The present invention provides articles of manufacture comprising biocompatible nanostructures comprising significantly increased surface area for, e.g., organ, tissue and / or
cell growth, e.g., for bone, tooth,
kidney or liver growth, and uses thereof, e.g., for
in vitro testing of drugs, chemicals or toxins, or as
in vivo implants, including their use in making and using artificial tissues and organs, and related, diagnostic, screening, research and development and therapeutic uses, e.g., as
drug delivery devices. The present invention provides biocompatible nanostructures with significantly increased surface area, such as with
nanotube and
nanopore array on the surface of metallic,
ceramic, or
polymer materials for enhanced
cell and
bone growth, for
in vitro and
in vivo testing, cleansing reaction, implants and therapeutics. The present invention provides optically transparent or translucent
cell-culturing substrates. The present invention provides biocompatible and cell-growth-enhancing culture substrates comprising elastically compliant protruding
nanostructure substrates coated with Ti, TiO2 or related
metal and
metal oxide films.