798 results about "Rodent" patented technology

The invention concerns HER<HIL><PDAT>2< / BOLD><PDAT>-transgenic non-human mammals, animal models for screening drug candidates for the treatment of diseases and disorders associated with the overexpression of HER<HIL><PDAT>2< / BOLD><PDAT>. In particular, the invention concerns animal models designed to test drug candidates for the treatment of HER<HIL><PDAT>2< / BOLD><PDAT>-overexpressing cancers, including breast cancer, that are not responding or poorly responding to current treatments.< / PTEXT>

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

The present invention relates to humanized immunoglobulins having binding specificity for α4β7 integrin, comprising an antigen binding region of nonhuman origin (e.g., rodent) and at least a portion of an immunoglobulin of human origin (e.g., a human framework region, a human constant region). In one embodiment, the humanized immunoglobulin can compete with murine Act-1 for binding to human α4β7 integrin. In a preferred embodiment, the antigen binding region of the humanized immunoglobulin comprises each of the complementarity determining regions of the light and heavy chains of the murine Act-1 antibody.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A noninvasive photoplethysmographic sensor platform for mobile animals such as small rodents, namely rats and mice is useful such as in a laboratory research environment. The noninvasive photoplethysmographic sensor platform may be a collar which provides an easily affixed, adjustable attachment mechanism that encircles the animal, such as the neck. The neck of the animal provides several particular advantages as a sensor mounting platform for photoplethysmographic sensors. For pulse oximetry, the neck location will provide significant blood flow under all conditions. For small mammals, such as rats and mice, transmittance pulse oximetry through the neck of the subject remains possible. The neck mounted collar also offers inherent bite resistance to the sensor platform.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.

A method and a device for automatically detecting and signaling the presence of prey caught in a trap. The trap has inlet ports equipped with a one-way inlet mechanism such that once a rodent has passed a central point the rodent is contained within the trap. After the rodent has passed the central point, the trap is reset to the start position in order to attract additional prey. The trap is provided with a device for signaling the presence of vermin in the trap. The mechanism may be operable via a push button operated by movement of the vermin. Alternatively, means for detecting the rodent may include the use of vertical or horizontally elongated elements that are actuated by the movement of the vermin. A further embodiment includes a photocell, or a sensor, to indicate the presence of rodents. The mechanism for signaling may include lights or sound devices that can be secured to the trap or remotely activated via wired or wireless means. The signaling device can be time delayed such that additional vermin can enter the trap before intervention by the operator and is also capable of monitoring several traps concurrently.

A robotic system and method for locomotion assessment and training of a mammal, exemplified by a rodent. A neurologically impaired animal is suspended over a moving surface in a harness, and the animal's hindlimbs are connected to robotic arms that apply force to the hindlimbs or measure limb movement characteristics. The moving surface can be a physical or virtual surface. A single robotic mechanism comprising two robotic arms can simultaneously apply force, measure limb movement, and provide a virtual surface. Manual or automatic adjustment of load support allows the mammal to step at varying body weight loads.

A preferred embodiment rodent trap (100, 200) includes a housing (101, 140, 201, 240), a trap assembly (118, 218), and a removable insert receptacle (120, 220). The trap assembly (118, 218) provides access to a cavity (119, 205) within the housing (101, 140, 201, 240). The removable insert receptacle (120, 220) fits within the cavity (119, 205) proximate the trap assembly (118, 218) to contain a rodent or rodents therein. The removable insert receptacle (120, 220) is preferably made of a non-destructible material to prevent escape. Further, the rodent trap (100) includes a base (101), a cover (140), and climbing assisting members (105). The base (101) has a wall portion (102) including an elevated platform (106). The cover (140) cooperates with the base (101) to define a cavity (119), which contains the elevated platform (106). The climbing assisting members (105) provide access to the elevated platform (106). The trap assembly (118) is operatively connected to the elevated platform (106), which elevates the trap assembly (118) within the cavity (119). The base (101), the cover (140), and the elevated platform (106) assist in preventing contaminants from entering the trap assembly (118) and the cavity (119).

A low cost, high performance flexible, rodent resistant reinforcement member that can be used for both optical and copper communications cable. The reinforcement members made according to the preferred process are more rigid than known reinforcement members, but are less rigid than glass pultruded rods. Communications cables utilizing these members are lightweight and exhibit an improved combination of strength and flexibility compared to traditional communications cables. Further, these communication cables may then be installed into underground ducts using more economical and faster installation techniques.

A bird feeder for preventing squirrels and other type rodent animals from consuming the bird food includes a top convex surface, a bottom convex surface and a concave middle surface. The top and bottom convex surfaces are inverted bowls having equal diameters and depths. The concave middle surface is a non-inverted bowl having a diameter less than the top and bottom inverted bowls, and has a greater depth. The middle bowl holds the bird food for birds to consume. The rim of the middle bowl may serve as a perch for the feeding birds to light upon. The top and bottom inverted bowls serve as protective shields that prevent rodent animals, such as squirrels from reaching the middle bowl. These shields are constructed from a substantially rigid material, having a substantially smooth surface. The smooth surface and the convex shape prevent squirrels or the like from establishing a foothold so that they may consume the bird food.

