide, dicumyl peroxide and benzoyl peroxide are used as free radical initiators. Simple post-treatment can be performed after the reaction so as to obtain a series of 2-primary, secondary or tertiary alkyl substituted chromanone compounds.