109results about How to "Fast excretion" patented technology

Disclosed are compounds that include two or more haptens conjugated by a spacer or a carrier. The haptens may include diethylenetriaminepentaacetate (DTPA), histimine-succinyl-glutamine (HSG), or combinations of DTPA and HSG. The compound also includes an effector molecule which may be conjugated to one or more of the haptens, the spacer / carrier, or both. The effector molecule may be conjugated by a number of linkages including an ester linkage, an imino linkage, an amino linkage, a sulfide linkage, a thiosemicarbazone linkage, a semicarbazone linkage, an oxime linkage, an ether linkage, or combinations of these linkages. Also disclosed are methods of synthesizing the compounds and / or precursors of the compounds.

Disclosed are novel methods for making cochleates and cochleate compositions that include introducing a cargo moiety to a liposome in the presence of a solvent. Also disclosed are cochleates and cochleate compositions that include an aggregation inhibitor, and optionally, a cargo moiety. Additionally, anhydrous cochleates that include a protonized cargo moiety, a divalent metal cation and a negatively charge lipid are disclosed. Methods of using the cochleate compositions of the invention, including methods of administration, are also disclosed.

The invention relates to the inhibition of DNA methyltransferase isoforms DNMT1 and DNMT3b2. The invention provides compounds and methods for inhibiting DNMT1 and DNMT3b2.

The invention discloses a disposal method of Barrier Lake for artificially regulating and controlling the drain flow and an application thereof. The method comprises the following steps of: digging a draining guide slot at the part of a relatively low-lying groove on a dam body of a barrier lake; in the draining intermediate stage of a Barrier Lake reservoir, carrying out artificial explosions or mechanical clearing on huge stones influencing downward erosion development in the draining guide slot so as to guarantee the stable growth of the down cutting flow; and in the draining later stage of the Barrier Lake reservoir, when the reservoir water drain flow in the draining guide slot reaches a set threshold value, putting an artificial structural body into the draining guide slot to stabilize a slot bed so as to control the quick down cutting of the slot bed and play a role of flow control. Compared with the prior art, the invention can avoid the phenomena that the draining efficiency in the initial stage is low, and the draining in the later stage is too quick and difficult to control, which are easy to appear when a conventional method is used for disposing the Barrier Lake, thus the invention greatly improves the emergency draining efficiency of the Barrier Lake and quickly reduces the risks of the Barrier Lake so as to greatly reduce the loss of an upstream flooding area and the risks of a downstream risk area.

The invention discloses Al18F-NOTA-PEG6-TATE of a targeted somatostatin receptor and a preparation method and application of Al18F-NOTA-PEG6-TATE. The preparation method of the label includes the steps that a somatostatin derivative TATE and a difunctional chelating agent NOTA are connected through PEG to generate a radiolabelled precursor, then positron nuclide 18F labeling is carried out through a one-pot method, and the 18F labeled somatostatin derivative Al18F-NOTA-PEG6-TATE can be obtained. The method can be carried out in an acetate buffer solution system or an acetonitrile reaction system, and the method has the advantages of being easy and convenient to operate and high in labeling rate and product purity. The prepared positron label of the targeted somatostatin receptor can be applied to preparation of a PET / CT molecular probe or tumor therapy medicine, and provides a novel thought for synthesis of the clinical PET / CT molecular probe.

The present invention relates to a group of new oligonucleotides sequences with human tumor necrosis factor α (TNF-α) inhibiting activity, which includes DNA sequences and RNA sequences. These oligonucleotides or aptamer can specifically be bound to TNF-α and inhibit the cytoxicity of TNF-α to L929 cells. Therefore, the aptamer of the present invention may be used to detect TNF-α and provide a therapeutic method for diseases related to the increasing level of TNF-α. Compared with other TNF antagonists such as monoclonal antibody and soluble receptor, the present invention has high specificity, high affinity, quick penetration to target tissue, rapid plasma clearance, and lower immunogenecity. Turthermore, it can be used repeatedly and keeps high concentration in target tissue and the like. It has the advantages of affinity and specificity similar to monoclonal antibodies and also has permeability and pharmacokinetics characteristics similar to small molecular polypeptide. The present invention also refers to derivative of the oligonucleotides sequence, including modified sequence. The present invention may further be manufactured as medicine for therapy and diagnosis of TNF-α related diseases.

