76 results about "Thionyl" patented technology

The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an amide linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

The preparation method of the fungicide intermediate (E)-2-(2'-chloromethyl)-2-methicillin imino acetic methyl ester is: 1) the phenyl phthalate and the thionyl dihalide react with the influence of a catalyst; the catalyst is the Louis acid and phosphonic derivative; 2) the product of the first step and the alkali metal cyanide react with the influence of the organic solvent and phase transfer catalyst; the organic solvent is selected from the non-polar aromatic solvent or the halogen hydrocarbon; the phase transfer catalyst is selected from the halide of the four-level nitride or the ammonium salt; the alkali metal cyanide is selected from the sodium cyanide and potassium cyanide; 3) the products of the second step and the methanol react under the condition with the organic solvent and the chlorinated hydrogen; 4) the products of the third step and the methicillin amine hydrochloride under the condition with the organic solvent; thus, the target product can be got. The energy consumption and production risk of the present invention are obviously lowered; the relative collection rate is high; the safety in the production process is improved; and the present invention has no drawbacks such as the obstruction.

Methods and compositions are described for preparing metal salts and selectively separating metals from substrates and other metals. The methods can include a thionyl reagent that reacts with a metal in a solution to produce a metal salt. The reaction can be controlled by varying reagents and conditions such that the method can be used to selectively separate one or more metals from another metal or from a substrate. The method can also be used for removing metals from a surface. Compositions produced by the method are also described.

The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty compounds bound by an amide linkage, or mixtures thereof produced by reacting creatine or derivatives thereof with an appropriate fatty acid in the presence of dichloromethane and a pyridine catalyst, previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

The invention provides a purification method of a crude sulfur hexafluoride product. The purification method comprises the following steps: cracking to remove impurities; washing to remove impurities;performing alkali washing to remove impurities; performing low-pressure adsorption; performing high-pressure adsorption; performing rectification to remove impurities. One to six stages of water washing towers are arranged, fluorine gas, low-sulfur fluoride and thionyl fluoride in the crude sulfur hexafluoride are effectively removed through multiple times of water washing, the purity of the sulfur hexafluoride is improved, meanwhile, by-product hydrofluoric acid in the water washing process is recycled, generation of waste water is reduced, and waste is turned into wealth. The one to six stages of alkaline washing towers are arranged, HF, CO2 and SO2 gas in sulfur hexafluoride is effectively removed through multiple times of alkaline washing, the purity of sulfur hexafluoride is improved, waste liquid generated by the alkaline washing towers is recycled after being treated with quick lime in an alkaline liquid collecting tank, generation of the waste liquid is avoided, pollution is reduced, and cost is saved.

This invention relates to a Li sub-battery cathode carrier. Composition and content of the slurry include 3-9 acetylene black, 0.2-1.5 Cu-electrolyte powder and 20-120 adhesives. The prepared-slurry is pressed to format or stacked on an under-pan to be caked and foamed for at least 15h under 180deg.C-200deg.C to increase its mechanical structure performance of the cathode carrier.

A process for producing optically active cysteine derivatives with high optical purity and good quality which is economically advantageous and is high in productivity even on a commercial scale is provided.A process for producing an optically active cysteine derivative which comprises synthesizing a D-form or L-form optically active cysteine derivative of the general formula (2) shown below (R1 represents an amino-protecting group of the urethane or acyl type, R0 represents a hydrogen atom or, taken together with R1, an amino-protecting group, R2 represents an alkyl, aryl or aralkyl group, R3 represents a univalent organic group and * represents the position of an asymmetric carbon) by reacting the corresponding D-form or L-form optically active amino acid derivative of the general formula (1) shown below with an alcohol of the general formula (3) shown below and a strong acid and / or a thionyl halide and recovering the above cysteine derivative (2) from the reaction mixture, the procedural series from reaction to recovery being carried out under conditions such that the medium contacting the above optically active cysteine derivative (2) is within the range from acidic to weakly basic to thereby recover the above cysteine derivative (2) from the reaction mixture while suppressing the decomposition and racemization thereof.

