5985 results about "Coupling reaction" patented technology

The invention discloses a method for preparing diethyl oxalate by CO coupling reaction. By applying a gas phase method, CO is coordinated with ethyl nitrite and is catalyzed by bimetallic supported catalyzer to couplingly generate crude diethyl oxalate, the reaction is a self-sealing circulation process, the CO gas mixed with the ethyl nitrite coming from a regeneration reactor is preheated and then enters into a coupling reactor, after the reaction, the gas is separated by condensation, so that the colorless and transparent condensed diethyl oxalate liquid is produced, and the uncondensed gas containing NO enters into the regeneration reactor to react with ethanol and oxygen in order to generate ethyl nitrite which is again circulated back to the coupling reactor for continuous use. The invention is carried out on the basis of previous laboratory research and under the background of industrial production and fulfils the continuous run examination of the bench scale test and pilot magnification under the condition of industrial operation, the temperature of the coupling reaction is low, and the concentration of products is increased. The method has the advantages of more energy saving, no pollution and high benefit. The total conversion rate of the CO generated by reaction is one hundred percent, and the selectivity of diethyl oxalate is over ninety six percent.

The invention discloses a method for synthesizing tyrosine kinase inhibitor PCI-32765. The method comprises the following steps of: 1) carrying out a coupled reaction between a compound 10 and a compound 15 to obtain a compound 6; 2) reacting the compound 6 with a compound 16 to obtain a compound 11 in the presence of a more ideal catalyst; 3) protecting the compound 11 to obtain a compound 12; 4) carrying out selective de-protection on the compound 12 to obtain a compound 13; 5) attacking the compound 13 which has only one position which can be attacked by a compound 17 to obtain a very pure compound 14; and 6) removing protecting groups, thus obtaining the PCI-32765. By the method, tyrosine kinase which serves as a main receptor signal of B cells can be inhibited, and the tyrosine kinase inhibitor PCI-32765 is not only capable of inhabiting the generation of hemocyte with little toxicity and side effects, but also is moderate in reaction conditions, simple to operate, convenient to purify, low in cost, environment-friendly, and suitable for large scale production.

The present invention provides a method for the preparation of 5-azacytidine, wherein 5-azacytidine is represented by the structure: The method involves the silylation of 5-azacytosine, followed by the coupling of silylated 5-azacytosine to a protected β-D-ribofuranose derivative. The coupling reaction is catalyzed by trimethylsilyl trifluoromethanesulfonate (TMS-Triflate).

Coupling reactions, suitable for use in organic or aqueous media, are performed by contacting a 1,2,4,5-tetrazine with a dienophile. The dienophile may be covalently bonded to a protein, and the coupling reaction may be performed in biological media such as those containing cells or cell lysates. The reactions may be performed in the presence of primary amines, thiols, acetylenes, azides, phosphines, and products of Staudinger and / or Sharpless-Huisgen reactions Novel 3-substituted cyclopropene compounds and trans-cyclooctenes are exemplary dienophiles for these reactions.

The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

Disclosed and claimed are: a composition including at least one glycosaminoglycan, e.g., CIS, at least one perfluorinated substance and at least one alginate, e.g., sodium alginate, wherein:the at least one glycosaminoglycan and / or the perfluorinated substance and / or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt; orthe at least one glycosaminoglycan, the perfluorinated substance and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS; orthe at least one glycosaminoglycan and / or the perfluorinated substance and / or the alginate are cross-linked or polymerized, e.g., the alginate is cross-linked or polymerized, for instance by addition of an inorganic salt, such as a calcium salt, and the at least one glycosaminoglycan and the alginate are covalently bound, e.g., by means of a coupling reaction involving a linker molecule such as DVS, and the covalent binding can have been performed prior to cross-linking or polymerizing or vice versa; and,gels comprising the composition; mixtures of such gels or of at least one such gel and at least one such composition; and,methods for making and using such compositions and gels, including products therefrom such as "paints", sprays, matrices, beads, microcapsules.

The present invention discloses a catalyst for methane oxidative coupling polymerization to prepare ethylene under the condition of pressurization, and said catalyst uses SiO2 as support, and its active component is formed from Mn2O3, Na2WO4 and SnO2, and its active component content is 10 wt%-20 wt%. Under the condition of no dilution gas, 0.6 MPa and high space velocity it can obtain 33.0% of methane conversion rate and 24.1% of C2 hydrocarbon yield.

