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Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens

A pathogenic and functional technology, applied in antiviral agents, metabolic diseases, and vector-borne diseases, can solve problems such as heavy economic costs and high medical costs

Active Publication Date: 2009-06-10
NUTRITION SCI N V
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This tolerance proves fatal to thousands of people each year and results in high medical costs and heavy economic costs (Barton, 1998)

Method used

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  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens
  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens
  • Tri and tetra-oligo-saccharides suitable as agglutination agents for enteric pathogens

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Example 1: Effects of trimannan oligosaccharides and tetramannan oligosaccharides on microbial ecology in poultry gastrointestinal tract system impact

[0049] 3×40 one-day-old chicks were provided with the following feeds: control feed, control feed supplemented with 3 ppm flavomycin, and control feed supplemented with 0.025% trimannooligosaccharides and / or tetramannoligosaccharides. The control feed was a mashed feed consisting of raw materials suitable as animal nutrition. Water and feed were provided ad libitum. Chicks were infected on day 2 with cecal contents of three-week-old chicks (the period when gastrointestinal problems were most severe). Chicks were dissected at regular intervals and enteropathogen content in the small intestine was determined by plate counting on McFarland agar. The results are summarized in figure 1 middle.

[0050] From figure 1 It is clearly seen that trimannanoligosaccharides and / or tetramannoligosaccharides have a positive ef...

Embodiment 2

[0051] Embodiment 2: Three galacturonic acid oligosaccharides and / or four galacturonic acid oligosaccharides (tri-and / or effect of tetra-galacturonic-oligo-saccharide) on chick performance

[0052] The same experimental conditions as described in Experiment 1 were used. Daily growth and feed conversion were monitored after 13 days in this example. The results are summarized in Table 1.

[0053] Table 1: Effects of Tetraoligosaccharides on Chick Performance

[0054]

[0055] From Table 1 it can be concluded that the use of trigalacturonan oligosaccharides and / or tetragalacturonan oligosaccharides in this particular test gave similar results to those obtained with the traditional growth promoter (flavinomycin). However, the mode of action is not comparable (see Example 1).

Embodiment 3

[0056] Example 3: Trigalacturonic acid oligosaccharides and / or tetragalacturonic acid oligosaccharides on the performance of piglets Impact

[0057] At the beginning of the experiment, 5 piglets were housed in each pen. Each column is equipped with a feed trough (arbitrary assembly) in order to give solid pellet feed. Each column is provided with a drinking nipple. Initially the temperature was 28°C until 10 days after weaning. The temperature was then lowered to 25°C. Administer a commercially available drug-free diet. Drug-free means that the piglets did not receive any therapeutic antibiotics before and during the experiment. The diet is administered in pellet form.

[0058] The diet is as follows:

[0059] -Co: control diet

[0060] -Tr: control diet + 0.125% mannan oligosaccharides

[0061] The experimental design was as follows: 2 treatments (Co and Tr) × 16 parallel determinations × 5 piglets.

[0062] At the start of the experiment, piglets (body weight ap...

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PUM

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Abstract

The present invention relates to the use of a composition comprising a homotrimer, heterotrimer, homotetramer and / or heterotretramer of a component selected from the group comprising pentose, hexose, a L or D isomers thereof, a or form thereof, combinations thereof, an oxidised derivative thereof, or any mixtures thereof, as an agglutination agent for agglutinating enteric pathogens. The present invention also provides a method for selectively controlling and regulating the microbial ecosystem in the gastrointestinal tract of a subject in need thereof.

Description

technical field [0001] The present invention relates to the use of trioligosaccharides and tetraoligosaccharides or their extracts or their derivatives or their mixtures as pathogen agglutination agents (agglutination agent). In particular, the present invention relates to trioligosaccharides and tetraoligosaccharides or their extracts or their derivatives or mixtures thereof for the improvement of microbiological activity in the gastrointestinal tract of animals by specific enumeration and subsequent specific excretion of enteric pathogens The use of the ecosystem thus improves animal weight gain, reduces feed conversion and in this way improves animal feed value, health and well-being. Background technique [0002] In modern animal production systems, the balance between the intestinal microflora and the host animal is a delicate one, and disturbance of this balance (eg by bacterial infection) will negatively affect the overall performance of the animal (Eckel, 1999). Kno...

Claims

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Application Information

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IPC IPC(8): A61K31/702A61P31/00A61P1/12
CPCA61K31/702A23L29/30A23L33/30A61P1/00A61P1/12A61P31/00A61P31/04A61P31/12A61P3/04Y02A50/30
Inventor 格特·布吕热曼卡特林·德谢佩
Owner NUTRITION SCI N V
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