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820 results about "Microbiome" patented technology

A microbiome is "the ecological community of commensal, symbiotic, and pathogenic microorganisms that literally share our body space." Joshua Lederberg coined the term, arguing the importance of microorganisms inhabiting the human body in health and disease. Many scientific articles distinguish "microbiome" and "microbiota" to describe either the collective genomes of the microorganisms that reside in an environmental niche or the microorganisms themselves, respectively. However by the original definitions these terms are largely synonymous. The human body contains over 10 times more microbial cells than human cells, although the entire microbiome only weighs about 200 grams, with some weight estimates ranging as high as 3 pounds. Some regard it as a "newly discovered organ" since its existence was not generally recognized until the late 1990s and it is understood to have potentially overwhelming impact on human health. Modern techniques for sequencing DNA have enabled researchers to find the majority of these microbes, since the majority of them cannot be cultured in a lab using current techniques.

Methods of combining metagenome and the metatranscriptome in multiplex profiles

InactiveUS20130121968A1Increased use of antibioticBiocideBacteriaBacteroidesMetabolite
The present invention describes changes in bacterial gastrointestinal, cutaneous and nasal microbiota associated various mammalian medical conditions. Described are diagnostic tests that arise from combining phylogenetic information about the families, genus, and species of the microbiome and their relative abundance with the metabolic information contained in the metatranscriptome to determine the presence and absence of a disease or medical condition. Provided are compositions of bacteria, co-cultures of bacteria and a carrier for use in treating the disclosed medical conditions. The described compositions restore or correct disease- or medical condition-related imbalances in the microbiome profile with culture-conditioned formulations in which the transcriptome activity of the administered organisms is optimized. Alternatively, formulations of metabolites that drive changes in the metatranscriptome native to the mammal that treat disease or a medical condition or restore health are taught.
Owner:ENSISHEIM PARTNERS

Method of treating gastrointestinal diseases associated with species of genus clostridium

The invention includes a method of treating gastrointestinal diseases associated with species of genus Clostridium such as clostridium deficit in human patients with gastrointestinal disorders having an etiological component such as a microbial agent producing a toxin where treated with an antimicrobial composition an amount effective to inhibit or eliminate the microbial agent. The antimicrobial composition in a form of probiotic mixture can be administrated alone or in combination with an antimicrobial agent, such as a bacteriophage which is specific for a bacterium producing toxin or antibiotics which are then used to eliminate or inhibit the clostridial species overgrown in a patient's gastrointestinal tract. Disorders that can be treated by the method of the invention include diarrhea or inflammatory bowel diseases such as colitis or Crohn's disease.
Owner:UNITED STATES OF AMERICA

Antimicrobial compositions and methods

InactiveUS20050058673A1Effective topical antimicrobial activityReduce usageAntibacterial agentsCosmetic preparationsEtherFatty acid ester
Antimicrobial compositions, especially those useful when applied topically, particularly to mucosal tissues (i.e., mucous membranes), including a fatty acid ester, fatty ether, or alkoxide derivative thereof. The compositions can also include an enhancer component, a surfactant, a hydrophobic component, and / or a hydrophilic component. Such compositions provide effective topical antimicrobial activity and are accordingly useful in the treatment and / or prevention of conditions that are caused, or aggravated by, microorganisms (including viruses).
Owner:3M INNOVATIVE PROPERTIES CO

Gut microflora as biomarkers for the prognosis of cirrhosis and brain dysfunction

A systems biology approach is used to characterize and relate the intestinal (gut) microbiome of a host organism (e.g. a human) to physiological processes within the host. Information regarding the types and relative amounts of gut microflora is correlated with physiological processes indicative of e.g., a patient's risk of developing a disease or condition, likelihood of responding to a particular treatment, for adjusting treatment protocols, etc. The information is also used to identify novel suitable therapeutic targets and / or to develop and monitor the outcome of therapeutic treatments. An exemplary disease / condition is the development of hepatic encephalopathy (HE), particularly in patients with liver cirrhosis.
Owner:VIRGINIA COMMONWEALTH UNIV +1

Methods for promoting weight loss and associated arrays

Methods of modulating body fat or weight loss are presented Nucleic acid and protein microarrays that comprise biomolecules associated with an obese host microbiome or a lean host microbiome are utilized for analysis.
Owner:WASHINGTON UNIV IN SAINT LOUIS

