440results about How to "Reduced survival rate" patented technology

The invention provides a cooperative air combat firepower distribution method based on an improved multi-target leapfrog algorithm and belongs to the technical field of computer simulation and method optimization. The method comprises the steps that firstly, required data information is obtained through a cooperative air combat formation command and control system; secondly, a multi-target optimization module of cooperative air combat firepower distribution is established; then a multi-target quantum leapfrog algorithm based on a self-adaptive mesh method is carried out, and a Pareto non-inferior solution of firepower distribution problem is solved; finally, rules can be selected independently according to the optimal distribution scheme, and the optimal firepower distribution scheme is selected from the non-inferior solution. The cooperative air combat firepower distribution method based on the improved multi-target leapfrog algorithm has the major functions that weapons on a fighter aircraft on an attack mission are distributed to multiple targets according to the optimal firepower distribution scheme, the formed cooperative air combat is enabled to realize the optimal cooperative attack effect, and the maximum operational effectiveness is obtained.

In one aspect, the invention provides methods of inhibiting the effects of MASP-2-dependent complement activation in a living subject. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation. In some embodiments, the MASP-2 inhibitory agent inhibits cellular injury associated with MASP-2-mediated alternative complement pathway activation, while leaving the classical (C1q-dependent) pathway component of the immune system intact. In another aspect, the invention provides compositions for inhibiting the effects of lectin-dependent complement activation, comprising a therapeutically effective amount of a MASP-2 inhibitory agent and a pharmaceutically acceptable carrier.

The invention relates to a method for alive preservation and transportation of sea cucumber, which belongs to the technical field of aquatic products. The method comprises the following steps: holding the transported sea cucumber (naturally fished and caught or artificially cultured) for at least two days, transferring the sea cucumber with strong vitality after holding into a cooling barrel which is disinfected in advance and contains filtered sea water for performing cooling treatment, then placing into a plastic bag (a small sponge after being soaked in the sea water at the temperature of 20 DEG C is arranged in the bag), exhausting the air in the bag, enabling the bag to be rapidly filled with oxygen, binding up a bag mouth, and boxing; loading two layers or three layers or four layers in each heat insulation box, determining according to the size of the sea cucumber and the size of space in each box, separating the layers by hardboards, using foam boards to support at the middle parts, preventing the plastic bag from being damaged by extrusion and further avoiding death caused by hypoxia of the sea cucumber or oppression on the sea cucumber; placing the upper layer of the hardboard into a bag which loads ice blocks in advance or a heat insulation bottle for heat insulation; and sealing with an adhesive tape after well boxing, marking and starting the transportation as soon as possible. By adopting the method, the survival rate of the sea cucumber during the transportation is effectively improved, and the transportation cost is reduced.

A method detects a biological condition and detects a change in the biological condition of a mammal. The device determines if the change in the biological condition exceeds a predetermined threshold and sends a signal based at least in part on the determination.

The present invention relates to a novel approach to prevent or treat mastitis both in humans and animals through the use of mammal milk-derived microorganisms obtained from healthy hosts of the homologous species; to those new probiotic microorganisms obtained from milk able to reduce infectious mastitis and the method of screening used for their obtaining; to the use of these probiotic bacteria for the prophylaxis or treatment against mastitis and other diseases; and finally, to compositions comprising these compounds.

The invention provides a preparation method of a multifunctional layered joint cartilage support. The multifunctional layered joint cartilage support capable of simulating the biological property andthe mechanical property of natural cartilage is prepared by taking hydrogel as a support material, taking mesenchymal stem cells, cartilage cells and osteoblasts as inducing and developing objects andby adopting a 3D printing technology. The multifunctional layered joint cartilage support can accurately simulate the internal tissue form and the contour of each layer of the natural cartilage and can realize that different layers have different mechanical and biological characteristics. The prepared artificial cartilage support cells are derived from patients, the support serves as a degradablehydrogel material and the rejection reaction after implantation is greatly reduced. Various nutritional substances and growth factors are mixed in the hydrogel support, so that the sustained releaseeffect can be achieved and regulation and control of the growth and development of the artificial cartilage can be realized.

