309 results about "Sulfamide" patented technology

The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.

The present invention is directed to novel sulfamide and sulfamate derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders.

The invention discloses a preparation method for lithium bis(fluorosulfonyl)imide. The preparation method comprises the following steps: 1) preparing fluorine sulfamide lithium; 2) preparing sulfuryl fluoride, and pumping the sulfuryl fluoride into the fluorine sulfamide lithium solution, and adding an acid-binding agent to prepare bifluorine sulfimide ammonium salt; 3) dissolving the bifluorine sulfimide ammonium salt in water solution, to obtain bifluorine sulfimide water solution through the acid resin exchange; 4) adding lithium carbonate, regulating the PH value to be neutral, filtering and removing undissolved substances, depressurizing and removing the most of the water, and adding a weak-polarity organic solvent to separate out a coarse product of the lithium bis(fluorosulfonyl)imide, further depressurizing and drying; and 5) adding a polarity solvent to the coarse product of the lithium bis(fluorosulfonyl)imide, stirring and dissolving, filtering and removing the undissolved substances, depressurizing and removing a strong-polarity solvent, and adding the weak-polarity organic solvent to perform the recrystallization, and depressurizing and drying to obtain a product after filtering. The preparation method is simple, the reaction time is short, the yield is high, and metal ion and negative ion impurities can be effectively controlled, so that the product with the high purity can be obtained.

The present invention is directed to novel benzo-fused heteroaryl sulfamide derivatives, pharmaceutical compositions containing them and their use in the treatment of epilepsy and related disorders. The present invention is further directed to a crystalline form of N-(benzo[b]thien-3-ylmethyl)-sulfamide and a process for its preparation.

The present invention is a method for the treatment of alcohol abuse and/or addiction comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and/or formula (II) as herein defined.

N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)benzyl aromatic sulfonamides and N-(3,5-bis-disubstituted aminomethyl-4-hydroxy)phenyl aromatic sulfonamides compounds in accordance with the animal test, are active in the prevention and the treatment of cardiac arrhythmia. These compounds are prepared as corresponding diamines by the condensation of optionally substituted aromatic sulfochlorides with p-hydroxybenzylamine, p-aminophenol, or the like, which followed by the Mannich reaction of the resulted corresponding aromatic sulfamides with formaldehyde and secondary amines; or directly obtained by the reaction of the aromatic sulfamides with 4-amino-2,6-bis-disubstituted aminomethylphenol. Subsequently, the diamines are reacted with various acids to provide their salts.

The present invention is a method for treating, preventing, reversing, arresting or inhibiting the occurrence, development and maturation of seizures or seizure-related disorders. More specifically, the present invention is directed to methods for the use of benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as described herein to therapeutically or prophylactically treat, prevent, reverse, arrest or inhibit epileptogenesis and epilepsy.

The invention discloses a fluorine-carbon gemini surfactant for oil extraction and a preparation method thereof. The preparation method of the surfactant is as follows: 1) perfluorooctsulfunyl fluoride is dissolved in ethyl acetate, is firstly mixed with polyethylene polyamines and then reacts with potassium hydroxide after being heated to obtain diperfluoro octyl sulfamide; 2) diperfluoro octyl sulfamide is mixed with 2-chlorethanol in an organic solvent and reacts with potassium hydroxide to obtain N-N-alcohol diperfluoro octyl sulfamide; 3) N-N-alcohol diperfluoro octyl sulfamide is mixed with hydrogen peroxide and reacts with potassium hydroxide to obtain the target product. The fluorine-carbon gemini surfactant for oil extraction provided by the invention has comparatively low using concentration, can obviously reduce the surface tension of aqueous phase system, is excellent in temperature and salt resistance, can be used as a surfactant component in polymer-surfactant binary compound flooding and alkali-polymer-surfactant ternary compound flooding systems and can also be directly applied in surfactant flooding.

The invention belongs to the field of chemistry, and relates to a method for testing the nitrite and nitrate in pickled vegetables. The method for rapidly testing the nitrite and nitrate in pickled vegetables comprises the following steps that: (1) the nitrite and the nitrate in pickled vegetable are extracted by ultrasonic waves; (2) a calibration curve is drawn by using nitrosonitrogen (NO2-) standard solution; and a calibration curve is drawn by using nitronitrogen (NO3-) standard solution; (3) by diazotizing sulfamide, the nitrite in the pickled vegetable is coupled with hydrochloric acid N-(1-naphthyl)ethylenediamine, so that rosy azo dye is produced, and the content of the nitrite is determined at 540nm; (4) the nitrate in the pickled vegetable is reduced to nitrite by a cadmium column, the nitrite is determined, the determined nitrite in the same sample is subtracted, and the nitrate content is worked out.