Apparati, methods, and compositions for universal microbial diagnosis, detection, quantification, and specimen-targeted therapy

InactiveUS20120129794A1Increase productivityAccurate and rapid and sensitive microbial diagnosis and detection and quantificationAntibacterial agentsBiocidePopulationMolecular Targeted Therapies
Microbial ecology of a specimen is evaluated using an approach (Level I) that utilizes nucleic acid amplification with specific gene primers that will identify panels of microorganisms and antibiotic-resistance factors generating a diagnostic report (optionally with quantification of each microorganism or antibiotic-resistance factor) and an approach (Level II) that utilizes universal or semi-universal primers to amplify conserved genes at a general or specific taxonomic level that are tagged specimen specifically using a genetic or chemical marker that is specific to the specimen from which it was derived, then sequencing the amplified products with highly-parallel, high-throughput technology to provide comprehensive sequences of the microbial population in the specimen followed by analysis of this sequence information and specific targeted information from Level I and / or Level II to generate a comprehensive analysis, interpretation, and / or diagnostic report.
Owner:DOWD SCOT E +2

Targeted antimicrobial moieties

This invention provides novel targeted antimicrobial compositions. In various embodiments chimeric moieties are provided comprising an antimicrobial peptide attached to a peptide targeting moiety that binds a bacterial strain or species.
Owner:C3 JIAN +1

Antimicrobial treatment of nonwoven materials for infection control

A material substrate having at least part of a surface treated with an antimicrobial composition is described. The antimicrobial composition exhibits at least a 3 log10 CFU reduction within a period of about 30 minutes after contact with various species of a broad spectrum of microorganisms. The substrate can be a nonwoven material that has good fluid barrier properties, which can be used in protective garments and sheets. Methods for manufacturing and imparting the antimicrobial treatment to the substrate are also provided.
Owner:KIMBERLY-CLARK WORLDWIDE INC

Topical anti-microbial compositions

Disclosed are topical compositions for the treatment of microbial infections on the skin or scalp which include a polyvalent metal salt of pyrithione and include a metal ion source. Also disclosed are methods for treating microbial infections of the skin or scalp using such compositions.
Owner:THE PROCTER & GAMBLE COMPANY +1

Methods of preparing antimicrobial compositions comprising ozone

The invention relates to the formation of antimicrobial solutions formed by ozonating a liquid containing organic precursor molecules. The preferred organic precursor molecules include carboxylic acids, most particularly octanoic acid with or without acetic acid, and alcohols, most particularly greater than 80 weight percent ethanol. The ozonating step is preferably performed with minimal or no water present in the liquid containing the organic precursors. After ozonation is complete, the ozonated liquid may be diluted with water or other solvent to form a use solution for contacting and cleaning a microbially contaminated surface or other medium.
Owner:LYNNTECH

Antimicrobial compositions and methods

The present invention is generally related to a product and process to reduce the microbial contamination on organic matter, such as processed meat, fruits and vegetables, plant parts, inanimate surfaces such as textiles and stainless steel, and in the mouth or on dental products. In particular, the invention is related to a product and process to disinfect surfaces using an antimicrobial composition containing an antimicrobial lipid, an enhancer selected from the group consisting of bacteriocins, antimicrobial enzymes, sugars, sugar alcohols, iron-binding proteins and derivatives thereof, siderophores, and combinations thereof, and optionally a surfactant.
Owner:3M INNOVATIVE PROPERTIES CO

In situ methanogenesis modeling and risk analysis

ActiveUS20110308790A1Enhancing methanogenic rateEnhance methanogenic degradationSurveyBacteriaComputational modelMicrobiome
This invention generally relates to natural gas and methylotrophic energy generation, bio-generated fuels and microbiology. In alternative embodiments, the invention provides nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis, or “methylotrophic” conversion. Additionally, the invention provides methods to develop nutrient amendments and microbial compositions that are both specifically optimized to stimulate methanogenesis in a given reservoir. The invention also provides methods for the evaluation of potentially damaging biomass formation and scale precipitation resulting from the addition of nutrient amendments. In another embodiment, the invention provides methods for simulating biogas in sub-surface conditions using a computational model.
Owner:CONOCOPHILLIPS CO

