6495results about How to "Easy to purify" patented technology

A red-light iridium match using quinoline-type azacyclic compound as its ligand is disclosed. It can be used to prepare the organic electroluminescent device emitting red light.

The invention provides methods of chemically synthesizing chimeric proteins comprising at least a portion of an immunoglobulin constant region and a biologically active molecule.

The invention discloses an organic electroluminescent material containing a tertiary aromatic amine structure. The organic electroluminescent material containing the tertiary aromatic amine structure is characterized in that: the structural formula is shown in the specifications; and in the structural formula, n1, n2 and n3 independently represent that the quantity of benzene ring is 0 or 1 respectively; a radical A represents a substituted carbazole radical; a radical B represents a structural radical containing substituted fluorenyl; and a structure C is a structure radical containing phenyl and substituted phenyl. The organic electroluminescent material is a fluorescent material which has high luminous efficiency; a result of the luminous efficiency in a solution can further indicate that the organic electroluminescent material which has high luminous efficiency and of which the brightness and performance can meet the industrial development can be applied to electroluminescent devices by serving as a luminous material or a luminous main body material or a transmission material. A synthesizing process has the advantages of reaction in two simple steps, easiness and convenience for operating, easiness for purifying, great increase in the industrial synthesizing yield, great reduction in cost, wide application, applicability to a plurality of materials for devices, and wide prospect. Meanwhile, a substituted radical is adjusted, so that the performance of the material further meets requirement of industrialization.

Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

The synthesis of capped / tagged RNA, methods of use and kits providing same are contemplated. Tagged RNA permits isolation of RNA transcripts in vitro. The ability to isolate and purify capped RNA results in improved transcription and translation and provides a tool for identifying RNA-protein interactions. Such capped RNA finds use in therapeutic applications, diagnosis and prognosis and in the treatment of cancers and HIV.

Methods and compositions for inhibiting interleukin-21 (IL-21) / IL-21 receptor (MU-1) activity using antagonists of IL-21 or IL-21 receptor (“IL-21R” or “MU-1”), are disclosed. IL-21 / IL-21R antagonists can be used to induce immune suppression in vivo, e.g., for treating, ameliorating or preventing autoimmune or inflammatory disorders, including, e.g., inflammatory bowel disease (IBD), rheumatoid arthritis (RA), transplant / graft rejection, psoriasis, asthma, fibrosis, and systemic lupus erythematosus (SLE).

An oxide semiconductor layer with excellent crystallinity is formed to enable manufacture of transistors with excellent electrical characteristics for practical application of a large display device, a high-performance semiconductor device, etc. By first heat treatment, a first oxide semiconductor layer is crystallized. A second oxide semiconductor layer is formed over the first oxide semiconductor layer. By second heat treatment, an oxide semiconductor layer including a crystal region having the c-axis oriented substantially perpendicular to a surface is efficiently formed and oxygen vacancies are efficiently filled. An oxide insulating layer is formed over and in contact with the oxide semiconductor layer. By third heat treatment, oxygen is supplied again to the oxide semiconductor layer. A nitride insulating layer containing hydrogen is formed over the oxide insulating layer. By fourth heat treatment, hydrogen is supplied at least to an interface between the second oxide semiconductor layer and the oxide insulating layer.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A compound shown by the following formula:wherein each of R1a, R2a, R3a and R4a represents a substituent selected from a non-reactive atom, a non-reactive group, a hydroxyl group and an amino group, and at least two members selected from R1a, R2a, R3a and R4a are a hydroxyl group, a carboxyl group or an amino group; is subjected to an esterification reaction or an amidation reaction with a polymerizable unsaturated compound (e.g., an alcohol, a carboxylic acid, an amine) in the presence of a catalyst comprising an element selected from the Group 3 elements, such as a samarium compound, to obtain a polymerizable adamantane derivative having at least one polymerizable unsaturated group in high yield.

The invention discloses a mixture of poly-pneumococcal capsular polysaccharide-protein conjugates. The mixture contains 13 pneumococcal capsular polysaccharide-protein conjugates and an immunity-enhancement adjuvant, wherein each pneumococcal capsular polysaccharide-protein conjugate is formed by combining corresponding serum-type pneumococcal capsular polysaccharide with a same protein carrier through a covalent bond; the 13 pneumococcal capsular polysaccharides are obtained by purifying and extracting 1, 3, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F and 23F bacteria; the protein carrier is A chain of a diphtherin mutant CRM197 obtained from expression of genetic recombinant escherichia coli. Meanwhile, the invention discloses a preparation method of the mixture. The mixture, compared to conventional bacterial fermentation total-chain diphtherin mutant CRM197, is easy to purify, high in yield and low in cost; experiments prove that the mixture disclosed by the invention is immunogenic, and is applicable to clinical inoculation.

