1049results about How to "Improve physical stability" patented technology

The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

A self-piercing pulse oximeter sensor is provided for attachment to subject, e.g., an individual or an animal. The device includes a flexible pulse oximeter sensor, an earring post, and a grommet. The earring post may be used as a piercing device if there is not a pierced body part suitable for attaching the pulse oximeter sensor to the body. Otherwise the earring post may be slid into the pierced hole. In either case, the tip of the earring post engages a grommet once passing through the body part. Thus, the pulse oximeter sensor functions in a transilluminance mode by transmitting light through the pierced body part.

The present invention relates to methods, kits, combinations, and compositions for treating, preventing or reducing the risk of developing a testosterone-deficient disorder, or the symptoms associated with, or related to a testosterone-deficient disorder in a subject in need thereof. The present invention also relates to a method of administering a steroid in the testosterone synthetic pathway to a subject in need thereof.

The present invention relates to the delivery of drug amines through an inhalation route. Specifically, it relates to aerosols containing drug amines that are used in inhalation therapy. In one aspect of the present invention, a method of delivering an amine drug in an aerosol form is provided. The method comprises: a) heating a coating, which includes an amine drug salt on a substrate contained in a device to a temperature sufficient to volatilize the amine drug from the coating, b) by said heating, forming an amine drug vapor, and c) during said heating, drawing air through said device, condensing said vapor to form aerosol particles containing less than 10% degradation products of the compound.

Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by:(i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and(ii) extruding the melted mixture, to obtain an extruded mixture.

Encapsulation compositions in which an encapsulate (A) is encapsulated in a matrix (B) may be prepared by:(i) mixing matrix (B) with a liquid plasticizer and encapsulate (A) in an extruder, to obtain a melted mixture of encapsulate (A) and matrix (B); and(ii) extruding the melted mixture, to obtain an extruded mixture.

Solid compositions of low-solubility drugs and poloxamers that provide concentration enhancement when administered to an aqueous environment of use are disclosed.

The present invention provides stabilized oil-in-water emulsions with an extended range of chemical, thermal and / or mechanical stabilities, and method(s) for their preparation. Such preparations provide an environmentally-protective biopolymer component exhibiting improved adherence to the dispersed phase, reducing or eliminating dissociation therefrom under such conditions, for use in the context of a range of food, pharmaceutical, personal care, health care, cosmetic and other end-use applications.

The present invention provides methods of making covalently crosslinked vinyl polymer hydrogels having advantageous physical properties, and covalently crosslinked vinyl polymer hydrogel compositions made by such methods, as well as articles of manufacture comprising such covalently crosslinked vinyl polymer hydrogel compositions. The physical properties of the produced hydrogels can be adjusted by varying controlled parameters such as the proportion of physical associations, the concentration of polymer and the amount of radiation applied. Such covalently crosslinked vinyl polymer hydrogels can be made translucent, preferably transparent, or opaque depending on the processing conditions. The stability of the physical properties of the produced vinyl polymer hydrogel can be enhanced by controlling the amount of covalent crosslinks.

A cooling module includes a thermally conductive plate, a bladder disposed on at least one side of the plate, the bladder have a chamber, and fluid disposed in the chamber of the bladder wherein the bladder in an inflated state impresses the cooling module against an adjacent electronic circuit card. where the cooling module is forcibly pressed against adjacent electronic circuit card providing increased physical stability to the electronic circuit card as well as provide a cooling technique for the circuit card.

The present invention concerns an oil-in-water emulsion wherein the oil droplets of a diameter in the range of 5 nm to hundreds of micrometers exhibit a nano-sized self-assembled structurization with hydrophilic domains having a diameter size in the range of 0.5 to 200 nm, due to the presence of a lipophilic additive and the oil-in-water emulsion contains an active element being present in the range comprised between 0.00001 and 79% based on the total composition.

[Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like. [Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained. wherein each symbol is as defined in the description.

The invention provides a composite separating membrane and a preparation method and application thereof. The composite separating membrane comprises a bottom membrane, and is characterized in that the bottom membrane is attached to a transition layer; the transition layer consists of metal organic frame materials. The invention also discloses a method for preparing the composite membrane. The method comprises the following steps: sequentially and ultrasonically dispersing the metal organic frame materials to form suspension; and coating the suspension made of the metal organic frame materials and a solution of separating layer materials on the bottom membrane to sequentially form the transition layer and a separating layer. The separating membrane is simple in preparation method and is easy to control and can be used for the preparation process of various composite membranes in the separating membrane industry. Compared with a conventional high polymer material transition layer, the composite separating membrane has high physical and chemical stability and mechanical performance and has wide application prospects.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

A correction ink of the present invention is used for correcting a micro defect in a color pattern, which comprises a coloring agent, polymer, monomer having reactivity functional group and a solvent, wherein an amount of the solvent is from 25% by weight to 70% by weight of the whole ink, and a viscosity is from 40 to 300 mPa.sec.

