The invention relates to a traditional Chinese medicinal preparation for curing malignant pleural effusion, which is body resistance-strengthening and expectoration-eliminating decoction. The malignant pleural effusion is the common complication of cancers, and intrathoracic chemotherapy can prolong control time but has bad unwanted effects. The traditional Chinese medicinal preparation can promote the repairing of the normal tissue of a human body and reduce damages of chemotherapeutic agents to the normal tissue, has the functions of strengthening effects and reducing toxic and side effects and therefore guarantees the smooth completion of the intrathoracic chemotherapy. The traditional Chinese medicinal preparation consists of the following medicaments of: codonopsis pilosula, astragalus membranaceus, prepared rhizome of rehmannia, Chinese angelica, bulbus fritillariae cirrhosae, poria cocos, semen lepidii, liquorice, dried orange peel, trichosanthes kirilowii maxim, grifola, rhizoma alismatis, the root of paris polyphylla, solanum lyratum and the like. Clinical application proves that: the traditional Chinese medicinal preparation has the characteristics of strengthening curing effect, reducing side effect, promoting the repairing of the normal tissue cells and protecting medullary hematopoiesis, increasing appetite, improving the quality of life, well controlling the cancers and the like and can be used as the medicament applied to the intrathoracic chemotherapy synchronously.