792 results about "Cyanine" patented technology

Cyanine and related dyes, such as merocyanine, styryl and oxonol dyes, are strongly light-absorbing and highly luminescent. Cyanine and related dyes having functional groups make them reactive with amine, hydroxy and sulfhydryl groups are covalently attached to proteins, nucleic acids, carbohydrates, sugars, cells and combinations thereof, and other biological and nonbiological materials, to make these materials fluorescent so that they can be detected. The labeled materials can then be used in assays employing excitation light sources and luminescence detectors. For example, fluorescent cyanine and related dyes can be attached to amine, hydroxy or sulfhydryl groups of avidin and to antibodies and to lectins. Thereupon, avidin labeled with cyanine type dyes can be used to quantify biotinvlated materials and antibodies conjugated with cyanine-type dyes can be used to detect and measure antigens and haptens. In addition, cyanine-conjugated lectins can be used to detect specific carbohydrate groups. Also, cyanine-conjugated fragments of DNA or RNA can be used to identify the presence of complementary nucleotide sequences in DNA or RNA.

A lithographic printing plate precursor comprising a support and an image-recording layer which contains (A) a cyanine dye including a solvent-soluble group and having an absorption maximum in an infrared wavelength region and is capable of being removed with at least one of printing ink and an aqueous component.

The present invention discloses a novel organic compound is represented by the following formula(A), the organic EL device employing the compound as blue emitting layer can lower driving voltage, prolong half-lifetime and increase the efficiency.

Wherein m represent an integer of 0 to 8, n represent an integer of 0 to 10, p represent an integer of 0 to 7, HAr represent a hydrogen, a halide, a cyanine group, a substituted or unsusbstituted heteroaryl group system having 5 to 6 aromatic ring atoms, R₁ to R₄ are identical or different. R₁ to R₄ are independently selected from the group consisting of a hydrogen atom, alkyl group having 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms.

The invention discloses a differential blood count reagent which comprises the following components: (1) a cyanine anion compound selected form compounds expressed by the formula I or formula II, (2) an anode surfactant expressed by the formula III, IV or V and (3) at least one nonionic surfactant. The invention also discloses a kit containing the differential blood count reagent and a method of the differential blood count. By utilizing the reagent, the kit and the method, five subclasses of leucocytes can be quickly identified within a very short time, four-classification count is at least carried out, and immaturate cells and abnormal cells can be distinguished.

A subject matter of the invention is cyanine derivatives of formula:

in which the dotted lines represent the atoms necessary for the formation of one or two fused aromatic rings, each ring comprising 5 or 6 carbon atoms;

• R₁, R₂, R₃ and R₄ represent, independently of one another: H; substituted or unsubstituted C₁-C₁₅ alkyl; C₁-C₆ alkoxy; (C₂-C₁₂)dialkylamino; C₁-C₆ alkoxycarbonyl; di(C₂-C₁₂)alkylamido; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a halogen atom; a nitro; an L1-W, L2-M, L2-A or L2-G group;
• R₅ and R₆ represent, independently of one another: substituted or unsubstituted C₁-C₁₅ alkyl; a substituted or unsubstituted aryl or arylalkyl group; an L1-W, L2-M, L2-A or L2-G group;
• X is chosen from: O, S or CR₇R₈; Y is chosen from: O, S or CR₉R₁₀;
• R₇, R₈, R₉ and R₁₀ independently represent: substituted or unsubstituted C₁-C₁₅ alkyl; substituted or unsubstituted aryl, arylalkyl or aryloxy; an L1-W, L2-M, L2-A or L2-G group;
• R₇ and R₈ and/or R₉ and R₁₀ can also together form a ring comprising 5 or 6 atoms or a heterocycle comprising 4 to 5 carbon atoms and an oxygen atom;
• B represents a polymethine bridge comprising 1 to 5 methine groups, said groups being in particular individually unsubstituted or substituted by a substituted or unsubstituted C₁-C₁₅ alkyl; a substituted or unsubstituted aryl, arylalkyl or aryloxy group; a nitro group; an L1-W, L2-M, L2-A or L2-G group;
• L1 and L2 are connecting arms; G is a reactive group; A is a coupling agent; M is a conjugated molecule, W is a phosphate or phosphonate ester (preferably diester), with the proviso that the cyanine derivative comprises at least one L1-W group and at least one L2-A, L2-G or L2-M group.