The invention relates to the technical field of fruit tree planting and particularly relates to a method for planting passion fruits. The method provided by the invention comprises the following steps: a. carrying out land preparation and seed preparation: deeply plowing land after Beginning of Spring, applying lime and carbendazim during deep plowing, sunning soil for 4 to 8 days, then, carrying out leveling, and digging passion fruit planting pits; b. shelving passion fruit planting shelves; c. planting the passion fruits: firstly, applying a bedding material to the bottom of each planting pit, planting passion fruit seedlings, covering the planting pits with soil, irrigating field planting water, and digging a round of dressing furrow in a manner of taking each passion fruit seedling as a center; d. carrying out field management: 3 years after planting, pulling out 1 / 4 to 1 / 3 of old vines in turn every year in a spaced manner; and e. carrying out harvesting: carrying out picking in a non-scheduled manner when the passion fruits are mature. According to the method provided by the invention, soil properties are improved, the problem, i.e., soil hardening is effectively solved, and the soil is high in permeability and plays roles in preserving moisture and heat; and by rational application of fertilizer, the utilization rate of the fertilizer is increased, yield and income are increased, and thus, a reference is provided for sustained development of the passion fruits.

The present invention relates to the technical field of agricultural planting, in particular to a planting method of kiwifruit, comprising: seedling cultivation, grafting, land arrangement, transplanting and scaffolding, cultivation management, pollination of kiwifruit plants, flower thinning and fruit thinning treatment, and pest control step. The effect of the present invention: by placing branches in the pits for planting kiwifruit, the root system of the kiwifruit after planting will not reduce the survival rate due to failure to drain water in time in the rainy season.

The invention discloses concentrated cloudy apple juice, which is a popular novel fruit juice product at present. The prior sterilization method causes serious damages to the heat sensitive substances in the concentrated apple juice and great loss of nutrients. The invention discloses a method for sterilizing the concentrated cloudy apple juice by using high voltage pulse electric fields and adopts a technical proposal comprising: building a sterilization room; arranging a temporary juice tank; a vacuum pump and a cooling device; arranging a high voltage pulse generator; setting working parameters; controlling sterilization temperature; concentrating and sterilizing cloudy juice; and detecting microbiological indexes. The method can kill harmful microorganisms in the concentrated cloudy apple juice effectively, reduce the survival rate of the harmful microorganisms to almost zero, and better protect the nutrients, color, scent and taste of the concentrated cloudy apple juice obviously than pasteurization. The sterilized concentrated cloudy juice meets national standards completely.

The invention discloses a cell therapy composition for treating osteoarthritis and cartilage defects. The cell therapy composition consists of stem cells and xanthan gum solution or gel; per 2 ml of the xanthan gum solution or gel at least contains 2x107 stem cells from a primary generation to a tenth generation; and the stem cells comprise adipose tissue derived stem cells, bone mesenchymal stem cells, umbilical cord blood derived stem cells and placenta derived stem cells. The intra-articular survival rate of the stem cells in the composition is high, conditions of the osteoarthritis and the cartilage defects can be improved, and damaged cartilage can be repaired.

The invention discloses a planting substrate for dendrobium officinale. The planting substrate comprises a substrate A, a substrate B and a substrate C which are arranged in a manner of being superposed sequentially from bottom to top, wherein the substrate A is prepared from 10-20 parts (by weight) of dried rice straws or dried sugarcane leaves; the substrate B is prepared from 5-20 parts (by weight) of medium sand, 10-30 parts (by weight) of edible fungus leftovers, and the like; and the substrate C is prepared from 15-45 parts (by weight) of biocarbon, 15-45 parts (by weight) of semi-corroded miscellaneous tree branches, 15-45 parts (by weight) of tung fruit peels, 15-45 parts (by weight) of corncobs, 15-45 parts (by weight) of pine barks, and the like. A preparation method for the planting substrate comprises the steps of preparing the biocarbon, preparing the substrate A, the substrate B and the substrate C and then carrying out superposition. The preparation method for the planting substrate is simple and easy to understand; and the planting substrate prepared by the preparation method has the advantages that the condition that the substrate is rotted, is air-proof and does not hold moisture in long-term use is overcome, the cost is low, the nutrition is complete, the growth of the dendrobium officinale is better facilitated, dendrobium officinale stems are promoted to grow more sturdy, and dendrobium officinale root systems are promoted to be more developed.

