7015 results about "Diarrhea" patented technology

The inventive subject matter relates to the methods for the induction of immunity and prevention of diarrhea resulting from Escherichia coli. The inventive subject matter also relates to the use Escherichia coli adhesins as immunogens and to the construction of conformationally stability and protease resistant Escherichia coli adhesin constructs useful for inducing immunity to Escherichia coli pathogenic bacteria. The methods provide for the induction of B-cell mediated immunity and for the induction of antibody capable of inhibiting the adherence and colonization of Escherichia coli including enterotoxigenic Escherichia coli, to human cells.

The invention includes a method of treating gastrointestinal diseases associated with species of genus Clostridium such as clostridium deficit in human patients with gastrointestinal disorders having an etiological component such as a microbial agent producing a toxin where treated with an antimicrobial composition an amount effective to inhibit or eliminate the microbial agent. The antimicrobial composition in a form of probiotic mixture can be administrated alone or in combination with an antimicrobial agent, such as a bacteriophage which is specific for a bacterium producing toxin or antibiotics which are then used to eliminate or inhibit the clostridial species overgrown in a patient's gastrointestinal tract. Disorders that can be treated by the method of the invention include diarrhea or inflammatory bowel diseases such as colitis or Crohn's disease.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

A novel product comprising a mixture of probiotic and prebiotic ingredients for the treatment of IBS, IBD, Crohn's disease, antibiotic induced diarrhea and other bowel disorders is described herein. Stabilized rice bran derivatives, including stabilized rice bran, RiSolubles, RiceMucil, and Cea100, are used as the source of prebiotics. The prebiotic source is not only rich in fructo-oligosaccharides, but also has potent antioxidants and phytonutrients for intestinal health and the proliferation of bifido-bacteria in the intestines. The probiotics used are different combinations and concentrations of Lactobacilli species, depending on the specific gastrointestinal disease which is targeted. When refrigerated, the products are shelf-stable (95-99%) for at least one year.

There are presented compounds of the formulaor a pharmaceutically acceptable salt thereof, which are active adenosine A2B receptor antagonists and useful in the treatment of diabetes, diabetic retinopathy, asthma and diarrhea.

The present invention provides compositions that contain magnesium and threonate, or a threonate precursor molecule, formulated for extended or modified release to provide physiological concentrations over a desired time period. The extended release or modified release form is particularly useful in providing Mg to a subject while avoiding adverse side effects such as diarrhea.

The invention relates to a feed for early weaned piglets, which belongs to the field of the feed. Main ingredients of the feed comprise expanded corn, full-fat soybean, fat powder, steam fish meal, acidified whey powder, fermented soybean meal, a complex enzyme preparation, a micro-ecological preparation, amino acids, complex vitamins, complex trace elements and the like. The digestive physiological characteristics of the weaned piglets are fully considered on the selection and the processing of raw materials, thereby greatly improving the palatability and the digestion rate of the feed; simultaneously, through the synergistic compatibility of an egg yolk antibody, lactein, sodium humate and the complex micro-ecological preparation, the diarrhea rate of the weaned piglets is reduced, the effects are superior to those of adding antibiotics into the feed, and the feed is the green, environmentally-friendly and nuisanceless feed. An animal feeding experiment proves that the feeding effects are ideal, the palatability is good, the piglets after weaning are high in average feed intake, fast in daily weight gain and low in diarrhea rate, and the feed has a good promoting effect for growth and health conditions of the weaned piglets and can meet the demands of most of raisers at present.

The present invention relates to compounds of Formula I or II, or pharmaceutically acceptable salts, esters, or prodrugs thereof:which relates to morphinan compounds useful as μ, δ, and / or κ receptor opioid compounds and pharmaceuticals containing same that may be useful for mediating analgesia, combating drug addiction, alcohol addiction, drug overdose, mental illness, bladder dysfunctions, neurogenic bladder, interstitial cystitis, urinary incontinence, premature ejaculation, inflammatory pain, peripherally mediated and neuropathic pain, cough, lung edema, diarrhea, cardiac disorders, cardioprotection, depression, and cognitive, respiratory, diarrhea, irritable bowel syndrome and gastro-intestinal disorders, immunomodulation, and anti-tumor agents.