A pest-combating composition including sodium lauryl sulfate and one or more of C6-12 fatty acids, preferably lauric and / or capric and / or caprylic acid, soy methyl ester, and 2-undecanone, and methods of combating pests utilizing same, are disclosed. The compositions can include a carrier oil such as silicon oil, soy methyl ester, or a vegetable oil, and can be in the form of an emulsion. The composition may be constituted as a spray composition, an aerosol, a lotion, a paste, or another compositional form. Pests that may be usefully combated with such composition include flying insects, including flies, mosquitoes, and wasps, ants, including arthropods such as fire ants, ticks, fleas, cockroaches, silver fish, thrips, gnats, aphids, Japanese beetles, and agricultural and horticultural arthropods and insects including beetles (potato and bean), flea beetles, fleahoppers, squash bugs, slugs, leaf hoppers, harlequin bugs, milk weed bugs, spiders, mites, lice, rodents, and deer.

An animal containment device that includes a top wall, a bottom wall, a front wall, a rear wall, and at least one side wall. In one aspect, the device may also include an opening in the rear wall for insertion of a monitoring module for monitoring the animals within the device. In another aspect, the animal containment device may include walls made from a translucent material having a photosensitive material for controlling the amount of light within the animal containment device. In still another aspect, the animal containment device may include one or more sensors in the device and a monitoring linkage and display for displaying the data from the sensors.

A remote notification electronic rodent trapping system and method is provided having a plurality of electronic rodent trapping devices configured to wirelessly communicate trap information to each other and to a PC or wireless device. According to one embodiment, each trap is equipped with an RF transceiver and the rodent trapping devices form a mesh network with one another in which the trapping devices act as repeaters so that if one trap loses connectivity with the PC, information from that trap can be transmitted to the PC via another trap. According to an alternative embodiment, the traps individually report directly to the base station or to the base station via one or more repeaters, the repeaters enabling the range of the direct individual reporting configuration to be greatly increased.

A highly flexible water-proof, rodent-proof cable, comprising an optically or electrically conductive center region, a layer of a yarn of high tensile strength and water blocking properties overlying the center region, a layer of soft annealed steel wires in the form of a braid overlying the yarn layer, and an outer jacket of a polymeric material overlying the steel-wire layer.

A device and related method for monitoring, detecting and / or controlling pests such as rodents and insects, including termites, are disclosed which comprises: (a) encouraging a first characteristic behavior by the pests that is indicative of the presence of one or more of the pests; (b) discouraging a second characteristic behavior by the pests that at least partially interferes with detection of the first characteristic behavior; and (c) observing, detecting or sensing an occurrence of the first characteristic behavior by one or more of the pests. In one embodiment, the device comprises at least one photonic device; a light conductive assembly in optical association with the at least one photonic device, the assembly comprising first and second spaced apart components having first and second opposed light transmitting surfaces forming between them a spatial region adapted to contain a pest bait member comprised of one or more materials susceptible to consumption or displacement by the pests.

A signaling rodent trap system, the system comprising a signal transmitting device, wherein said signal transmitting device includes a motion triggered switch, a rf transmitter electronically connected to said switch for generating a rf signal only when said motion trigger switch is activated, a power source that is utilized to power said rf transmitter only when said motion triggered switch is activated, and, means for attaching said signal transmitting device to a rodent trap; and, a signal receiving device, wherein said signal receiving device includes a rf receiver for receiving said rf signal from said transmitter, a signaling mechanism for indicating a rf signal has been received by said receiver, a processor electronically connected between said signaling mechanism and said rf receiver for activating said signaling mechanism when a rf signal is received by said receiver, and, a power source for powering said signal receiving device.

The INK4A (MTS1, CDKN2) gene encodes a specific inhibitor (InK4a-p16) of the cyclin D-dependent kinases CDK4 and CDK6. InK4a-p16 can block these kinase from phosphorylating the retinoblastoma protein (pRb), preventing exit from the G1 phase of the cell cycle. Deletions and mutations involving the gene encoding InK4a-p16, INK4A, occur frequently in cancer cells, implying that INK4a-p16, like pRb, suppresses tumor formulation. However, a completely unrelated protein (ARF-p19) arises in major part from an alternative reading frame of the mouse INK4A gene. Expression of an ARF-p19 cDNA (SEQ ID NO:1) in rodent fibroblasts induces both G1 and G2 phase arrest. Economical reutilization of protein coding sequences in this manner is without precedent in mammalian genomes, and the unitary inheritance of INK4a-p16 and ARF-p19 may reflect a dual requirement for both proteins in cell cycle control.

The invention pertains to a trap for rodents, particularly for mice and rats, with a trigger device in the form of a plate (10) that is supported in a rocker-like fashion and provided with a constantly accessible receptacle for accommodating bait, with a striking device that is supported on the base plate (1) such that it can be pivoted about a first axis (7), wherein the striking device can be subjected to the force of a tension spring (18) and released from a first, armed position when an animal acts upon the plate such that it is pivoted about a second axis (9) supported on the base plate (1) from an idle position into a triggering position, in which a release element in the form of an eccentrically supported, elastic driving element that is separably engaged with the striking device (8) in the first, armed position can be pivoted by the rocker-like plate (10), wherein the striking device (8) that can be pivoted about the first axis (7) is released from its first, armed position and the force of the tension spring (18) causes the striking device to instantly swing with a high striking force into a second position, in which it humanely kills the animal. Due to its rotative moment, the eccentrically supported elastic driving element (17) is always rotationally prestressed in the direction of its home position, in which a collar (35) of the driving element (17) is engaged with an abutment (27) of the plate (10), wherein the striking device (8) is separably locked in its first, armed position on the driving element (17). The collar (35) of the driving element (17) that is tensioned during the movement of the latter into the release position such that the driving element (17) is turned back in the direction of its home position due to the spring-back of the spring arm (36).