47results about How to "Significant hypoglycemia" patented technology

The invention relates to the technical field of crude drug, more specifically to a linaloe leaf extract. The invention also discloses its preparation and use in pharmaceuticals and health products.

The invention relates to an application of a seaweed polypeptide in preparing a health-care product for reducing blood fat and blood sugar as well as a beverage containing the polypeptide for reducing the blood fat and the blood sugar. The seaweed polypeptide is prepared by the following steps of: milling a mixture of immersed porphyra haitanensis and water through a colloid mill to obtain porphyra haitanensis slurry; adopting AS.1398 neutral protease to carry out enzymolysis on the porphyra haitanensis slurry for 5-10 hours under the conditions that the temperature is 45-55 DEG C, the pH (Potential of Hydrogen) is 7.2-7.8, the enzyme adding amount E / S is 8000-12000 U / g and the weight / volume ratio concentration of a substrate is 3-7%, so as to obtain an enzymolysis solution; centrifuging the enzymolysis solution and collecting liquid supernatant; and carrying out ultra-filtering separation on the liquid supernatant to obtain an active component with the molecular weight of less than 10000 Da. An animal experiment shows that agars are subjected to biological enzymolysis to obtain the seaweed polypeptide which has the obvious effects of reducing the blood fat, the blood sugar and blood pressure; and after the seaweed polypeptide is taken for a long period, the weight can be prevented from too fast increase and the happening possibility of arteriosclerosis can be reduced.

The invention provides a thrombin activity based chimeric peptide with double targeting effects, a preparation method and an application thereof. The chimeric peptide provided by the invention contains three segments: segment 1 has an amino acid sequence having 20th to 90th amino acid from N-terminal of HMGB1 protein; segment 2 has an amino acid sequence of Exendin-4 protein; and segment 3 which contains cleavage sites of thrombin and dipeptidyl peptidase is a junction fragment of segment 1 and segment 2. According to the preparation method provided by the invention, the thrombin activity based chimeric peptide with double targeting effects can be obtained by synthesis of a polypeptide synthesis technology or construction of an expression vector which contains nucleotide sequence encoding the chimeric peptide, expression of the protein in a gene engineering strain and purification of the protein. The chimeric peptide provided by the invention has double targeting effects of inhibiting inflammatory response and decreasing blood glucose, and can be applied in the preparation of anti-inflammatory and / or hypoglycemic drugs.

The anti-aging longevity noodles comprise of more than 10 food, such as animal and plant food, sea food , algae food and vegetables, said ingredients through careful selection, rinsing, drying and powdering, and through noodles machine, instant noodle machine and squeezer machine for a kind of noodle made by buckwheat, sorghum flour etc., then light dark green colored nutrition balanced food to be finished, shaped as vermicelli, instant noodles and said kind of noodles.

The invention discloses a hypolipidemic and hypoglycemic bitter buckwheat tea and a preparation method thereof. The preparation method comprises the following steps: cooked or toasted bitter buckwheat rice is taken as the raw material; an extracting solution and the hot cooked bitter buckwheat rice are directly sprayed and enhanced by the proportion of 0.5-3 ml:1 g; the cold-toasted bitter buckwheat rice is placed in a drying oven and heated for 15-20 min in the temperature of 100 DEG C and then sprayed and enhanced together with the extracting solution by the proportion of 1 g:0.5-3 ml; and the sprayed and enhanced bitter buckwheat rice is placed in the drying oven and dried in the temperature of 40-50 DEG C till the moisture content is 3-5 percent to obtain the product. The extracting solution is formed by resolving 0-4 parts of Zijuan Pu-erh Tea extracts, 1-3 parts of Broadleaf Holly Leaf extracts and 0-2 parts of Angelica Keiskei extracts with 65-precent alcohol of which the volume is 0.5-2.5 times of the total mass of the extracts. The hypolipidemic and hypoglycemic bitter buckwheat tea has not only the nutrition and functional ingredients but also the specific bitter taste of bitter buckwheat and is remarkable in both hypolipidemic and hypoglycemic effects.

