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95 results about "Sulfonylurea compounds" patented technology
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Sulfonylureas (UK: sulphonylurea) are a class of organic compounds used in medicine and agriculture. They are antidiabetic drugs widely used in the management of diabetes mellitus type 2. They act by increasing insulin release from the beta cells in the pancreas.
Remedy for Diabetes
ActiveUS20080319077A1Good secretion effectGood hypoglycemic effectBiocideMetabolism disorderAgonistDiabetic patient
The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.
Owner:TAKEDA PHARMA CO LTD
Novel non-selective cation channel in neuronal cells and methods for treating brain swelling
The present invention is directed to therapeutic compounds, treatment methods, and kits affecting the NCCa-ATP channel of neural tissue, including neurons, glia and blood vessels within the nervous system, and methods of using same. The NCCa-ATP channel is newly expressed in neural tissue following injury such as ischemia, and is regulated by the sulfonylurea receptor SUR1, being inhibited by sulfonylurea compounds, e.g., glibenclamide and tolbutamide, and opened by diazoxide. Antagonists of the NCCa-ATP channel, including SUR1 antagonists, are useful in the prevention, diminution, and treatment of injured or diseased neural tissue, including astrocytes, neurons and capillary endothelial cells, that is due to ischemia, tissue trauma, brain swelling and increased tissue pressure, or other forms of brain or spinal cord disease or injury. Agonists of the NCCa-ATP channel may be are useful in the treatment neural tissue where damage or destruction of the tissue, such as a gliotic capsule, is desired.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
Agent for treating diabetes
InactiveUS20070072810A1Excellent insulin-secretingGood hypoglycemic effectBiocidePeptide/protein ingredientsDipeptidyl peptidaseDipeptidyl-Peptidase IV Inhibitors
An agent for treating diabetes with sulfonylurea secondary failure which comprises a dipeptidyl peptidase IV inhibitor. The agent of the present invention is an agent for treating diabetes with sulfonylurea secondary failure showing excellent insulin-secreting and hypoglycemic effects on even diabetic patients on whom a sulfonylurea compound or a fast-acting insulin secretagogue has no insulin-secreting effect and therefore no sufficient hypoglycemic effect.
Owner:TAKEDA PHARMA CO LTD
Compounded herbicide composition for rice field
The invention relates to a compounded herbicide composition for rice fields, which contains the following two effective components: component (A): pyribenzoxim; component (B): a herbicide which is one of the following compounds: triazines compounds, heterocyclic compounds, phenoxy compounds, amide compounds, diphoenyl ether compounds, sulfonylurea compounds, phenoxyalkanoic acid compounds, botanical compounds, organic phosphorus compounds, urea compounds, dinitroaniline compounds, benzamide compounds and carbamate compounds; and wherein, the weight ratio of the component (A) to the component (B) is 1-50: 1-50.
Owner:FMC CHINA INVESTMENT
Methods for treating neural cell swelling
A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.
Owner:U S GOVERNMENT REPRESENTED BY THE DEPT OF VETERANS AFFAIRS
Sulfonylurea derivative and pharmaceutical composition and application thereof
The invention relates to a preparation method and application of a sulfonylurea compound and a composition containing the same component as FXR and / or TGR5 agonist, the FXR and / or TGR5 agonist is a compound shown as a formula (I), or a pharmaceutically acceptable salt, a solvate, a prodrug, an isomer and a stable isotope derivative thereof. The compounds can be used for treatment of FXR and / or TGR5 mediated diseases including primary biliary cirrhosis, nonalcoholic fatty liver, portal hypertension, bile acid diarrhea and cholestasis, type II diabetes and obesity and other field.
Owner:SHANGHAI DE NOVO PHARMA
Combination Therapy
The present invention features a novel therapy for treating diabetes, hypertension, migraine, epilepsy, sleep apnea, depression, impulse control disorders or alcohol addiction which involves treating a subject with a sympathomimetic agent (e.g., phentermine or a phentermine-like drug) in combination with an anticonvulsant sulfamate compound (e.g., topiramate) or an anticonvulsive sulfonylurea compound (e.g. zonisamide).