Disclosed is the use of paeonol in preparing medicament for the prevention or treatment of fatty liver, and also the use of medicinal combination preparation of paeonol with medicinal carrying agent in preparing medicaments for the prevention and treatment of fatty liver disease, the dose forms of the medicament include soft capsules, drop pills, pills, powders, tablets, capsules, granules, injections, fluid infusions, freeze-dried powders for injection, suppositories, film agents, tiny capsules, tincture, syrup, oral liquids and other pharmaceutically acceptable dose forms.

The invention relates to a preparation method of coarse cereal powder delicate in taste. The specific preparation method comprises the following steps of (1) washing, wherein coarse cereals are weighed, and coarse cereal raw materials are washed with clear water respectively and fished out; (2) wet-cloth germination accelerating; (3) steaming, wherein the germinant coarse cereals are steamed out of water respectively; (4) freeze drying; (5) crushing, wherein the coarse cereals subjected to freeze drying are crushed separately; (6) mixing, wherein coarse cereal powder is mixed, and bagging is conducted to obtain a product; the coarse cereal raw materials are 20-35 parts of pearl barley and 15-30 parts of buckwheat. The product is relatively delicate in taste, and during swallowing, no obvious discomfort exists.

The present invention relates to the technical field of drink processing and more particularly relates to alcoholism preventing drink and a preparation method thereof. The alcoholism preventing drink is mainly prepared from 20-25 parts of sugarcanes, 15-20 parts of calendula arvensis herbs, 15-20 parts of celeries, 20-25 parts of radix notoginseng, 15-20 parts of roselle, 5-7 parts of origanum majorana, 10-15 parts of radix puerariae, 5-7 parts of bergamots, 10-15 parts of wax apples, 25-30 parts of mulberries, 25-30 parts of gooseberries, 25-30 parts of hovenia acerba fruits, 7-10 parts of tomatoes, 7-10 parts of watermelons, 7-10 parts of grapes, 5-7 parts of pomegranates, 10-15 parts of cucumis melo var. agrestis fruits, 3-5 parts of honey, etc. The alcoholism preventing drink is prepared by the steps of raw material treating, boiling, centrifuging and filtering, homogenizing, decolorizing, degassing, sterilizing, etc. The alcoholism preventing drink has very good effects of preventing alcoholism, can rapidly prevent alcoholism, alleviates body physical discomfort symptoms caused by drunkenness, protects liver and stomach, helps to quit wine drinking, and is also simple in preparation method and easy to produce.

The invention discloses an amino acid positron emission tomography (PET) imaging agent, and a preparation method and application thereof. The imaging agent belongs to the field of N-substituted positron nuclide labeled glutamic acid compound and has a structure as shown in the specification; and the L*represents -11CH3, CH2CH218F, and -COCH (18F) CH3. The novel imaging agent N-(2-18F-fluoropropionyl)-glutamic acid shows good tumor PET imaging sensitivity and specificity, has high uptake on tumor (such as S180 fibrosarcoma), and no obvious uptake on other tissues and organs (except for bladder) in the body, and indicates high tumor to background ratio. In vitro-in vivo experiments show that N-(2 - 18F -fluoropropionyl)-glutamic acid is stable in vitro and in vivo and shows good pharmacokinetic properties.

The invention relates to canned foods, particularly to a chicken bone paste pet canned food. A matured product is mainly prepared from the following raw materials in parts by weight: 50-75 parts of chicken bone paste, 5-15 parts of soybean protein, 10-20 parts of gluten meal and 0.5-1.5 parts of red yeast rice meal; then, the matured product and a cooking liquor are mixed in a weight ratio of 14-17:20-29 to prepare a pet food. The preparation method of the chicken bone paste pet canned food comprises the concrete steps of chicken framework processing, kneading, steaming, cutting, vacuum pumping, canning and sterilization. High calcium chicken bones are used as main raw materials, chicken bone paste is used as a substitute of meat, the nutrient content of the chicken bone paste is richer than that of the meat, and the calcium content of the meat is further incomparable with the chicken bone paste. Meanwhile, soybean protein, corn starch, modified starch and the like are added to improve the nutrient content of the chicken bone paste pet canned food, thus the chicken bone paste pet canned food is suitable for the growth requirements of pets. The chicken bone paste pet canned food has simple production process, rich nutrient content of the prepared product as well as convenient eating, storage and transportation.

