1054 results about "Hypoglycemic Effects" patented technology

An agent for treating diabetes with sulfonylurea secondary failure which comprises a dipeptidyl peptidase IV inhibitor. The agent of the present invention is an agent for treating diabetes with sulfonylurea secondary failure showing excellent insulin-secreting and hypoglycemic effects on even diabetic patients on whom a sulfonylurea compound or a fast-acting insulin secretagogue has no insulin-secreting effect and therefore no sufficient hypoglycemic effect.

The invention relates to exenatide joined with polyethylene glycol. The structural general formula of exenatide is (I), mPEG represents residue of methoxy polyethylene glycol, the selected value of n is 0-3, R represents an exenatide molecule from which an amino is removed, the amino is of lysine residue or of N-end histidine residue in the exenatide molecule, and the molecular weight of the exenatide joined with polyethylene glycol is 9,800-110,000. The invention further relates to a preparation method of the compound and application of the compound in preparing medicines for curing type 2 diabetes mellitus. The exenatide joined with polyethylene glycol has the advantages of being long in half-life period and good in stability and hypoglycemic effect.

The invention provides a preparation method of arctium fruit extract for decreasing blood sugar, wherein the extract comprises Arctiin, Matairesinol, Lappaol A, Lappaol C, Lappaol Fú¼LappaolHú¼Arctignan Eú¼beta-sitosterol and daucosterol.

The invention discloses a total triterpenoid extract of inonotus obliquus with a hypoglycemic function, which is prepared through the following steps: (1) crushing and sieving inonotus obliquus, adding ethanol aqueous solution for immersion, carrying out ultrasonic extraction, separating the supernatant, and concentrating and drying the supernatant, thereby obtaining ethanol extract; (2) dispersing the ethanol extract into distilled water, oscillating and extracting with petroleum ether, and separating the extract from water-phase residues generated in extraction; and (3) oscillating and extracting the water-phase residues with n-butanol, separating the extract, mixing, concentrating and drying, thereby obtaining the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function, wherein the content of the triterpenoid is 70-300mg / g. the total triterpenoid extract of the inonotus obliquus with the hypoglycemic function provided by the invention can obviously reduce the fasting blood glucose level of mouse with hyperglycemia, can significantly ease the diabetes symptoms of the mouse with hyperglycemia, and has no significant toxicity to major organs.

The invention relates to a production technology of purslane polysaccharide. The production technology comprises the following steps that: impurities in purslane are removed; purslane is washed, cut into segments, and dried; processed purslane is immersed in water for 30 minutes, and is extracted 3 times through microwave auxiliary extraction; in a vacuum heating condition, pressure reduction concentration is carried out on the purslane extract, such that a condensed purslane extract is obtained; a small amount of ethanol is added to the condensed purslane extract, and the mixture is stirred and well-mixed; the mixture is then stood for 24 hours, and a precipitate is obtained; the precipitate is diluted with a proper amount of water; chloroform and n-butanol are added to the diluted precipitate, and the mixture is mixed and oscillated for 30 minutes. Obtained protein-removed crude purslane polysaccharide is diluted with a small amount of water, and the diluted crude purslane polysaccharide is eluted in macroporous adsorption resin; active carbon is added to a polyamide eluate for adsorbing, and active carbon is removed; hydrogen peroxide is added to the obtained material, the mixture is well-mixed, decolored, and heated; residual hydrogen peroxide is then removed; the obtained material is vacuum-dried, such that purslane polysaccharide with a relatively high purity is obtained. The produced purslane polysaccharide has functions of immunity improving, tumor resisting, oxidation resisting, and aging resisting. The purslane polysaccharide has a hypoglycemic effect, and can be used for changing diabetes symptoms. Purslane polysaccharide has a good anti-tumor function, and can be applied in the development of anti-tumor medicines.