The invention discloses a synthetic method of a covalent organic framework (COF) material. The method comprises the following steps: after mixing 1,3,5-benzenetricarboxaldehyde with 2,5-di(N,N-dimethyl)amino-1,4-benzdihydrazide uniformly in an organic solvent, reacting in the presence of a catalyst acetic acid to obtain the COF material, wherein the mole ratio of 1,3,5-benzenetricarboxaldehyde to 2,5-di(N,N-dimethyl)amino-1,4-benzdihydrazide is 1:(0.5-3). The COF material obtained by adopting the method has relatively large specific surface area and regular open framework structure with adjustable diameter, thus being beneficial for mass transfer of reactants and products in photoabsorption and catalytic processes; the material can serve as a photocatalyst and can increase the yield of the dehydrogenative coupling reaction between 2-phenyl-1,2,3,4-tetrahydroisoquinoline and nitromethane from 39% in the absence of catalysts to 89%.

Oligonucleotide chemistry is central to the advancement of core technologies such as DNA sequencing, forensic and genetic analysis and has impacted greatly on the discipline of molecular biology. Oligonucleotides and their analogues are essential tools in these areas. They are often produced by automated solid-phase phosphoramidite synthesis but it is difficult to synthesize long DNA and RNA sequences by this method. Methods are proposed for ligating oligonucleotides together, in particular the use of an azide-alkyne coupling reaction to ligate the backbones of oligonucleotides together to form longer oligonucleotides that can be synthesized using current phosphoramidite synthesis methods.

Force feedback in large, immersive environments is provided by device which a gyro-stabilization to generate a fixed point of leverage for the requisite forces and / or torques. In one embodiment, one or more orthogonally oriented rotating gyroscopes are used to provide a stable platform to which a force-reflecting device can be mounted, thereby coupling reaction forces to a user without the need for connection to a fixed frame. In one physical realization, a rigid handle or joystick is directly connected to the three-axis stabilized platform and using an inventive control scheme to modulate motor torques so that only the desired forces are felt. In an alternative embodiment, a reaction sphere is used to produce the requisite inertial stabilization. Since the sphere is capable of providing controlled torques about three arbitrary, linearly independent axes, it can be used in place of three reaction wheels to provide three-axis stabilization for a variety of space-based and terrestrial applications.

The invention discloses novel liquid polycarbosilane which is low in viscosity and high in storage stability and is crosslinkable, a preparation method of novel liquid polycarbosilane, and an application of novel liquid polycarbosilane. Polycarbosilane is prepared by adopting chloromethyl alkoxy silane or mixtures of chloromethyl alkoxy silane as raw materials by virtue of Grignard coupling reaction and reduction reaction, and the structure of polycarbosilane is shown in a formula (I) in the specification. The structure simultaneously contains Si-H bonds and unsaturated bonds such as C=C bonds, can be subjected to self-crosslinking and curing under a certain condition, has relatively high ceramic yield, and can be used as a silicon carbide precursor of a polymer precursor impregnation pyrolysis (PIP) process. Polycarbosilane disclosed by the invention is adjustable in structural composition, good in storage stability, low in viscosity and relatively low in boiling point, and has the utilization potentiality of being used as a silicon carbide ceramic precursor for chemical vapor deposition / chemical vapor infiltration (CVD / CVI). In addition, polycarbosilane can also be used for replacing commonly-used divinyl benzene to serve as a crosslinking agent of solid-state polycarbosilane (PCS).

The invention discloses an isolated cell type silicon rubber foam material and the manufacture method and the application. The feature is that it is made up of 100 portions silicone rubber, 15-80 portions reinforcing agent, 2-15 portions constitution controller, 3-15 portions foaming agent, 0-3 portions blowing promoter, and 0-4 portions coupling assistant agent, after taking radiation by electron beam or gama radiation, the silicon rubber takes coupling reaction, and the radiation dose is 5-20KGy. Decomposing foaming by heating, the silicon rubber could immediately taking electron beam or gama radiation to take the second radiation coupling, the radiation dose is 20-50KGy to improve the complex performance of the silicon rubber foam material. The invention could be used as sealing, damping, insulating, sound insulating and thermal insulating material.

