1054 results about "Hypoglycemic Effects" patented technology

The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.

The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and / or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) γ. A compound represented by the general formula (I):[wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.

An agent for treating diabetes with sulfonylurea secondary failure which comprises a dipeptidyl peptidase IV inhibitor. The agent of the present invention is an agent for treating diabetes with sulfonylurea secondary failure showing excellent insulin-secreting and hypoglycemic effects on even diabetic patients on whom a sulfonylurea compound or a fast-acting insulin secretagogue has no insulin-secreting effect and therefore no sufficient hypoglycemic effect.

The present invention is process of extracting 1-deoxy nojirimycin (DNJ) from mulberry leaf. Mulberry leaf extract is treated with inorganic acid, cooled to eliminate impurity and column chromatographically separated to obtain DNJ. Animal experiment of mouse shows that the mulberry leaf extract has obvious blood sugar reducing effect, so that the present invention may be used in preparing blood sugar reducing health product. The present invention has low preparation cost, and is suitable for industrial production.

The present invention relates to metformin glycinate salt and pharmaceutical compositions thereof for the treatment of diabetes mellitus. The method includes administration of the metformin glycinate salt by various routes selected from oral, intravenous injectable, intramuscular injectable, nasal, intraperitoneal, or sublingual, in order to achieve a reduction in blood glucose levels. The invention further relates to the synthesis of a new 1,1-dimethylbiguanide glycinate salt, called Metformin Glycinate. The resulting salt exhibits advantages over other metformin salts. These advantages are due, in the first place, to the fact that the glycine counterion exhibits hypoglycemic effects by itself. Moreover, the salt exhibits more rapid absorption, reaching higher plasma concentrations than those produced with metformin hydrochloride.

A compound represented by the formula (I) wherein one of R1 and R2 is a hydrogen atom or a substituent and the other is an optionally substituted cyclic group; W is a bond or a divalent aliphatic hydrocarbon group; Y is a group of the formula: —OR3 (wherein R3 is a hydrogen atom, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group or an optionally substituted acyl group) or an optionally esterified or amidated carboxyl group, or a salt thereof or a prodrug thereof has a superior insulin secretion promoting action and a hypoglycemic action and shows low toxicity. Therefore, the compound is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of diabetes and diabetic complications, and the like.

The invention discloses a probiotic solid drink with a hypoglycaemic effect and a preparation method of the probiotic solid drink. The probiotic solid drink comprises components in percentage by weight as follows: 5%-15% of complex probiotics, 14%-28% of xylooligosaccharide, 50%-80% of L-arabinose and 4%-6% of dietary fiber. Complex probiotic powder contains lactobacillus rhamnosus, lactobacillus reuteri and bifidobacterium adolescentis. With the adoption of the probiotic solid drink, a large quantity of probiotics can be proliferated, the colonization rate and survival rate of exogenous probiotics on the intestinal mucosa are increased, a balanced system of intestinal flora is improved, immunity of a human body is improved, an organism is promoted to repair various functions, so that the auxiliary hypoglycaemic effect is realized. With the adoption of a dry blending technology, nutrient substances with different characteristics are subjected to optimizing and compounding combination, so that the problems of need for refrigeration, short guarantee period, single flora constitution, low viable counts and the like of a conventional liquid probiotic drink are solved, and the market prospect of products is broad.

The invention provides a cassia obtusifolia tea bag with functions of weight reduction, hypotension and hypoglycemic effect, which is characterized in that the production process comprises the following steps: washing, cleaning and drying the cassia obtusifolia stem, leaf and grain, crushing by a pulverizer to 280 meshes, uniformly stirring, packing, disinfecting to obtain the cassia obtusifolia tea bag with functions of lipid lowering, hypotension and hypoglycemic effect. The optimal composition and the weight part ratio of the tea bag are: 40-60 parts of dried cassia obtusifolia stem, leaf and grain, 10 parts of dried lotus leaf, 5 parts of haw, 5 parts of dried balsam pear, 5 parts of Chinese wolfberry, 10 parts of Pu'er tea, 10 parts of cassia seed, 5 parts of mulberry leaf, 5 parts of folium apocyni veneti, 5 parts of Chinese yam as medicine, 3 parts of rhubarb, 2 parts of chrysanthemum, 2 parts of honeysuckle flower, 1 part of boat-fruited sterculia, 5 parts of cassia seed, 5 parts of kudzu root and 10 parts of additive. The additive is composed of fatty acid sucrose ester, xylitol, mannitol crystal, natural menthol, citric acid, trisodium phosphate, sodium saccharin and steviosid; the above components are carried out the processes of crushing, mixing, uniformly stirring, packing and disinfecting to obtain the tea bag.

