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482 results about "Pet imaging" patented technology

PET Imaging. Positron emission tomography (PET) is a nuclear imaging technology (also referred to as molecular imaging) that enables visualization of metabolic processes in the body. The basics of PET imaging is that the technique detects pairs of gamma rays emitted indirectly by a positron-emitting radionuclide (also called radiopharmaceuticals,...

Adjusting acquisition protocols for dynamic medical imaging using dynamic models

ActiveUS20100183206A1More standardizedBetter quantifiableImage enhancementImage analysisDynamic modelsHemodynamics
The invention relates to automatically adjusting an acquisition protocol for dynamic medical imaging, such as dynamic CT, MRI or PET imaging. The protocols are adjusted based on anatomic and dynamic models (10, 12, 14) which are individualized or fitted to each patient based on a scout scan (6, 8). The adjustment can compensate for changes in the patient due to patient motion (e.g. breathing or heartbeat) or flow of contrast or tracing agent during the sequence. This ensures that changes in the reconstructed images are indicative of pathological changes in the patient and not caused by patient motion or changes in scanning parameters or timing. The dynamic model can be a motion model (12) used to predict the motion of anatomic / physiologic features, typically organs, during scanning, or a haemodynamic model (14) used to predict flow of the contrast agent allowing for precise timing of the scanning sequence.
Owner:KONINKLIJKE PHILIPS ELECTRONICS NV

Signal processing equipment of PET detector based on neural network localizer

InactiveCN101606846AImproved real-time performance of signal processingHighly integratedComputerised tomographsTomographyPeak valueProper time
The invention provides signal processing equipment of a PET detector based on a neural network localizer. The equipment integrates and realizes procedures for processing a series of signals from a photoelectric switching signal outputted by a detector to the action position coordinate of the gamma ray counted by a neural network in real time. The equipment comprises a compression read processing circuit to an array pixel signal outputted by a photoelectric switching device, an analog-digital switching circuit, an energy identifying and timing circuit, a proper time judging circuit, a base line recovery circuit, a signal peak value estimating circuit, a neural network real-time computing circuit, a USB interface circuit, etc. Due to the realization of the technology for processing various digital nuclear signals based on FPCA and especially the real-time computing of the neural network, the instantaneity and the integration level of the system are greatly improved. The invention has compact structure, complete performance, strong on-line data processing performance, and can be conveniently assembled into an integral detector module with the PET detector, wherein the detector module is important intermediate equipment for researching and developing novel PET imaging equipment based on neural network positioning.
Owner:UNIV OF SCI & TECH OF CHINA

Ligands for imaging cardiac innervation

Novel compounds that find use as imaging agents within nuclear medicine applications (PET imaging) for imaging of cardiac innervation are disclosed. These PET based radiotracers may exhibit increased stability, decreased NE release (thereby reducing side effects), improved quantitative data, and / or high affinity for VMAT over prior radiotracers. Methods of using the compounds to image cardiac innervation are also provided. In some instances the compounds are developed by derivatizing certain compounds with 18F in a variety of positions: aryl, alkyl, a keto, benzylic, beta-alkylethers, gamma-propylalkylethers and beta-proplylalkylethers. Alternatively or additionally, a methyl group a is added to the amine, and / or the catechol functionality is either eliminated or masked as a way of making these compounds more stable.
Owner:LANTHEUS MEDICAL IMAGING INC

Fully digital processing device for positron emission tomography electronics system

The invention relates to a fully-digitalized processing device of a positron emission tomography imaging electronic system, relating to the technical field of medical imaging, in particular to the field of positron emission tomography imaging, more particularly relating to electronics, signal processing and data processing methods and equipment in the positron emission tomography imaging system. The technical scheme of the invention is that the positron emission tomography imaging electronics system comprises detectors, a fully-digitalized electronics system and an image working station, wherein the detectors are annularly arranged in an arrayed way. According to the invention, the structure and the system are greatly simplified; and because the PET (Positron Emission Tomography) signal detection and processing, data acquisition, and the like are realized in a fully-digitalized way, the system integration level is high, the functions are powerful, the processing real-time property is good, the performance is stable and reliably, and the system function adjusting and upgrading are convenient. In the assembly process, the system can be conveniently adjusted and corrected, and the production cost and the production cycle of PET imaging equipment are effectively reduced.
Owner:JIANGSU SINOWAYS (ZHONGHUI) MEDICAL TECH CO LTD