The invention relates to a feed additive, in particular to a feed additive quinocetone and a preparation method thereof and belongs to the technical field of chemical engineering. In the preparation method, o-nitroaniline is used as the starting raw material and the method comprises the following steps: oxidizing with sodium hypochlorite, and then reacting with acetylacetone and benzaldehyde to obtain quinocetone. Quinocetone can inhibit the synthesis of bacterial DNA to inhibit the growth of pathogenic microorganisms in the digestive tract, prevent or reduce diseases, protect good intestine bacteria and intestinal wall from the harms of microorganisms or parasites and promote the digestion and absorption of various nutrients. Therefore, the growth of animals can be promoted and the feed conversion rate can be increased.

The invention relates to a natural pueraria drink. The technical scheme of the invention is characterized by comprising the pueraria, water, honey and citric acid, wherein every 100 parts of Pueraria liquid is added with 30 parts of water, 5 parts of honey and 3 parts of citric acid. The pueraria drink is advantageous by having efficacies of clearing heat, decomposing alcohol, sobering, strengthening stomach, alleviating hangover and protecting liver, and have demonstrable effect on reducing blood lipids, blood pressure, and blood sugar, and on adjuvant treatment of coronary heart disease, angina, neurological headaches, etc. The drinking amount can be greatly increased if the pueraria drink is infused and taken before the wine; rapid decomposition and excretion of the alcohol can be promoted if the pueraria drink is infused and taken after the wine; and blood lipids, blood pressure, and blood sugar can be reduced and the liver and the stomach can be protected if the pueraria drink is taken for a long time.

Described herein are Tz / TCO-based pretargeting strategies using an Al[18F]-NOTA-labeled tetrazine radioligand. This imaging strategy enables delineation of cancer at earlier time points compared to other imaging strategies and further decreases the radiation dose to healthy tissues compared to directly labeled antibodies. Al-based 18F imaging of small molecules, such as tetrazine, has not been previously achieved due to the decomposition of tetrazine during radiofluorination. Radiofluorination is advantageous over other radiolabeling methods because, in addition to having a shorter half-life, 18F is more readily available to produce and therefore integrated into hospital workflows.

The invention belongs to the field of tea preparation, and particularly relates to dark tea with radix puerariae and herba taraxaci. The dark tea is prepared from raw materials including 15 to 25 weight parts of radix puerariae, 5 to 10 weight parts of herba taraxaci and 70 to 75 weight parts of tea through fermentation. The invention also discloses a preparation method of the dark tea. The raw materials are weighed according to the ratio of all ingredients; the raw materials are subjected to first time steam steaming at 80 to 100 DEG C, are then subjected to fermentation treatment, and are next subjected to second time steam steaming at 100 to 120 DEG C; finally, compression, shaping and drying are performed to obtain the dark tea. The dark tea provided by the invention has the advantagesthat all ingredients achieve synergic action; the functions of the dark tea can be obviously improved.

The invention relates to a pasty pet canned food which is prepared by the following raw materials in parts by weight: 30-50 parts of chicken-bone paste, 3-10 parts of animal liver, 2-7 parts of corn starch, 0.1-0.5 part of D-sodium erythorbate, 0.1-0.3 part of edible salt and 0.005-0.01 part of sodium nitrite. The preparation method comprises the following steps: processing the chicken bone frame, stirring, grinding, secondary stirring, evacuating, canning and sterilizing. In the invention, high-calcium chicken bone is adopted as a main raw material, the nutritional ingredients thereof are richer than meat, and the calcareous content is far incomparable than that of the meat; the D-sodium erythorbate is an important antioxidant preservative in food industry, can keep color and natural taste of food, prolong quality guarantee period, eliminate adverse phenomena, such as discoloring, foreign taste and turbidness and the like, and has no toxic and side effects. The pasty pet canned food of the invention has simple process and is convenient for popularization and edibility, is easy to be preserved and transported; and the nutritional ingredients of the prepared product are richer.

