197results about How to "Strong antiproliferative activity" patented technology

The invention relates to a polysubstituted isoindoline compound represented by a general formula (I), and a preparation method, a pharmaceutical composition and an application thereof. Specifically, as a CRL4CRBNE3 ubiquitin ligase regulator with a novel structure, the polysubstituted isoindoline compound provided by the invention has stronger anti-tumor activity and an anti-tumor spectrum, and can be used for preparing medicines for treating diseases related to CRL4CRBNE3 ubiquitin ligase.

The invention discloses synthetic peptide sp2 and application thereof. The amino acid sequence of the sp2 is shown by SEQ ID NO.1. The efficacy characteristics are that the synthetic peptide sp2 has obvious activity of resisting tumor growth against xenograft tumor such as nude-mouse subcutaneous human pancreatic cancer, human cervical cancer and human ovarian cancer in dose-effect and time-effectrelationships, and realizes the functions of delaying transfer and prolonging the lifetime for the nude-mouse orthotopic transplantation human pancreatic cancer and lung adenocarcinoma. The safety characteristic is that toxic reaction or death does not occur after 2,000 mg / kg BW of sp2 is applied to an animal through intravenous injection. The sp2 is also applied to: (1) the prevention and / or treatment of tumor; (2) inhibition of the proliferation and / or growth and / or invasion of tumor cells; (3) enhancement of anti-tumor immunoreaction; (4) induction of tumor cell differentiation; (5) preparation of class-A anti-tumor drugs; (6) inhibition of tumor telomerase activity; (7) control of tumor cell cycle; (8) preparation of products for regulating and controlling tumor cell cycle.