1104results about How to "Good hypoglycemic effect" patented technology

The present invention relates to a therapeutic agent for diabetes with sulfonylurea secondary failure, which contains a GPR40 agonist. According to the present invention, a therapeutic agent for diabetes with sulfonylurea secondary failure that affords a superior insulin secretion effect and a superior hypoglycemic effect even in diabetic patients for whom a sulfonylurea compound or a fast-acting insulin secretagogue fails to provide an insulin secretion effect and therefore, fails to provide a sufficient hypoglycemic effect can be provided.

The present invention relates to a novel pyridine derivative or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the derivative or ester, which has an excellent hypoglycemic effect or treats and / or prevents the onset of a disorder of carbohydrate or lipid metabolism or a disease mediated by peroxisome proliferator-activated receptor (PPAR) γ. A compound represented by the general formula (I):[wherein R represents a pyridyl group substituted with 1 to 3 group(s) independently selected from Substituent Group A, and Substituent Group A represents a halogen atom, a C1-C6 alkyl group and a C1-C6 alkoxy group] or a pharmacologically acceptable ester thereof, or a pharmacologically acceptable salt of the compound or ester.

The present invention is process of extracting 1-deoxy nojirimycin (DNJ) from mulberry leaf. Mulberry leaf extract is treated with inorganic acid, cooled to eliminate impurity and column chromatographically separated to obtain DNJ. Animal experiment of mouse shows that the mulberry leaf extract has obvious blood sugar reducing effect, so that the present invention may be used in preparing blood sugar reducing health product. The present invention has low preparation cost, and is suitable for industrial production.

The invention discloses a composition and an application thereof in regulating intestinal flora of animals. The composition contains aloe, probiotics and prebiotics, wherein the mass ratio of the aloe to the probiotics to the prebiotics is (6 to 3 to 1)-(6 to 1 to 3). The inventor discovers that the composition disclosed by the invention can effectively promote the proliferation of useful bacteria such as bifidobacterium and lactobacilli in animal intestines, so as to effectively regulate the intestinal flora of animals; therefore, the composition can be used for preventing or treating diabetes on the basis of the effect of the intestinal flora.

The present invention provides one oral liquid for treating diabetes based on the treating principle of benefiting vital energy, nourishing Yin, invigorating spleen and activating thin fluid. The composite medicine has 14 kinds of Chinese medicinal materials including ginseng, sealwort, atractylodes rhizome, flavescent sophora root, ophiopogon root, etc. The pharmacological test shows that the medicinal oral liquid of the present invention can reduce the blood sugar level of rat of hyperglycaemia and raise the activity of SOD while producing no obvious effect on the secretion of insulin and blood fat.

The invention discloses a traditional Chinese medicine composition for treating insulin dependent diabetes and insulin resistant diabetes. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal raw materials: ginseng, astragalus root, angelica sinensis, stir fried bighead atractylodes rhizome, tuckahoe, Chinese atractylodes, Chinese yam, kudzu root, prepared rehmannia root, fenugreek, white peony root, beef kidney, cinnamon, wolfberry fruit, magnolia vine fruit and the like. The invention also relates to a preparation method of the traditional Chinese medicine composition, and application thereof in preparing medicaments for treating insulin dependent diabetes and insulin resistant diabetes. The composition disclosed by the invention has multiple advantages of good curative effect, convenience in taking, no adverse reaction and the like.

The invention relates to a fusion protein of a human glucagon-like peptide -1(hGLP-1) analogues and the preparation method for the fusion protein, wherein, the fusion protein is a pro-drug with high biological stability and long half-life in vivo that releases active GLP-1 molecule after being degraded by enzyme in vivo and then brings into playing the pharmacological action. The scope of the invention extends to the treatment application of the products made by the production technique. The fusion protein can be used for treating and preventing the diseases or disorders relating the GLP-1 activity, in particular to the 2 Diabetes Mellitus. The fusion protein of a human glucagon-like peptide -1(hGLP-1) analogues and the preparation method for the fusion protein relates to the biotechnological field, with the fusion protein prepared by the gene engineering method, which has the advantages of much lower production cost than the chemical synthetic method, simple operation, and easy acquisition of raw material, and has possibility for commercial production.