The invention relates to the technical field of bulk fresh water fish culture, and provides a salinization weight-reducing bighead carp culture method. Selected bighead carps are subjected to pond recuperation and salinization culture, and the bighead carps discharge vivotoxin while swimming by the aid of flowing water so as to remove redundant fat; the bighead carps with weight reduced are subjected to salinization culture with appropriate salinity, harvested bighead carps are good in meat quality, delicious and high in economic value, and cultured bighead carps are bright in body color, strong, free of muddy taste, less in fat and chemical residue, good in taste and high in quality.

The invention discloses a Dendrobium officinale culture medium, which comprises a base layer, a buffer layer and a medium layer, wherein the base layer, the buffer layer and the medium layer are successively overlaid from bottom to top; according to parts by weight, the base layer is prepared from 10-20 parts of dry wheat straw or 10-20 parts of dry sugarcane top, the buffer layer is prepared from the mixture of 5-10 parts of silkworm excrement, 10-20 parts of leaf mold and the like, and the medium layer is prepared from the mixture of 15-25 parts of modified charcoal, 15-45 parts of rotten wood or tree, 5-15 parts of expanded perlite and the like. The preparation method of the plantation medium is obtained by overlapping the preparation of the modified charcoal and the preparation of the base layer, the buffer layer and the medium. The preparation method is simple and easy to understand. The plantation medium prepared from the Dendrobium officinale culture medium overcomes the defects that the medium is rotten and airtight and does not realize water retention after the medium is used for a long time. The Dendrobium officinale culture medium has the advantages of low cost and complete nutrition, is favorable for the growth of Dendrobium officinale and accelerates the stem of the Dendrobium officinale to be thicker and the root system of the Dendrobium officinale to be developed.

The invention belongs to the technical field of biological medicines and particularly provides an anti-tumor platinum pro-drug and a nanometer hydrogel drug and a preparation method thereof.The pro-drug is obtained by conducting hydrogen peroxide oxidation on an anti-tumor platinum drug to obtain a Pt(IV) sexadentate complex and then making the sexadentate complex react with anhydride or carboxylic acid containing double bonds.The pro-drug can be in self-polymerization or can be copolymerized with other hydrophilic monomers for the preparation of drug micro-spheres having high drug loading capacity.The micro-spheres are uniform in particle size and controllable in size and can keep long-term stability in an aqueous solution by using a stabilizer.The preparation method is simple, an obtained nanometer hydrogel drug carrier has glutathione stimulus responsibility, so that nanometer hydrogel is kept stable in a low-glutathione-concentration environment outside tumor cells, the drug is rarely leaked after long-time cycle, the nanometer hydrogel is rapidly degraded in the reducing environment within the tumor cells and converted into a linear chain of small molecular weight, the drug is quickly released, and the targeted killing effect on the target tumor cells is achieved.

The invention belongs to the field of biological medicines, and relates to application of Bcl-xL inhibitor and oncolytic virus to preparation of anti-tumor medicines. It is found for the first time that Bcl-xL inhibitor can be used for preparing oncolytic virus anti-tumor synergist. The invention meanwhile relates to a pharmaceutical composition containing Bcl-xL inhibitor and oncolytic virus, a medicine suit containing Bcl-xL inhibitor and oncolytic virus, and application of Bcl-xL inhibitor and oncolytic virus to treatment of tumors, especially tumors not sensitive to oncolytic virus.

The invention discloses a dendrobium officinale planting substrate containing modified biochar, which comprises substrate A, substrate B and substrate C arranged sequentially from bottom to top; according to the ratio of parts by weight, substrate A is 10-20 parts of dry rice straw Or 10-20 parts of dry sugarcane leaves; substrate B is 5-20 parts of silkworm excrement, 10-30 parts of rice bran, etc.; 45 copies etc. The preparation method of the planting substrate is the preparation of modified biochar, the preparation of substrates A, B and C, and then superposition. The preparation method of the present invention is simple and easy to understand, and the planting substrate prepared by the present invention overcomes the long-term use of the substrate, rots and airtight, does not retain water, and has low cost and complete nutrition, which is more conducive to the growth of Dendrobium candidum, and promotes the growth of Dendrobium candidum Stronger and more developed root system.