The invention provides a feeding plant essential oil additive. The prescription of the feeding plant essential oil additive comprises the following components by weight percent: 8.5%-12% of cinnamyl aldehyde, 2%-6.5% of thymol, 1.8%-3% of eugenol, 2%-3.5% of carvacrol, 18-30% of palm oil and 50%-60% of a carrier. The invention further provides a preparation method and application of the feeding plant essential oil additive. By reasonably proportioning different types of plant essential oils, the efficient pollution-free plant essential oil feed additive with pretty good food attraction effect is obtained, the incidence rates of diseases including diarrhea, respiratory disease complex and the like can be effectively reduced, the health level of an animal can be obviously improved, animal food intake is increased, and production efficiency is improved.

Guanylin cyclase C compound of the inventions are disclosed. Conjugated compounds comprising guanylin cyclase C compound of the inventions conjugated to detectable or therapeutic moieties are disclosed. Methods of detecting, imaging and treating cancer and treating diarrhea are disclosed.

The present invention discloses a sanitary handwear being a hygienic mitten to be worn about the hand of the user for protection of the hand of the user to be used to clean, wipe babies, self, or older people with bowel control problems. The present invention has a single compartment to house all of the fingers of the hand and a separate compartment for the thumb and has a defined wrist area. The mitten of the present invention is made of two layers. The first, inner layer is waterproof and impermeable, and, the second, outer layer is a moist, extra absorbent cloth-like disposable material containing moisturizers. The mitten is comprised of disposable material so that it may be easily and economically disposed of after use. The mitten also has an internal pull tab to aid in removal of the glove from the hand of the user.

The invention provides compound probiotics fermented Chinese herbal medicine active health care liquid and a preparation method thereof. The health care liquid is prepared by the following raw materials: folium ginkgo, gingko pollen, fructus lycii, tea leaves, bacillus natto, saccharomyces cerevisiae, lactobacilli, acetobacter xylinum, bifidobactirium, white granulated sugar, brown sugar, defatted soy flour, honey, oligosaccharide, sodium chloride, deionized water and the like. The compound probiotics fermented Chinese herbal medicine active health care liquid integrates disease treatment and health care functions of several single products, contains Chinese herbal medicine active ingredients with the functions of preventing and treating hyperlipidemia, hyperglycemia and hypertension, preventing tumors and cancers, enhancing memory, protecting livers, improving immunity, preventing and treating coronary heart diseases, and also contains probiotics groups and metabolic products of the probiotics groups which can regulate balance in the stomach and intestines, resist aging, prolong the life, facilitate digestion, expel toxin for beauty, and prevent and treat thrombi, constipation and diarrhea. The health care liquid integrates health care and treatment, is very wide in market prospect, and conforms to the existing medical viewpoint of people that the prevention, health care, treatment and recovery are combined.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-6 or encompassed by formulas I-VI) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-2 or encompassed by formulas I-II) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The invention discloses a complex enzyme preparation for feeding piglets. The complex enzyme preparation for feeding piglets comprises the following seven enzymes: acid protease, amylase, xylanase, beta-glucanase, cellulase, pectinase and phytase; and the enzymatic activity ratio of the seven enzymes is 1: 1: (8-10): (3.3-4): 1: (0.5-0.55): (0-0.02). By applying the complex enzyme preparation disclosed by the invention, various anti-nutritional factors in feed can be degraded, the viscosity of chyme in an intestinal tract can be reduced, and the metabolic energy of the feed can be improved; the protein and starch digestibility of the piglets can be improved; excessive reproduction of harmful microorganisms in the intestinal tract can be reduced, damage to the intestinal wall can be reduced, and the microecological balance of the intestinal tract can be regulated; the survival rate and disease resistance of the piglets can be improved, the diarrhea rate can be reduced, and the overall uniformity is improved; and the weight gaining of the piglets can be promoted, and the cultivation cost is reduced.