Owner:VIVUS
Fused heterocyclic sulfonylurea compound herbicide containing the same and method of controlling weed with the same
InactiveUS20050032650A1Broad weeding spectrumHigh weeding effectBiocideOrganic chemistryAlkoxy groupBULK ACTIVE INGREDIENT
The present invention provides a compound represented by the formula: wherein Q represents a fused heterocyclic group, X and Y are the same or different and each represent an optionally halogenated lower alkyl group, an optionally halogenated lower alkoxy group, etc., or a salt thereof, as well as a herbicide comprising the compound or a salt thereof, which exhibits a significant effect for control of sulfonylurea herbicide-resistant weeds in paddy fields and can reduce the number of active ingredients in a combined preparation and a method of controlling sulfonylurea herbicide-resistant weeds which comprises using the same.
Owner:SUMITOMO CHEM CO LTD
Herbicidal composition having the herbicidal effect enhanced, and method for enhancing the herbicidal effect
ActiveUS20060154824A1Improve weed control effectExcellent herbicidal effectBiocideDead animal preservationOrganic chemistrySulfonylurea compounds
A herbicidal composition comprising a herbicidal sulfonylurea compound or its salt, and an alkoxylated glyceride. A method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount of the herbicidal composition to the undesired plants or to a place where they grow. A method for enhancing the herbicidal effect of a herbicidal sulfonylurea compound or its salt by means of an alkoxylated glyceride.
Owner:ISHIHARA SANGYO KAISHA LTD
Herbicidal composition
Owner:ISHIHARA SANGYO KAISHA LTD
Methods of Altering Poppy Characteristics
ActiveUS20080269058A1Reduce the overall heightWeight increaseBiocideAnimal repellantsSulfonylurea compoundsAgronomy
The present invention relates to the use of sulfonylurea compounds to alter physical and / or growth characteristics of poppy plants.
Owner:SUN PHARMA IND AUSTRALIA LTD
Herbicide composition and application thereof
ActiveCN101961023AGood synergyImprove weed control effectBiocideAnimal repellantsWater dispersibleSulfonylurea compounds
The invention provides a herbicide composition. The herbicide composition comprises a fluroxypyr derivative, mesotrione and a sulfonylurea compound, wherein the weight part ratio of the fluroxypyr derivative to the mesotrione to the sulfonylurea compound is 0.1-5:0.1-10:0.1-10. The composition can be prepared into emulsifiable concentrate, liquor, aqua, dense emulsion, microemulsion, wettable powder, water suspension, oil suspension, water dispersible granules or soluble powder (granules). The herbicide composition of the invention can be used for preventing and controlling annual and perennial grasses and broadleaves.
Owner:北京颖泰嘉和分析技术有限公司
2,4-dioxo-3-quinazolinylaryl sulfonylureas
2,4-Dioxo-3-quinazolinylaryl sulfonylurea compounds are provided that are useful for the inhibition of ADP-platelet aggregation, particularly in the treatment of thrombosis and thrombosis related conditions or disorders.
Owner:ALEXION PHARMA INC
Herbicidal Composition
InactiveUS20070232492A1Growth inhibitionBiocideDead animal preservationHydrogen atomBensulfuron methyl
To provide a herbicidal composition having a wide herbicidal spectrum, being highly active and having a long lasting effect. A herbicidal composition comprising (α) a compound of the formula (I) or its salt: wherein R is a hydrogen atom or —COCH2OCH3 and (β): at least one compound selected from the group consisting of the following compounds, as active ingredients: at least one sulfonylurea compound selected from (B1.1) bensulfuron-methyl, (B1.2) azimsulfuron, etc.; (B2.1) pyriminobac-methyl; an acetamide compound such as (B3.1) pretilachlor, etc.; at least one benzoyl compound selected from (B4.1) benzobicyclon, (B4.2) mesotrione, etc.; (B5.1) simetryn; and so on.