PCT No. PCT / KR97 / 00133 Sec. 371 Date May 4, 1999 Sec. 102(e) Date May 4, 1999 PCT Filed Jul. 2, 1997 PCT Pub. No. WO98 / 00389 PCT Pub. Date Jan. 8, 1998This invention relates to a novel 2-hydroxypropionic acid derivative and its manufacturing method. Based on its mechanism to inhibit the CPT I, 2-hydroxypropionic acid derivative of this invention has blood glucose lowering effects so that the derivative may be effectively used as an antidiabetic agent having remarkable antidiabetic activity and fewer side effects.

The invention relates to exenatide joined with polyethylene glycol. The structural general formula of exenatide is (I), mPEG represents residue of methoxy polyethylene glycol, the selected value of n is 0-3, R represents an exenatide molecule from which an amino is removed, the amino is of lysine residue or of N-end histidine residue in the exenatide molecule, and the molecular weight of the exenatide joined with polyethylene glycol is 9,800-110,000. The invention further relates to a preparation method of the compound and application of the compound in preparing medicines for curing type 2 diabetes mellitus. The exenatide joined with polyethylene glycol has the advantages of being long in half-life period and good in stability and hypoglycemic effect.

A water soluble extract of M.charantia named MC6, methods for its preparation and methods for its use in the treatment of hyperglycemic disorders are provided. The active MC6 is characterized by moving as a single band on SDS-PAGE having a molecular weight of less than 10 kDal, and by comprising three peptides. Also provided is a peptide component of MC6 named MC6.1, as well as analogues and mimetics thereof. The active MC6, MC 6.1, MC6.2, and MC6.3 exhibit hypoglycemic activity, even following oral administration. Also provided are methods of using the active agents to treat hyperglycemic disorders, particularly diabetes, where the active agents are preferably orally administered.

The invention relates to a health functional drinking liquid, in particular to a pure plant composite concentrated drinking liquid with a blood sugar reducing effect. The pure plant composite concentrated drinking liquid is mainly prepared from the following raw materials in part by weight: 25 to 40 parts of bitter gourd, 15 to 30 parts of kudzu root, 10 to 25 parts of folium mori, 5 to 20 parts of tartary buckwheat and 5 to 20 parts of corn silk. The formula is scientific and reasonable, an extraction process is advanced, pure plant essence is concentrated, the blood sugar reducing effect is obvious, and side effects are avoided. The invention also provides a method for preparing the pure plant composite concentrated drinking liquid.

The present invention relates to a mutant polypeptide of glucagon-like peptide-1 (GLP-1) and a modified compound thereof. In particular, a lysine is added in front of the end N of the glucagon-like peptide-1 to form the mutant polypeptide, and the glucagon-like peptide-1 includes natural GLP-1(7-36)amide or GLP-1(7-37) and a partial amino acid-subsituted derivative. Not only do the GLP-1 mutant polypeptide and the modified compound thereof show the effects of promoting insulin secretion and lowering blood sugar, but also, compared with the natural GLP-1, the stability and internal action time of the GLP-1 mutant polypeptide and the modified compound thereof are notably increased in respect to proteolytic enzyme, and the GLP-1 mutant polypeptide and the modified compound thereof can be used for the preparation of drugs treating diabetes or adiposity.

The invention provides a preparation method of arctium fruit extract for decreasing blood sugar, wherein the extract comprises Arctiin, Matairesinol, Lappaol A, Lappaol C, Lappaol Fú¼LappaolHú¼Arctignan Eú¼beta-sitosterol and daucosterol.

The invention discloses balsam pear fermented mung bean milk with a hypoglycemic effect. The fermented mung bean milk is prepared by the following raw materials, by weight, 3 to 5 parts of hypoglycemic fruit and vegetable puree, 6 to 7 parts of hypoglycemic Chinese medicinal solutions, 0.5 to 0.7 part of freeze-dried powder of balsam pear, 0.3 to 0.4 part of coptis powder, 4 to 5 parts of stevioside, 2 to 4 parts of mung beans, 1 to 2 parts of corns, 1 to 2 parts of soybeans, 1 to 2 parts of coix seeds, 2 to 4 parts of pitted red dates, 80 to 90 parts of fresh milk, and an appropriate amount of yoghourt zymophyte. The balsam pear fermented mung bean milk with a hypoglycemic effect of the invention has characteristics of special fragrance of baked bean dregs, and a hypoglycemic effect because of proper compatibility of the hypoglycemic Chinese medicinal solutions; and the fruit and vegetable puree enriches nutrition of the balsam pear fermented mung bean milk, and neutralizes bitter taste of the hypoglycemic Chinese medicinal solution.

