1781 results about "Natural medicine" patented technology

The invention relates to a method of preparing antivirus and antitumor natural medicine arctigenin, and its characteristic: crushing the Arctium lappaL., using organic solvent to degrease, and obtaining a crude arctiin, then using snailase to make fermentation and enzymolysis the on the crude arctiin in an enzyme reaction system, and finally terminating the enzymolysis reaction by alcohol-containing water-soluble organic solvent and extracting enzymolysis products, then separating the enzymolysis products by using silica gel column chromatography and solvent recrystallization, purifying and obtaining the pure arctigenin; the yield of the method is increased by at last over 20 times as compared with that of separating natural-existing arctigenin in plants like Arctium lappaL.

The invention relates to a method for extracting cyaniding and belongs to the technical field of extracting natural medicaments. The method adopts the process of ultrasonic-assisted enzyme method extraction, flocculation, ultrafiltration, macroporous resin adsorption, nanofiltration condensation, spray drying and high-purity cyaniding. Compared with the traditional processes, the method has the advantages of overcoming the defects in the traditional processes, effectively improving the yield and the quality of the product, greatly lowering the consumption and the loss of the organic solvents,reducing energy consumption, lowering production cost, having practicability and progress and reaching the domestic leading level.

The invention discloses a novel turmeric salt and a preparation method thereof, belonging to the field of food seasonings. By using turmeric and table salt as the main raw materials, the table salt is ingeniously adopted as the carrier, and proper amounts of effective extracted substances of turmeric are added in different modes and uniformly mixed, thereby obtaining the novel turmeric salt product. The turmeric salt prepared by the technical line has the functions of flavor enhancement and flavoring in the table salt, and also has the peculiar pleasant turmeric flavor and health-care function in the turmeric. The preparation method is simple. The preparation method is convenient to operate, has the advantages of wide raw material sources, low cost, environment friendliness and high product stability, and is convenient for large-scale industrial production. The proportion of the turmeric effective extracted substances to the table salt can be controlled to control the content of the turmeric effective extracted substances in the product; and the method is suitable for preparing natural drug active effective components, such as other turmeric derivatives and the like.

The invention relates to the fields of natural medicine and medicinal chemistry, in particular to a class of oridonin and ent-6,7-ring-opened kaurene-type oridonin fluorine-containing derivatives with antitumor activity. The invention also discloses the preparation method of these oridonin A and ent-6,7-opening ring oridonin A fluorine-containing derivatives, the pharmaceutical composition containing the compound and the use of the compound in the treatment of tumor diseases Applications.

The invention disclosed the application of celery seed coumarins and flavanoid in preparing arthrifuge, anti-inflammatory agent or health food, which belongs to the natural occurring drugs and medical technology domain. The coumarins and flavanoid is the extract from acetic ether. The preparing method includes the following steps: selecting 10kg celery dry seed, adding 15-20 times of 75-95%(V / V) as the seed or extracting with 4-5 times of 75-95%(V / V) alcohol at higher temperature, heating for 1-1.5h every time; vacuum condensing the extracts until nearly all the alcohol is away; adding 1-2 times of water, extracting with 1 / 3 volume of the diluted solution sherwood oil (60-90DEG C) for 2-3 times; reclaiming the sherwood oil; extracting the water layer with 1 / 3 volume of acetic ether for 4 times; reclaiming the acetic ether to get the extracts. The invention has very simple preparing technologies; the product in the invention has obvious anti-inflammatory function; it can also decrease the amount of serum uric acid of rats.

The invention relates to the field of natural medicines and medicinal chemistry and particularly relates to derivatives with modified 13-N of evodiamine. The invention discloses a preparation method of the 13-N furazan NO donor substituted evodiamine derivatives and evaluation of the anti-tumor activity. The structure of the compounds is shown in the specification, wherein R1 and R2 are (CH2)n or (CH2)n1O(CH2)n2, and n, n1 and n2 are integers between 1 and 8.

The invention relates to a natural medicine composition as well as a preparation method and application thereof in preparation of a toxicity reducing and efficacy enhancing medicament in radiotherapy and chemotherapy of cancer. The natural medicine composition is prepared from a ginger and long pepper decorated concentrated extract, gingerol, a long pepper ethanol extract and piperine at a ratio of (2-8):(1-4):(2-4):(3-9). The composition has an extremely good efficacy for vomiting and other side effects caused by radiotherapy and chemotherapy of cancer, and simultaneously plays a role in suppression of tumors.