Owner:ISHIHARA SANGYO KAISHA LTD
Novel non-selective cation channel in neuronal cells and method for treating brain swelling
Owner:UNIV OF MARYLAND
Sulfonyl urea compounds and herbicidal activity thereof
The invention relates to a sulfonylurea compound synthesizing method and grass-clearing active. The general formula of the compound is (I), in which R1 is 1-6 alkyl, 1-6 alkoxy, 1-6 carbonyl, halogen or nitro group; R2 is 1-6 alkyl, 1-6 alkoxy, 1-4 alkyl sulfide, 1-4 alkylamino radical, halogen or nitro group; R3 is 1-6 alkyl, 1-6 alkoxy, 1-6 alkyl substitution, 1-6 acylaminosulfonamides, 1-6 alkylamine, aryl, aryl substituent, halogen or nitro group. The invention possesses elite grass-clearing active and selective to crop, and it especially can be used as weed killer to eliminate broadleaf weed in corn field.
Owner:NANKAI UNIV
Rice field weeding composite and preparation thereof
ActiveCN103283760ADelay drug resistanceImprove efficiencyBiocideAnimal repellantsBULK ACTIVE INGREDIENTActive ingredient
The invention relates to the field of pesticide preparations, and discloses a rice field weeding composite and a preparation thereof. The weeding composite is prepared from sulphonamide compound pyrimisulfan and a sulfonylurea compound with a ratio weight of 1:10-20:1. According to the rice field weeding composite and the preparation thereof, the sulphonamide compound pyrimisulfan and the sulfonylurea compound are compounded to serve as an active ingredient; the sulphonamide compound pyrimisulfan and the sulfonylurea compound, which complement each other in advantages and synergistically act, can be used for slowing the generation of herbicide resistance of weeds and meanwhile has a synergistic effect on rice field weeding; the use amount and the number of use times of the herbicide are reduced greatly, so that the composite and the preparation thereof have the advantages of safety, high efficiency, environment friendliness and the like and can be widely used for preventing and controlling rice field weeds.
Owner:LIANBAO CROP TECH
Chemical weedicide induced promoter and application thereof
InactiveCN1385527AFermentationVector-based foreign material introductionBiotechnologyNucleic acid sequencing
The present invention belongs to the field of genje engineering technology. It particular, it relates to a promoter segment capable of separating and utilizing nucleic acid. Said promoter is originated from some genes which are sensitive to sulfonylurea compounds (such as chlor-sulfuron and ethametsulfuron) and related compounds in the plants of rice, etc. The nucleic acid sequence of the coded desired target product gene and one above-mentioned promotor segment are fused to obtain recombinant DNA, then this recombinant DNA is used to transform plant, and a new transgenic plant can be obtained. The expression of target gene being in said recombinant DNA in the new plant is controlled by proper chemical inducer.
Owner:FUDAN UNIV
Herbicide and uses thereof
InactiveCN101548685AGood effectExcellent weed killing effectBiocideAnimal repellantsFilling materialsGlyphosate
The invention discloses a herbicide, which is composed of glyphosate or glyphosate salt and sulfonylurea compounds; the weight ratio of glyphosate or glyphosate salt: sulfonylurea compounds = 10-100:1. the invention further discloses a powder form herbicide prepared from the above herbicide, which comprises the following components with contents of: 25-85% of herbicide and 3-12% of ammonium sulfate, 7-18% of auxiliary agent, 0-42% of filling material and 2-60% of sodium sulphate. The herbicide is used for controlling water area weed.
Owner:ZHEJIANG UNIV
Herbicidal composition having the herbicidal effect enhanced, and method for enhancing the herbicidal effect
ActiveUS8575067B2Improve weed control effectGood effectBiocideDead animal preservationChemical compositionSulfonylurea compounds
A herbicidal composition comprising a herbicidal sulfonylurea compound or its salt, and an alkoxylated glyceride. A method for controlling undesired plants or inhibiting their growth, which comprises applying a herbicidally effective amount of the herbicidal composition to the undesired plants or to a place where they grow. A method for enhancing the herbicidal effect of a herbicidal sulfonylurea compound or its salt by means of an alkoxylated glyceride.