The invention relates to a method for preparing hydrophilic / oleophobic oil-water separation stainless steel net films. Stainless steel nets are used as bases. The method includes constructing a poly-dopamine medium layer on the surface of each stainless steel net in dip-coating or spraying modes; dipping the stainless steel nets with the poly-dopamine medium layers in zwitter-ionic polymers with active ester groups; or spraying the zwitter-ionic polymers with the active ester groups on the surfaces and meshes of the stainless steel nets with the poly-dopamine medium layers; carrying out amidation coupling reaction on the zwitter-ionic polymers and each poly-dopamine medium layer to form a stable hydrophilic polymer film on the surface and the meshes of the corresponding stainless steel net. The method has the advantages that the hydrophilic / oleophobic oil-water separation stainless steel net films prepared by the aid of the method are super-hydrophilic and are high in water flux, stable in structural performance and high in anti-pollution capacity; the method has a broad application prospect in the aspects of recycling marine oil slick, removing water from crude oil, treating oily sewage and the like.

New synthetic methods for the preparation of macrocyclic amido-N donor ligands are provided. The primary method of the present invention involves in general only two synthetic steps. In the first step, an alpha or beta amino carboxylic acid is allowed to react with an optimal (approximately stoichiometric) amount of an activated malonate or oxalate derivative with mild heating. Upon completion of the double coupling reaction, hydrolysis of the reaction mixture yields a diamide containing intermediate (a macro linker). In the second step, stoichiometric amounts of a diamine, preferably an orthophenylene diamine, are added to the macro linker intermediate in the presence of a coupling agent and heat. This second double coupling reaction, is allowed to proceed for a period of time sufficient to produce a macrocyclic tetraamido compound. The substituent groups on the alpha or beta amino carboxylic acid, the malonate, and the aryl diamine may all be selectively varied so that the resulting tetraamido macrocycle can be tailored to specific desired end uses. The macrocyclic tetraamide ligand may then be complexed with a metal, such as a transition metal, and preferably the middle and later transition metals, to form a robust chelate complex suitable for catalyzing oxidation reactions.

The present invention relates to catalysts of transition metal complexes of N-heterocyclic carbenes, their methods of preparation and their use in chemical synthesis. The synthesis, ease-of-use, and activity of the compounds of the present invention are substantial improvements over in situ catalyst generation. Further, the transition metal complexes of N-heterocyclic carbenes of the present invention may be used as precatalysts in metal-catalyzed cross-coupling reactions.

The invention relates to a method for producing oxalic ester by CO coupling, which mainly solves the problems of the prior art such as low selectivity and low CO single pass conversion in producing the oxalic ester by CO coupling. In the invention, firstly CO and nitrite ester are put into a coupling reactor and then contacted with a catalyst containing Pd; liquid phase reaction effluent II and gas phase reaction effluent III are obtained from effluent I through gas-liquid separation; the gas phase reaction effluent III, O2 and monohydric alcohol of C1-C4 are taken as raw material and put into a regeneration reactor for reaction to generate gas effluent IV containing nitrite ester; the gas effluent IV returns to the coupling reactor for continuous reaction and the mol ratio of nitrogen oxide:O2:monohydric alcohol of C1-C4 is 1:0.3-0.5:1-1.5. The technical proposal of obtaining the oxalic ester product by separating the liquid phase reaction effluent II better solves the problem and can be applicable to the industrial production of oxalic ester.

The invention provides aliphatic-aromatic copolyester, a preparation method and application thereof. Polymerization monomers comprise a compound selected from aliphatic dibasic acid, and naphthenic base dibasic acid or the ester, the anhydride and the acyl halide thereof, a compound selected from aromatic dibasic acid or the ester, the anhydride and the acyl halide thereof, a compound simultaneously with two functional groups selected from an amino-group, a mercapto group or a hydroxy or a compound of a derivative of the amino-group, the mercapto group or the hydroxyl with an epoxy group and an azepine ring, a compound selected from unsaturated acid with at least one C-C, C-O, C-N or C-S double bond and C-C or C-N triple bond or the ester, the anhydride and the acyl halide thereof and a compound of unsaturated alcohol with at least one C-C double bond or a C-C triple bond or an epoxide thereof. The aliphatic-aromatic copolyester is prepared by carrying out esterification and polycondensation after mixing the polymerization monomers, polymerizing the double bonds and / or the triple bonds on the polymerization monomers under the action of an initiator and then carrying out a graftingand / or coupling reaction.