The invention relates to a preparation method of a zinc oxide visible-light-induced photocatalyst sensitized by squarylium cyanine. The preparation method comprises the following steps: dissolving Zn(Ac)22H2O and glucose into deionized water; carrying out ultrasonic processing to form a settled solution; after transferring the solution into a liner of a polytetrafluoroethylene autoclave, performing hydrothermal reaction for 12 to 24 hours at a temperature of 140 to 180 DEG C; after cooling to room temperature, carrying out centrifugal washing on the obtained black powder respectively with the deionized water and absolute ethyl alcohol; drying at a temperature of 60 DEG C to obtain a zinc oxide and carbon composite precursor; placing the precursor into a muffle furnace to calcine for 3 hours at a temperature of 400 to 600 DEG C, so as to obtain zinc oxide microspheres; mixing the zinc oxide microspheres and the squarylium cyanine as well as an organic solvent; at a temperature of 30 to 60 DEG C, carrying out ultrasonic processing on the mixture for 0.5 to 2 hours; then removing the organic solvent under the condition of pressure reduction; and finally, drying the obtained solid at a temperature of 60 DEG C. The zinc oxide visible-light-induced photocatalyst sensitized by the squarylium cyanine can be used for photocatalysis processing on organic pollutants in air, soil and sewage.

The invention relates to a heptamethine indocyanine dye containing N-fatty esters or N-fatty amide side chains, a synthetic method thereof and applications thereof in tumor targeting imaging and treatment. The heptamethine indocyanine dye which possesses or individually possesses near infrared absorption, fluorography and antineoplastic activity allows present research and development ideas and treatment levels of tumor targeting treatment medicaments to be greatly improved, and has great significances to aspects of early discovery, control and the like of various tumors.

Provided is a photoelectric conversion device capable of improving a conversion efficiency. In a dye-sensitized photoelectric conversion device including a working electrode and a facing electrode, and an electrolyte inclusion, a dye is carried on a metal-oxide semiconductor layer of the working electrode. The dye includes cyanine dye having a benzyl group and an indolenine skeleton. Therefore, crystallization of the dye on the surface of the metal-oxide semiconductor layer is suppressed.

Cyanine and Indocyanine dye compounds and bioconjugates are disclosed. The present invention includes several cyanine and indocyanine dyes, including bioconjugates of the same, with a variety of bis- and tetrakis (carboxylic acid) homologues. The compounds of the invention may be conjugated to bioactive peptides, carbohydrates, hormones, drugs, or other bioactive agents. The small size of compounds of the invention allows favorable delivery to tumor cells as compared to larger molecular weight imaging agents. Further, use of a biocompatible organic solvent such as dimethylsulfoxide may be said to assist in maintaining the fluorescence of compounds of the invention. The compounds and bioconjugates herein disclosed are useful in a variety of medical applications including, but not limited to, diagnostic imaging and therapy, endoscopic applications for the detection of tumors and other abnormalities, localized therapy, photoacoustic tumor imaging, detection and therapy, and sonofluorescence tumor imaging, detection and therapy.

Boron complexes of certain bis-heterocyclic compounds are provided. The complexes resemble monomethine cyanines and are useful for imparting fluorescent properties to materials by covalent and noncovalent association. The compounds have the following general formula:wherein the dotted lines Z1 and Z2 represent the atoms necessary to complete a structure selected from the group consisting of one ring, two fused rings, and three fused rings, each said ring having five or six atoms, and each said ring comprising carbon atoms and, optionally, no more than two atoms selected from oxygen, nitrogen and sulfur, and R1 through R5 represent various atoms or groups and M is Cl or F.

The invention provides compositions useful as molecular probes. In particular, the invention provides activatable cell penetrating peptides comprising a fluorescence donor and a fluorescence acceptor. Exemplary fluorescence donors and fluorescence acceptors include compounds derived from cyanine. Also provided are ratiometric, multispectral, and excitation lifetime imaging methods for detecting the molecular probes provided herein.

The invention provides type I unsymmetrical cyanine fluorescent dye, wherein X, n, R1, R2, R3, R4, R5 and Y<-> are defined as in the instruction book. The invention also provides the conjugate and the preparation method of the fluorescent dye, the combination containing the fluorescent dye and the biological dyeing method by using the fluorescent dye or the combination.

The invention provides novel use of a cyanine dye in the detection of a G-quadruplex DNA. The detection of the G-quadruplex DNA by using the cyanine dye has the advantages of simplicity, quickness and relatively low prices and overcomes the drawbacks of the prior detection technology such as long period, high price and high technical and equipment requirements. The use of the cyanine dye in the detection of the G-quadruplex DNA makes whether a DNA sample in solution has a G-quadruplex structure or a linear double helical structure determined quickly by a UV-visible absorption spectrum, fluorescence spectrum or confocal laser scanning microscopy. By using confocal laser scanning microscopy, the DNA sample assembled on the surface of Au can be marked visually, so the structure of the DNA sample can be recognized and the specific assembly position of the DNA sample on the surface of the Au can be marked at the same time.