173 results about "Pterostilbene" patented technology

Formulations and methods of treatment and putative prevention for aging (anti-aging composition) and for diseases or conditions of all reactive oxygen species-dependant illnesses, such as Alzheimer's disease, Parkinson's disease, diabetes mellitus, cardiovascular disease, cancer, hepatitis, and disorders associated with estrogen deficiencies including osteoporosis and breast cancer and for improving athletic performance of humans include resveratrol and two (2) or more of the following features or additional active ingredients: (1) slow release formulation of resveratrol; (2) pterostilbene; (3) quercetin; (4) fisetin, and (5) naringenin. Slow release is defined for the purposes of the present invention as releasing 95% of the active agent or agents in eight (8) hours through normal human gastrointestinal absorption.

Resveratrol and/or pterostilbene are added to a chewable carrier, to enhance absorption of resveratrol and/or pterostilbene buccally or through the mucous membranes of the mouth. The composition containing the resveratrol and/or pterostilbene is designed to be retained in the mouth for at least 20 seconds and up to 20 minutes to ensure absorption of the resveratrol and/or pterostilbene through the mucous membranes of the mouth.

The invention discloses a method for oxidation synthesis of stilbenes by hexamethylenetetramine, comprising the following steps: preparing halogenated hydrocarbon by substituted benzyl alcohol, oxidizing the halogenated hydrocarbon by the hexamethylenetetramine to prepare corresponding substituted benzaldehydes, and preparing stilbene derivatives by condensation of Wittig-Horner. The method is simple and easy to implement; the reactants involved in the process of synthesis are safe; the resultants produce no pollution to the environment, have low cost and high yield and are suitable for industrially producing stilbenes having antibacterial action, such as resveratrol, pterostilbene and 3, 5-dimethoxy-4-isopropyl stilbene, etc.

The invention discloses endophytic fungi from huperzia serrata. The invention is obtained through being separated from the living body of pteridophyta huperzia serrata by adopting endophytic fungi separation and purification technology, and is identified through biosystematics to be acremonium endophytium. The preservation number of the strain is CCTCC M 206118. The invention generates Huperzine A analogous compound through the strain liquid fermentation of the endophytic fungi from huperzia serrata, and is significant micro organism for searching the Huperzine A new resource of the active component for curing the presenile dementia.

The invention discloses the synthesis of pterostilbene. The method comprises the following steps: using p-hydroxyphenyl acetic acid and veratraldehyde as raw material, carryingout Perkin reaction, getting (Z)-2(4-acetoxylation phenyl)-3-(3, 5- dimethoxy benzoic) acroleic acid, deacetylation, decarboxylation, and getting pterostilbene. The invention has the advantages of cheap raw material, simple technology, easy operation and high productivity. The invention has the advantages of low cost, good economy benefit and environment protection.

Resveratrol and/or pterostilbene are added to wines to preserve the wine from oxidation, bacteria and fungi. The resveratrol and/or pterostilbene can be added to grape must prior to fermentation and/or to fermented wine prior to bottling.

The invention discloses a sustained/controlled release microsphere of a chitosan coated stilbene compound using a biological extract Genipin as a cross-linking agent and a preparation method thereof. In the microsphere, a cross-linked condensation compound layer of the chitosan and the Genipin serves as a capsule shell and is used for coating a medicament 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol or piceatannol; the medicament stability of the product is improved; the sustained/controlled release of the medicament is realized; and the released Genipin after in vivo metabolism of the capsule shell has the characteristics of biocompatibility, no cytotoxicity and the like. The invention is applicable to the sustained/controlled release microspheresof Genipin cross-linked chitosan coated 3,5-dihydroxyl-4-isopropyl stilbene, resveratrol, pterostilbene, oxidized resveratrol, piceatannol and other stilbene compounds and a preparation method thereof. The preparation method is low in requirements on the control condition and easy to operate. In the microspheres, the quality is uniform; the grain size is 0.1 to 100 mu m; the surface of the microsphere has a multiporous structure; and the entrapment rate of the capsule shell to the medicament is 30 to 90 percent.

The invention discloses a whitening and freckle-fading composition and application thereof. The whitening and freckle-fading composition is prepared from the following raw materials: egg yolk oil andshea butter, pterostilbene and vitamin E, hydrolyzed ceramide III, an orange peel extract, a yeast extract, a thyme extract, a white willow bark extract, a verbascose flower extract, a sea lily nerveactivity whitening factor, a scutellaria baicalensis extract, oxyresveratrol, a lactobacillus fermentation lysate, tranexamic acid, VC ethyl ether, water-soluble fullerene, 4-butyl resorcinol and Ectoin; the invention also discloses application of the whitening and freckle-fading composition in cosmetics. The whitening and freckle-fading composition is good in safety and free of toxic and side effects, the whitening active ingredients are compounded, generation of melanin is inhibited from two ways of inhibiting saccharification and tyrosinase activity, and the whitening and freckle-fading effects are remarkable.