The invention provides a traditional Chinese medicine patch for preventing piglet diarrhea as well as a preparation method and application thereof, belonging to the field of veterinary drugs. The traditional Chinese medicine patch comprises the following components: 10-20 parts of largehead atractylodes rhizome, 15-25 parts of gordon euryale seed, 8-12 parts of costustoot, 8-12 parts of clove, 15-22 parts of officinal magnolia bark, 15-20 parts of radix bupleuri, 10-18 parts of baical skullcap root, 10-20 parts of radix astragali, 10-20 parts of liquorice root, 10-15 parts of radix codonopsis and 3-9 parts of dried ginger. The product can be directly applied to navels of piglets, is fast in medicine absorption, has the effect of overcoming the defects of poor palatability and slow absorption of oral medicines, has the functions of reducing the diarrhea rate, improving the immunities of the piglets and promoting development of digestive organs, has the advantages of nature, no toxic or side effect, no medicine resistance, no residues, fast excretion, and the like, has short course of treatment and high cure rate, has piglet diarrhea cure rate of 88.4%, achieves good treatment effects and does not irritate skins. The preparation process is simple and practicable, is low in cost and is suitable for industrial production.

Hypoglycemic soluble granules containing alfalfas. The invention relates to the field of beverage. Alfalfa, radix astragali and corn stigma are employed as raw materials and are combined together to obtain a cooperative effect among each drug so that diabetes can be prevented and an immunity of a human body can be improved. The soluble granules have effects of reducing blood fat and blood glucose, alleviating digestion rate in the human body and most quickly excreting cholesterol so that the blood glucose and the cholesterol in blood can be controlled under a most ideal level. With pure plants as raw materials, a pharmacologic damage caused by side effect since a diabetes patient takes a western medicine. Meanwhile, the soluble granules are low in raw material cost so that common people are capable of purchasing the soluble granules. The soluble granules not only are an excellent health-caring product to the diabetes patients but also have a good health-caring effect on the common people.

The invention discloses a highway bridge deck water drainage facility. The highway bridge deck water drainage facility comprises a mounting seat; a placing groove is formed in the top of the mountingseat; two misplaced filtering nets sticking to each other are placed in the placing groove; fixing blocks are both fixedly mounted at the bottoms of the two filtering nets; first clamping grooves areformed in the bottoms of the fixing blocks; two first clamping grooves are formed in the internal wall of the bottom of the placing groove; rotating grooves are formed in the internal walls of the bottoms of the first clamping grooves; and the same rotating columns are rotationally mounted in the rotating grooves and the first clamping grooves. When a drainage pipeline is clogged and the filteringnets are inconvenient for working personnel to clean, the vertical distance between the two filtering nets is increased by using an adjusting handle so that the blocked filtering nets generate a water drainage space; and therefore, accumulated water on the deck can be rapidly drained; and meanwhile, by lifting the filtering nets, the filtering nets can be rapidly and conveniently lifted from themounting seat so that the cleaning of the filtering nets is made convenient.

The present invention discloses a selenium-rich dietary fiber biscuit for preventing diabetes and a preparation method of the selenium-rich dietary fiber biscuit, and belongs to the technical field offood processing. The selenium-enriched dietary fiber biscuit is prepared by using apple pomace powder, oat flour, buckwheat flour, red bean flour and wheat flour as main raw materials, using mushroompowder, low-fat milk, eggs, olive oil, pumpkins, bitter gourds, celery, Ziyang selenium-enriched green tea and other foods as auxiliary materials, and also being supplemented with parts of vitamins,trace elements, a traditional Chinese medicine extract mainly containing medicinally and edibly homogenous substances, xylitol, a swelling agent, edible salt, etc. The selenium-enriched dietary fiberbiscuit is prepared by raw and auxiliary material preparing, mixing, dough preparing, baking and packaging. In the raw and auxiliary materials of the biscuit, the six substances of high dietary fiberapple pomace powder, food for reducing blood sugar, blood fat and blood pressure, high protein food, vitamins, trace elements and formula traditional Chinese medicines are selected, so that the selenium-rich dietary fiber biscuit plays a role in integrally regulating metabolism of a plurality of systems and various substances of human body, further reduces risk of diabetes, plays an effective regulation function on glucose metabolism of organism from multi-targets, and at the same time also plays functions of preventing diabetes, assisting in reducing glucose and assisting in preventing type 2diabetes complications. Aiming at 4 common constitutions of yin deficiency type, qi-yin deficiency type, yang deficiency type and mild type, 4 biscuits with different formulas are prepared, so that health-care effects of the biscuit is more accurate and effective. The prepared biscuit is rich in nutrition, can also effectively improve dietary nutritional structure of people, and is beneficial toprolonging life after being eaten for a long time.