The invention relates to a preparation method of abiraterone acetate. The method comprises: taking dehydroepiandrosterone as the raw material, which successively reacts with hydrazine hydrate and idoine so as to obtain 17-iodo-adrost-5, 16-diene-3beta-ol, which then undergoes a Negishi coupling reaction with 3-pyridine zinc halide to obtain abiraterone, and finally conducting esterification with acetyl chloride or acetic anhydride, thus obtaining the target product abiraterone acetate.

The invention belongs to the technical field of organic light emitting materials, and discloses an aggregation-induced light emitting material simultaneously containing a triphenylethylene structure and a tetraphenylethylene structure. During synthesis, a triphenylethylene intermediate containing a functional group and a tetraphenylethylene intermediate containing a functional group are connected together by coupling reaction. A synthesis method of the invention has the advantages of simple process and convenient purification; and the synthesized organic light emitting material simultaneously containing the triphenylethylene structure and the tetraphenylethylene structure has the advantages of obvious aggregation-induced light emitting performance, high thermal stability, high glass-transition temperature and high luminous intensity and is suitable for preparing a light emitting layer material in an organic electroluminescent material device.

The invention discloses a method for synthesizing fluorine-containing antiform alkyl cyclohexyl biphenyl single liquid crystal; in the method, bromobenzene and magnesium are selected to carry out Grignard reaction; then the reactants are coupled and hydrolyzed with alkyl cyclohexanone; dehydration, hydrogenation, transformation and iodization are carried out to synthesize alkyl cyclohexyl iodide; the Grignard reaction is carried out on fluorobromobenzene and magnesium, then low temperature coupling is carried out to synthesize p-fluoropheyl boric acid; finally, coupling reaction is carried out to synthesize the target compound; the method of the invention has the characteristics of use of highly active load catalyst, high yield, low production cost, little discharge of three wastes, reduction of generation of isomers and improvement of selectivity and yield of the target compound.

The invention relates to a graphene oxide supported Schiff base palladium catalyst as well as a preparation method and application thereof. A catalyst carrier is a graphene oxide prepared by an improved Hummers process, ligand is Schiff base and an active ingredient is palladium salt; the capacity of the palladium in the active ingredient palladium salt is 5.0%-10.0% of the total mass of the catalyst, the diameter of the graphene oxide is 1 mu m-5 mu m, the thickness of the graphene oxide is 0.8 nm-1.2 nm, and the particle diameter of a palladium nano particle is 3 nm-8 nm. The graphene oxide-supported Schiff base palladium catalyst can be used for preventing the palladium from losing in a catalysis process, meanwhile, the graphene oxide has a unique two-dimensional planar structure and can also be used for improving dispersing performance of the palladium nano particle on the surface of the graphene oxide to prevent the palladium from gathering in the catalysis process, so that the catalytic activity of the supported type catalyst is improved. Therefore, the graphene oxide-supported Schiff base palladium catalyst disclosed by the invention can be used for preventing the palladium from gathering and losing better in a catalytic C-C (Carbon-Carbon) coupling reaction process, and has higher catalytic activity and better recycling performance.

The present invention provides a method of manufacturing high-melting-tension heat-resistant transparent or opaque sheets, boards, and moulds from polyethylene terephthalate (PET). The method is characterised in that a mixture of: (1) PET polyester whose melt flow rate (MFR) is 45-130 g / 10 minutes (a); (2) coupling agent master batch (f) comprising coupling agent (d) and substrate (e), wherein coupling agent (d) is a mixture of compounds containing 2 epoxy groups (b) and compounds containing 3 or more epoxy groups (c); and (3) catalyst master batch (i) comprising coupling reaction catalyst (g) and substrate (h); is melted in a reaction-extruder to give PET polyester whose MFR is 40 g / 10 minutes or less. The resulting PET polyester is moulded into amorphous sheets or boards, and then heated again to a predetermined temperature to give transparent heat-resistant sheets or boards; or then vacuum-, pressure-, or vacuum-pressure-formed following heat-setting to give transparent heat-resistant or white opaque highly-heat-resistant mould articles.