The invention relates to a drug for treating senile postoperative acute mental disorders. The drug is prepared from the following substances in proportion by weight: common alstonia bark leaves, herba selaginellae, ophicslcite ophicalcitum, fagopyrum cymosum, fiveleaf akebia fruits, euryale ferox, pummelo peel, celosia cristata, stalactite, folium polygoni tnctorii, seeds of Chinese dodder, grand torreya seeds, litchi, dyosma difformis, eucommia ulmoides, exocarpium benincasae, peucedanum decursivum maxim, tuber fleeceflower stems, chingma abutilon seeds, longan pulp, semen lepidii, soybean germinated, biotite schist and mica, valeriana jatamansi jones, saxifraga stolonifera, spina gleditsiae, folium turpiniae, Chinese honey locust, glechoma longituba, nodular branches of pine, adonis, impatiens balsamina, caulis bambusae in taeniam, desert asparagus, murraya paniculata, saururus chinensis, string beans, leaves of purpleflower holly, veronicastrum herb, Chinese starjasmine stems, abalone, lysionotius pauciflorus maxim, radix ampelopsis, radix scrophulariae, microcos paniculata, dayflowers, fructus piperis longi, corn stigmas, huperzia serrata and amethyst. The drug for treating senile postoperative acute mental disorders disclosed by the invention is prepared from natural medicines, has a clear curative effect, can be used for effectively treating the senile postoperative acute mental disorders, and therefore, the drug is very suitable for clinical application.

The invention relates to an anti-tumor natural medicine coupled with a nitric oxide donor and medical use thereof. The medicine has a chemical structure shown in the general formula (I), which couples an anti-tumor natural medicine and a nitric oxide donor and can be used for preparing a medicament for preventing and curing tumor and cancer diseases. After entering a human body, the medicament can release nitric oxide and the components of the natural medicine at the disease symptom points in vivo, double suppression effects on the tumor or cancer lesion cells can be realized, and the toxic or side effect of the natural medicine is avoided.

The invention discloses a method for preparing fungi polysaccharide, namely a multi-stage dissolvent-cycle dynamic-thermal-reflux extraction condensation method. The method comprises the technological steps of raw material crushing, mixing with a solvent, extraction, condensation, deposition in alcohol, filtering and drying so as to obtain a finished product. The method for preparing fungi polysaccharide integrates extraction, condensation, solvent recovery and the like together, and is completely carried out in an enclosed system, without any bad occurrence of escaping, steaming, leakage and dripping, etc. The production practice shows that the method can shorten the extraction cycle by 50 percent to 85 percent so as to improve the production rate; the ration between raw material to solvent can be reduced to 1:3-8 (as the traditional method has a ration between raw material and solvent higher than 1:20), and the amount of an extractant used can also be saved by 25 percent to 80 percent; primary / secondary steam can be put into fullplay and cooling water is saved so that the effect of energy conservation is very significant. Compared with the traditional method, the method can save 30 percent to 70 percent of steam amount; and the medical material does not need to be crushed finely, which is favorable to the further operation. The method can be largely applied to the development and production of the fungi polysaccharide and other related polysaccharides or natural medical materials.

The invention discloses compound edible fungus powder and a preparation method thereof. The compound edible fungus powder, by weight ratio, comprises the following components: 160-250 fruit body powder, 6-15 dry matrimony vine, 2-8 ginseng powder, 8-20 astragalus powder, 3-12 Chinese angelica powder, 5-15 Chinese date powder, 8-18 Chinese yam powder, and 2-10 rhizoma atractylodis macrocephalae powder. The compound edible fungus powder is high in nutritional value, is convenient to conserve, carry and eat, and has natural medicine food homologous material; matrimony vine, ginseng, astragalus, Chinese angelica, Chinese date, Chinese yam and rhizoma atractylodis macrocephalae and other ingredients have the effects of replenishing qi to invigorate the spleen, nourishing blood to tranquilize mind, building body and retaining youthful looks, calming the liver and improving eyesight, and promoting gastrointestinal digestion, and also have very good health care effect.