The invention belongs to the technical filed of medicines, and concretely relates to optically pure benzyl-4-chlorophenyl C-glucoside derivatives represented by formula (II) and formula (III), a method for preparing the above compounds and intermediates thereof, a medicinal preparation and a medicinal composition containing the compounds, and an application of the optically pure benzyl-4-chlorophenyl C-glucoside derivatives in the preparation of medicines for treating and / or preventing insulin-dependent diabetes, non-insulin dependent diabetes, insulin resistance diseases or obesity, various diabetes and relevant diseases as a sodium-glucose cotransporter (SGLT) inhibitor.

The present invention is sand sage polysaccharide, prepared with sand sage seed deoiling dreg as material and through extraction, separation, enzymolysis and chromatographic separation, and its preparation process and application. The preparation process features 50-80 concentration alcohol solution extraction, extraction with mixed chloroform and normal butyl alcohol liquid, enzymolysis with papain, and chromatographic separation in sephadex G-20 column. Sand sage polysaccharide is used in treating alloxan diabetes, reducing the damage of liver and kidney caused by diabetes, lowering the content of glutamic-oxaloacetic transminase, glutamic-pyruvic transminase and urea nitrogen in blood, and inhibiting diabetes caused weight loss.

The invention discloses a health care product with the function of reducing blood sugar. The health care product comprises L-arabinose, chromium-enriched yeast and any one or more of taurine, Chinese wolfberry extract, L-carnitine tartrate and bitter melon extract. The health care product has the functions of reducing the blood sugar and controlling blood fat simultaneously, has good taste, and is particularly suitable for patients with diabetes.

The invention discloses a natural medicament with the functions of hyperglycemic and lipid lowering as well as weight losing. The medicament is a resveratrol compound pigeon bean acid ketone A which can be prepared into a medicament preparation for curing diabetes or adiposity, and can also be prepared into a health-care food which is beneficial to a diabetes suffer or an adiposity suffer. The invention simultaneously discloses a compound of a plant source containing the pigeon bean acid ketone A as well as the use of the medicament and the health-care food thereof used for curing the diabetes.

The present invention provides a lactam compound, a sugar transport enhancement agent containing this compound as an active ingredient, an agent for the prevention and / or treatment of diabetes mellitus, diabetic peripheral neuropathy, diabetic nephropathy, diabetic retinopathy, diabetic macrovascular disease, glucose tolerance anomaly, obesity and the like. In addition, the present invention also provides a preparation method for the novel lactam compound, and a preparation intermediate thereof.

The invention discloses balsam pear fermented mung bean milk with a hypoglycemic effect. The fermented mung bean milk is prepared by the following raw materials, by weight, 3 to 5 parts of hypoglycemic fruit and vegetable puree, 6 to 7 parts of hypoglycemic Chinese medicinal solutions, 0.5 to 0.7 part of freeze-dried powder of balsam pear, 0.3 to 0.4 part of coptis powder, 4 to 5 parts of stevioside, 2 to 4 parts of mung beans, 1 to 2 parts of corns, 1 to 2 parts of soybeans, 1 to 2 parts of coix seeds, 2 to 4 parts of pitted red dates, 80 to 90 parts of fresh milk, and an appropriate amount of yoghourt zymophyte. The balsam pear fermented mung bean milk with a hypoglycemic effect of the invention has characteristics of special fragrance of baked bean dregs, and a hypoglycemic effect because of proper compatibility of the hypoglycemic Chinese medicinal solutions; and the fruit and vegetable puree enriches nutrition of the balsam pear fermented mung bean milk, and neutralizes bitter taste of the hypoglycemic Chinese medicinal solution.