Oligonucleotide chemistry is central to the advancement of core technologies such as DNA sequencing, forensic and genetic analysis and has impacted greatly on the discipline of molecular biology. Oligonucleotides and their analogues are essential tools in these areas. They are often produced by automated solid-phase phosphoramidite synthesis but it is difficult to synthesize long DNA and RNA sequences by this method. Methods are proposed for ligating oligonucleotides together, in particular the use of an azide-alkyne coupling reaction to ligate the backbones of oligonucleotides together to form longer oligonucleotides that can be synthesized using current phosphoramidite synthesis methods.

The present invention relates to nucleic acid amplification, and is especially multiple PCR process based on selective probe for simultaneous amplification of several nucleic acid segments and its application. The multiple PCR process includes the following steps: 1. constructing selective probe; 2. extension-coupling reaction; 3. PCR amplification; and 4. detecting PCR amplification product. The present invention features the selective probe and the PCR amplification product with difference in length. The process has greatly increased analysis flux, saving in the nucleic acid template consumption for detecting the sample, high compatibility of the detection system and other advantages.

A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.

The present invention discloses new coupling reaction process for preparing beta-carotene. Organic phosphine salt is first prepared through reacting vitamin A derivative and triphenyl phosphine, and then made to produce coupling reaction in the presence of oxidant to obtain beta-carotene. The present invention features that the coupling reaction is completed in a two phase system of water phase and water insoluble organic solvent phase, so that the produced beta-carotene is extracted constantly by the organic solvent phase, decreasing the possibility of oxidizing produced beta-carotene and raising beta-carotene yield.

The invention discloses a methane oxidative coupling catalyst and a preparation method thereof. The method comprises: under an ultrasonic condition, subjecting a carrier to first dipping in a metal compound aqueous solution, and conducting drying, then carrying out second dipping in a metal compound aqueous solution under the ultrasonic condition, and performing drying and roasting. The preparation method of the methane oxidative coupling reaction catalyst is simple and easy to operate, and the methane oxidation coupling reaction catalyst prepared by the method has uniformly distributed active components with small particle size. By applying the methane oxidative coupling catalyst prepared by the method to methane oxidative coupling reaction, the conversion rate of methane and the selectivity of C2 hydrocarbons can be increased simultaneously.

The invention discloses a preparation method of a modified polymer film material for effectively removing trace heavy metal ions in a water body, which comprises the following steps: 1) carrying out plasma treatment on a polymer film; 2) respectively preparing an initiator solution, a monomer solution, a buffer solution, an activating solution and a polyethylene polyamine water solution; 3) immerging the polymer film in the initiator solution, and carrying out surface activation by ultraviolet irradiation; 4) putting the polymer film into the monomer solution to carry out grafting reaction under ultraviolet irradiation; 5) activating the polymer film in the activating solution; and 6) putting the activated film into a polyethylene polyamine water solution to carry out coupling reaction, thereby preparing the modified film material capable of removing trace heavy metal ions in a water body. In the polymer film modifying process, carboxyl and amino groups are introduced to carry out hydrophilization and endow the modified film with complexing capacity, thereby removing the trace heavy metal ions. The invention has the advantages of simple technique, favorable treatment effect, wide application range, low cost, high unit mass adsorption capacity, time saving, high efficiency and energy saving.

The present invention discloses a manganese-sodium-tungsten-silicon composite oxide oxidative coupling of methane catalyst containing or not containing titanium, obtained by loading manganese-sodium-tungsten onto a titanium-silicon molecular sieve or a pure silicon molecular sieve by means of a step-by-step impregnation method and calcination. The manganese-sodium-tungsten-silicon composite oxide catalyst containing or not containing titanium has the following structural formula: vMnO2·xNa2O·yWO3·zTiO2·(100-v-x-y-z)SiO2, the v, x, y, and z respectively representing the fractional quality occupied by metal manganese oxide, sodium oxide, tungsten oxide and titanium oxide, 0.3≤v≤16, 0.1≤x≤5, 0.6≤y≤21, 0.0≤z≤4. The manganese-sodium-tungsten-silicon composite oxide catalyst containing or not containing titanium set forth in the present invention is used for oxidative coupling of methane reactions, having excellent low-temperature catalytic activity and ethylene / propylene selectivity generation and reaction stability.