The invention discloses a novel longevity-type catalyst with high activity and selectivity of high alcohol hydrogenation and chemical stability and physical stability under reacting condition, the preparation method and the application. The catalyst of the invention adopts metal as the catalyst framework, so that the hydrothermal stability and alkali tolerance of the catalyst are high. The catalyst can be prepared by the melting method, the machine-alloying method and the chemical synthesis method. The invention can be used for high alcohol hydrogenation, in particular for the preparation of hydrogenation low-carbon polyatomic alcohol by using regenerated material as D-sorbitol which is made from corn.

A conductive nanowire film based on a high aspect-ratio metal is disclosed. The nanowire film is produced by inducing metal reduction in a concentrated surfactant solution containing metal precursor ions, a surfactant and a reducing agent. The metal nanostructures demonstrate utility in a great variety of applications.

The invention belongs to the field of water treatment, and relates to a method for strengthening the activity of anaerobic ammoxidized microorganisms through polyvinyl alcohol-sodium alginate-activated carbon embedment. The method comprises the following steps of: soaking activated carbon in anaerobic ammoxidized basic inorganic salt solution, and preparing an embedding medium by using polyvinyl alcohol, sodium alginate and the activated carbon into in a proportion; and uniformly mixing treated anaerobic ammoxidized sludge and the embedding medium in a volume ratio to obtain immobilized balls, and culturing to obtain the anaerobic ammoxidized microorganisms steadily coupled on the activated carbon. The invention aims at wastewater with low carbon-nitrogen ratio, and can provide a method for embedding the anaerobic ammoxidized sludge by using the sodium alginate and the polyvinyl alcohol as carriers and the activated carbon as a strengthening agent, and a technology for strengthening the activity of the anaerobic ammoxidized microorganisms and enabling the anaerobic ammoxidized microorganisms to resist the influence of adverse environment. By the method, sewage plants can run more steadily for a long time, and the conditions of actual operation management of the sewage plants are met.

A light emitting diode (LED) package is provided. The LED package includes a printed circuit board (PCB), an electrode pad, an LED, a wire, and first and second moldings. The electrode pad and the LED are formed on the PCB. The wire electrically connects the LED with the electrode pad. The first molding is formed on the LED and the second molding is formed on the first molding.

The invention relates to an enveloping agent applied to sustained release fertilizer, using chitosan 1-10wt%, amylum 30-40wt%, vinol 45-55wt%, cross-linking agent 2-10wt%, glycerol 6-8wt%, tween 1-3wt% and NH4Cl 0.5-1.5wt% as main raw materials, reacting for 1-2 hours at pH value of 2-5 and at 85-95 deg.C to make it. Its preparation is simple and its raw material source is wide and it has no environmental pollutions.

Stable aqueous pharmaceutical suspension compositions containing lecithin as a stabilizing additive and lacking a polymeric suspending agent are disclosed.

A polymer gel electrolyte includes an electrolyte solution composed of a plasticizer with at least two carbonate structures on the molecule and an electrolyte salt, in combination with a matrix polymer. Secondary batteries made with the polymer gel electrolyte can operate at a high capacitance and a high current, have a broad service temperature range and a high level of safety, and are thus particularly well-suited for use in such applications as lithium secondary cells and lithium ion secondary cells. Electrical double-layer capacitors made with the polymer gel electrolyte have a high output voltage, a large output current, a broad service temperature range and excellent safety.

The invention relates to salts of the active substance base 1-[N2-[3,5-dibromo-N-[[4-(3,4-dihydro-2(1H)-oxoquinazolin-3-yl)-1-piperidinyl]carbonyl]-D-tyrosyl]-L-lysyl]-4-(4-pyridinyl)-piperazine [BIBN4096] of formula I, the preparation thereof, a process for preparing an inhalation powder containing a salt of the active substance BIBN4096 as well as the inhalation powders which can be obtained by the process.

Disclosed are improved polymer materials. Also disclosed are fine fiber materials that can be made from the improved polymeric materials in the form of microfiber and nanofiber structures. The microfiber and nanofiber structures can be used in a variety of useful applications including the formation of filter materials.

The coenzyme Q10 injection emulsion has coenzyme Q10 as the effective medicine component, and each 1000 ml emulsion contains coenzyme Q10 1-10g, vegetable oil for injection 0-200g, emulsifier 1-50g, isoosmotic regulator 5-50g, antioxidant 0.05-5g, pH regulator in the quantity of regulating pH value to 3.0-9.0, co-emulsifier 10-500g and water for injection for the rest. It provides the patient with treating medicine and essential nourishing matter. It has high physical stability and may be prepared into freeze dried preparation for further raised stability and convenient storing and transportation. The coenzyme Q10 injection emulsion has certain targeting effect, so that it has raised bioavailability and lowered toxic side effect.

It is an object of the present invention to provide a catalyst for manufacturing a carboxylic ester, which has superior catalytic activity. The present invention relates to a catalyst for preparing a carboxylic ester, used in a) a reaction for preparing a carboxylic ester by reacting oxygen, an aldehyde, and an alcohol, or b) a reaction for manufacturing a carboxylic ester by reacting oxygen and one or more types of alcohol, comprising a carrier and 1) ultrafine gold particles and / or 2) ultrafine metal particles containing gold and a second element other than gold, having an average particle diameter of not more than 6 nm, are supported on the carrier.