The invention relates to a buckwheat beverage or tea bag and a production method of the buckwheat beverage or tea bag, wherein the buckwheat beverage or tea bag is prepared from buckwheat, Chinese wolfberry fruit, radix polygonati officinalis, kudzuvine root and rhizoma polygonati. The buckwheat is prepared into buckwheat particles according to the following methods that: the buckwheat is weight, water is added for soaking, stewing and baking are carried out, the buckwheat is stir-fired to golden yellow at high temperature, crushing is carried out, and the buckwheat particles are obtained. The medicine and food homologous materials with the hypoglycemic effect, such as Chinese wolfberry fruit, radix polygonati officinalis, kudzuvine root and rhizoma polygonati are added into the buckwheat beverage or tea bag, the problem of single ingredient of the existing buckwheat beverage is solved, and meanwhile, the effect of synergetic hypoglycemic effect by various active ingredients is reached.

The invention relates to the use of a Fibroblast Growth Factor 21 (FGF21 ) compound and a Glucagon-Like Peptide 1 (GLP-1 ) compound in combination for the preparation of a medicament for the treatment of diabetes, more in particular type 2 diabetes, as well as pharmaceutical compositions comprising certain FGF21 and GLP-1 compounds in combination, together with a pharmaceutically acceptable carrier. The combination has a significant effect on parameters of relevance for diabetes type 2, viz. on the viability of [beta] cells ex vivo in the presence of free fatty acids, on caspase activity of [beta] cells ex vivo (a measure of cell apoptosis), and a blood glucose lowering effect on db / db mice in vivo.

The invention discloses a total triterpenoid extract of inonotus obliquus with a hypoglycemic function, which is prepared through the following steps: (1) crushing and sieving inonotus obliquus, adding ethanol aqueous solution for immersion, carrying out ultrasonic extraction, separating the supernatant, and concentrating and drying the supernatant, thereby obtaining ethanol extract; (2) dispersing the ethanol extract into distilled water, oscillating and extracting with petroleum ether, and separating the extract from water-phase residues generated in extraction; and (3) oscillating and extracting the water-phase residues with n-butanol, separating the extract, mixing, concentrating and drying, thereby obtaining the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function, wherein the content of the triterpenoid is 70-300mg / g. the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function provided by the invention can obviously reduce the fasting blood glucose level of mouse with hyperglycemia, can significantly ease the diabetes symptoms of the mouse with hyperglycemia, and has no significant toxicity to major organs.

The invention discloses a bitter-gourd nutritious food with an auxiliary hypoglycemic effect, which is prepared from the following raw materials in parts by weight: 20-30% of soybean flour, 10-25% of expanded powder, 10-25% of maltodextrin, 5-15% of whole milk powder, 1-15% of ultrafine bitter-gourd powder, 1-10% of activated oat fiber and 1-3% of inulin. The invention further discloses a preparation method of the bitter-gourd nutritious food. The bitter-gourd nutritious food contains a variety of blood sugar regulating factors such as bitter-gourd polysaccharides, saponins and activated oat fiber, has delicate taste, is convenient to eat and easy to accept by the consumers and can be used as the dietary supplement or diet substitute to assist to reducing the blood sugar of the patients with diabetes.

The invention provides a composition for preventing and treating diabetes, which comprises the following ingredients by weight: 1-100 parts of cinnamon, 1-100 parts of mulberry leaf and 1-100 parts of bitter gourd. The composition has good hypoglycemic effect, and is especially suitable for preventing and treating of spleen and kidney insufficiency type diabetes.

The invention discloses a mixture of momordica saponins and polysaccharides, which is obtained by the following preparation methods: the balsam pear is used as a raw material and is added with an organic solvent to undergo ultrasound-microwave assisted extraction; a momordica saponins extract is obtained after filtration; momordica filter residues are extracted in alkaline solution; the obtained extract is namely the momordica polysaccharides extract; the momordica saponins extract and the momordica polysaccharides extract are respectively concentrated, dried and mixed to obtain a mixture of momordica polysaccharides and saponins; the invention also discloses an extraction process and application of the mixture of the momordica saponins and polysaccharides; the mixture has various physiological functions such as blood sugar level reduction, cancer resistance, virus resistance, blood lipids regulation, immunity increasing and the like; the mixture can be used for preparing health food with the function of reducing blood sugar level; the extraction process adopts step-by-step extraction technology and has the characteristics of high raw materials utilization rate, mild extraction conditions, high speed, high efficiency and the like; compared with the single extraction technology, for the extraction process of the invention, the extraction time is shortened by more than 20% and the purity of the product is improved by more than 15%.

