2401 results about "Inducer" patented technology

A gas turbine engine cooling system includes a heat exchanger in fluid communication with a source of cooling air, a first cooling circuit including a first heat exchanger circuit in the heat exchanger and a first bypass circuit with a first bypass valve for selectively bypassing at least a portion of first airflow around the first heat exchanger circuit. A second cooling circuit may be used having a second heat exchanger circuit in the heat exchanger and a shutoff control valve operably disposed in the second cooling circuit upstream of the second heat exchanger circuit and the heat exchanger. A circuit inlet of the first cooling circuit may be used to bleed a portion of compressor discharge bleed air for the first airflow to cool turbine blades mounted on a rotor disk using an annular flow inducer downstream of the first bypass valve and the heat exchanger.

The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

The present invention is directed to substituted 3-aryl-5-aryl-[1,2,4]-oxadiazoles and analogs thereof, represented by the Formula I: wherein Ar1, Ar3, A, B and D are defined herein. The present invention also relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

The present invention relates to a new method for the detection, identification and / or quantification of multiple gene-specific siRNA or stRNA, respectively, the inducers of RNAi. In particular the present invention relates to a method for detecting the presence or change in concentration of siRNA in a cell, which change may be induced by environmental conditions.

A centrifugal pump has a pump base with inlet inducer openings that receive molten metal into an impeller chamber. An impeller structure in the impeller chamber passes the metal in a radial direction through an outlet inducer opening into a volute passage for discharge into the pool of metal in which the pump is located.

The invention relates to peptide conjugates including at least one turn inducer wherein the turn inducer comprises a 5-7 membered saturated or unsaturated nitrogen containing heterocyclic ring and methods of making the peptides. Libraries of these peptides, methods of making the libraries are also described and methods of screening the libraries for therapeutic activity are also described.

A method for retrofitting DNA in a single-copy or high-copy vector, such as a fosmid or BAC, whereby an artificial transposon is used to introduce a conditional multi-copy origin of replication (“ori”) into the DNA in said vector. Following random in vitro or in vivo transposition of the ori-containing transposon into DNA in the single-copy or low-copy vector, the resulting insertion clones are introduced into a special host strain that contains a gene which encodes a polypeptide required for replication from the multi-copy ori. However, since the gene for this polypeptide is expressed from a tightly-regulated inducible promoter, the polypeptide is not expressed in the absence of inducer. On addition of inducer to the culture medium, the host cell synthesizes the polypeptide, which in turn activates replication from the multi-copy ori, thereby increasing the amount of clone DNA synthesized by the cell.

The present invention relates to a new method for the detection, identification and / or quantification of multiple gene-specific mRNA or stRNA, respectively, the inducers of RNAi. In particular the present invention relates to a method for detecting the presence or change in concentration of mRNA in a cell, which change may be induced by environmental conditions.

The invention relates to bivalent mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

Expression systems are disclosed for the direct expression of peptide products into the culture media where genetically engineered host cells are grown. High yield was achieved with novel vectors, a special selection of hosts, and / or fermentation processes which include careful control of cell growth rate, and use of an inducer during growth phase. Special vectors are provided which include control regions having multiple promoters linked operably with coding regions encoding a signal peptide upstream from a coding region encoding the peptide of interest. Multiple transcription cassettes are also used to increase yield. The production of amidated peptides using the expression systems is also disclosed.

The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, dipeptidyl peptidase IV, calpain, aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

Novel compounds, their methods of preparation and use in therapies related to cancer and inflammation are provided. Compounds comprise esters of cinnamic acid, vanillic acid and 4-hydroxy cinnamic acid and derivatives and salts thereof. Compounds with novel benzofuran lignan structure as a potent antimitotic agent and inducer of apoptosis are provided. Formulations and methods for treatment of diseases mediated by NF-kappaB are also provided.

A furnace control system for controlling a gas-fired induced-draft furnace having a variable speed inducer blower. A control apparatus, responsive to a signal corresponding to the magnitude of a pressure difference between an inlet and outlet of the combustion chamber, controls blower motor speed to maintain the pressure difference at a predetermined magnitude corresponding to a selected gas flow rate. Inducer blower motor speed is varied directly and precisely to maintain an optimal pressure drop across the combustion chamber. The control system can be used in multi-stage and modulating furnace systems and in furnace systems utilizing pressure-assist modulating gas valves.