The invention provides compound feed for teaching piglets to eat foods other than breast milk, which is used for weaning piglets and teaching the piglets to eat foods other than breast milk, and comprises the following components in part by weight: 212.4 parts of corn starch, 154.0 parts of bulked corn, 100.0 parts of 46 percent of bulked bean pulp, 40 parts of fish meal, 100 parts of wheat flour, 5 parts of calcium powder, 21 parts of calcium hydrophosphate, 2 parts of table salt, 20 parts of soybean oil, 5 parts of lysine, 2 parts of threonine, 1.5 parts of choline chloride, 10 parts of premix, 0.2 part of complex enzyme, 0.3 part of pig Duowei, 0.2 part of sweetener, 0.3 part of flavouring agent, 3 parts of baking soda, 20 parts of cane sugar, 30 parts of glucose, 50 parts of egg powder, 70 parts of soy protein concentrate, 50 parts of fermented bean pulp, 6 parts of acidizer, 100 parts of whey powder, 0.5 part of mould removing agent, 0.3 part of antioxidant and 0.3 part of mildewpreventive. In the invention, the problems of incomplete immune functions, low disease resistance, inadequate digestive ferment, incomplete upper gastrointestinal development, low digestion and absorption ability, susceptibility to diarrhea and the like of piglets.

The invention provides a pig feed capable of preventing piglets from diarrhea. The pig feed comprises a feed carrier, nano-montmorillonite, acidifier, a probiotic additive, propolis, fish meal, zinc sulfate, chromium nicotinate, methionine, lysine, choline chloride, salt, vitamin A, vitamin E, riboflavin and a traditional Chinese medicine feed additive. The use of the pig feed can decrease diarrhea rate, reduce the occurrence of diseases, promote the fast growth of piglets and increase economic benefits of farmers.

There is disclosed herein a composition for treating gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the composition comprising: (i) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (ii) at least one anti-clostridial agent selected from the above combined with an opioid blocking agent. There is also disclosed herein a method of treating various gastrointestinal or neurological disorders, constipation, functional constipation, irritable bowel syndrome, diverticulitis, travelers diarrhea, chronic idiopathic nausea, IBD-associated constipation and diarrhea, pseudo-obstruction, diabetic gastroparesis, cyclic vomiting, reflux oesophagitis, autism enteropathy, flatulence, halitosis, chronic fatigue, bloating, proctalgia fugax, Parkinsons disease, MS, Alzheimers Disease, Motor Neurone Disease or autism, the method comprising administering orally, via enema or by suppository: (i) a composition of the invention; (ii) at least two anti-clostridial agents selected from the group consisting of: vancomycin, vancomycin derivatives, a multi-valent polymer of vancomycin, aminoglycosides, nitroimidazoles, ansamysins, nifuroxazide, colchicine, prucalopride, prokinetic agent and 5-aminosalicylic acid; or (iii) at least one anti-clostridial agent selected from the above and an opioid blocking agent to a patient in need of such treatment.

The invention discloses a method for propagating market hogs. According to the different growth and physiological stages of the market hogs, the growth of the market hog comprises the stages of lactation and luring, weaning and stress, pigling breeding, growing development and beef gain, fodder with good nutrition, smell, and luring performance is provided in the stage of lactation and luring; fodder with diarrhea resistance and high nutrition concentration and capable of keeping the healthy of intestinal tract is provided in the stage of weaning and stress; fodder capable of strengthening immunity, promoting growth and exercising the intestinal tract is provided in the pigling breeding; fodder for increasing nutrition and protein synthesis is provided in the stage of growing development;the fodder with high energy and high amino acid is provided in the beef gain. According to the method, the fodder is schemed according to the physiology and development stage and the stress conditions; the method has the advantages of low mortality, quick growth speed, short propagation period, low feed conversion ratio, high weight and the like; in addition, the propagation cost of the market hog is lowered, and the economic benefits of propagating market hog are improved.