Owner:ISHIHARA SANGYO KAISHA LTD
Weed killing composition containing pyraflufen ethyl and sulfonylurea compounds
InactiveCN102428943ADelay drug resistanceReduce developmentBiocideAnimal repellantsWater dispersibleMicroemulsion
The invention relates to a weed killing composition containing pyraflufen ethyl and sulfonylurea compounds. The composition is mainly characterized in that the pesticide composition contains 1-60% of effective ingredient A, 1-80% of effective ingredient B and the balance of auxiliaries. The effective ingredient A is pyraflufen ethyl, and the effective ingredient B is selected from tribenuron-methyl or thifensulfuron methyl. The composition can be prepared into wettable powder, water dispersible granules, microemulsions, emulsions in water, oil suspensions and suspending emulsions. The pesticide composition provided by the invention can be used for controlling weeds in wheat fields and corn fields.
Owner:SHAANXI MEIBANG PHARMA GRP CO LTD
New compound in sulfonyl ureas, and medicine use
This invention relates to a novel sulfonylurea compound or its pharmaceutical salt, their preparation method and pharmaceutical application. The novel sulfonylurea compound or its pharmaceutical salt can be used in drugs for preventing and treating diabetes or other diseases. The compound can be manufactured into oral liquids, injections and external use preparations.
Owner:唐仲雄 +2
Herbicide composition and application thereof
ActiveCN101961023BGood synergyImprove weed control effectBiocideAnimal repellantsWater dispersibleFluroxypyr
The invention provides a herbicide composition. The herbicide composition comprises a fluroxypyr derivative, mesotrione and a sulfonylurea compound, wherein the weight part ratio of the fluroxypyr derivative to the mesotrione to the sulfonylurea compound is 0.1-5:0.1-10:0.1-10. The composition can be prepared into emulsifiable concentrate, liquor, aqua, dense emulsion, microemulsion, wettable powder, water suspension, oil suspension, water dispersible granules or soluble powder (granules). The herbicide composition of the invention can be used for preventing and controlling annual and perennial grasses and broadleaves.
Owner:北京颖泰嘉和分析技术有限公司
Preparation method of sulfonylurea and sulfonamide formate compounds
ActiveCN104649945AImprove universalityImprove reaction efficiencySulfonic acid amide preparationGroup 3/13 element organic compoundsArylHalogen
The invention relates to a preparation method of a compound represented by a formula (I). The compound is prepared by reacting a compound represented by a formula (II) with a compound represented by a formula (III) in a solvent under the catalysis of a palladium catalyst in carbon monoxide atmosphere, wherein X is O or N; N is 0 or 1; when X is O, n is equal to 0; when X is N, n is equal to 1; R1 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R2 is selected from aryl, heteroaryl, alkyl, alkenyl or alkynyl; R3 is selected from H, R2 forms a ring, or R2 and R2 are linked to form a ring; R4 is N3 or a halogen atom; when R4 is the halogen atom, a system further contains sodium azide. The preparation method has the beneficial effects that the reaction does not require strict anhydrous and anaerobic conditions and high-pressure carbon monoxide atmosphere, the operation is convenient and simple, and the reaction has very good tolerance and universality to functional groups; meanwhile, the use level of a catalyst is extremely low, the reaction cost is very low, and the method can be widely applied to the preparation of sulfonylurea compounds.
Owner:CHINA AGRI UNIV
Aqueous suspension herbicidal composition
The object is to prepare an aqueous suspension-type herbicide composition which can avoid the decomposition of a herbicidal sulfonylurea compound in water and can also retain a stable suspension state, without the need of using any complicated step. An aqueous suspension-type herbicide composition comprising: (1) at least one herbicidal sulfonylurea compound selected from the group consisting of 1-[3-[(4,6-dimethoxypyrimidin- 2-ylcarbamoyl)sulfamoyl]-2-pyridyl]-2-fluoropropyl methoxyacetate, N-[(4,6-dimethoxypyrimidin-2- yl)aminocarbonyl]-2-(2-fluoro-1-hydroxypropyl)-3- pyridinesulfonamide and salts thereof; (2) an inorganic salt; (3) at least one sulfonate salt selected from the group consisting of an arylsulfonate, an alkylarylsulfonate and formalin condensates thereof; and (4) water.
