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Method for rapidly dissolving/swelling water-soluble high polymer suspending agent in drug suspension

A technology of water-soluble polymers and suspending agents, which can be used in pharmaceutical formulations, organic active ingredients, liquid transportation, etc., and can solve problems such as the physical stability of suspensions, and achieve the effects of saving preparation time and improving production efficiency

Inactive Publication Date: 2018-12-07
CHONGQING BULL ANIMAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Suspensions mainly have physical stability problems

Method used

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  • Method for rapidly dissolving/swelling water-soluble high polymer suspending agent in drug suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of Sulfadiazine Suspension

[0013] Prescription: Sulfadiazine 10.0g

[0014] Propylene glycol 15.0ml

[0015] Ethylparaben 0.004g

[0016] Butylparaben 0.001g

[0017] Sodium carboxymethyl cellulose 1.0~1.2g

[0018] Add purified water to 100ml

[0019] Preparation method: Weigh 0.004g of ethylparaben and 0.001g of butylparaben, stir and dissolve them in 15.0ml of propylene glycol to obtain solution A; weigh 1.0g of sodium carboxymethylcellulose, and stir Add it into solution A, stir and mix well to get mixed solution B; accurately weigh 10.0g of qualified sulfadiazine raw material, add it to about 70ml of water, stir it evenly to get mixed solution C; slowly add mixed solution B to mix In solution C, stir and mix evenly while adding, and finally add purified water to make up to 100ml to get ready. After passing the inspection, subpackage, cover, label, pack, inspect, and store.

Embodiment 2

[0020] Example 2 Preparation of Enrofloxacin Suspension Injection

[0021] Prescription: Enrofloxacin 10.0g

[0022] EDTA-2Na 0.01g

[0023] Polyethylene glycol 10ml

[0024] NaHSO 3 0.2g

[0025] Ethylparaben 0.1g

[0026] Butylparaben 0.025g

[0027] Hydroxyethylcellulose 0.5g

[0028] Sodium citrate 0.2g

[0029] Add water for injection to 100ml

[0030] Preparation method: Weigh the prescribed amount of ethylparaben and butylparaben, dissolve them in 10ml of polyethylene glycol to obtain solution A; weigh the prescribed amount of hydroxyethyl cellulose, add it to solution A, and Stir while adding until evenly dispersed to obtain mixed liquid B; weigh the prescribed amount of EDTA-2Na, NaHSO 3 , enrofloxacin, dissolved / dispersed in about 70ml of water for injection in sequence to obtain mixed solution C; slowly add mixed solution B to mixed solution C, stirring while adding, after fully mixing, add the prescribed amount of lemon Sodium acid, stir and mix, add wat...

Embodiment 3

[0031] Example 3 Preparation of Albendazole Suspension

[0032] Prescription: Albendazole 20g

[0033] Propylene glycol 20ml

[0034] Sodium Carboxymethyl Cellulose 1.0g

[0035] Methylparaben 0.30g

[0036] Add purified water to 200ml

[0037] Preparation:

[0038] Preparation method 1: Take about 100ml of purified water, sprinkle the prescribed amount of sodium carboxymethyl cellulose in the water, stir and mix, and let it stand for about 10 hours until it is fully dissolved to obtain solution A; add the prescribed amount of Albenda Add azole to about 70ml of purified water, stir and mix to obtain mixed solution B; dissolve 0.30g of methylparaben in 20ml of propylene glycol to obtain solution C; add B and C to solution A in turn, and stir while adding Mix well, add purified water to make up to full volume, and you get it.

[0039] Method 2: Weigh the prescribed amount of methylparaben and sodium carboxymethylcellulose, first dissolve methylparaben in 20ml of propylene ...

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Abstract

The invention discloses a method for rapidly dissolving / swelling a water-soluble high polymer suspending agent in drug suspension. The method comprises the following steps: adding the suspending agentinto an organic solvent mixable with water, uniformly stirring and mixing until no granule exists, and adding the organic solvent with the suspending agent dispersed therein into a dispersion mediumcontaining drugs and excipients. When the suspended solution is prepared by the traditional method, the high polymer suspending agent easily floats on the water surface or block mass that is wet in exterior and dry in interior is formed, the suspending agent needs to be added into water to be uniformly stirred and mixed in the small-amount multiple manner, and the agent needs to be completely dissolved or swelled in water within 10-20 hours even longer time. Moreover, when the high polymer suspending agent is dispersed in the organic solvent, the suspending agent can be directly added into theorganic solvent, uniformly stirred and mixed and then mixed with the aqueous solution, the dispersed suspending agent can be rapidly and fully contacted with water and can be fully dissolved or swelled within 5-30 minutes, the drug preparation time can be greatly saved, and the production efficiency is improved.

Description

technical field [0001] The invention relates to a pharmaceutical preparation technology, in particular to a method for rapidly dissolving / swelling a water-soluble polymer suspending agent in a pharmaceutical suspension. Background technique [0002] Suspension refers to a non-uniform liquid preparation formed by dispersing poorly soluble solid drugs in a dispersion medium in a particulate state. The drug particles in the suspension are generally between 0.5 and 10 μm, the small ones can be 0.1 μm, and the large ones can reach 50 μm or larger. Suspensions are thermodynamically unstable coarse dispersion systems, and most of the dispersion media used are water, and vegetable oil can also be used. Suspensions mainly suffer from physical stability problems. The large dispersion of drug particles in the suspension makes the suspended particles have high surface free energy and are in an unstable state. In order to improve the physical stability of the suspension, it is often n...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K31/63A61K31/496A61K31/4184A61K47/38A61K47/10
CPCA61K9/10A61K31/4184A61K31/496A61K31/63A61K47/10A61K47/38
Inventor 姜波吴俊伟曾杨梅陈红伟邓开锋
Owner CHONGQING BULL ANIMAL PHARMA
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