Maximum posteriori reconstruction method of PET (positron emission tomography) image based on generalized entropy and MR (magnetic resonance) prior

The invention discloses a maximum posteriori reconstruction method of a PET (positron emission tomography) image based on generalized entropy and MR (magnetic resonance) prior. The method comprises the following steps: (1) acquiring detection data before PET imaging by PET imaging equipment, meanwhile, obtaining various data correction parameter values in the imaging equipment and a system matrixof the imaging equipment; (2) constructing a mathematic statistical model for reconstructing the PET image; (3) obtaining a PET initial value image by a maximum likelihood method on the basis of mathematic statistical model solution; (4) registering the previously obtained MR image and the PET initial value image; (5) introducing anatomical prior by virtue of the generalized entropy and the registered MR image, carrying out reconstruction model transformation on the mathematic statistical model of the PET image by adopting a maximum posteriori method so as to obtain an optimization equation with a constraint objective function; and (6) carrying out iterative computation by a one-step-behind algorithm so as to finally obtain the final reconstructed medical image. By adopting the method, the visual effect and the quantitative index of the PET reconstructed image can be improved.
Owner:SOUTHERN MEDICAL UNIVERSITY

Compositions and methods for detecting and treating cancer

Macrophages within the tumor microenvironment, also called tumor associated macrophages (TAMs) have been shown to play a major role in the growth and spread of many types of cancer. Cancer cells produce cytokines that cause the macrophages to differentiate into an M2 subtype. We have designed a mannosylated liposome (MAN-LIPs) and successfully showed it to accumulate in TAMs in a mouse model of pulmonary adenocarcinoma. These liposomes are loaded with 64Cu to allow tracking by PET imaging, and contain a fluorescent dye in the lipid bilayer permitting subsequent fluorescence microscopy. MAN-LIPs are a promising new vehicle for the delivery of imaging agents to lung TAMs. In addition to imaging, they hold the potential for delivery of therapeutic agents to the tumor microenvironment.
Owner:UNIV OF VIRGINIA ALUMNI PATENTS FOUND

Curcumin Derivatives for Amyloid-Beta Plaque Imaging

InactiveUS20110208064A1Significant fluorescence property changeImprove lipophilicityNervous disorderMagnetic measurementsInfraredAmyloid beta
The present invention provides curcumin-derived near infrared (NIR) imaging probes. Upon interacting with amyloid β aggregates, these probes undergo a range of changes, qualifying them as “smart” probes. The inventors have demonstrated that probes of the invention have the capacity to monitor the progression of Alzheimer's disease in an in vivo animal model. In addition, the present invention encompasses probes useful as PET imaging agents, MRI imaging agents and multimodal imaging agents, as well as related methods of detecting and imaging amyloid β aggregates and plaques.
Owner:THE GENERAL HOSPITAL CORP

Methods of perispinal extrathecal administration of large molecules for diagnostic use in mammals

This application concerns novel methods which enable or improve the ability of molecules, particularly large molecules, to cross the blood-brain barrier, the blood-eye barrier, and / or the blood-nerve barrier and therefore be of improved diagnostic and / or therapeutic use in humans and other mammals. These methods involve perispinal administration of imaging agents without direct intrathecal injection. Perispinal administration is defined as administration of the molecule into the anatomic area within 10 cm of the spine. Perispinal administration results in absorption of the imaging agent into the vertebral venous system. The vertebral venous system is capable of transporting molecules into the brain, the eye, the retina, the auditory apparatus, the cranial nerves, the head, the spine, the spinal cord, the vertebral bodies, the dorsal root ganglia, and the nerve roots via retrograde venous flow, thereby bypassing the blood-brain barrier and similar barriers and delivering the molecules to the brain, the eye, the retina, the auditory apparatus, the cranial nerves, the head, the spine (including the vertebral bodies), the spinal cord, the dorsal root ganglia, or the nerve roots. This method may be utilized for a wide variety of diagnostic agents, including, but not limited to biologics, monoclonal antibodies, fusion proteins, monoclonal antibody fragments, antibodies to tumor antigens, hormones, cytokines, anti-cytokines, interleukins, anti-interleukins, interferons, colony-stimulating factors, cancer chemotherapeutic agents, growth factors, anti-virals and antibiotics, including those which are radiolabeled, iodinated, or otherwise altered to facilitate diagnostic imaging. Included in these novel methods are perispinal delivery of amyloid imaging agents, and other ligands radiolabeled with [11C] or [18F] to faciliate PET imaging of the brain.
Owner:TACT IP
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