The invention provides silkworm pupa oil, an extracting method and an application thereof. The silkworm pupa oil consists of the following components with the weight percentage of 0.2 percent of hexadecanoic acid, 1.0 percent of palmitoleic acid, 27.2 percent of oleic acid, 10.7 percent of linoleic acid, 54.6 percent of alpha-linolenic acid and 6.3 percent of other unsaturated acids. The extracting method of the silkworm pupa oil extracts unsaturated fatty acid in the silkworm pupas by a method which combines a microwave extracting technology and urea clathration. The application of the silkworm pupa oil is that the silkworm pupa oil is applied to effectively reducing the blood sugar and the level of diabetic and is especially used for preventing and curing the diabetes. The silkworm pupa oil has the advantages of shortening extracting time, reducing energy consumption, reducing solvent dosage, improving the content of necessary fatty acid and especially the content of the alpha-linolenic acid in the silkworm pupa which benefit human body, reducing the oxidative damage to the unsaturated fatty acid, protecting a double-health structure, economic and simple extracting method, being grasped easily, being convenient for realizing industrialized mass production, the more outstanding pharmacological action of the silkworm pupa oil represented in the aspect of reducing blood sugar, etc.

The invention provides a hypoglycemic ferment compound comprising the following components: 40-60 percent of protein, zinc (50-5000mg / kg), selenium (0.5-1000mg / kg) and chromium (0.5-1000mg / kg), wherein ferment is active ferment or inactive ferment. As a preference, the ferment compound further comprises one or more components selected from the following components: balsam pear or balsam pear extract, kudzu roots or kudzu root extract, gingko extract, green tea extract, ginseng or ginseng extract, glossy ganoderma or glossy ganoderma extract, glossy ganoderma leavening, glossy ganoderma spore powder, sealwort or sealwort extract, yam or yam extract, coix seed or coix seed extract, oats, tartary buckwheat, vitamin C, vitamin E, pearl powder, calcium and iron. The invention also relates to apreparation method of the ferment compound.

The invention provides a polypeptide used for preventing and treating diabetes and lipid metabolic disturbance. The polypeptide has obvious curative effect to type II diabetes, the blood sugar reducing function is realized on the basis of hyperglycemia, and the blood sugar concentration is reduced by virtue of glucose, thus being capable of not causing hypoglycaemia, having good safety and protecting pancreas beta cells. The polypeptide also has the function of obviously reducing triacylglyceride in blood and can be taken as a medicine used for preventing and treating diabetes and lipid metabolic disturbance. The polypeptide is resistant to enzymolysis, thus being applicable to being developed into oral preparations.

The invention relates to long-acting glucagon-like peptide 1 (GLP-1) analogues and a synthesis method thereof. GLP-1 analogues with longer pharmacological action time are obtained through adding a modified 37th amino acid to natural GLP-1, the synthesis of target polypeptides is quickly realized through a microwave-promoted solid-phase synthesis method, and crude products are purified and freeze-dried to obtain the GLP-1 analogues.

The invention discloses hyperglycosylated Extendin-4, fusion protein of analogue thereof, and a preparation method and the application of fusion protein. The fusion protein comprises Extendin-4, the analogue of the Extendin-4, a flexible peptide joint, at least one human chorionic gonadotropin beta carboxyl terminal peptide rigid unit and a human immunoglobulin Fc fragment. The invention also discloses the preparation method and the application of the fusion protein. The fusion protein has optimal biological activity, obviously prolonged circulation half-time, lowered immunogenicity and improved bioavailability. The fusion protein can be used for treating diabetes, obesity and other diseases benefited by lowering fasting plasma glucose, inhibiting stomach and / or bowel movement and inhibiting and / or bowel evacuation or inhibiting food intake.

The invention discloses pumpkin polysaccharide and the preparation method thereof. The preparation method comprises the steps as follows: pre-treating pumpkin, extracting in water for 0.5-3h, filtering to obtain filtrate, centrifuging the filtrated supernatant, purifying the supernatant with a resin column chromatography, and colleting eluent; concentrating the eluent, and precipitating with ethanol; and dissolving the precipitate into water, adding trichloroacetic acid, centrifuging for deproteinization to obtain supernatant, concentrating the supernatant, drying and pulverizing. The washing number of times is reduced, the technological process is simplified, and the extraction condition and technological parameter are optimized to shorten the time of the extraction and purification processes by purifying the pumpkin polysaccharide with advanced resin chromatography technology. Therefore, the preparation method has the advantages of simple technological process, short production period, easily-controlled production, and low production cost. The purity of the obtained pumpkin polysaccharide is as high as more than 80%, and the extraction rate is as high as more than 25%.