The invention provides a method for preparing total triterpenoids with a hypoglycemic effect from leaves of Cyclocarya paliurus. The leaves of the Cyclocarya paliurus are taken as a raw material and subjected to extraction with an ethanol-water mixed solvent and liquid-liquid extraction with an organic solvent, polyamide column chromatography based organic solvent elution and macroporous resin column chromatography based ethanol-water elution are performed for separation and purification, and high-purity total triterpenoids can be obtained. Research proves that main components such as arjunolic acid, asiatic acid, cyclocaric acid B and a compound 4 in the total triterpenoids can effectively increase glucose uptake of 3T3-L1 adipose cells and have antidiabetic activity, and the total triterpenoids and the main components of the total triterpenoids can be used for preparing products such as hypoglycemic and antidiabetic drugs, health food and functional food. The method for preparing thetotal triterpenoids from the leaves of Cyclocarya paliurus and an application of the total triterpenoids and the compound 4 to preparation of the antidiabetic drugs are developed, reference is provided for popularization, utilization and deep processing of traditional Chinese medicinal materials, and a new application direction is provided.

The invention provides a cultivation method of lucid ganoderma for reducing blood sugar. In the method, a Chinese medicinal herbal composition for reducing the blood sugar in a certain rate is added into a culture base stock, so that nutrient components in the culture base stock are fully absorbed by the lucid ganoderma in the growth and development process; therefore, the cultivated lucid ganoderma has the effect of efficiently reducing the blood sugar, medicines for reducing the blood sugar can be completely replaced, various complications brought to a patient by the medicines for reducing the blood sugar are greatly reduced, and the quality of life of the patient is improved.

The invention discloses a method for processing sealwort bean curd. The sealwort bean curd is prepared from the following raw materials in parts by weight: 50-60 parts of soybeans, 4-6 parts of sealwort, 3-5 parts of jujubes, 3-5 parts of mango, 5-10 parts of green beans, 1-2 parts of pseudo-ginseng, 1-1.5 parts of cushaw flowers, 0.8-1.2 parts of chestnut leaves, 0.7-1.1 parts of coptis chinensis, 0.8-1.2 parts of mulberry leaves, 0.5-0.8 part of hawthorn seeds, 0.6-0.9 part of pomegranate leaves, 0.6-1.2 parts of herba epimedii and 0.6-0.8 part of pseudostellaria heterophylla. According to the method provided by the invention, the process steps are simple; the sealwort bean curd is prepared by smashing a health-maintenance liliaceous plant, namely the sealwort, the jujubes and the like, and mixing the smashed materials with bean curd; Chinese herbal medicines such as the pseudo-ginseng and the coptis chinensis with an effect of reducing blood sugar are added, so that the function of a human body is improved and the sealwort bean curd has a healthcare value.

The invention relates to a production technology of purslane polysaccharide. The production technology comprises the following steps that: impurities in purslane are removed; purslane is washed, cut into segments, and dried; processed purslane is immersed in water for 30 minutes, and is extracted 3 times through microwave auxiliary extraction; in a vacuum heating condition, pressure reduction concentration is carried out on the purslane extract, such that a condensed purslane extract is obtained; a small amount of ethanol is added to the condensed purslane extract, and the mixture is stirred and well-mixed; the mixture is then stood for 24 hours, and a precipitate is obtained; the precipitate is diluted with a proper amount of water; chloroform and n-butanol are added to the diluted precipitate, and the mixture is mixed and oscillated for 30 minutes. Obtained protein-removed crude purslane polysaccharide is diluted with a small amount of water, and the diluted crude purslane polysaccharide is eluted in macroporous adsorption resin; active carbon is added to a polyamide eluate for adsorbing, and active carbon is removed; hydrogen peroxide is added to the obtained material, the mixture is well-mixed, decolored, and heated; residual hydrogen peroxide is then removed; the obtained material is vacuum-dried, such that purslane polysaccharide with a relatively high purity is obtained. The produced purslane polysaccharide has functions of immunity improving, tumor resisting, oxidation resisting, and aging resisting. The purslane polysaccharide has a hypoglycemic effect, and can be used for changing diabetes symptoms. Purslane polysaccharide has a good anti-tumor function, and can be applied in the development of anti-tumor medicines.

