394 results about "Hydrobromide" patented technology

The invention relates to 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole shown as a chemical structural formula I and a salt thereof. The chemical structural formula I is shown in the specifications, wherein R is selected from H, alkyl with 1-2 carbon atoms, or straight chain alkyl or branch chain alkyl with 3-4 carbon atoms; and X1, X2, X3, X4 and X5 is selected from hydrogen, alkyl with 1-2 carbon atoms, hydroxyl, methoxyl, oxethyl, trifluoromethyl, fluorine, chlorine, bromine, nitro or amino. A preparation method of the 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole comprises the following steps of: feeding 2-(1,2,4-triazol-1-yl)-2-bromoalkylketone and aryl thiourea in the molar ratio of 1:1, and carrying out a reflux reaction in ethanol; and after reacting, distilling under reduced pressure to remove a solvent, adding ethyl acetate for washing, filtering, drying to obtain 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole hydrobromide, neutralizing the hydrobromide with ammonia water, extracting with ethyl acetate, drying, and distilling under reduced pressure to obtain 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole. The 4-alkyl-2-aryl amino-5-(1,2,4-triazol-1-yl)thiazole has high antitumor activity, and can be applied to preparation of an anticancer medicament.

Preparation of sinomontanine A and its hydrobromic acid salt are disclosed. The procedure is carried out by crushing block root of Gaowutou, extracting by alcohol reflux or acid water leakage or alcohol immersion, concentrating to thin paste to obtain crude extract, acidifying crude extract to pH=1-5, obtain acidified liquid, adsorbing the acidified liquid by exchange resin cation or macroporous adsorbing resin or alumina, washing by water, washing by chloroform or/and alcohol, collecting eluent, concentrating extractive, dissolving the extractive into alcohol, laying aside for 1 day, crystallizing and washing by alcohol to obtain final product. It has higher purity.