The invention provides a yoghurt capable of reducing blood sugar, wherein the yoghurt comprises the following components by weight: 80-120 parts of milk, 10-20 parts of astragalus mongholicus, 10-20 parts of smoked plum, 5-15 parts of medlar, 5-15 parts of root of red-rooted salvia and 5-15 parts of green tea, and further comprises 10<6>-10<9>cfu / ml probiotics. The invention further provides a preparation method of the yoghurt. The yoghurt capable of reducing blood sugar is rich in nutrition and common in raw materials; by using the combination of astragalus mongholicus, red-rooted salvia, medlar, smoked plum, and green tea, the yoghurt has the function of reducing blood sugar after being taken for a long time. The yoghurt capable of reducing blood sugar is scientific in compatibility of medicines, and has the effects of protecting pancreas islet function, improving glycometabolism, reducing sugar absorption, and the like, so that the yoghurt has a significant blood sugar reducing effect.

The invention relates to a processing method for preserved fruits, discloses a processing method for health-caring preserved pumpkin, and belongs to the technical field of food processing. The processing method is characterized by adopting the process method comprising the steps of cleaning raw materials, slicing the raw materials, soaking the raw materials, boiling the raw materials, sugaring the raw materials, drying the raw materials twice, softening the raw materials and packaging the raw materials. According to the processing method, the raw materials are dried twice, so that loss of nutrient substances is reduced, the processed health-caring preserved pumpkin is bright in color and crisp and tender in taste, and has the good hypoglycemic effect, the process is simple, and implementation is convenient. By carrying out deep processing on the pumpkin raw materials, local economy development can be promoted, a leading industry can be formed, the yield of agriculture can be increased, and the income of farmers can be increased.

The invention provides a blood glucose-lowering food containing okra and a preparation method of the blood glucose-lowering food containing okra, wherein the blood glucose-lowering food is characterized by comprising components by weight as follows: 30-60 parts of okra, 15-45 parts of balsam pear and 15-45 parts of Chinese yam. The food uses okra, balsam pear and Chinese yam with higher value as raw materials, and above materials are pure natural plants and contains comprehensive nutrients, trace elements and dietary fibers necessary for human body; the finished product is obtained by mixing and grinding, filtering, drying and sterilizing; the preparation process is simple, the price is cheap, the taste is good, and the effect of lowering blood glucose is obvious; each component plays a role of supplementing each other in lowering blood glucose; adverse reactions caused by long-term consumption can be cancelled out; the applicable group is greatly enlarged; and the finished product used as the food is convenient to eat and has functions of improving microcirculation and improving organism immunity.

The invention relates to a health care tea capable of reducing blood sugar and a preparation method thereof and belongs to the technical field of natural plant processing. The preparation method comprises the following steps of: cleaning fresh sweet potato leaves, mulberry leaves and tea leaves, soaking with electrolysed water, removing green, and then drying; and mixing in proportion, carrying out coarse crushing, and drying, so that the health care tea capable of reducing blood sugar is prepared. Clinical verifications show that the conventional oral blood sugar reducing medicine and the health care tea capable of reducing blood sugar provided by the invention can enhance the blood sugar reducing effect of a blood sugar reducing medicine and also obviously relieve symptoms such as swirl, thirst, fatigue, soreness of waist and leg weakness, and the total effective rate is 89%. The health care tea provided by the invention is unique in taste and has good blood sugar reducing health care function.

