461results about How to "Has antitumor activity" patented technology

The invention relates to a derivative of 4-(4-benzoyl amino-phenoxy)-2-(methyl ammonia formyl) pyridine and a preparation method and purposes thereof, belonging to the chemical medicine field. The structure of the derivative is shown as Formula I: R1 is hydrogen, halogenated base, trifluoromethyl, nitro, alkoxy, dimethoxy or amino; R2 is hydrogen, halogenated base, trifluoromethyl, nitro, alkoxy, dimethoxy or amino; R3 is hydrogen, halogenated base, trifluoromethyl, nitro, alkoxy, dimethoxy or amino. The derivative can be used for preparing anti-tumor medicines.

The present invention relates to antibodies that have a therapeutic effect on tumors. That is, the present invention relates to antibodies that bind to B7-H3 to exhibit antitumor activity. An object of the present invention is to provide a drug having a therapeutic effect on tumors. By obtaining an anti-B7-H3 antibody that binds to B7-H3 to exhibit anti-tumor activity, a pharmaceutical composition for treating tumors comprising the antibody and the like is obtained.

The invention relates to a 4-1,2,3-triazole-coumarin derivative and its preparation method and application, belonging to the field of chemical medicine. The present invention needs to achieve the technical purpose of providing a novel 4-1,2,3-triazole-coumarin derivative of formula I. The derivative has antitumor activity, and provides the development and application of antitumor drugs with a new selection.

The present invention concerns chimeric cancer therapeutic molecules comprising a targeting moiety and an anti-cell proliferation moiety. The anti-cell proliferation moiety may comprise a cytotoxic agent or an apoptosis-inducing factor, in specific embodiments. In particular embodiments, the anti-cell proliferation mechanism of the chimeric molecules comprises apoptotic pathways. In additional embodiments, the chimeric molecules of the present invention provide sensitivity to chemotherapy in a cell that is resistant to the chemotherapy.

The invention discloses a multifunctional tumor imaging agent, a preparation method and application, and belongs to the field of tumor imaging agents. The tumor imaging agent has tumor target and magnetic resonance imaging and anti-tumor properties. Fe3O4 is used as a nucleus; and nano particles coated with fluorescent dye rhodamine isothiocyanate B and porous magnetic nano ferroferric oxide which serve as nuclei and silicon dioxide serving as a shell are prepared by a micro-emulsion method. Tumor targeting arginine-glycine-aspartic acid (RGD) peptide and methoxy polyethylene glycol are modified on the surface of the SiO2, and the tumor targeting multifunctional composite imaging agent is finally obtained. The imaging agent has tumor targeting peptide induced tumor cell active targeting property, can be used as a magnetic resonance imaging identification agent for tumor cells and normal cells, can be applied to clinical magnetic resonance imaging monitoring treatment medicaments, and realizes constant monitoring of a tumor treatment process, but the conventional anti-tumor medicament applied in clinic only has tumor inhibiting performance and cannot realize real-time monitoring ofthe medicament treatment process.

The invention relates to a new compound separated from Mythic Fungus, a preparation method thereof and a medicinal purpose thereof. The invention discloses a compound with the chemical structural formula shown in the specification. The preparation method of the compound comprises the following steps: 1, extracting Mythic Fungus with alcohol or an alcoholic solution once or more than twice, filtering, collecting a filtrate, carrying out reduced pressure concentration, and drying to obtain an alcohol extract; 2, adding water to the alcohol extract, extracting with petroleum ether for degreasing, extracting with ethyl acetate, extracting an obtained ethyl acetate extract with an aqueous solution of NaHCO3, taking an ethyl acetate phase, and evaporating to dryness to obtain a crude product; and 3, carrying out chromatogram separating separation and purification on the obtained crude product to obtain the compound. The compound of the present invention can be treated as a medicine for treating tumors.

The invention relates to polyphenol substances, a synthesis method and use thereof, in particular to flavanone derivatives, a preparation method and use thereof, which solves the problem that the prior natural flavanone compounds are difficult to extract, not easy to obtain and incapable of extensive use. The compounds have a structure (as above), wherein R1, R2 and R3 are selected from hydrogen, 1 to 8 carbonic alkyl groups, halogen, nitro group, 1 to 8 carbonic alkoxy or amino groups respectively; R4 and R5 can be selected from 1 to 8 carbonic alkyl groups, 1 to 8 alkoxy or alkenyl groups respectively; and the compounds are obtained through the reaction of compound 6-hydroxy-2,4-hydroxy acetophenone substances and aromatic aldehydes or heterocyclic aldehyde substances in polyalcohol solvent by taking high-boiling-point acid as a catalyst, and can be applied to the preparation of medicaments for resisting tumors and cardiovascular and cerebrovascular diseases. The flavanone derivatives have the activity of resisting tumors and inhibiting the cardiovascular and cerebrovascular diseases, thereby opening up a new way for preparing the medicaments and bringing new breakthroughs for the medicament field. Moreover, the synthesis method has the advantages of mild conditions and easy operation.