A heating or cooling system, such as an HVAC system, of variable output has a number of control elements and may include a variable speed compressor, a variable speed combustion (induced or forced draft) blower motor; a variable speed circulator blower motor; a variable output gas valve or gas / air premix unit; and a controller specifically developed for variable output applications. The system may utilize a pressure sensor to determine the actual flow of combustion airflow in response to actual space conditions, vary the speed of the inducer blower, and subsequently vary the gas valve output to supply the correct amount of gas to the burner system. A temperature sensor may be located in the discharge air stream of the conditioned air to provide an input signal for the circulator blower.

A gas turbine engine cooling system includes a heat exchanger in fluid communication with a source of cooling air, a first cooling circuit including a first heat exchanger circuit in the heat exchanger and a first bypass circuit with a first bypass valve for selectively bypassing at least a portion of first airflow around the first heat exchanger circuit. A second cooling circuit may be used having a second heat exchanger circuit in the heat exchanger and a shutoff control valve operably disposed in the second cooling circuit upstream of the second heat exchanger circuit and the heat exchanger. A circuit inlet of the first cooling circuit may be used to bleed a portion of compressor discharge bleed air for the first airflow to cool turbine blades mounted on a rotor disk using an annular flow inducer downstream of the first bypass valve and the heat exchanger.

The present invention relates to novel fluorescent dyes, novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of caspases and other enzymes involved in apoptosis in whole cells, cell lines and tissue samples derived from any living organism or organ. The reporter molecules and assay processes can be used in drug screening procedures to identify compounds which act as inhibitors or inducers of the caspase cascade in whole cells or tissues. The reagents and assays described herein are also useful for determining the chemosensitivity of human cancer cells to treatment with chemotherapeutic drugs. The present invention also relates to novel fluorogenic and fluorescent reporter molecules and new enzyme assay processes that can be used to detect the activity of type 2 methionine aminopeptidase, HIV protease, adenovirus protease, HSV-1 protease, HCMV protease and HCV protease.

The present invention relates to methods and compositions for the protection of skin and mucous membranes from undesirable side effects of ionizing radiation in a patient undergoing ionizing radiation therapy. In particular, the application describes compositions and methods comprising the topical use of Nrf2 inducers.

Disclosed are methods and devices for detection of bacteria based on recognition and infection of one or more selected strains of bacteria with bacteriophage genetically modified to cause production of an inducer molecule in the bacterium following phage infection. The inducer molecule is released from the infected bacterium and is detected by genetically modified bacterial bioreporter cells designed to emit bioluminescence upon stimulation by the inducer. Autoamplification of the bioluminescent signal permits detection of low levels of bacteria without sample enrichment. Also disclosed are methods of detection for select bacteria, and kits for detection of select bacteria based on the described technology.

The invention provides methods of increasing the production of polypeptides, optionally recombinant polypeptides, from mammalian cells using xanthine derivatives or hybrid polar compounds and cultures containing the same. Combinations of inducers including a hybrid polar compound and / or a xanthine derivative and / or an alkanoic acid can also be used, optionally at temperatures less than 37° C.

A medium and high pressure pump systems supplies a cryogenic fluid from a storage tank. The system comprises a pump that is operable to pump cryogenic liquid or a mixture of cryogenic liquid and vapor. The pump preferably comprises an inducer with at least two chambers and means for recycling excess fluid within the inducer instead of returning excess fluid to the storage tank. The reciprocating pump is preferably double acting such that fluid is discharged from the pump during both extension and retraction strokes.

The invention relates to a plant stress-resistant inducer, which takes Chitosan oligosaccharide solution as an effective active component. The invention adopts Chitosan oligosaccharide to induce crops to resist drought, waterlog, cold and freeze. Leaves of the crops are sprayed with the Chitosan oligosaccharide or roots of the crops are irrigated with the Chitosan oligosaccharide in order to induce the stress resistance (drought, waterlog, cold and freeze resistance) of the crops. By inducing the leaves of the crops, the content of resistant enzyme is increased in different degrees; the praline content is obviously increased; the opening degree of stomata obviously declines; the chlorophyll content is obviously increased; and the stress resistance of the crops is improved. The external application of the Chitosan oligosaccharide can improve the stress resistance of the crops, is free from toxicity, causes no environmental pollution, and is simple in usage.

The present invention relates to methods and compositions for the prevention and treatment of keratin-based skin diseases. In particular, the application describes compositions and methods of treating a patient suffering from skin blistering comprising the use of phase II enzyme inducers.

The invention relates to conformationally constrained mimetics of Smac which function as inhibitors of Inhibitor of Apoptosis Proteins. The invention also relates to the use of these mimetics for inducing apoptotic cell death and for sensitizing cells to inducers of apoptosis.