The invention discloses a Chinese herbal medicine composition for curing diabetes, comprising aweto, wolfberry bark, scutellaria, trichosanthin, liriope, kudzu, phellodendron bark, anemarrhena, root of rehmannia, xuanshen, schisandra, cassia bark, astragalus, Chinese yam, lanceolata, malt, medicated leaven, coix seed, crab apple and tartarian buckwheat root and rhizome. The preparation method of the Chinese herbal medicine composition comprises the following steps: wolfberry bark, scutellaria and liriope are boiled, immersed with trichosanthin and then dried; phellodendron bark, anemarrhena and root of rehmannia are boiled, immersed with kudzu and then dried; malt, medicated leaven and crab apple are boiled, evenly immersed with lanceolata and then dried; tartarian buckwheat root and rhizome, coix seed, cassia bark and aweto are dried; then, the dried trichosanthin, kudzu, Chinese yam and lanceolata are crushed and added to starch to make into pills with water. The Chinese herbal medicine composition can reinforce the sensibility of insulin, can obviously reduce lipid, regulate lipid and reduce blood viscosity, and has the advantages of simple making method, fast effects and stable therapeutic effects.

The invention relates to the field of medicine synthesis, and discloses a GIP / GLP-1 analogue. The GIP / GLP-1 analogue is used for preparing a pharmaceutical composition for treating diseases, and the pharmaceutical composition is used for preparing a medicine for treating at least one of the following diseases: type-II diabetes, impaired glucose tolerance, type-I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive disorder, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory intestinal syndrome and / or dyspepsia orgastric ulcer, hepatic fibrosis disease and pulmonary fibrosis disease.

The invention relates to the field of pharmaceutical synthesis, and discloses a tiripa peptide analogue. The tiripa peptide analogue is used for preparing pharmaceutical compositions for treatment ofdiseases, use of the pharmaceutical compositions to preparation of drugs for treatment of one or more of the following diseases is disclosed, and the diseases include type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, liver fibrosis diseases and pulmonary fibrosis diseases.

The invention discloses a barberry bark extractive. The invention also discloses a new use of barberry bark and an extractive thereof. The barberry bark and the extractive thereof can activate PPAR Delta, PPAR Alpha and Lxr Alpha, improve the human body glucose and lipid metabolism and increase the insulin sensitivity and has the remarkable effects of reducing the blood sugar and the blood lipid; and meanwhile, the barberry bark and the extractive thereof also can partially resist PPAR Gamma, overcome the adverse effect of a simple PPAR Gamma activator, block the fat formation and avoid the weight gain, cholesterol level rise and other side effects generated by the existing insulin sensitizer (PPAR Gamma activator), thereby providing a new choice for clinically treating metabolic diseases.

The invention provides a liver protecting and kidney reinforcing tea. The active components of the liver protecting and kidney reinforcing tea comprise the following raw materials in parts by weight: 5-10 parts of medlar, 12-18 parts of ampelopsis grmsedntara leaves, 12-16 parts of mulberry leaves, 6-10 parts of cyclocarya paliurus, 6-12 parts of raspberry, 5-10 parts of golden camellia, 6-12 parts of moringa oleifera leaves and 2-6 parts of cordyceps militaris, wherein the active components cooperate with one another so that the liver protecting and kidney reinforcing tea has good liver protecting and kidney reinforcing effects. In addition, the invention further provides a preparation method for the liver protecting and kidney reinforcing tea. The preparation method provided by the invention is simple, easy to operate, and has a wide application scope.

A micron-class health-care sour milk for decreasing fat and losing weight is prepared from traditional milk, micron-particles of gingko leaf, gynostemma penta phyllum, haw and konjak, chitosan, isomaltose ketone and useful intestinal bacteria through proportional mixing, processing and fermenting. Its advantages are high effect and rich nutrients including vitamins, minerals, etc.