Owner:ISHIHARA SANGYO KAISHA LTD
6- methylcoumarin-7-sulfonylurea compound and synthetic method thereof
InactiveCN101643463AThe synthesis method is simpleOrganic chemistryMetabolism disorderStructural formulaSulfonylurea compounds
The invention discloses a 6-methylcoumarin-7-sulfonylurea compound with the following structural formula and a synthetic method of the compound. Proofed by an initial pharmacological test, the hypoglycemic activity of the 6-methylcoumarin-7-sulfonylurea compound is similar to 6-bit substitution, and the 6-methylcoumarin-7-sulfonylurea compound can be used as a substitution product of a coumarin-6-sulfonylurea compound. The synthetic method of the 6-methylcoumarin-7-sulfonylurea compound is easy and has an industrialization prospect.
Owner:祁刚
Construction and application of endoplasmic reticulum targeted nano drug delivery system
ActiveCN112472822APromote accumulationGood treatment effectMaterial nanotechnologyAntipyreticLysosomeReticulum cell
The invention provides construction and application of an endoplasmic reticulum targeted nano drug delivery system. By modifying sulfamide or sulfonylurea compounds with endoplasmic reticulum tendencyinto endoplasmic reticulum targeting nano-compounds constructed in a nano-carrier, the constructed novel endoplasmic reticulum targeting liposome can load water-soluble and fat-soluble drugs and quickly transfer the drugs to the endoplasmic reticulum part, so that accumulation of the drugs at the action part of the liposome is improved, and the bioavailability of the drugs is improved. The medicine treatment effect is enhanced, and the toxic and side effect is weakened; the delivery of nucleic acid drugs needing lysosome escape can be remarkably improved, and a new strategy is provided for exerting the curative effect of the drugs. The nano-carrier disclosed by the invention is not only limited to lipidosome, but also can be solid lipid nanoparticles, nano-emulsion, polymer micelles and the like. The endoplasmic reticulum targeted modification nano-carrier provided by the invention is novel in scheme and simple in preparation method, and has good industrial production and applicationprospects.
Owner:ZHEJIANG UNIV
Substituted-(quinazolinyl)phenyl thiophenyl-sulfonylureas, methods for making and intermediates thereof
The present invention provides sulfonylurea compounds of formula (VIII) and pharmaceutically acceptable derivatives thereof and a process for making thereof. The compounds in their various forms are effective platelet ADP receptor inhibitors and may be used in various pharmaceutical compositions, and are particularly effective for the prevention and / or treatment of cardiovascular diseases, particularly those diseases related to thrombosis. The invention also provides intermediate compounds useful in the process, as well as final products produced by the process, and salts or prodrugs thereof. The invention also provides a method for inhibition platelet ADP receptor and preventing or treating thrombosis and thrombosis related conditions in a mammal comprising the step of administering a therapeutically effective amount of a compound of formula (VIII) or a pharmaceutically acceptable salt or forms thereof.
Owner:ALEXION PHARMA INC
Pyrazole Sulfonylurea Compound and Herbicide
There is provided a novel herbicide. A pyrazole sulfonylurea compound of formula (1): wherein R1 is C1-3alkyl, etc., R2 is hydrogen atom, C1-3alkyl, C1-3haloalkyl, etc., R3, R4, R5 and R6 independently of one another are hydrogen atom, C1-3alkyl, etc., with a proviso that at least one of R3, R4, R5 and R6 is C1-3alkyl or C1-3haloalkyl, X and Y independently of each other are C1-3alkyl, etc., Z is nitrogen atom or methyne, and a salt thereof that is acceptable as an agrochemical; an agrochemical containing at least one of the compound and the salt thereof that is acceptable as an agrochemical as an active component, and a herbicide containing at least one of the compound and the salt thereof that is acceptable as an agrochemical as an active component.
Owner:NISSAN CHEM IND LTD
Herbicidal composition
Herbicidal composition comprises a sulfonylurea herbicide (I) and a safener (II), where (I) is metsulfuron, thifensulfuron, tribenuron, chlorsulfuron or a salt or ester thereof and (II) is mefenpyr, isoxadifen, cloquintocet, fenchlorazol or its salt or ester. - An INDEPENDENT CLAIM is also included for controlling harmful plants in crops by applying the components of a composition as above together or separately to the harmful plants, the crop plants, plant seeds or growing surface. - ACTIVITY - Herbicide. - MECHANISM OF ACTION - None given.
Owner:BAJER KROPSAJENS LTD
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