The present invention relates to a preparation method of polysulfone-polyoxyethylene block copolymer. Said preparation method includes the following steps: firstly, making polyoxyethylene whose end group is hydroxyl group and thionyl halogen undergo the process of heating reaction under the protection of inert gas, evaporating and removing residual thionyl halogen to obtain the polyoxyethylene whose end group is halogen atom, then under the protection of inert gas stirring the above-metnioned obtained polyoxyethylene whose end group is halogen atom and dihaloarylsulfone, dihydric phenol, inorganic alkaline substance, organic solvent and arene, heating them and boiling, evaporating and removing arene and water, making copolymerization reaction so as to obtain the invented polysulfone-polyoxyethylene block copolymer.

The present invention relates to oligomer compounds, including dimers and trimers, formed by a disulfide, sulfinyl thio, olefin or hydrocarbon bond, or a hydrazone exchange bond between two or more monomers. Methods of making the monomers and the oligomers is also disclosed. Use of the compounds for inhibiting the activity of target RNA molecules, particularly those having a secondary structure that include a stem or stem-loop formation. Dimer compounds capable of inhibiting the activity of an HIV-1 RNA frameshifting stem-loop and a (CUG)n expanded repeat stem-loop are disclosed, as are methods of treating diseases associated with these target RNA molecules.

The invention belongs to the technical field of flame-retarding composite materials and discloses a functionalized graphene flame retardant and a polylactic acid composite material enhanced by the functionalized graphene flame retardant. The functionalized graphene flame retardant is prepared by the following steps: completely dissolving graphene oxide into a solvent; then adding thionyl chlorideand stirring and refluxing to react; cooling to room temperature and filtering; after washing with water until a solution is neutral, drying in vacuum to obtain an intermediate product; adding the obtained intermediate product and DOPO-HQ into a solvent, and stirring and refluxing to react; after cooling to room temperature, filtering; drying obtained precipitate. Polylactic acid and the functionalized graphene flame retardant are fused and blended, and then a mixture is subjected to compression molding to obtain the polylactic acid composite material enhanced by the functionalized graphene flame retardant. The vertical combustion grade of the prepared polylactic acid composite material can reach a grade V-0, and has good flame-retarding performance and thermal stability; meanwhile, the mechanical properties of the material are not damaged; the polylactic acid composite material has a wide application prospect in the fields including building materials, automotive interior trims, electronic products and the like.

The present invention describes compounds produced from an orotic acid molecule and an amino acid molecule. The compounds being in the form of amino acid orotate compounds bound by an amide linkage and produced by one of two disclosed methods; 1) reacting orotic acid or derivatives thereof with a thionyl halide, and then combining the acyl halide with an amino acid in the presence of dichloromethane and a DMAP catalyst; or 2) protecting the carboxylic acid of an amino acid and then combining the amino acid with a DCC activated orotic acid, followed by removal of the carboxylic acid protecting group. The resulting amino acid orotate amide has an enhanced stability in solution as compared to a related ester. In addition, specific benefits are conferred by the particular amino acid used to form the compounds in addition to, and separate from, the orotate substituent.

The invention discloses a preparation method of 2, 5-furandicarboxylic acid-based block copolyester, and relates to the technical field of polyester preparation. The preparation method comprises the following preparation steps of: 1) mixing 2, 5-furandicarboxylic acid and / or ester thereof, dihydric alcohol, a catalyst and a heat stabilizer for an esterification reaction to obtain an ester A; 2) mixing 2, 5-furandicarboxylic acid and thionyl dihalide for a reaction to obtain a furandicarboxylic acid halide; 3) performing an esterification reaction among the furandicarboxylic acid halide, bio-based rigid cyclic diol, a catalyst and a heat stabilizer to obtain an ester B; 4) carrying out a pre-polycondensation reaction on the ester B to obtain a prepolymer; and 5) mixing the prepolymer and the ester A prepared in the step 1) to carry out polycondensation to obtain the 2, 5-furandicarboxylic acid-based block copolyester. The method provided by the invention is simple and feasible, is suitable for industrial production, and the product has good toughness, good hue and excellent thermodynamic properties, and can be widely applied to the fields of packaging, fibers and the like.

A process for producing an optically active 3-azide-carboxylic acid ester by reacting an optically active 3-hydroxycarboxylic acid ester and a thionyl halide in the presence of a basic substance in an organic solvent to produce an optically active 3-halogenocarboxylic acid ester which is then reacted with an azide salt represented by the formula: MN3 (wherein M is an alkaline metal) in water or a mixture of water and a water soluble organic solvent.