The invention relates to a method for planting saffron crocus in a Tibet region and belongs to the technical field of natural medicine plantation. The method comprises the steps of field seed ball breeding and indoor cultivation flower picking. The field seed ball breeding comprises the sub-steps of selection of seed corms, plantation preparation, plantation, field management, harvesting of the seed corms and storage of the seed corms. The indoor cultivation flower picking comprises the sub-steps of loading into flat baskets, shelving, cultivation management, and harvesting and processing of the saffron crocus. The saffron crocus is planted in a large field in the Tibet region by using the plantation method, sunlight is sufficient, the plantation time of the seed corms in the land is long, flowers are picked in the land, and the cost is reduced; by virtue of the selection and the cooperation of various plantation parameters according to the technical scheme, filaments of the produced saffron crocus are long, the appearance is good, and the yield is high; the content of saffron crocus essence and saffron crocus bitter principle is greatly higher than that of the saffron crocus produced in the prior art, the medicinal value is high, and pesticide residues are eliminated; moreover, seed balls are large, low in lesion and low in degeneration.

The invention discloses a natural medicament with the functions of hyperglycemic and lipid lowering as well as weight losing. The medicament is a resveratrol compound pigeon bean acid ketone A which can be prepared into a medicament preparation for curing diabetes or adiposity, and can also be prepared into a health-care food which is beneficial to a diabetes suffer or an adiposity suffer. The invention simultaneously discloses a compound of a plant source containing the pigeon bean acid ketone A as well as the use of the medicament and the health-care food thereof used for curing the diabetes.

The invention relates to field of natural medicine and medicinal chemistry, in particular to novel pentacyclic triterpene and melbine salt I of the derivative thereof. The salt compound can be used for preparing medicaments curing diabetes mellitus and complicating disease thereof, cerebral ischemia, angiocardiopathy, atherosclerosis, hepatitis, fatty liver and metabolic syndrome or tumour, descendens blood fat drugs and anti-obesity drugs. The invention also relates to the preparation method of the salt compound.

The invention belongs to the technical fields of natural medicines and natural foods, in particular to a method for preparing total glycollic glucoside by using royal paulownia (original variety) fortune paulownia wood as raw material and applications of the same to foods and medicines. The total glycollic glucoside of royal paulownia (original variety) fortune paulownia wood with the purity of 40-60 percent is prepared by using the royal paulownia (original variety) fortune paulownia wood as the raw material and extracting, leaching and separating the raw material, can remarkably eliminate DPPH free radicals and can be used for preparing oxidation-resistant foods and oxidation-resistant medicines.

The invention discloses an anti-halitosis toothpaste containing natural drug compound components, and aims to provide a toothpaste which is capable of effectively inhibiting halitosis pathogens in the oral cavity and efficiently eliminating halitosis, takes natural Chinese herbal medicines as components for eliminating halitosis, and is safe and healthy. The anti-halitosis toothpaste containing the natural drug compound components is composed of toothpaste base materials and an active component compound, wherein the content of the active component compound is 0.601-5.9% in percentage by weight and the balance is the toothpaste base materials; and the active component compound is composed of tea polyphenol, vitamin C, zinc citrate, triclosan and sodium alginate.

The invention provides a preparation method and application of physiologically active notoginseng polysaccharide. The method comprises the steps of refining and purifying by applying resin column chromatography, activated carbon and membrane separation and purification technology, and the like, so as to obtain the notoginseng polysaccharide. The notoginseng polysaccharide obtained by the preparation method provided by the invention has the characteristics of low protein, heavy metal and ash contents and stable quality, has the physiological activities of immunity regulation, liver injury protection, blood glucose decrease, tumor resisting and the like, and can be used singly or combined as raw materials for natural medicines and health products. The preparation method of the notoginseng polysaccharide, provided by the invention, is simple to operate, applicable for industrial production and low in cost and reaches the purposes of energy saving and consumption reduction and realizing comprehensive development and sustainable utilization of the rare Chinese traditional medicine, namely, notoginseng.