A method is provided for treating an individual for a cellular proliferative disorder, including administering to the individual in need of such treatment a therapeutically effective amount of the compound pterostilbene wherein UDP-glucuronosyltransferase (UGT) activity is increased. In an embodiment, 12-HETE levels can be reduced by administration of pterostilbene.

The invention relates to a use of pterostilbene in preparation of drugs for inhibiting liver cancer cell proliferation and inducing liver cancer cell apoptosis. The effective concentration of pterostilbene in the drug for inhibiting liver cancer cell proliferation and inducing liver cancer cell apoptosis is in a range of 20-140 micromoles per liter. A liver cancer cell line HepG2 is subjected to routine culture, and through a MTT method, an inverted microscope and flow cytometry method, real-time quantitative PCR and a Western blot method, HepG2 cell vitality influence caused by different concentrations of pterostilbene, apoptosis case of HepG2 cells treated by pterostilbene, and expression cases of Bax, Bcl-2, Fas, Cycs (cytochrome C) and Caspase3 gene mRNA and protein can be respectively determined. An experiment result fully proves that pterostilbene can be used in preparation of drugs for inhibiting liver cancer cell proliferation and inducing liver cancer cell apoptosis. Pterostilbene as natural substance extract has a wide application prospect in the field of anti-tumor drug treatment.

The invention provides a pterostilbene submicron lipid particle and a preparation method thereof, and belongs to the technical field of a carrier system in cosmetic preparation technology. The pterostilbene submicron lipid particle consists of pterostilbene, lipid, an emulsifier, a co-emulsifier, a stabilizer and water. According to the invention, the color change situation of the pterostilbene caused by long-time illumination is solved. The pterostilbene submicron lipid particle prepared by the invention can be well dispersed in the water, with high stability, and the pterostilbene submicron lipid particle, after dispersed in hot water, is fully transparent while the lipid particle is not separated out at low temperature; and the pterostilbene submicron lipid particle can be optionally matched with any cosmetic formulas.

The present invention provides a scalable process for the preparation of stilbenes by (i) condensing 3,5-dialkylbenzyl phosphonates with 4′-O-tetrahydropyranyl benzaldehyde to get 3,5-alkyl-4′-O-tetrahydropyranyl Stilbene and (ii) deprotecting the obtained 3,5-Dialkyl-4′-O-tetrahydropyranylstilbene to yield stilbenes. The present invention also provides a novel intermediate 3,5-Dialkyl-4′-O-tetrahydropyranyl stilbene, which is a key intermediate for the synthesis of stilbenes such as Pterostilbene and Resveratrol. The present invention also provides characteristics of various solid forms of Pterostilbene, methods for their preparation, as well as dosage forms containing the same for administration to or consumption by humans.

The present invention provides: a composition which has an effect of preventing or improving skin conditions including the formation of small wrinkles and the sagging of the skin; and an external preparation for the skin or a functional food, each of which contains the composition. The present invention relates to: a composition comprising carotenoid and pterostilbene; and an external preparation for the skin or a functional food, each of which contains the composition.

A biosynthetic method of making pterostilbene including expressing a 4- coumaratexoenzyme A ligase (4CL) in a cellular system, expressing a stilbene synthase (STS) in the cellular system, expressing a resveratrol O-methyltransferase (ROMT) in the cellular system, feeding p-coumaric acid to the cellular system, growing the cellular system in a medium, and producing pterostilbene.

Cocrystals of pterostilbene are disclosed, including: pterostilbene:caffeine cocrystal, pterostilbene:carbamazepine cocrystal, pterostilbene:glutaric acid cocrystal, and pterostilbene:piperazine cocrystal. The pterostilbene:caffeine cocrystal is polymorphic. Forms I and II of the pterostilbene:caffeine cocrystal are disclosed. The therapeutic uses of the pterostilbene cocrystals and of pharmaceutical/nutraceutical compositions containing them are also disclosed. The disclosure sets out various methods of making and characterizing the pterostilbene cocrystals.

The present invention provides a pterostilbene phosphate disodium salt synthesis method, wherein an aprotic solvent is adopted to dissolve pterostilbene, a dialkoxyl phosphoryl halide is adopted as a phosphorylation regent, acylation is performed under catalysis effects of an acid removing agent and 4-dimethylaminopyridine to obtain pterostilbene-alkoxyl-phosphate ester, and hydrolysis, salt formation and crystallization are performed to obtain the pterostilbene phosphate disodium salt. The method has characteristics of mild reaction conditions, short reaction time, no requirement of purification of the phosphorylation intermediate, simple process, high yield, good product quality and low energy consumption, and is suitable for industrial production.