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Stopping bleeding spraying adhesive, preparing method and use thereof

An adhesive and compound technology, applied in surgical adhesives, applications, medical science and other directions, can solve the problems of low adhesive bonding strength, hepatitis C virus infection, anti-viral infection and other problems, achieve high bonding strength, prevent bacterial infection , the effect of increasing the bond strength

Inactive Publication Date: 2004-07-07
FUALIE SCI & TECH DEVING BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The purpose of the present invention is to overcome the disadvantages of inconvenient use caused by the need for low-temperature storage of existing medical adhesives; it is also to overcome the disadvantages of existing adhesives such as low bonding strength, slow polymerization, large odor, and poor diffusivity, and is limited to Limitation of body surface use; also in order to avoid the risk of iatrogenic CJD spongiform cerebrovascular lesions, antiviral infection, hepatitis C virus infection and AIDS caused by the use of blood products; thus providing an α-cyanoacrylic acid A hemostatic spraying adhesive blended with alkoxy esters, that is, methoxy α-cyanoacrylate and other straight-chain high-carbon alkyl esters, and its preparation method and use

Method used

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  • Stopping bleeding spraying adhesive, preparing method and use thereof
  • Stopping bleeding spraying adhesive, preparing method and use thereof
  • Stopping bleeding spraying adhesive, preparing method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] The specific preparation method is as follows:

[0039] 1. Use raw materials with the following qualities:

[0040] (1). The monomers are 20 grams of n-octyl α-cyanoacrylate; and 80 grams of n-butyl α-cyanoacrylate; the content of both monomers is higher than 99%;

[0041] (2). Monomer appearance: colorless or light yellow transparent liquid;

[0042] (3). Monomer viscosity: lower than 3SPS;

[0043] (4). Monomer polymerization speed: 0.5-8 seconds;

[0044] Second, with glue

[0045] In a 100,000-level cleanliness workshop with constant temperature and humidity, the proportions of the monomers that are all qualified above are weighed in the above table: 20 grams of n-octyl cyanoacrylate; n-butyl α-cyanoacrylate Esters 80 grams; And according to α-cyanoacrylate n-octyl and α-cyanoacrylate n-butyl ester are loaded in the container (for example into the there-necked flask with stirrer), then stirred for 50 minutes;

[0046] 3. Filtration

[0047] The product ...

Embodiment 2

[0049]

[0050] The specific preparation method is the same as in Example 1.

Embodiment 3

[0053] The specific preparation method is as follows:

[0054] 1. Raw materials with the following qualities:

[0055] (1). Take the monomers as 30 g of n-octyl α-cyanoacrylate; 30 g of n-butyl α-cyanoacrylate; 40 g of methoxyethyl α-cyanoacrylate; The content is higher than 99%;

[0056] (2). Monomer appearance: colorless or light yellow transparent liquid;

[0057] (3). Monomer viscosity: lower than 3SPS;

[0058] (4). Monomer polymerization speed: 0.5-8 seconds;

[0059] Second, with glue

[0060] In the 100,000-level cleanliness workshop with constant temperature and humidity, the monomers that are qualified for the above indicators are weighed according to the proportions in the above table: 30 grams of n-octyl α-cyanoacrylate; Butyl 30 g; and methoxyethyl alpha-cyanoacrylate 40 g; Put into a container (for example, into a three-necked flask with a stirrer), then stir for 70 minutes;

[0061] 3. Filtration

[0062] The product obtained by stirring in the seco...

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Abstract

A spray-type staltic adhesive is prepared from the alpha-n-octyl cynoacrylate (1-50 wt.%) and the alpha-n-butyl cynoacrylate (1-80 wt.%) through proportioning, sequentially loading them in a container, stirring for 30-80 min, filtering by 0.45-micron medical film, and biological testing to be negative. Its advantages are high polymerizing speed, adhesion and diffusivity, less intradermal reaction, and high safety. It can be used in human body.

Description

technical field [0001] The present invention relates to the field of organic chemistry, in particular to an organic compound for preparing an adhesive, an adhesive containing the compound, and a preparation method and application of the adhesive. Background technique [0002] In the field of clinical medicine, it has been envisaged that adhesives can be used to replace sutures during surgery, or to block intractable fistulas with adhesives, or to embolize abnormal blood vessels, and to stop bleeding in large areas of diffuse oozing or small blood vessel bleeding. Due to the continuous clinical needs, the development of the medical glue business has been promoted. For example, in 1960, Nathan in the United States conducted a screening experiment on 28 kinds of synthetic resins for bonding small blood vessels, and the results proved that α-methyl cyanoacrylate had the best adhesion and hemostatic performance. Subsequently, a large number of animal and clinical tests were carri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/04
Inventor 田霞卢永顺
Owner FUALIE SCI & TECH DEVING BEIJING
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