The invention provides a convenient, economical, practical and efficient new drug, namely a tincture for treating various pain caused by rheumatism, which is capable of achieving the optimal treatment effect that previous similar achievements fail to reach and is applicable to external use so as to diminish inflammation and relieve pain; the tincture for treating various pains caused by rheumatism is a secret prescription handed down from YAN Keqin family in Yuncheng of Shanxi, and the tincture includes a solvent preparation method of the secret prescription; the secret prescription: 36 kinds of Chinese herbal medicines such as flos carthami, rhizoma galangae, radix angelicae sinensis, radix notoginseng, rhizoma ligustici wallichii, radix astragali and the like as well as a solvent namely alcohol; functions: expelling wind, removing cold and dredging collaterals, repairing damaged nerve cells, promoting regeneration of body's new tissues. Major function: the secret prescription is effective on treating various pain syndromes such as rheumatic pain, pain in neck, shoulders, waist and legs, and the like. The medicine (the tincture), in accordance with 'Impregnation Method', is prepared by mixing the 36 kinds of Chinese herbal medicines according to the secret prescription, preparing an obtained mixture into powder by virtue of a nano-granulating technology, sealing the obtained powder, together with the solvent, in a container, then storing the container in a cellar or a sealed chamber, shaking once every day and shaking once every other day after one week; filtering and removing dregs on the 16th day after 15 days, collecting an obtained medicine and performing packaging, so that a finished product is obtained. The tincture is applicable to external use and is smeared in affected parts. The optimal therapy method: firstly, cupping for 15 min, removing cups and smearing the medicine, covering the medicine with a film, massaging and ending.