The invention relates to a Chinese medicine compound preparation for treating diabetes mellitus. The preparation comprises the following compositions: 0.1 to 99 percent of mulberry (a mulberry leaf or / and mulberry branch or / and white mulberry root-bark or / and mulberry syncarp), 0.1 to 99 percent of cassia cinnamon, 0.01 to 20 percent of hydrangea aspera don, 0 to 50 percent of stevia, 0 to 50 percent of rhizoma anemarrhenae, 0 to 50 percent of rhizoma polygonati, 0 to 15 percent of folia eriobotryae, 0 to 50 percent of radix platycodi, 0 to 50 percent of rehmanniae, 0 to 50 percent of radices saussureae, 0 to 50 percent of faenum graecum, 0 to 50 percent of radices puerarire, 0 to 50 percent of rhizoma atractylodis, 0 to 50 percent of radices pseudoginseng, 0 to 50 percent of glossy ganoderma, 0 to 50 percent of rhizoma atractylodis alba, 0 to 50 percent of acanthopanax, 0 to 50 percent of herba epimedii, 0 to 50 percent of Chinese yam, 0 to 50 percent of cortex acanthopanacis radicis, 0 to 50 percent of fructus corni, 0 to 50 percent of fructus mume and the like. The raw materials are decocted with water for 10 to 120 minutes to be filtered to obtain an extracting solution; and after the extracting solution is dried by concentration, the concentrated substance can be capsulated or tabletted; or the extracting solution can be concentrated to half to one twentieth of the weight of Chinese medicine raw materials, and the concentrated solution is sterilized and bottled. The product has obvious hyperglycemic effect according to 1 to 50 grams or 5 to 500 milliliters of concentrated solution per person everyday.

The invention provides yoghourt with a stomach nourishing function. The yoghourt is prepared from the following components by weight: 80-120 parts of milk, 5-15 parts of red dates, 5-15 parts of pearl barley, 5-15 parts of yam, 5-15 parts of radix ophiopogonis and 5-15 parts of honey and also comprises 106-109 cfu / ml of probiotics. The yoghourt with a stomach nourishing function is rich in nutrition, is prepared from low-price raw materials including red dates, pearl barley, yam, radix ophiopogonis and honey and has the functions of nourishing and protecting stomach after being taken for a long term.

The invention discloses a medicine combination with the function of lowering blood sugar level as well as a preparation method and application thereof. The existing medicines for lowering blood sugar level are mostly western medicines which have certain dependence and side effect. The active ingredients of the medicine combination comprises total alkaloid and total amino acid which are extracted and separated from any one or the composition of moraceae plants such as cortex mori radicis, ramulus mori, folium mori and mulberry; in all active ingredients of the extractive obtained from extraction and separation, the mass percentage of the total alkaloid is 9.8%-44.6%, the mass percentage of the total amino acid is 30.0%-70.4% and the combined content of the two account for more than 50% of the mass percentage composition of the extractive. In the invention, the total alkaloid and the total amino acid, the active ingredients extracted from the traditional Chinese medicine can achieve noticeable effect through combined use, features in fine synergistic effect and enjoys better blood-sugar-level lowering effect than when the total alkaloid and the total amino acid are independently used.

The invention relates to a long-effecting exenatide (Exendin-4) analogue and a synthetic method thereof. The Exendin-4 is modified to obtain the Exendin-4 analogue with longer pharmacologic action time, the synthesis of target polypeptide is quickly realized through an orthogonally protection strategy solid-phase synthesis method, and a crude product is purified and freeze-dried to obtain the Exendin-4 analogue.

The invention provides a composition for preventing and treating diabetes, which comprises the following ingredients by weight: 1-100 parts of cinnamon, 1-100 parts of mulberry leaf, 1-100 parts of root of kudzu vine, 1-100 parts of Poria cocos, 1-100 parts of Chinese yam and 1-100 parts of bitter gourd. The composition possesses good hypoglycemic effect, and is especially suitable for preventing and treating of spleen and kidney insufficiency type diabetes.

The invention discloses a drug compound for preventing and curing diabetes mellitus, which at least comprises two components including Timosaponin B-II and berberine. Preventing and curing effect can be improved by adding one or a plurality of components from mangiferin, Timosaponin A-III and Timosaponin B-III. The drug compound can also be compounded by anemarrhena extractive and golden cypress extractive, or can be directly extracted from anemarrhena and golden cypress. The drug compound has the advantages of obvious blood sugar reduction effect, and high effective component content, easy quality control. The preparation process of the drug compound is easy for industrialization, and can be applied as drugs to prevent and cure diabetes mellitus.