The invention provides a one pot method for preparing aryl-alpha-keto ester based on arylethyl ketone, belonging to the technical field of organic chemical engineering. The method comprises the following steps: using arylethyl ketone as raw material to place in a reaction container, adding pyridine, piperidine or triethylamine used as solvent in the reaction container in turn, adding selenium dioxide to perform oxidation reaction and obtain aryl-keto acid, adding methanol and a defined amount of molecular sieve, placing the reaction container in ice bath, then dropwise adding thionyl chloridein the reaction container to perform esterification reaction, adding strong acid in the reaction container to perform hydrolysis reaction, then performing neutralization reaction and finally obtaining aryl-alpha-keto ester by washing, drying and filtrating. Compared with the prior art, the invention can greatly reduce the cost and simplify the operation while maintaining the yield; the raw materials can be obtained easily, the reaction yield is high, the synthesis cost is low and the yield can reach 80%.

A 6-oxo-7-oxa-B-Homo-cholesta-3-thionylhydrazone compound has the following chemical structural formula: the 6-oxo-7-oxa-B-Homo- Cholesta-3-thionylhydrazone compound is formed from cholesterol through the chemical method of PCC oxidation, NaBH4 reduction, Bayer-Villiger oxidation, Corrin oxidation and addition. Experiments have proved that the 6-oxo-7-oxa-B-Homo-cholesta-3-thionylhydrazone compound of the present invention has obvious inhibitory effect on various tumor cell lines, and can be used as in the application.

The invention discloses a preparation method of fluoride and an intermediate thereof. The preparation method disclosed by the invention comprises the following step: in the presence of an alkaline reagent, carrying out a reaction of a compound III and thionyl fluoride in an organic solvent to obtain a compound shown as a formula I, according to the preparation method, the fluorosulfite compound isobtained with high yield, and the fluorosulfite compound has good functional group compatibility and substrate universality.

The present invention relates to an ortho-halogenated arylamine compound and a synthesis method thereof. The ortho-halogenated arylamine compound has a structure represented by a formula (III), and in the formula (III), X is Cl or Br, Ar is one of substituted naphthyl, phenyl and heteroaryl, and R is one of a benzoyl group, an acetyl group, a pivaloyl group, an ester group, a t-butyloxycarbonyl group, a carbobenzoxy group and a methyl group. According to the invention, cheap and easily available thionyl dihalide reacts with the aryl hydroxylamine compound, efficient synthesis of o-haloarylamine is realized under mild conditions, the universality is good, and various functional groups can well tolerate.

The invention discloses a preparation method of L-valine methyl ester hydrochloride, which comprises the following steps of: firstly, adding absolute methanol in a reactor and controlling the temperature between 8 DEG C below zero and 10 DEG C below zero, dripping thionyl phthalyl chloride by stirring, reacting for 0.8-1.5 hours at the temperature, adding L-valine under the cooling condition, raising the temperature to the ambient temperature and stirring for 2.5-3.5 hours, then heating and refluxing, and reacting for 7-9 hours at the temperature of 60-70 DEG C; and secondly, reducing pressure to distill after the reaction, cooling residues for crystallization, carrying out vacuum filtration, and recrystallizing with absolute methyl-ethyl ether to prepare L-valine methyl ester hydrochloride, wherein the reaction materials have the mole ratio that n (L-valine):n (SOC12):n (absolute methanol)=1.0:1-1.5:20-21. The preparation method of the invention is simple, has fewer steps and small economic investment, and only requires commonly-used devices, and the prepared L-valine methyl ester hydrochloride is high in purity and yield and can satisfy the use requirements.

The invention provides an environmentally friendly galvanized metal repair agent and a preparation method thereof. The environmentally friendly galvanized metal repair agent is prepared from, by mass, 15-20 parts of attapulgite, 20-30 parts of amino clay, 1-7 parts of aluminum distearate, 4-8 parts of ceramic ultrafine powder, 4-15 parts of composite nano-powder, 3-6 parts of sodium potassium silicate, 3-5 parts of gamma-thionyl trimethoxysilane, 2-6 parts of gamma-aminopropyl triethoxysilane, 12-18 parts of waterborne polyurethane, and 3-5 parts of poly trimethoxysilane. The preparation method of the environmentally friendly galvanized metal repair agent comprises the steps of mixing, heating, kneading, grinding and the like, the prepared environmentally friendly galvanized metal repair agent has the advantages of being good in abrasive resistance, anti-corrosion and lubricating, high in metal bonding strength, and long in service life.