Compositions and methods for providing relief from pain and / or discomfort associated with gastrointestinal disorders, including, for example, bloating, crying, gas, cramping, regurgitation, diarrhea and gastrointestinal pain, associated with colic comprising, at least one antiflatulent, at least one histamine H1-receptor antagonist, and optionally, one or more prebiotic and / or one or more probiotic.

The invention provides a targeted sgRNA for editing a pig APN gene and a modified carrier as well as a preparation method and application thereof, and relates to the technical field of gene engineering. The sgRNA and the gene modified carrier provided by the invention are strong in speciality, and effectively edit the pig APN gene on cell level by a CRISPR / Cas9n system, and positive cells are edited by the obtained APN gene into donor cells to carry out somatic cell cloning and embryo transferring, so that the obtained APN gene edited cloning pig has ability of resisting piglet diarrhea. According to the preparation method of the piglet diarrhea resistant pig provided by the invention, a receptor of a virus causing the piglet diarrhea is destroyed, any other exogenous genes cannot be introduced except edition of a targeted gene APN, non-speciality edition on a non-APN gene area on a gene group cannot be carried out, a genetic background is clean and clear, and a late safety assessment work of transgenesis is greatly reduced.

The present invention relates to a piglet feed additive and a preparation method thereof, particularly to a weaned piglet feed additive with functions of feed utilization rate increase and piglet diarrhea reduction, and a preparation method thereof. In the prior art, piglets are easily subjected to diarrhea so as to affect feed intake and growth and development of piglets, and a piglet feed utilization rate is not high. To overcome the defects in the prior art, the present invention provides a new piglet feed additive, which does not contain antibiotics, and adopts probiotics, biological enzymes, amino acids and other materials as main components. After the piglet feed additive is added to a piglet feed, piglet diarrhea after weaning can be substantially relieved, a feed utilization rate can be significantly increased, and piglet growth and development conditions can be improved. In addition, the additive is suitable for popularization and application in the aquaculture industry.

The present invention relates to compositions and methods for treating a disease in an animal, which disease is responsive to inhibiting of functional cystic fibrosis transmembrane conductance regulator (CFTR) polypeptide by administering to a mammal in need thereof an effective amount of a compound defined herein (including those compounds set forth in Tables 1-14 or encompassed by formulas I-XII) or compositions thereof, thereby treating the disease. The present invention particularly, relates to a method of treating diarrhea and polycystic kidney disease.

The invention provides a therapeutical composition comprising purified fractions of compounds being or containing a pathogen-inhibiting oligosaccharide sequence for use as a medicament. The present invention especially describes an oligosaccharide-containing substance or receptor binding to diarrheagenic Escherichia coli and / or zoonotic Helicobacter species, and use thereof in, e.g., pharmaceutical, nutritional and other compositions for prophylaxis and treatment of conditions due to the presence of Escherichia coli and / or zoonotic Helicobacter species. The invention is also directed to the use of the receptors for diagnostics of Escherichia coli and / or zoonotic Helicobacter species.

The invention belongs to the field of feed additives, more particularly relates to a compound micro-ecological preparation. The compound micro-ecological preparation contains probiotic bacteria, probiotics, saccharicterpenin and carriers according to the weight proportion of 1:1-2:0.1-1:1-10. The compound micro-ecological preparation realizes the optimally-effective proportioning of the probiotic bacteria, the probiotics and the saccharicterpenin, and the proportioning is reasonable and can fully give the synergy of the probiotic bacteria, the probiotics and the saccharicterpenin; the compound micro-ecological preparation can be taken as a substitute product of antibiotics while being used as a feed additive, eliminates drug residues and improves the quality of products, such as meat, eggs, milk, and the like; and the compound micro-ecological preparation can be also used for preventing and curing various animal diarrheas, improving immunity and disease resistance and reducing the death ratio of animals, can improve the feed conversion ratio and the animal production performance (increase the output of meat, eggs and milk), has better effects to livestock and poultry in all growth stages and is convenient for purifying barn environment and protecting and improving the ecological environment.

