1124 results about "Tartrate" patented technology

A method for the separation of R-(+)- and S-(-)-isomers of amlodipine (I) from mixtures thereof, which comprises the reaction of the mixture of isomers with either L- or D-tartaric acid in an organic solvent containing sufficient dimethyl sulphoxide (DMSO) for the precipitation of, respectively, a DMSO, solvate of an L-tartate salt of R-(+)-amlodipine, or a DMSO solvate of a D-tartrate salt of S-(-)-amlodipine.

The invention relates to a novel preparation method of 1-(4-fluorobenzyl)-3-(4-isobutoxybenzyl)-1-(1-methylpiperidyl-4-yl)urea hemitartrate (pimavanserin tartrate), particularly a pharmaceutical compound for treating Parkinson's disease, of which the structural formula is disclosed as Formula (I). The invention also relates to a novel intermediate of the preparation method.

A novel tartaric acid salt of Isofagomine (Isofagomine tartrate) that can be used for the treatment of Gaucher disease is provided. The invention also provides a crystalline form of isofagomine tartrate, method for preparing the salt, a pharmaceutical composition containing the salt, and a method of treating Gaucher disease.

Disclosed is an electrode whose surface includes an organic/inorganic composite porous coating layer comprising heat-absorbing inorganic particles and a binder polymer, wherein the heat-absorbing inorganic particle is at least one particle selected from the group consisting of antimony-containing compounds, metal hydroxides, guanidine-based compounds, boron-containing compounds and zinc tartrate compounds. A separator using the heat-absorbing inorganic particles as a component for forming or coating the separator, and an electrochemical device including the electrode and/or the separator are also disclosed. The separator using the heat-absorbing inorganic particles as a component for forming or coating the separator can ensure excellent thermal safety and minimizes degradation of the quality of a battery.

The invention belongs to the technical field of medicine, and relates to a synthetic method of a tartrate of N-(4-fluorobenzyl)-N-(1-methylpiperidine-4-yl)-N'-(4-isobutoxybenzyl)urea. According to the synthetic method, 4-hydroxybenzylamine is taken as a raw material, and N-protecting group-4-isobutoxybenzylamine is obtained via amino protection and hydrocarbylation reaction; key intermediate 4-isobutoxybenzylamine is obtained via deprotection reaction; N-(4-isobutoxybenzyl)phenyl carbamate is obtained via reaction with phenyl chloroformate; N-(4-fluorobenzyl)-N-(1-methylpiperidine-4-yl)-N'-(4-isobutoxybenzyl)urea is prepared via ammonolysis reaction with another intermediate N-(4-fluorobenzyl)-1-methyl-4-piperidylamine; and the tartrate of N-(4-fluorobenzyl)-N-(1-methylpiperidine-4-yl)-N'-(4-isobutoxybenzyl)urea is obtained via salifying with tartaric acid. The raw materials are easily available; operation is simple and mild; production period is short; yield is high; safety is high; cost is low; and the synthetic method is suitable for industrialized production.

The present invention concerns oral dosage forms of some particular salts of cisapride, more particularly cisapride-(L)-tartrate, cisapride-(D)-tartrate, cisapride-sulfate, or cisapride citrate, which avoid drugfood interaction and which allow comedication of agents that increase the pH of the stomach. The invention particularly relates to solid oral dosage forms suitable for rapid dissolution. The present invention also concerns tablets which can be prepared via direct compression.

The invention relates to a magnalium alloy phosphide solution and the phosphide technique. The magnalium alloy phosphide solution is composed of the following components: 1 to 4.5g of zinc oxide, 10 to 45g of phosphoric acid, 0 to 20g of tartrate, 0.1 to 6g of sodium nitrate and 0.5g to 4.5g of sodium fluoride. The process of the phosphide technique is: degrease the surface of the magnalium alloy and get rid of the film of oxygenation-> washing with water->phosphide->washing with water->drying; the temperature of the phosphide is 15 to 80deg.C and the time is 0.1 to 50 minutes. The advantages are good protection, thicker than the chromate and uniformity on the surface of the magnalium alloy. The film is stable, has strong power of adhesion and anti-corrosion, stability, easy control and low cost.

The invention relates to novel AZD 9291 pharmaceutical salt. The chemical structural formula of AZD 9291 is shown in the specification. The pharmaceutical salt is sulfate or tosilate or tartrate or acetate or citrate. The AZD 9291 pharmaceutical salt has solubility equivalent to or higher than that of AZD 9291 mesylate, can meet bioavailability and efficacy requirements, is higher in bio-safety and lower in hygroscopicity, solves the problems that existing AZD 9291 mesylate is high in toxicity and prone to deliquescence, and is more suitable for drug development.

The invention provides a novel synthesis method for pimavanserin. The method comprises the steps that a compound formula (1a) is adopted as a raw material for preparing an active urea compound formula (1) and then subjected to a reaction with a compound formula (2) under an alkaline system to obtain a pimavanserin free alkali formula (3), and then pimavanserin free alkali forms a salt with tartaric acid to obtain a pimavanserin half tartrate formula (4). The method is simple in technological path, low in cost and suitable for industrial production. The formula is shown in the description, wherein HmA is the general formula of m-basic acid, HnA is the general formula of n-basic acid, m and n are 1 or 2 or 3, and the m-basic acid and the n-basic acid are selected from sulfuric acid, hydrochloric acid, phosphoric acid, p-toluenesulfonic acid, benzenesulfonic acid, methanesulfonic acid, methanoic acid, acetic acid, trifluoroacetic acid, oxalic acid, citric acid or tartaric acid.

