The invention discloses laser-cladding high-entropy alloy powder. The laser-cladding high-entropy alloy powder comprises the following elements in percentage by weight: 10%-15% of Fe, 14%-17% of Cr, 22%-25% of Ni, 22%-24% of Co, 22%-24% of Mn, 0%-4% of Si and 0%-4% of B. The invention further discloses a scheme of adding another element Al based on the gradients of the scheme, and a method for preparing a high-entropy alloy coating by using the laser-cladding high-entropy alloy powder. According to the technical scheme, after laser cladding, good coating quality is realized; a phase structure of the coating retains peculiar solid solution structure of high-entropy alloy, and the atomic percent of each main metal element in the cladding coating satisfies nominal category of the high-entropy alloy; the coating has a plurality of excellent performances of high rigidity, high temperature resistance, wear resistance, corrosion resistance and the like; the technical repeatability and operability are both greatly improved, so that the high-entropy alloy is popularized and applied in surface modification of laser materials.