The present invention is slimming hypoglycemic milk powder prepared through adding airflow crushed micron level gingko leaf powder, micron level gynostemma pentaphylla powder, micron level haw powder, micron level konjack powder, chitosan and isomaltose into traditional milk powder. The slimming hypoglycemic milk powder has obvious effects of slimming, reducing blood fat and strengthening immunity. The present invention makes it possible for obese medium aged and old people to absorb the effective components of konjack powder, gingko leaf powder, gynostemma pentaphylla flower powder, etc. to strengthen health functions of promoting blood circulation, reducing blood fat, dispersing blood clots and reducing weight while obtaining various vitamins, minerals, etc.

The invention relates to the field of functional tea, in particular to medicine and food homology functional tea and a preparing method thereof. The medicine and food homology functional tea is prepared from, by weight, 5-10 parts of radix pueraiae, 3-7 parts of mulberry, 4-8 parts of fructus lycii, 1-5 parts of seabuckthorn fruits, 1-5 parts of flos chrysanthemi and 0.1-0.5 part of stigma croci. The medicine and food homology functional tea is prepared through drying, smashing, granulation and subpackaging. Based on pathogenesis, six medicine and food homology medicines including seabuckthorn fruits which can enhance immunity and regulate in-vivo metabolic function, flos chrysanthemi which can elevate clear qi to lower turbid qi and reduce blood pressure, fructus lycii which can tonify kidney to strength the body and balance blood glucose, and the stigma croci which can promote blood circulation to remove blood stasis and achieve beautifying and defatting are carefully selected, and blood glucose reduction, lipid reduction and blood pressure reduction effects are remarkable through accurate component matching and scientific nursing. The medicine and food homology functional tea is easy to prepare and is packaged in bags so as to be taken and eaten conveniently.

The invention discloses a production method of manual minor cereal cat-ear-shaped noodle, wherein the formula comprises the following components: wheat flour, minor cereals flour, edible salt, Chinese chestnut powder, walnut powder, high-calcium powder, vegetable juice and water; and the method is as follows: Chinese chestnuts and walnuts are ripely fried, smashed, and respectively made into the Chinese chestnut powder and the walnut powder, vegetables are pressed and filtered so as to obtain the vegetable juice, the vegetable juice and the edible salt are added into hot water, and are stirred uniformly, 60 percent of the wheat flour is prepared to be pasty by the mixed hot water, the other wheat flour and other ingredients are stirred uniformly, and kneaded into the flour paste, so that the flour is kneaded well, the kneaded flour is pressed into flour slices, and then is cut into noodles, the noodles are pulled into flour blocks with size of a broad bean manually, the flour blocks are twisted into cat-ear-shaped noodles, and the produced cat-ear-shaped noodles fast are transmitted into a freezing tunnel machine, then are packed, and are stored under the condition that the temperature is 16 DEG C below zero-18 DEG C below zero. After being cooked thoroughly, the cat-ear shaped noodle is not pasted, not soft, and is smooth in gluten and tasty and refreshing, has a better food therapy effect on diseases such as diabetes mellitus and the like, and is a delicious food in catering industry and families.

The invention relates to a mare's milk composition and a preparation method thereof. The mare's milk composition comprises the following raw material components in parts by weight of 30-40 parts by weight of mare's milk powder, 12-15 parts by weight of buckwheat, 8-10 parts by weight of lily bulbs, 2-4 parts by weight of Chinese wolfberry fruits, 5-7 parts by weight of poria cocos, 2-6 parts by weight of lotus leaves, 3-5 parts by weight of lotus seeds, 1-3 parts by weight of chrysanthemums, 8-10 parts by weight of kelp, 3-7 parts by weight of radix puerariae, 4-6 parts by weight of coix seedsand 3-7 parts by weight of folium eucommiae. Various medicinal and edible raw materials of the mare's milk powder, the buckwheat and the like are in perfect combination, so that the prepared mare's milk composition is pleasant in mouth feel and coordinated in taste, has the significant efficacy of reducing blood pressure, reducing blood sugar and reducing blood lipid, is significant in effects, takes effect quickly, does not have any side effects, and is suitable for people to eat for a long term.

