88 results about "Drug suspension" patented technology

Suspending vehicles and pharmaceutical suspensions that include a biocompatible polymer that can be combined with a hydrophobic solvent and a hydrophilic solvent to provide vehicles and suspensions that are substantially free of stiff gels upon contact with an aqueous medium are provided. Vehicles and suspensions remain flowable out of a pump-driven dosage form over the life of the dosage form. Such vehicles and suspensions are also biocompatible, suitable for creating and maintaining drug suspensions, and capable of providing stable drug formulations.

Pharmaceutical suspension aerosol formulations containing a therapeutically effective amount of a drug and HFC 134a, HFC 227, or a mixture thereof.

An aqueous oral liquid pharmaceutical composition system with reduced propensity for agglomeration and phase separation which is particularly amendable to the suspension of one or more pharmaceutical actives that are substantially insoluble in water. The oral liquid pharmaceutical composition may further comprise pharmaceutical actives that are soluble in water and dissolve in the aqueous medium. In the composition of the invention both suspended and any dissolved active agents are distributed homogeneously.

A liquid pharmaceutical composition comprises an aqueous medium having suspended therein a solid particulate Bc1-2 family protein inhibitory compound such as ABT-263, having a D₉₀ particle size not greater than about 3 μm; wherein the aqueous medium further comprises at least one pharmaceutically acceptable surfactant and at least one pharmaceutically acceptable basifying agent such as sodium bicarbonate in amounts that are effective together to inhibit particle size increase. The composition is suitable for oral or parenteral administration to a subject in need thereof for treatment of a disease characterized by overexpression of one or more anti-apoptotic Bc1-2 family proteins, for example cancer.

A conducting silicone matrix incorporating a suspension of a drug in ionized and non-ionized phases in an emulsion of a hydrophobic polymer. In one version, the drug is prepared as a concentrated aqueous suspension incorporated in a silicone matrix with a silicone surfactant. An electrolyte may be incorporated into the silicone matrix for increasing its conductivity. When a current is applied, the drug in individual globules in the drug suspension migrates away from the electrode and becomes concentrated at the distal side of the globules eventually resulting in an increase in the drug concentration distal to the electrode and adjacent to the skin and thereby resulting in transfer of the active drug through the skin. This system provides a matrix with minimal electroendosmotic flow that is current efficient and provides a drug reservoir that can last for several days during application of the drug.

The invention relates to the formulation and quality control of liquid drug suspensions. In particular, the invention relates to methods of formulating liquid suspensions comprising drug-containing resin particles. The invention also relates to methods of confirming the acceptability of drug-containing resin particles for use in formulating liquid drug suspensions. The invention further relates to methods of formulating liquid suspensions in which drug-containing resin particles, the liquid suspension, or both are modified to achieve a desired in vitro dissolution profile. The invention also relates to a novel dissolution method and methods of predicting in vivo bioequivalence based on in vitro dissolution methods.

The invention features a pharmaceutical suspension containing drug particles, a drug delivery device anchored in the mouth for continuously administering the pharmaceutical suspension, and methods of their use.

A drug delivery device is provided herein, the device including a reservoir for containing a medicament. The medicament includes a suspension of solids in a liquid carrier. The device also includes a needle having a distal end for injection into a patient, a proximal end in communication with the reservoir, and a lumen extending between the distal and proximal ends. A path is defined from the reservoir to the distal end of the needle through the lumen, the path having an inner diameter that decreases in the proximal to distal direction along at least a portion thereof. Advantageously, with the subject invention, a flow path may be defined which provides a more gradual transition in diameter from the reservoir to the distal tip of a needle. In this manner, changes in velocity of the suspension may be less abrupt than in the prior art, thus better maintaining solid particles in the suspension.

The present invention provides pharmaceutical suspensions of D-methionine in which the aqueous solubility of D-methionine is exceeded, thereby allowing oral administration of higher doses. The present invention also provides processes for preparing these suspensions. The present invention further provides methods for preventing, treating, or ameliorating oral mucositis, hearing loss due to chemotherapy, antibiotics and noise, neuronal damage due to various CNS disorders and injuries, and anthracycline toxicity.

The present invention in general relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one active ingredient and at least one dicarboxylic acid. It in particular relates to a pharmaceutical suspension comprising nano-sized cocrystals of at least one anthelmintic drug and at least one dicarboxylic acid. The invention further relates to uses, methods for use and methods for manufacturing the pharmaceutical suspension according to this invention.

Density-matching is used to provide suspending vehicles, pharmaceutical suspensions, dosage forms, and kits as well as methods of making and using the vehicles, suspensions, and dosage forms. Pharmaceutical suspensions comprising a pharmaceutically active agent having an active agent density, ρ_A, and a suspending vehicle having a suspending vehicle density, ρ_SV; wherein the suspending vehicle density, ρ_SV is substantially equal to the active agent density, ρ_A, are provided. Suspending vehicles comprise at least one suspending agent. The suspending vehicles can further comprise at least one density-modifying solid in such a combination with the suspending agent as to create a suspending vehicle that has a density that substantially matches the density of a desired drug particle or combination of drug particles. Pharmaceutical suspensions that remain homogenous during prolonged storage can be obtained.

The invention discloses a method for rapidly dissolving/swelling a water-soluble high polymer suspending agent in drug suspension. The method comprises the following steps: adding the suspending agentinto an organic solvent mixable with water, uniformly stirring and mixing until no granule exists, and adding the organic solvent with the suspending agent dispersed therein into a dispersion mediumcontaining drugs and excipients. When the suspended solution is prepared by the traditional method, the high polymer suspending agent easily floats on the water surface or block mass that is wet in exterior and dry in interior is formed, the suspending agent needs to be added into water to be uniformly stirred and mixed in the small-amount multiple manner, and the agent needs to be completely dissolved or swelled in water within 10-20 hours even longer time. Moreover, when the high polymer suspending agent is dispersed in the organic solvent, the suspending agent can be directly added into theorganic solvent, uniformly stirred and mixed and then mixed with the aqueous solution, the dispersed suspending agent can be rapidly and fully contacted with water and can be fully dissolved or swelled within 5-30 minutes, the drug preparation time can be greatly saved, and the production efficiency is improved.