The invention discloses a ginseng drink and its production technology. Every 1000ml of the ginseng drink contains: 10g of ginseng, 10g of honeysuckle, 10g of mulberries, 10g of Chinese wolfberries, 0.1g of sucralose, 1g of potassium sorbate, and the balance drinking water. The ginseng drink is prepared by the technological steps of: material selection, material washing, slicing, drying, ginseng extract extraction and concentration, extraction and concentration of honeysuckle, mulberry and Chinese wolfberry extract, and ginseng drink preparation. Taking the ginseng drink provided in the invention can strengthen human constitution and improve disease resistance. The ginseng drink of the invention has the effects of clearing away heat and toxic materials, enriching blood and nourishing yin, promoting the secretion of saliva or body fluid and moistening dryness, and can also enhance nonspecifc immunity, delay ageing, resist liver injury, lower blood sugar, reduce blood pressure, tonify the kidney, protect the liver, resist fatigue and tumors.

The invention relates to a processing method for preserved fruits, discloses a processing method for health-caring preserved pumpkin, and belongs to the technical field of food processing. The processing method is characterized by adopting the process method comprising the steps of cleaning raw materials, slicing the raw materials, soaking the raw materials, boiling the raw materials, sugaring the raw materials, drying the raw materials twice, softening the raw materials and packaging the raw materials. According to the processing method, the raw materials are dried twice, so that loss of nutrient substances is reduced, the processed health-caring preserved pumpkin is bright in color and crisp and tender in taste, and has the good hypoglycemic effect, the process is simple, and implementation is convenient. By carrying out deep processing on the pumpkin raw materials, local economy development can be promoted, a leading industry can be formed, the yield of agriculture can be increased, and the income of farmers can be increased.

Based on the main treating principle of tonifying qi and yin, nourishing spleen and tonifying kidney and promoting blood circulation and removing blood stasis, the invention provides a medicinal composition for treating symptom-complex of excessive eating (diabetes) and a method for preparing the same, and belongs to the technical field of Chinese medicinal preparations. In the method, astragalus, ginseng, manyflower solomonseal rhizome, Chinese magnoliavine fruit, fresh rehmannia, dwarf lilyturf tuber, medlar, golden thread, kudzuvine root, Chinese angelica, Mongolian snakegourd root and root of red-rooted salvia serving as raw materials undergo processes of grinding, solvent extraction, alcohol precipitation, condensation, drying, granulation and the like to form the finished product. The pharmacodynamic tests prove that by pharmacotherapeutic administration, the medicinal composition of the invention has obvious effect of reducing blood sugar of rats with tetraoxypyridine-induced hyperglycemia, mice with tetraoxypyridine-induced hyperglycemia and mice with adrenalin-induced hyperglycemia.

The invention relates to a pharmaceutical composition having a blood sugar reducing effect. The pharmaceutical composition is prepared from the following raw materials: astragalus membranaceus, gorgon fruit, fructus rosae laevigatae, seed of Chinese dodder, burdock root, rhizoma anemarrhenae, yam, lalang grass rhizome, angelica, chrysanthemum, purslane, root of red-rooted salvia, radix ophiopogonis, ginseng, rhizoma atractylodis, folium mori, dendrobe, polished round-grained rice, medlar, root of Chinese trichosanthes, root of common peony, baked ginger, dogwood, raspberry, radix polygonati officinalis, myrrh, root of kudzu vine, ligusticum wallichii, prepared rehmannia root and fruit of Chinese magnoliavine. The pharmaceutical composition has high effective rate on diabetes and avoids relapse after curing; the pharmaceutical composition is simple in process, can low production cost and relieve economic burden of patients, and has a broad application prospect.

The invention provides a control system and method for a hypoglycemic rice cooker. By controlling the hypoglycemic cooking commands such as soaking temperature, soaking time, and cooking time, it can firstly control the hypoglycemic filter to turn the The ingredients are soaked to remove part of the sugar in the ingredients, and then the rise of the controllable sugar-reducing filter is used to separate the ingredients from the water surface, and the sugar in the ingredients is further removed by steam heating. Sugar can not only enhance the taste of ingredients, but also greatly reduce the sugar content in ingredients. Moreover, the soaking temperature, soaking time and cooking time in the control method can be modified at any time during the cooking process according to different food materials, and the compatibility is strong.