A tooth brushing system adapted to simultaneously clean a set of maxilla teeth or a set of mandible teeth. The system comprises a vibration inducer, a controller for the vibration inducer, a power source and a handle adapted to enclose the vibration inducer, the controller for the vibration inducer and the power source. The system further comprises a plurality of brushes adapted to simultaneously contact the set of maxilla teeth or the set of mandible teeth, a vibration isolation plate integral with the handle and a vibration transfer plate connected to the vibration inducer and the plurality of brushes and releasably connected to the vibration isolation plate, wherein the handle is adapted to be effectively held within a hand of a user and the vibration isolation plate is adapted to isolate vibration from the set of maxilla teeth or the set of mandible teeth not contacted by the plurality of brushes.

Insulin sensitivity increasing substances (ISIS), including but not limited to D-chiro-inositol, thiazolidinedione and derivatives, and biguanides, are useful in the treatment of hair loss and other disorders of the pilosebaceous apparatus (hirsutism, acne, etc.) associated with conditions of excess insulin and / or insulin resistance. The treatment comprises administering to a mammal, such as a human, at least one ISIS either alone or in combination with at least one agent, such as an androgen receptor blocker (ARB) and / or a steroid enzyme inhibitor or inducer (STI). Additionally, an activity enhancing agent may be included for topical administration.

A draft inducer blower for high efficiency furnaces, including a blower housing which facilitates maximum air flow efficiency through the blower housing while having an overall radial dimension which conforms to the industry standard arrangement of mounting holes on the walls of the furnaces. The blower housing generally includes a housing body and housing cover, the housing body including a plurality of mounting lugs spaced around the housing body through which bolts may be inserted to secure the blower housing to the mounting holes in the wall of a furnace. The housing cover and housing body each define portions of a volute which extends around the outer periphery of the blower housing from the cutoff region to the exhaust transition of the blower housing. The volute includes a cross-sectional area which substantially continuously increases in the axial direction of the blower housing from the cutoff region to the exhaust transition. In this manner, the blower housing has a radial dimension which conforms to the industry standard mounting hole arrangements for furnaces, yet includes a volute having an increasing cross-sectional area around the blower housing to provide a diffuser section within the blower housing to maximize air flow efficiency. The housing cover is positioned close to the impeller periphery to prevent recirculation. The housing cover is provided with a conical section and ribbing to minimize assembly-caused inlet deflection and to optimize air flow.

The invention relates to topical use of at least one UGT inducer for the preparation of a cosmetic or dermopharmaceutical composition comprising a dermatologically acceptable carrier to protect and / or enhance the state of the skin and prevent and / or treat imperfections of the skin.

The present invention describes materials and methods related to synthetic peptides which block the secretion of neurotransmitters and induce muscle relaxation, and use of said peptides as inhibitors of neurotransmitter secretion and muscle contraction, and as inducers of muscle relaxation.

The present invention provides the compound having the structure: ##STR1## wherein each of R.sub.1 and R.sub.2 are independently the same as or different from each other; when R.sub.1 and R.sub.2 are the same, each is a substituted or unsubstituted arylamino, cycloalkylamino, pyridineamino, piperidino, 9-purine-6-amine, or thiozoleamino group; when R.sub.1 and R.sub.2 are different, R.sub.1 =R.sub.3 --N--R.sub.4, wherein each of R.sub.3 and R.sub.4 are independently the same as or different from each other and are a hydrogen atom, a hydroxyl group, a substituted or unsubstituted, branched or unbranched alkyl, alkenyl, cycloalkyl, aryl, alkyloxy, aryloxy, arylalkyloxy, or pyridine group, or R.sub.3 and R.sub.4 bond together to form a piperidine group and R.sub.2 is a hydroxylamino, hydroxyl, amino, alkylamino, dialkylamino or alkyloxy group; and n is an integer from about 4 to about 8. The present invention also provides a method of selectively inducing terminal differentiation of neoplastic cells and thereby inhibiting proliferation of such cells. Moreover, the present invention provides a method of treating a patient having a tumor characterized by proliferation of neoplastic cells. Lastly, the present invention provides a pharmaceutical composition and a therapeutically acceptable amount of the compound above.

Provided are bifunctional small molecules of Formula (I): or pharmaceutically acceptable salts thereof, wherein M represents a small organic molecule which binds, covalently or non-covalently, a kinase, such as Her3 protein kinase; L1 represents a linker; and RH represents a hydrophobic group. An example of a compound of Formula (I) is a compound of Formula (II): Also provided are pharmaceutical compositions comprising a compound of Formula (I) or (II) and methods of using such compounds for treating proliferative diseases.