395results about How to "Fast aggregation" patented technology

Embodiments of the invention are directed to a method of estimating the physical stability of a protein formulation. A particular embodiment of the invention places the protein formulation under an agitational stress that causes the protein to aggregate at an accelerated rate. In one embodiment, the change in protein aggregation is monitored spectroscopically using Thioflavin-T. Embodiments of the invention then utilize a survival curve analysis to ascertain the relative physical stability of the different protein formulations under study. This method was used to develop novel surfactant-stabilized insulin formulations in a rapid, cost efficient manner, thus illustrating the utility of the inventive method to the discovery and development of pharmaceutical protein formulations.

Hydrogels of polymerized and crosslinked macromers comprising hydrophilic oligomers having biodegradable monomeric or oligomeric extensions, which biodegradable extensions are terminated on free ends with end cap monomers or oligomers capable of polymerization and cross linking are described. The hydrophilic core itself may be degradable, thus combining the core and extension functions. Macromers are polymerized using free radical initiators under the influence of long wavelength ultraviolet light, visible light excitation or thermal energy. Biodegradation occurs at the linkages within the extension oligomers and results in fragments which are non-toxic and easily removed from the body. Preferred applications for the hydrogels include prevention of adhesion formation after surgical procedures, controlled release of drugs and other bioactive species, temporary protection or separation of tissue surfaces, adhering of sealing tissues together, and preventing the attachment of cells to tissue surfaces.

The present invention relates to a silicone (meth)acrylamide monomer, and this silicone (meth)acrylamide monomer is particularly suitable for use in contact lenses, intraocular lenses, artificial cornea, and the like.

The present invention relates to a curing assembly comprising at least two light sources combined into one light path, wherein the light sources are capable of curing a material exposed to the combined light path. The invention also relates to a method of curing a material or material in contact with a heat sensitive material comprising providing a curable material or a material associated with a heat sensitive material and exposing curable material to a combined light path from the curing assembly.

The present invention discloses a new class of triarylsulfonium salt photoacid generators (PAGs), which are thermally stable and can be activated by long wavelength UV or visible light. The sulfonium PAGs of the present invention are additionally soluble in monomers that can be polymerized by cationic polymerization chemistry, and mixtures of said sulfonium PAGs and monomers can be stored for long periods of time without undergoing polymerization. Furthermore, typical holographic recording media comprising one of these sulfonium PAGs, polymerizable monomer(s), a sensitizing dye, and a binder can be stored for long periods of time without exhibiting significant loss of recording sensitivity. Preferred sulfonium PAGs of the present invention are sulfonium PAGs substituted with one or more fluoro or fluoroalkyl groups.

Disclosed is a presensitized plate composed of a support having thereon an image recording layer which includes: an infrared absorber (A) that is a cyanine dye having at least one fused ring composed of a nitrogen-containing heterocycle in combination with an aromatic ring or a second heterocycle, and having on the aromatic ring or second heterocycle an electron-withdrawing group or a heavy atom-containing group, a radical generator (B), and a radical-polymerizable compound (C), and which is removable with printing ink and / or dampening water. The presensitized of the present invention can be imaged with an infrared light-emitting laser to directly record an image from digital data on a computer or the like and is then subjected to on-machine development without carrying out a development step, which is capable of providing a large number of good impressions with a practical amount of energy.

An active energy ray curable ink which is quickly polymerized by an active energy ray, high in crosslinking degree of a cured material formed, excellent in adhesive property, low in viscosity, excellent in long-term storability and also excellent in ejection stability, and an ink-jet recording process, an ink cartridge, a recording unit and an ink-jet recording apparatus using such an ink are provided. In the active energy ray curable aqueous ink comprising at least water and a polymerizable material which is radically polymerized by an active energy ray, the polymerizable material is a water-soluble polymerizable material represented by the following general formula (I). An ink-jet recording process, an ink cartridge, a recording unit and an ink-jet recording apparatus using such an ink

An acrylamide derivative of the following general formula (I) is used to prepare a polymer or copolymer:wherein R1 represents a hydrogen atom, a straight-chain or branched alkyl group containing 1 to 4 carbon atoms or a C3-6 cycloalkyl group, R2 and R3 each independently represent an alkylene group containing 1 to 6 carbon atoms or R2 and R3 may be combined to form a ring, X represents a hydrogen atom, an amino group, a hydroxyl group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group, and Y represents an amino group, a halogen atom, a carboxyl group or a -COOR4 group wherein R4 represents a C1-6 straight-chain or branched alkyl, C3-6 cycloalkyl, phenyl, substituted phenyl, benzyl or substituted benzyl group. The thus obtained polymer or copolymer is a polymer or hydrogel incorporating many functional groups while maintaining the sensitive temperature response.

The invention provides a software development method and device based on crowdsourcing. The method comprises the following steps: receiving original software requirements input by a demand provider; distributing the original software requirements to a product manager to enable the product manager to generate and publish a PRD (Product Requirement Document) according to the original software requirements; generating a first MDT (Module Development Task) corresponding to the PRD; distributing the first MDT to a product architect to enable the product architect to generate a plurality of second MDTs according to the first MDT and publish the plurality of second MDTs to internet users; receiving at least one group of deliverable products submitted by the internet users, and distributing the at least one group of deliverable products to the product architect to enable the product architect to generate a software product corresponding to the original software requirements according to the at least one group of deliverable products. According to the method, large-scale concurrence development can be realized, and software development speed is greatly improved.

An arcless, atmospheric-pressure plasma generating apparatus capable of producing a large-area, temperature-controlled, stable discharge at power densities between about 0.1 W / cm3 and about 200 W / cm3, while having an operating gas temperature of less than 50° C., for processing materials outside of the discharge, is described. The apparatus produces active chemical species, including gaseous metastables and radicals which may be used for polymerization (either free radical-induced or through dehydrogenation-based polymerization), surface cleaning and modification, etching, adhesion promotion, and sterilization, as examples. The invention may include either a cooled rf-driven electrode or a cooled ground electrode, or two cooled electrodes, wherein active components of the plasma may be directed out of the plasma and onto an external workpiece without simultaneously exposing a material to the electrical influence or ionic components of the plasma.

A method of collecting and authenticating electronic signatures and documents signed thereby, including the steps of storing a representation of a first handwritten signature and an associated first authenticated electronic signature of a first signatory in a database, storing a representation of a second handwritten signature and an associated second authenticated electronic signature of a second signatory in the database, creating a message digest for a document file associated with a document to be signed, appending the message digest to the document file, transmitting the document file with the appended message digest to the first and second signatories, receiving the document file with the appended message digest from the first and second signatories after the first and second signatories have affixed their first and second electronic signatures, respectively, to the document file, and, authenticating the first and second signatures, respectively, and the electronically signed document file. An apparatus for implementing the method is also disclosed.

A spray-type staltic adhesive is prepared from the alpha-n-octyl cynoacrylate (1-50 wt.%) and the alpha-n-butyl cynoacrylate (1-80 wt.%) through proportioning, sequentially loading them in a container, stirring for 30-80 min, filtering by 0.45-micron medical film, and biological testing to be negative. Its advantages are high polymerizing speed, adhesion and diffusivity, less intradermal reaction, and high safety. It can be used in human body.