Methods and compositions relating to microbial treatment and diagnosis of skin disorders

The present disclosure provides methods, systems, compositions, and kits to address the need for microbiome-related treatment of health conditions and disease. The disclosure provides compositions and methods for the treatment of skin disorders using microbial compositions to a subject.
Owner:WHOLE BIOME

Cationic Steroid Antimicrobial Compositions and Methods of Use

The invention provides methods for decreasing or inhibiting human immunodeficiency virus (HIV) infection or pathogenesis (e.g., illness) of a cell in vitro, ex vivo or in vivo, a symptom or pathology associated with human immunodeficiency virus (HIV) infection or pathogenesis (e.g., illness) in vitro, ex vivo or in vivo, or an adverse side effect of human immunodeficiency virus (HIV) infection or pathogenesis (e.g., illness) in vitro, ex vivo or in vivo. In one embodiment, a method of the invention includes treating a subject with an invention compound (e.g., cationic steroid antimicrobial or CSA).
Owner:BRIGHAM YOUNG UNIV +1

Methods and systems for microbiome characterization, monitoring and treatment

ActiveUS20150259728A1Better clinical outcomeHigh risk of diseaseBiocideBacteriaMedicineMicrobiome
The present disclosure provides methods for profiling a microbiome and therapeutic compositions for treatment. Additionally, the methods, systems, compositions and kits provided herein are directed to assessing or predicting health status in a subject. Some of the embodiments include generating a report.
Owner:WHOLE BIOME

Stable antimicrobial compositions including spore, bacteria, fungi, and/or enzyme

The present invention relates to a stable antimicrobial and cleaning compositions including an amine antimicrobial agent; a borate salt; and spores (bacterial or fungal), vegetative bacteria, fungi, or enzyme, and to methods of using the composition. The composition can also include a polyol.
Owner:ECOLAB USA INC

Antimicrobial compositions, methods and systems

InactiveUS20080033026A1Broad antimicrobial activity spectrumEfficacious activityBiocideDead animal preservationDecenoic AcidPHENOL LIQUID
The invention provides methods for treating a surface, the method including steps of applying a surface treatment composition to a surface, wherein the surface treatment composition includes a substantially phenol-free cleansing agent and an antimicrobial agent, the antimicrobial agent comprising 9-decenoic acid, a salt of 9-decenoic acid, an ester of 9-decenoic acid, or a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to control microbial growth. Also described are methods for treating a surface that include the step of applying a surface treatment composition having a pH in the range of 4.1 to 8.5 to a surface, wherein the surface treatment composition includes a cleansing agent and an antimicrobial agent, the antimicrobial agent comprising 9-decenoic acid, a salt of 9-decenoic acid, an ester of 9-decenoic acid, or a combination thereof, wherein the antimicrobial agent is present in an amount sufficient to control microbial growth. Also described are surface treatment compositions including the antimicrobial agents.
Owner:ELEVANCE RENEWABLE SCIENCES INC

Altered microbiome of chronic pelvic pain

Provided herein are kits, compositions, and methods for diagnosing and treating interstitial cystitis (IC) and / or interstitial cystitis / bladder pain syndrome (IC / BPS) based on finding lower levels of certain bacteria in a subject's stool sample (e.g., O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis). In certain embodiments, then present invention provides probiotic formulations containing live bacteria (e.g., from O. splanchnicus, F. prausnitzii, C. aerofaciens, E. sinensis, L. longoviformis, and R. intestinalis).
Owner:THE BOARD OF TRUSTEES OF THE UNIV OF ILLINOIS +1

Use of blood group status iii

The present invention relates to a microbial composition which is tailored based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from the intestine of secretor individuals. The present invention further relates to a method of tailoring a microbial composition based on the spectrum of microbes found more frequently from the intestine of non-secretor individuals than from that of secretor blood group status. The present invention relates to use of the secretor status of an individual as a criterion for microbial supplementation tailored based on the differences in the spectra of microbes found between secretor and non-secretor individuals.
Owner:DUPONT NUTRITION BIOSCIENCES APS