Active surface coupled polymerases, surfaces that include such polymerases, and methods of making and using surface-attached polymerases are provided.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.

The invention relates to preparation methods of bis(fluorosulfonyl)imide and alkali metal salts thereof. The bis(fluorosulfonyl)imide is prepared by subjecting bis(chlorosulfonyl)imide to react with a fluorinating agent namely hydrogen fluoride. The alkaline metal salts of bis(fluorosulfonyl)imide is prepared by subjecting bis(chlorosulfonyl)imide and alkali metal halides to react with hydrogen fluoride taken as the fluorinating agent and the solvent. The preparation methods can reduce the raw material costs, reduce the material consumption and generation of wastes, improve the raw material utilization rate, product yield, and product purity; moreover, the product purification is easier, the preparation technology process is more concise and more efficient, and the preparation methods provides a very good technical foundation for massive industrial production of bis(fluorosulfonyl)imide and alkali metal salts thereof.

Certain benzopyran antiestrogens are disclosed for treating estrogen sensitive diseases such as breast cancer. Prodrug forms provide ease of manufacturing, good shelf life, and bioavailability, and preferred stereoisomers are shown to be more effective than racemic mixtures.

The present invention discloses a fluid purification and disinfection system, which includes a housing, an ultraviolet lamp and a photocatalytic oxidation device. Said housing therein is an enclosed case that is fitted with an inlet and an outlet. Furthermore, said ultraviolet lamp is mounted inside the housing. Said photocatalytic oxidation device is a disinfection core coated with photocatalyst. Said disinfection core is installed around said ultraviolet lamp, and is fixed onto said housing. Said photocatalyst therein is titanium dioxide. The working principle of the fluid purification and disinfection device in accordance with the present invention is to utilize ultraviolet light to irradiate the titanium dioxide-coated surface of the photocatalytic oxidation device to generate the photocatalytic oxidation process. As a result, Escherichia coli, Vibriocholerae and pathogenic organisms that contact the surface of photocatalytic oxidation device can be quickly killed, and contaminants in the fluid can be eliminated. By this way, water or fluid that flows through said disinfection device is disinfected and purified.

The invention provides methods of synthesizing and purifying methyl esters and specifically biodiesel fuels. The methods include acid-catalyzed transesterification of a triglyceride source followed by formation of an acidic emulsion that is subjected to an electric field to break the emulsion and recover the purified methyl esters. After recovery, the purified methyl esters may be used as a highly purified and stable biodiesel fuel without further treatment. The electric field may be efficiently applied to the acidic emulsion in an electrochemical reactor such as an electrocoagulation chamber.

The present invention provides a class of Conformationally Assisted Probes comprising (a) a nucleic acid moiety; (b) an energy donor moiety; (c) an energy acceptor moiety; and (d) one or more stabilizing moieties.

The invention relates to an AM / NaAA / allyl cyclodextrin polymerization with a inclusion function and a synthesis method of the AM / NaAA / allyl cyclodextrin (CD) polymerization, which comprises three structure units of acrylamide, sodium acrylate and allyl cyclodextrin. The synthesis method is as follow: the allyl cyclodextrin is synthesized with DMSO and DMF as solvent, CD as raw material and under the temperature of 0 to 10 DEG C. Then AM is put into the allyl-beta-cyclodextrin water solution, then initiator is added to prepare AM / allyl-beta-cyclodextrin binary copolymer under the conditions that monomer concentration is 10 to 20 percent, initiation system concentration is 40 to 80 mg / l, the temperature is 30 to 50 DEG C, and the time is for 1 to 8 hours. NaOH solution is put into the binary copolymer to hydrolyze, then the AM / NaAA / allyl cyclodextrin polymerization is obtained. The synthesis method of the polymer is processed under the mild condition with simple operation, the product is easy to be purified and separated. The AM / NaAA / allyl cyclodextrin polymerization can be used in the fields such as petroleum exploitation, waste water treatment, chemistry and medicine.

It is an object to provide a method of suitably analyzing the amount of gene expression of a single-cell.A method of detecting a nucleic acid comprisinga step of sampling a single-cell from a sample containing at least a single-cell,a cell lysis step of lysing cell membrane of the sampled single-cell and extracting nucleic acids from the cell,a DNase treatment step of degrading DNA of the extracted nucleic acids with DNase,a step of hybridizing mRNA of the total RNA contained in the single-cell with oligo (dT) fixed onto a carrier,a step of performing reverse transcription of the mRNA hybridized with the oligo (dT) to fix cDNA derived from the single-cell onto the carrier, thereby preparing a single-cell derived cDNA library fixed onto a carrier, anda step of amplifying cDNA fixed onto the carrier and simultaneously detecting an amplification amount of the cDNA.