The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

The invention relates to a method for compartment analysis of ferulic acid glycerol monobutyralte through the high performance liquid chromatography, comprising the following: firstly, a step of pretreatment, during which, ferulic acids and absolute ethyl alcohols generate reflux heating reaction under the catalysis of thionyl chlorides and are dissolved in aether and then ferulic acid methyl ethyl oxalate is obtained after extraction through sodium bicarbonate; under the temperature of between 30 and 50 DEG C, tertiary butyl alcohol is used as reaction medium and the ferulic acid glycerol monobutyralte is obtained through oscillating reaction of the ferulic acid methyl ethyl oxalate, glycerol monobutyralte and Novozym435 lipase in an air bath; the ferulic acid glycerol monobutyralte is dissolved in methanol, filtered and then diluted by HPLC-level methanol; secondly, a step of compartment analysis, which is to adopt a chromatographic column (Ph-3 column Inertsil, IDx250mm) with a column temperature of ambient temperature. A solid phase adopts silica gel filler and the ultraviolet detection wavelength is between 280 and 325 nanometers; a moving phase is gradient mixing of methanol and water; the sample feeding quantity is 5 mu L and the flow speed is 1mL / min. The method selects filler of the chromatographic column and the special ultraviolet scanning wavelength according to the characteristics of materials to be comparted, is quick, high-efficient and accurate and is convenient for industrial analysis and application.

The present invention describes compounds produced from a creatine molecule and a fatty acid molecule. The compounds being in the form of creatine-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting creatine or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental creatine with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

The present invention relates to a method for the preparation of (3S,4S)-3-hexyl-4-((R)-2-hydroxytridecyl)-oxetan-2-one and a product of the method. The method includes the following steps: a) reducing a substance represented by formula (II) to obtain a substance represented by formula (III), and then oxidizing the substance represented by formula (III) to form a substance represented by formula (IV); b) acylating n-octanoic acid to obtain n-octanoyl chloride using thionyl dichloride, then condensing the obtained n-octanoyl chloride with 2-mercapto-pyridine under basic condition to form a substance represented by formula (V), and then converting the substance represented by formula (V) to a substance represented by formula (VI); c) reacting the substance obtained in the step a) with the substance obtained in the step b) under catalytic condition of Lewis acid to generate a substance represented by formula (VII), and then reacting with a Lewis acid. The meanings of the signs in these formulas are the same as those in the description.

The present invention describes compounds produced from an amino acid molecule and a fatty acid molecule. The compounds being in the form of amino-fatty acid compounds being bound by an anhydride linkage, or mixtures thereof made by reacting amino acids or derivatives thereof with an appropriate fatty acid previously reacted with a thionyl halide. The administration of such molecules provides supplemental amino acids with enhanced bioavailability and the additional benefits conferred by the specific fatty acid.

The invention discloses a startup preparation method of a hydrotreating device. The method is used for the starting process of the ex-situ prevulcanization type hydrotreating catalyst containing the thionyl compound. Especially in the airtight process, the constant-pressure heating section, the constant-pressure constant-temperature section and the constant-pressure heating section are arranged, so heat generated by hydrogenolysis of sulfide and / or auxiliaries in the airtight starting process is reasonably distributed and controlled, the phenomenon of centralized heat release is avoided, and the risks of over-temperature and temperature runaway are reduced. The method provided by the invention thoroughly solves the obstacles in the industrial application process of the catalyst, not only improves the use activity of the catalyst, but also eliminates the hidden danger of environmental protection caused by the leakage of the vulcanizing agent, and has a very good application prospect.

A compound of formula (I) having metalloprotease inhibitor activity: R represents a substituted or unsubstituted phenoxy, phenylsulfanyl, phenylsulfinyl, phenylsulfonyl, phenylamino or phenylmethyl residue radical, and R2 represents an optionally substituted aryl or heteroaryl residue.