The present invention relates to preparation process of fat reducing and slimming granule, capsule and tablet. The fat reducing and slimming granule, capsule and tablet are prepared with superfine crushed micron gingko leaf powder, micron gynostemma pentaphylla powder, micron haw powder, micron konjack powder, chitosan and other material, and through combination and processing. They have obvious functions of reducing fat, slimming and strengthening immunity. They can provide obese middle aged people and old people with rich vitamins, minerals, active enzymes and other nutritious matters, to improve health.

The invention provides a manufacturing method of a preserved fig, and relates to a fruit deep processing method. The manufacturing method comprises following steps: fig picking, sterilizing, microwaveprocessing, impregnating, fermenting, and drying. Through fermentation, sugar of figs is converted into acids, pectin is converted into pectic acid, and proteins are decomposed into micromolecular peptides or AA, which can be more easily absorbed by human body. The sugar curing step in a conventional preserved fruit manufacturing method is eliminated, and fermentation is carried out so that the sugar content of preserved fig is largely reduced, thus the preserved fig is suitable for people who need to control the blood sugar; the manufactured preserved fig can be stored for a long term without using any preservative, and the preserved fig is not hard and is elastic.

The invention relates to the field of medicaments, and particularly relates to a compound shown in Formula I, a preparation method thereof and application thereof as a novel DPP-4 inhibitor medicament, especially application in preparation of antidiabetic medicaments. In vivo / in vitro pharmacodynamic experiment results indicate that the compound shown in Formula I has obvious inhibiting action on DPP-4, shows superior blood sugar reducing effect and has higher acting effect in comparison with a similar medicament linagliptin. Meanwhile, the compound provided by the invention is short in preparation route, accessible in raw materials, simple in process and suitable for industrial large-scale production, and has great developing prospects.

The invention discloses a rearing method for improving fattening pig meat quality, and relates to the technical field of breeding. Fermented mulberry leaves accounting for 5.5-8.5% of the weight of feed are added into the feed for feeding fattening pigs 25-28 days before slaughtering of the fattening pigs, the fattening pigs are fed for three times every day, gravel accounting for 0.02-0.05% of the weight of the feed is added into the feed for feeding the fattening pigs every three days, and free choice feeding and free water drinking are performed until slaughtering. The mulberry leaves are fermented, polyhydroxylated alkaloids 1-deoxynojirimycin and other active substances in the mulberry leaves can be effectively released and added into the feed, the content of inosinic acid in pork canbe remarkably increased, and lean meat percentage is improved.

A micron-class health-care milk for decreasing sugar and losing weight is prepared from traditional milk, micron-particles of konjak, pine pollen, bee pollen and tuckahoe, glucomannan, and xylitol through proportional mixing, processing and fermenting. Its advantages are high effect and rich nutrients including vitamins, minerals, etc.

The invention relates to a novel composition for treating diabetes. The composition is characterized by being prepared from black tartary buckwheat, fructus arctii, rhizoma seu radix notopterygii, rhizoma atractylodis macrocephalae, rhizoma polygoni cuspidati, radix astragali, radix puerariae, herba lycopodii, radix scrophulariae, water chestnuts, fructus momordicae, cordyceps sinensis and probiotics, wherein the probiotics include at least one of bifidobacterium, streptococcus, lactobacillus and saccharomycetes. The composition has the significant treatment effects of reducing blood sugar and resisting diabetes, and also has the effects of tonifying qi and activating blood, clearing and activating the channels and collaterals, resisting fatigue, reducing blood pressure, reducing blood lipid and resisting aging.

The present invention is slimming hypoglycemic soybean milk prepared through adding airflow crushed micron level gingko leaf powder, micron level gynostemma pentaphylla powder, micron level haw powder, micron level konjack powder, chitosan and isomaltose into traditional soybean milk. The slimming hypoglycemic soybean milk has obvious slimming and blood fat reducing effect. The present invention makes it possible for obese medium aged and old people to absorb the effective components of konjack powder, gingko leaf powder, gynostemma pentaphylla flower powder, etc. to strengthen health functions of promoting blood circulation, reducing blood fat, dispersing blood clots and reducing weight while obtaining various vitamins, minerals, etc.