The invention discloses a natural drug two-dimensional preparation chromatographic instrument with integrated functions of separation method development and online separation-enrichment and a work method thereof, belongs to the technical field of natural medical component separation, and can be applied to development fields such as traditional Chinese medicine, plant drugs, marine drugs, and the like. The chromatographic instrument comprises a control system, a pumping system, an injection system, a detection system, a one-dimensional chromatographic column system, a two-dimensional chromatographic column system, and a two-position eight way valve. Separation method development and optimization and natural drug two-dimensional orthogonal chromatogram separation and preparation can be achieved in one instrument. Complicated natural products are separated into 18 components or effective parts that can be repeatedly obtained. Then 18 components or effective parts are subjected to two-dimensional separation to further separate the components or effective parts so as to obtain pure compounds. All separation operations are carried out under the control of a computer, the efficiency for separating and preparing natural drugs such as traditional Chinese herbals is greatly improved, and an efficient and reliable platform is provided for separating the effective parts and components from traditional Chinese herbals, plant drugs, and marine drugs and carrying out active screening.

The present invention discloses a mutton preservative and the preparation method; the preservative is made by distilling four natural medicine-food plants. The weight proportion of every raw material is that forsythia extract 2 to 9 percent, ageratum extract 3 to 10 percent, clove extract 1 to 10 percent, liquorice extract 1 to 10 percent and the rest is water. The preparation method is that the four plants are separately ground into powder by a muller and mixed with water of a proper amount; the mixture is placed in a water bath for heating and then the mixture is put into a centrifugal machine for centrifugal processing; a proper amount of supernatant liquid of the solution after being processed is taken and mixed with water according to the proportion to obtain the mutton anti-staling agent. If people apply the preservative on fresh mutton for a preservation test, the result represents that the developed mutton preservative has obvious preservative effect and the quality-guaranteed period is 9 to 13 days under 15 Celsius degrees and 2 to 5 days above 15 Celsius degrees.

The invention belongs to the technical field of natural medicines, in particular to a preparation method of a walnut green husk total tannin and an application of the same in antineoplastic medicines. The walnut green husk total tannin is prepared by using walnut green husk as raw material and extracting, leaching, precipitating, separating and purifying the raw material, has light color and high purity, and the preparation method has the advantages of high yield, low production cost and simple and standard process. The walnut green husk total tannin prepared by the invention can remarkably inhibit the growth of tumor cells and can be used for preparing the antineoplastic medicines.

The invention belongs to the field of separation of natural medicines and particularly relates to a method for extracting total saponins from pokeberry root. The method comprises the following steps: 1) grinding pokeberry root medicinal material, adding 50 to 70 percent ethanol solution, soaking for 2 to 3 times, filtering extract, subjecting the filtrate to ultrafiltration by an ultrafiltration membrane, adding the filtrate to a nanofiltration membrane for concentration and obtaining concentrate; and 2) extracting the concentrate by using double water phases, collecting an upper phase, concentrating under reduced pressure, and drying to obtain total saponins. In the method, the total saponins of the pokeberry root is extracted by using membrane separation and double-water-phase extraction technology; the method has the advantages of low energy consumption, little pollution and low production cost; and the obtained total saponins does not require of controlling residual solvent and meet requirements of pharmacopeia.

The invention relates to the field of natural drug and medicinal chemistry, in particular to ursane-type pentacyclic triterpenoid amino acid derivatives (I), and the preparation method and the medicinal application thereof. The compounds have effect on inhibiting glycogen phosphorylase, and can be used for preparing drugs for resisting diabetes, cerebral ischemia, cardiovascular diseases, hyperlipemia, obesity, atherosclerosis and tumor. The invention also relates to the preparation method of the compounds and drug preparations containing the compounds.

The invention belongs to the technical field of natural medicines, and in particular relates to a method for preparing astragalus polysaccharides. The astragalus polysaccharides prepared by the method are high in yield and purity. The method comprises the following steps of: A, extracting astragalus with water to obtain water extract; B, heating the water extract, cooling, and discarding sediments on the bottom layer to obtain supernate; C, concentrating the supernate obtained in the step B into paste, adding ethanol for precipitation, and filtering to obtain crude astragalus polysaccharides;and D, refining the crude astragalus polysaccharides to obtain refined astragalus polysaccharides. The yield of the refined astragalus polysaccharides extracted by the method is 12 to 15 percent, thepolysaccharide content is over 94 percent, and the astragalus polysaccharides can be used for preparing immune medicines and health products. The yield of the polysaccharides in the method is improved by 8 to 11 percent compared with that of the traditional water extraction and ethanol precipitation method, the utilization rate of dry astragalus roots is improved and the production cost is reduced.