The invention provides a waterproof coating, which belongs to the technical field of coatings. The waterproof coating comprises, by weight, 1 to 2 parts of triethanolamine, 2 to 4 parts of dibutyltin dilaurate, 1 to 2 parts of DOP, 1 to 2 parts of polyether glycol, 1 to 2 parts of tartrate, 5 to 8 parts of chlorinated paraffin, 0.5 to 0.8 part of zinc oxide, 4 to 6 parts of bentonite, 6 to 12 parts of epoxy resin, 3 to 6 parts of acrylic resin, 3 to 6 parts of polyvinyl alcohol, 1 to 2 parts of titanium dioxide, 2 to 6 parts of stearic acid, 1 to 3 parts of sodium tripolyphosphate, 2 to 3 parts of silica, 6 to 9 parts of chlorinated polypropylene resin, 2 to 4 parts of polyurethane acrylate, 1 to 2 parts of phosphoric acid, 4 to 7 parts of fluoro-olefin resin, 2 to 4 parts of phenolic resin, 3 to 8 parts of polyamide resin and 10 to 20 parts of water. The waterproof coating provided by the invention has excellent waterproof performance and strong adhesion with a substrate.

The invention discloses a making method of chiral (R/S)-a-phenethylamine (+/-)-tartrate, which is reacted by R or S-patterned phenethylamine and (+) or (-) tartaric acid, wherein the chiral salt can be catalyst in the asymmetrical reaction with not less than 99%.

The invention discloses a health care product with the function of reducing blood sugar. The health care product comprises L-arabinose, chromium-enriched yeast and any one or more of taurine, Chinese wolfberry extract, L-carnitine tartrate and bitter melon extract. The health care product has the functions of reducing the blood sugar and controlling blood fat simultaneously, has good taste, and is particularly suitable for patients with diabetes.

The invention relates to a handwork-dough-modeling and plasticine dual-purpose material. The handwork-dough-modeling and plasticine dual-purpose material comprises, by weight, 8 parts of wheat flour, 5 parts of glutinous rice flour, 1 part of malt sugar, 0.5 part of refined salt, 0.5 part of condensed milk, 2 parts of fresh milk, 0.8 part of honey, 2 parts of diatom soil, 2 parts of modified starch, 1 part of waxiness corn starch, 1.5 parts of kaolin, 0.5 part of bone glue, 1 part of calcium carbonate, 0.8 part of glycerin, 0.2 part of sodium diacetate, 0.5 part of potassium hydrogen tartrate, 0.5 part of food colorant, 1.5 parts of aloe gel, 0.1 part of olive oil, 0.2 part of sun screen and 5 parts of water. When children make handwork artware, the handwork-dough-modeling and plasticine dual-purpose material can be used as a dough modeling material so that dough modeling handwork artware can be made, and can also be used as a plasticine material for playing, multiple kinds of modeling can be made in a pinched mode, and the handwork-dough-modeling and plasticine dual-purpose material has the advantages of being green, nontoxic, harmless, free of cracking, antibacterial, long in retention time, good in modeling and proper in rigidity.

The invention relates to a strength-restoring health-care food and preparation method thereof. The health-care food is made of soybean oligopeptide as main component and polysaccharide, complex vitamines, mineral matter, etc, viz. soybean oligopeptide, high-maltose powder, white granulated sugar, vitamine B1, vitamine B2, vitamine C, vitamine E, nicotinic acid, calcium lactate, potassium chloride, sodium chloride, zinc gluconate, L-carnitine tartrate, anhydrous citric acid, acesulfame-k, and IFF concentrated vanilla. The invention is provided with unique formulation, and can rapidly supplying energy and nutrient, especially protein, for dissipating fatigue, promoting restoration of skeletal muscle, strengthening immunologic function, improving motion ability, rapidly restoring physical strength, etc, thereby it can contribute to health, disease-resistance improvement, and motion score improvement, accordingly, the health-care food can be used for soldiers, sportsmen, moderate or hard physical labors in training or working, and be suitable for acute or chronic fatigue patients to use for a long time.

The invention discloses a hydrogel dressing capable of promoting wound healing and a preparation method thereof. The hydrogel dressing consists of: by mass, 25-35% of glycerin, 0.1-0.5% of sodium hyaluronate, 5-10% of a skeletal material, 0.1-0.2% of tartrate, 0.01-0.2% of disodium ethylene diamine tetraacetate, 0.1-0.2% of ethylparaben, 0.1-0.4% of a cross-linking agent, 0.5-1.5% of a filler, 0.01-0.1% of an essential component and 60-65% of deionized water. Due to the interaction between an oil phase and a water phase, a compact net structure is formed and water and the essential component are held in a gel, and after solidification and sterilization, the hydrogel dressing capable of promoting wound healing is prepared. The dressing is applicable to postoperative wound nursing of surgery and gynaecology and obstetrics, and helps to make the surface of the wound keep moist, effectively promote wound healing and inhibit scar hyperplasia.

The invention relates to a method for the production of a nanometer boehmite with a plurality of patterns, in particular relates to a method for the production of nanometer boehmite materials such as nano-fibers, core shell inner balls, solid balls and hollow balls, and belongs to the technique field of inorganic nano-material preparation process. The method of the invention is characterized in that: a given amount of soluble aluminum salt is dissolved in water then an organic auxiliary solvent is added thereto, a given amount of pattern control agent is added as well under agitation, then the mixed liquid is put into a hydrothermal kettle for reaction at the temperature of between 160 and 250 DEG C for two to sixty hours, the reaction product is separated and the prepared deposition is washed with deionized water and ethanol, finally, the boehmite materials with specific patterns are obtained by being dried at the temperature of between 60 and 80 DEG C. The pattern control agent is one of citrate, tartrate, oxalate and disodium ethylenediamine tetraacetic acid, and the quantity added thereto is ranging from 0 to 20mmol.