The present invention relates to a high-grade compound micrometer pine pollen konjak milk weight-reducing sugar-reducing milk powder with the health-care functions of reducing weight, reducing sugar, discharging toxic material and nourishing face and its preparation method. It is made up by adding micrometer konjak powder, micrometer pine pollen powder, micrometer Melissa powder, micrometer poria powder, glucomannan powder and xylital powder into various traditional milk powders.

A micron-class health-care sour bean milk for decreasing fat and losing weight is prepared from traditional bean milk, micron-particles of gingko leaf, gynostemma penta phyllum, haw and konjak, chitosan, isomaltose ketone and useful intestinal bacteria through proportional mixing, processing and fermenting. Its advantages are high effect and rich nutrients including vitamins, minerals, etc.

The invention relates to a preparation method of a cedrela sinensis composite polysaccharide beverage. The preparation method comprises the following steps: (1) preparing juice; (2) blending to obtaina polysaccharide mixed solution; (3) filtering, obtaining supernatant, i.e., cedrela sinensis composite polysaccharide beverage; (4) homogenizing: homogenizing the filtered cedrela sinensis compositepolysaccharide beverage by using a high-pressure homogenizing machine; and (5) sterilizing and bottling: implementing the industrialized mass production. The raw materials adopted in the preparationmethod such as folium cedrelae sinensis, Chinese yam, semen cassiae and barley are medicinal and edible and nontoxic and free from side effect and apparent in glucose reduction and antioxidant effect,the characteristic fragrance ingredients and flavor of the raw materials are reserved, the granularity of the material is effectively reduced, the specific surface area is increased, the dissolutionof active ingredients and biological absorption utilization rate of the polysaccharide can be greatly improved, the antioxidant and blood glucose reduction effect is more apparent, and the digestion and absorption of the human body can be facilitated.

The present invention is slimming hypoglycemic soybean milk prepared through adding airflow crushed micron level gingko leaf powder, micron level gynostemma pentaphylla powder, micron level haw powder, micron level konjack powder, chitosan and isomaltose into traditional soybean milk. The slimming hypoglycemic soybean milk has obvious effects of slimming, reducing blood fat and strengthening immunity. The present invention makes it possible for obese medium aged and old people to absorb the effective components of konjack powder, gingko leaf powder, gynostemma pentaphylla flower powder, etc. to strengthen health functions of promoting blood circulation, reducing blood fat, dispersing blood clots and reducing weight while obtaining various vitamins, minerals, etc.

A micron-class health-care sour milk for decreasing sugar and losing weight is prepared from traditional milk, micron-particles of konjak, pine pollen, bee pollen and tuckahoe, glucomannan, xylitol, and useful intestinal bacteria through proportional mixing, processing and fermenting. Its advantages are high effect and rich nutrients including vitamins, minerals, etc.

The invention discloses a Chinese herbal medicine composition for curing diabetes, comprising aweto, wolfberry bark, scutellaria, trichosanthin, liriope, kudzu, phellodendron bark, anemarrhena, root of rehmannia, xuanshen, schisandra, cassia bark, astragalus, Chinese yam, lanceolata, malt, medicated leaven, coix seed, crab apple and tartarian buckwheat root and rhizome. The preparation method of the Chinese herbal medicine composition comprises the following steps: wolfberry bark, scutellaria and liriope are boiled, immersed with trichosanthin and then dried; phellodendron bark, anemarrhena and root of rehmannia are boiled, immersed with kudzu and then dried; malt, medicated leaven and crab apple are boiled, evenly immersed with lanceolata and then dried; tartarian buckwheat root and rhizome, coix seed, cassia bark and aweto are dried; then, the dried trichosanthin, kudzu, Chinese yam and lanceolata are crushed and added to starch to make into pills with water. The Chinese herbal medicine composition can reinforce the sensibility of insulin, can obviously reduce lipid, regulate lipid and reduce blood viscosity, and has the advantages of simple making method, fast effects and stable therapeutic effects.