The invention discloses a lithium ion battery cathode material embedded nano metal loaded carbon nanosheet as well as a preparation method and an application thereof. By taking sugar (chitosan, cane sugar, fructose and glucose) as a carbon source, nitrate of transitional metals (Fe, Co and Ni) as a metal source and a catalyst and inert salts (sodium sulfate, sodium chloride, potassium chloride and cesium chloride) as a template and a dispersant, a two-dimensional carbon nanosheet which uniformly loads embedded nickel (or iron or cobalt) nanoparticles is prepared by a pyrolytic method in one step. The two-dimensional carbon nanosheet which uniformly loads embedded nickel (or iron or cobalt) nanoparticles prepared by the method is high in degree of graphitization, relatively high in specific surface area and high in conductivity, uniform in distribution and easy to separate, and the surface of the nanosheet is in a porous structure. The nanosheet as the lithium ion battery cathode material has relatively good circulating and rate performances.

The present invention is process of preparing 3-hydroxy propionate and 1, 3-propylene glycol with epoxide as material. The present invention prepares 3-hydroxy propionate with epoxide, CO and alcohol under the action of cobalt catalyst and co-catalyst, and prepares 1, 3-propylene glycol under the action of 3-hydroxy propionate hydrogenating catalyst. The present invention has the advantages of simple reaction apparatus, simple operation, mild reaction condition, high catalyst activity, no environmental pollution, low production cost, etc.

A proton pump inhibitor containing a compound represented by the formula (I)wherein X and Y are the same or different and each is a bond or a spacer having 1 to 20 carbon atoms in the main chain, R1 is an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, R2, R3 and R4 are the same or different and each is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted thienyl group, an optionally substituted benzo[b]thienyl group, an optionally substituted furyl group, an optionally substituted pyridyl group, an optionally substituted pyrazolyl group, an optionally substituted pyrimidinyl group, an acyl group, a halogen atom, a cyano group or a nitro group, R5 and R6 are the same or different and each is a hydrogen atom or an optionally substituted hydrocarbon group, which has a superior proton pump action and shows an antiulcer activity and the like after conversion to a proton pump inhibitor in the body, or a salt thereof. or a prodrug thereof is provided.

A water purification method comprising adding a purification agent to water having a contaminant concentration of 1 μg / L to 10 g / L, the purification agent containing an adsorbent having an average particle size of 100 nm to 500 μm, an iron-based flocculant, and an alkaline substance; causing the adsorbent to adsorb at least a part of the contaminants in water; settling the adsorbent with the adsorbed contaminants by the iron-based flocculant; and removing the sediment from water, wherein the purification agent is added in an amount of 0.01 g to 20 g per liter of water, can purify contaminated water conveniently and efficiently.

The catalyst is compound formed with 4, 5-diazefluorene-9-ketobenzoyl hydrazone and its derivative as ligand, NiCl2.6H2O and CoCl2. The catalyst is activated with cocatalyst MAO before used for catalyzing oligomerization of ethylene. The catalyst has high catalytic activity, is suitable for mass production and storage and has better industrial application foreground.

A transistor includes a gate, a source, and a drain, the gate is electrically connected to the source or the drain, a first signal is input to one of the source and the drain, and an oxide semiconductor layer whose carrier concentration is 5×1014 / cm3 or less is used for a channel formation layer. A capacitor includes a first electrode and a second electrode, the first electrode is electrically connected to the other of the source and the drain of the transistor, and a second signal which is a clock signal is input to the second electrode. A voltage of the first signal is stepped up or down to obtain a third signal which is output as an output signal through the other of the source and the drain of the transistor.

It is an object to provide a method of suitably analyzing the amount of gene expression of a single-cell.A method of detecting a nucleic acid comprisinga step of sampling a single-cell from a sample containing at least a single-cell,a cell lysis step of lysing cell membrane of the sampled single-cell and extracting nucleic acids from the cell,a DNase treatment step of degrading DNA of the extracted nucleic acids with DNase,a step of hybridizing mRNA of the total RNA contained in the single-cell with oligo (dT) fixed onto a carrier,a step of performing reverse transcription of the mRNA hybridized with the oligo (dT) to fix cDNA derived from the single-cell onto the carrier, thereby preparing a single-cell derived cDNA library fixed onto a carrier, anda step of amplifying cDNA fixed onto the carrier and simultaneously detecting an amplification amount of the cDNA.

Carboxymethylgalactose derivatives represented by general formula (1);and salts thereof, which exhibit reactivity to selectins and are useful as inhibitors against selectin-related diseases such as various inflammations and cancerous metastasis; In said formula, R is a group rep resented by formula (1a), (1b) or (1c).