Antimicrobial compositions, products and methods employing same

Antimicrobial compositions that provide enhanced immediate and residual anti-viral and antibacterial efficacy against rhinovirus, rotavirus, coronovirus, respiratory syncytial virus, Gram-positive bacteria, Gram-negative bacteria and combinations thereof. More specifically, antimicrobial compositions comprising an organic acid or organic acid mixture and a short-chain anionic surfactant having at least one of a large head group; a branched alkyl chain and an unsaturated alkyl chain. Further, products incorporating the antimicrobial compositions of the present invention and methods of using the antimicrobial compositions and products are disclosed herein.
Owner:THE PROCTER & GAMBLE COMPANY

Antimicrobial composition comprising benzoic acid analog and metal salt

The present invention relates to antimicrobial compositions which provide enhanced immediate as well as residual anti-viral and antibacterial efficacy. The antimicrobial compositions of the present invention provide previously unseen residual effectiveness against Gram negative bacteria, Gram positive bacteria, and viruses, fungi, and improved immediate germ reduction upon use. These compositions comprise: a) a safe and effective amount of a benzoic acid analog; b) a safe and effective amount of a metal salt; and c) a dermatologically acceptable carrier for the acid and salt wherein said composition has a pH of from about 1 to about 7. The invention further relates to methods of use for the present compositions as well as antimicrobial products which incorporate the compositions.
Owner:THE PROCTER & GAMBLE COMPANY

Method and system for microbiome-derived diagnostics and therapeutics for conditions associated with gastrointestinal health

Methods, compositions, and systems are provided for detecting one or more a gastrointestinal issues by characterizing the microbiome of an individual, monitoring such effects, and / or determining, displaying, or promoting a therapy for the gastrointestinal issue. Methods, compositions, and systems are also provided for generating and comparing microbiome composition and / or functional diversity datasets. Methods, compositions, and systems are also provided for generating a characterization model and / or therapy model for constipation issues, diarrhea issues, hemorrhoids issues, bloating issues, and lactose intolerance issues.
Owner:PSOMAGEN INC

Therapeutic antimicrobial compositions and methods

InactiveUS20050271711A1Applied to skinImmediate and residual effectivenessAntibacterial agentsBiocideOrganic acidRotavirus RNA
Therapeutic antimicrobial compositions and methods for providing enhanced immediate and residual anti-viral and antibacterial efficacy against rhinovirus, rotavirus, coronovirus, respitory syricytial virus, Gram-positive bacteria, Gram-negative bacteria and combinations thereof. More specifically, therapeutic antimicrobial compositions comprising an organic acid or organic acid mixture and a short-chain anionic surfactant having at least one of a large head group; a branched alkyl chain and an unsaturated alkyl chain, and therapeutic methods of use thereof.
Owner:THE PROCTER & GAMBLE COMPANY

Method and system for microbiome-derived diagnostics and therapeutics

A method for diagnosing and treating an immune microbial dysfunction in a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the immune microbial dysfunction based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset, wherein the characterization is diagnostic of at least one of Crohn's disease, inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), ulcerative colitis, and celiac disease; based upon the characterization, generating a therapy model configured to correct the immune microbial dysfunction; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
Owner:PSOMAGEN INC

Antimicrobial compositions and applications therefore

InactiveUS20100092398A1Negligible level of toxicityLow toxicityBiocideHydroxy compound active ingredientsEssence oilMelaleuca
A composition derived from an essential oil obtained from one or more plants of the Melaleuca family in which at least 80% of the monoterpene content of the oil has been removed. Practical uses of the composition including antimicrobial, antiviral and therapeutic applications. Medical devices to which the composition has been applied and / or absorbed thereon.
Owner:REYNOLDS MAX

Antimicrobial compositions and methods of use

The present invention relates to compositions and methods for decreasing the infectivity, morbidity, and rate of mortality associated with a variety of pathogenic organisms and viruses. The present invention also relates to methods and compositions for decontaminating areas colonized or otherwise infected by pathogenic organisms and viruses. Moreover, the present invention relates to methods and compositions for decreasing the infectivity of pathogenic organisms in foodstuffs. In particular, decreased pathogenic organism infectivity, morbidity, and mortality is accomplished by contacting the pathogenic organism with an oil-in-water nanoemulsion comprising an oil, an organic solvent, and a surfactant dispersed in an aqueous phase.
Owner:RGT UNIV OF MICHIGAN
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