It is intended to provide a compound represented by the following general formula (1) or a pharmaceutically acceptable salt thereof. Because of having a sufficiently high antitumor activity, this compound or its salt is useful as a remedy for cell proliferative diseases, in particular, cancer. It is also intended to provide a medicinal composition which contains the above-described compound or its salt as the active ingredient. [Chemical formula 1] (1) wherein X is selected from heteroaryl, etc.; Y<1> and Y<2> are selected from -N=, etc.; Y<3> and Y<4> are selected from -CH=, etc.; A is selected from sulfamide, etc.; R<1> is selected from hydrogen, etc.; and R<2> is selected from C1-6 alkyl, etc.

The invention relates to a process for preparing a fluoro compound of formula:

R₂—(SO₂)—NX—(SO₂)—F   (III)

• • comprising:
  • (a) a first step for obtaining the chloro compound of formula:

R₁—(SO₂)—NX—(SO₂)—Cl;   (II)

• • this first step comprising the reaction of the sulfamide of formula:

R₀—(SO₂)—NH₂   (I)

with a sulfureous acid and a chlorinating agent; and

• • (b) a second step for obtaining the fluoro compound of formula (III), this second step comprising the reaction of the chloro compound of formula (II) with anhydrous hydrofluoric acid in at least one organic solvent;

in which:

X represents either a hydrogen atom or a monovalent cation M;

R₁ represents an electron-withdrawing group having a positive Hammett parameter σ_p;

if R₁ represents Cl, then R₀ represents OH; otherwise, R₀ is identical to R₁; and

if R₁ represents Cl, then R₂ represents F; otherwise, R₂ is identical to R₁.

The invention discloses a tanshinone IIA derivative. A connecting arm, phosphocreatine and an analogue of the phosphocreatine form a conjugate of which the structure is as shown in formula (I) in the specification, wherein n is equal to 1-3, m is equal to 0-3, R1 and R2 respectively independently represent hydrogen atoms, C1-C5 alkyl, cycloalkyl, vinyl and alkynyl, the R1 and the R2 also can form ternary to hexatomic rings, and M represents metal ions, like sodium ions. The compound can be used for improving the water solubility of the whole molecule through sodium phosphate in the phosphocreatine on the premise of maintaining the activity of the tanshinone IIA; moreover, a phosphocreatine fragment in the molecule can play a dual protection effect on myocardial muscles.

The invention discloses a method for synthesizing perfluoroalkyl sulfimide alkali metal salt (M[Rf1SO2NSO2Rf2]) which is abbreviated to M[PFSI], wherein Rf1 and Rf2=CmF2m+1, m=1-8, M=Li, Na, K, Rb, and Cs. The method utilizes potassium (rubidium and cesium) salt of perfluoroalkyl sulfamide and perfluoroalkyl sulfonyl fluoride for reaction in the existence of potassium carbonate (rubidium and cesium), so that the potassium (rubidium and cesium) salt of the perfluoroalkyl sulfimide can be conveniently prepared with high yield which is 70-90%; the high-purity corresponding lithium (or sodium) salt (M[PFSI], M=Li and Na) can be obtained through double decomposition exchange reaction of the potassium (rubidium and cesium) salt and lithium perchlorate (or sodium) in aprotic polar solvent (such as acetonitrile, dimethyl carbonate, nitromethane and the like); and the hydrophobic functionalized ionic liquid composed of cations of sulfonium, ammonium or phosphorus with the [PFSI] through reaction of the prepared alkali metal salt and the sulfonium salt, ammonium salt or phosphorus salt of which the side chain contains functionalized functional groups.

The invention discloses a chemical oxygen demand (COD) degradation agent for removing sulfamide from industrial wastewater in the field of environment sewage treatment. The degradation agent is formed by compounding the following components in percentage by mass: 70 to 85 percent of inorganic strong oxidant, 1 to 5 percent of catalyst and 10 to 29 percent of genetic engineering bacteria enzyme, wherein the inorganic strong oxidant is one or two of sodium chlorate, potassium ferrite, ammonium persulfate and sodium bismuthate; the catalyst is one of nickel oxide, copper oxide, titanium oxide and lead oxide; the genetic engineering bacteria enzyme is one or two of cyclic amide hydrolase, lignocellulose hydrolase, protein hydrolase, organic phosphorus hydrolase and amylase; and the wastewater is added with 1 to 5 percent of degradation agent and continuously stirred, so that the concentration of the sulfamide in the wastewater is reduced to below 0.5mg/L from 1,000mg/L, and the removal rate is more than 99.9 percent. The degradation agent is easy to use and cannot produce secondary pollution; raw materials are readily available; and precipitates are not produced.