The invention provides methods for diagnosing impending diarrhea in an asymptomatic animal. The methods comprise obtaining a fecal sample from the animal; identifying one or more microorganisms in the fecal sample; and diagnosing impending diarrhea in the animal based on the presence or absence of one or more of the microorganisms.

The invention discloses a traditional Chinese medicine vegetable feed additive containing honeysuckle and a preparation method thereof. The formula of the traditional Chinese medicine vegetable feed additive includes honeysuckle, forsythia, herba houttuyniae, mulberry leaves, radix scutellariae, radix isatidis, liquorice, haws, dried tangerine peels, pine needles, argy wormwood leaves, plantain and the like. The honeysuckle, the forsythia, the herba houttuyniae and the mulberry leaves have the efficacy of clearing heat, removing toxicity, resisting bacteria and diminishing inflammation; the haws and the dried tangerine peels have the efficacy of invigorating the stomach and improving digestion; the pine needles have the efficacy of dispelling wind, eliminating dampness, killing parasites,relieving itching, nourishing the heart and soothing the nerves; the argy wormwood leaves have the effects of reducing dampness, killing parasites and dispelling cold to relieve pain; and the plantain can reduce fever, cause diuresis, eliminate phlegm, relieve a cough, drain dampness and check diarrhea. After the formula is partially extracted with water or alcohol or partially ground, the formula and spray-dried extract powder are then mixed and produced into granules, which are dried. When in use, the traditional Chinese medicine vegetable feed additive is directly added into feed accordingto a certain proportion, consequently, the immunity of animals can be enhanced, various cold and gastrointestinal diseases can be prevented and treated, the quality of the feed is improved, the appetite of animals can be increased, the feed utilization rate can be increased, and the quality of livestock and poultry products can be increased.

Methods, compositions, and systems are provided for detecting one or more a gastrointestinal issues by characterizing the microbiome of an individual, monitoring such effects, and / or determining, displaying, or promoting a therapy for the gastrointestinal issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and / or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and / or therapy model for constipation issues, diarrhea issues, hemorrhoids issues, bloating issues, and lactose intolerance issues.

This invention relates to novel compounds which are inhibitors of the Rearranged during Transfection (RET) kinase, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination, for the normalization of gastrointestinal sensitivity, motility and / or secretion and / or abdominal disorders or diseases and / or treatment related to diseases related to RET dysfunction or where modulation of RET activity may have therapeutic benefit including but not limited to all classifications of irritable bowel syndrome (IBS) including diarrhea-predominant, constipation-predominant or alternating stool pattern, functional bloating, functional constipation, functional diarrhea, unspecified functional bowel disorder, functional abdominal pain syndrome, chronic idiopathic constipation, functional esophageal disorders, functional gastroduodenal disorders, functional anorectal pain, inflammatory bowel disease, proliferative diseases such as non-small cell lung cancer, hepatocellular carcinoma, colorectal cancer, medullary thyroid cancer, follicular thyroid cancer, anaplastic thyroid cancer, papillary thyroid cancer, brain tumors, peritoneal cavity cancer, solid tumors, other lung cancer, head and neck cancer, gliomas, neuroblastomas, Von Hippel-Lindau Syndrome and kidney tumors, breast cancer, fallopian tube cancer, ovarian cancer, transitional cell cancer, prostate cancer, cancer of the esophagus and gastroesophageal junction, biliary cancer, adenocarcinoma, and any malignancy with increased RET kinase activity.

The invention provides a novel safe biological feed which comprises basic ration, sodium humate, montmorillonite and synbiotics. To feed the livestock and poultry with the novel safe biological feed of the invention can reduce the condensation of ammonia gas in animal houses and improve cultivation environment, meanwhile, the invention enhances the immunity of animal organism, keeps balance of intestinal flora of the livestock and poultry to avoid diarrhea and dysentery and advances the feed conversion ratio and egg production rate.