The invention belongs to natural medicine field and in particular relates to guaiane sesquiterpenoid with general formulaIwhich is distilled from Chinese herb ainsliaeafragrans; wherein R1 is OH or 0- beta-D-GIc; R2 is OH or H; R3 is alpha-H, beta-CH3 or =CH2. The invention further relates to the preparation method of the compound, the medicine combination with the compound as active component, and the application of the compound and the medicine combination thereof in curing acute or chronic inflammation and relevant diseases, including cervicitis, pelvic inflammation, endometritis, upper respiratory tract infection, quinsy as well as faucitis.

The invention relates to the natural medicine preparation field, and in particular, relates to a bulleyaconitine A preparation method; the preparation method comprises four steps: extraction, extraction separation, column chromatography separation purification, and crystallization purification. According to the bulleyaconitine A preparation method provided by the invention, alumina column chromatography is used for replacing silica gel column chromatography, so that the production cost is saved; a petroleum ether-diethylamine binary system is used as an eluent and is easy to recycle and reuse, so as to reduce environmental pollution.

The invention relates to the technical field of natural medicine and particularly relates to the use of a flavonoid compound originated from Dracocephalum moldavica in protecting myocardial ischemia reperfusion injury. A pharmacology experiment proves that the effect of protecting myocardial ischemia reperfusion injury of lonicerin, kaempferol and galuteolin is better than that of other flavonoid compounds and than that of general flavone of Dracocephalum moldavica.

The invention relates to mouth cleaning products, in particular to natural medicine toothpaste with saussurea involucrata as a major material, radix zanthoxyli, kamuning and other specific medicine. The natural medicine toothpaste with saussurea involucrata as the major material has the advantages that taste is improved and simultaneously active constituents of medicine are not prone to lose by blending the active constituents of the medicine in spice; and acting time of toothpaste in the mouth is greatly prolonged to enable pesticide effects to fully act. Simultaneously, the natural medicinetoothpaste is simple in manufacture process, low in price and free of side effects and has functions of natural inflammation diminishment, analgesia and hemostasis. Effective medicine constituents are all natural extractives.

The invention relates to the separation of natural medicines, in particular to a separation and preparation method of liquiritin; wherein, extracting solution is obtained by decocting the ground licorice plants with ten times of water, and then extract is obtained after the extracting solution is concentrated, and then ethanol is added for alcohol precipitation twice, and then a 6000Da molecular weight membrane separator is used for separating the extract, and then membrane separation permeation liquid is separated by X-5 macro-porous absorption resin and is eluted with the ethanol water, and the obtained macro-porous resin separation components are separated by an efficient industrial chromatographic column and eluted with gradients with the methanol water and then the liquiritin is obtained by collecting, concentrating, freezing and drying the eluting solution. The method is high in product purity, great in preparation amount and stable and reliable in process and especially suitable for separating and preparing great amount of highly purified liquiritin compounds from the traditional Chinese medicine licorice.

The invention specifically relates to novel polypeptide and Periplaneta americana total polypeptide extract capable of promoting tissue repair, and application thereof, belonging to the fields of traditional Chinese medicines and crude drugs. The novel polypeptide capable of promoting tissue repair is named as Periplapeptide A and has a structure as shown in a formula I H-Ala-Ala-Pro-Tyr-Ala-His-Val-Ala-Ala-Pro-Tyr-Ala-His-Phe-OH. The Periplaneta americana total polypeptide extract capable of promoting tissue repair is prepared by subjecting the bodies of Periplaneta americana to alcohol extraction, degreasing and enrichment via a reversed-phase material, wherein the mass percentage content of total polypeptide is greater than 50%, and the extract contains Periplapeptide A. The novel polypeptide and the Periplaneta americana total polypeptide extract containing novel polypeptide in the invention can promote propagation of mouse embryo fibroblasts and migration of immortalized human epidermal cells at low concentrations, have low toxic and side effect and good medicinal prospects, and are applicable to preparation of medicines used for treating wounds, burns and ulcers or cosmetics and daily chemical articles used for beautifying the skin.

This invention relates to the field of nature medicament and high molecular material, specifically relates to a kind of former medicine (1)of polietilenglicol. This invention also discloses the method for preparing the former medicine and the medicine composition that taking (1) as active constituent and their application in tumour threatment.