An injection of compound xylazine for the anesthesia of wild animal is prepared through dissolving xylazine and EDTA in distilled water, adding the solution of dihydroetorphine hydrochloride, stirring, filling it in ampules, and sterilizing.

The present invention relates to the use of a composition comprising a homotrimer, heterotrimer, homotetramer and / or heterotretramer of a component selected from the group comprising pentose, hexose, a L or D isomers thereof, a or form thereof, combinations thereof, an oxidised derivative thereof, or any mixtures thereof, as an agglutination agent for agglutinating enteric pathogens. The present invention also provides a method for selectively controlling and regulating the microbial ecosystem in the gastrointestinal tract of a subject in need thereof.

An injection or freeze-dried powder injection of kakonein is proportionally prepared from kakonein, propanediol, alkaline amino acid (arginine and / or lysine), and nicotinamide.

The present invention provides Nalidixic acid and analogues of Nalidixic acid, pharmaceutical compositions including at least one of Nalidixic acid and analogues of Nalidixic acid, and methods for treating inflammatory ophthalmic disorders by local administration. The ophthalmic disorders may be characterized by ocular inflammation, dry eye disorders, pathological ocular angiogenesis, or retinal or sub-retinal edema.

The invention discloses a wheat flour milling process method and a plurality of wheat products prepared by the method. The wheat flour milling process method is characterized in that the particle size D [90] is subjected to secondary control by utilizing a micro-crushing and grading process, and the gluten protein activity in wheat can be reserved to the greatest extent on the premise of not needing special stabilizing treatment, so that the wheat products which can be stable for a long time, meet the standard and are wide in application are obtained. The invention also discloses an application of the wheat products prepared by the process method in preparation of food or intermediate products of the food.

The invention relates to a diagnostic reagent for Helicobacter pylori and a preparation method thereof. The diagnostic reagent for Helicobacter pylori comprises a radioactive urea [14C] capsule and a gas collection agent supporting the use of the capsule; the radioactive urea [14C] capsule is encapsulated with a urea [14C] ethanol solution and a capsule filler and has radioactivity of 0.85-115mu Ci; the filler is a mixture of mannitol and urea; and the gas collection agent is an absolute methanol solution of hyamine hydroxide and phenolphthalein, wherein the concentration of hyamine hydroxide is 0.475-0.525 mol / L, and the concentration of phenolphthalein is 0.70-0.80 g / L. The diagnosis for Helicobacter pylori infection with the diagnostic reagent provided by the invention has the characteristics of convenience, accuracy and safety.

The invention discloses a bridge expansion joint monitoring connecting device which comprises a bridge body, and an expansion joint being arranged on the bridge body. mounting seats, arranged in the expansion joint, the number of the mounting seats being two, and fixing anchor bolts being arranged on one sides of the two mounting seats; and a monitoring base, arranged between the two mounting bases. Telescopic cavities are formed in the two ends of the monitoring base correspondingly, telescopic detection rods are arranged on the two sides of the monitoring base correspondingly, one end of each telescopic detection rod extends into the corresponding telescopic cavity, and a first pressure sensor is arranged in each telescopic cavity. An elastic head is arranged between the first pressure sensor and the telescopic detection rod, and the elastic head is attached to the first pressure sensor. The working performance of the bridge expansion joint is monitored, and the expansion joint can be repaired in time, so that the use effect of the bridge expansion joint is ensured, vehicles pass stably, and the safety performance of vehicle passing is improved.