The invention discloses a brown planthopper sialaden secretor gene N1MLP and an application OF brown planthopper NIMLP in paddy resisting against brown planthopper after the gene N1MLP is restrained. A complete cDNA sequence of the brown planthopper sialaden secretor gene N1MLP is shown as SEQ ID No.1; ds RNA of the N1MLP enters the brown planthopper in the manner of micro-injection, so that the N1MLP gene expression quantity is reduced, the feeding of the brown planthopper is affected and the survival rate of the brown planthopper is reduced; the ds RNA of the N1MLP is stably expressed in the paddy plant; after the brown planthopper eats the paddy, the N1MLP gene expression quantity is reduced, so that the brown planthopper weight is reduced and the survival rate of the brown planthopper is reduced. According to the invention, the N1MLP, of which the expression is restrained, has significance in researching the paddy resisting against brown planthopper and preventing and treating the brown planthopper in agricultural production.

The invention belongs to the field of porous organic materials and in particular discloses a hydrogen bond organic framework material based on condensed ring ligand construction as well as a preparation method and application thereof. The material is prepared by taking condensed ring ligands as an organic framework by utilizing a synergistic effect of pi-pi interaction of multiple hydrogen bonds and condensed ring ligands. The condensed ring ligands are selected from carboxyl-containing poly-benzene ring conjugated aromatic hydrocarbons, and the particle size of the material is 200nm to 50 microns. The organic framework material has the characteristics of being high in specific surface area, permanent in pore channel, high in chemical and thermal stability, mild in synthesis conditions andexcellent in singlet oxygen production capacity and the like. Moreover, the material is simple in preparation method, high in operability and capable of freely controlling the particle size of particles. The material has excellent biocompatibility and low biotoxicity, has excellent compound chemical-photodynamic therapy capacity after further compounding anti-cancer drugs, and achieves an excellent cancer treatment effect, and the cancer cell survival rate is low.

The invention discloses an application of a cyclopeptide compound for preventing tumors, and a preparation method of the cyclopeptide compound, belonging to the technical field of biological medicines. The cyclopeptide compound CP-1 or CP-2 has the functions of inhibiting cancer cell growth and proliferation, adjusting and controlling cancer cell periods and adjusting and controlling cancer cell periodic protein expression, so that the cyclopeptide compound can be used for preparing anti-cancer medicaments and / or health care products. The invention further relates to the preparation method of the cyclopeptide compound CP-1 or CP-2. The preparation method comprises the following steps of: with streptomycete as a stain, optimizing the cultivation and fermentation conditions, treating the fermented product, separating the fermented product by using a silica gel column and a reverse phase silica gel column, and finally separating by using a preparative chromatography column so as to obtain the cyclopeptide compound with activity. Compared with the prior art, the preparation method is simple, feasible, environmental-friendly, low in cost and high in yield; and according to the preparation method, the yield of microbial activity secondary metabolite is effectively increased.

The invention discloses a wild-imitating planting substrate for dendrobium huoshanense. The wild-imitating planting substrate comprises a bottom-layer substrate, a middle-layer substrate and an upper-layer substrate which are arranged in a manner of being superposed sequentially from bottom to top, wherein the bottom-layer substrate is prepared from 10-20 parts (by weight) of dried corn stalks or dried sugarcane leaves; the middle-layer substrate is prepared from a mixture of 5-15 parts (by weight) of vermiculite and the like; and the upper-layer substrate is prepared from a mixture of 15-35 parts (by weight) of modified biocarbon, 15-45 parts (by weight) of rotten wood and the like. A preparation method for the planting substrate comprises the steps of preparing the modified biocarbon, preparing the bottom-layer substrate, the middle-layer substrate and the upper-layer substrate and then carrying out superposition. The preparation method for the planting substrate is simple and easy to understand; and the planting substrate prepared by the preparation method has the advantages that the condition that the substrate is rotted, is air-proof and does not hold moisture in long-term use is overcome, the cost is low, the nutrition is complete, the growth of the dendrobium huoshanense is better facilitated, dendrobium huoshanense stems are promoted to grow more sturdy, and dendrobium huoshanense root systems are promoted to be more developed.

The present invention relates to a novel approach to prevent or treat mastitis both in humans and animals through the use of mammal milk-derived microorganisms obtained from healthy hosts of the homologous species; to those new probiotic microorganisms obtained from milk able to reduce infectious mastitis and the method of screening used for their obtaining; to the use of these probiotic bacteria for the prophylaxis or treatment against mastitis and other diseases; and finally, to compositions comprising these compounds.

The invention relates to a honeybee feed and belongs to the field of animal feeds. By virtue of the feed, the yields of honeybees from July to October are improved. According to the honeybee feed, a queen bee feed comprises the following components in percentage by mass: 56%-64% of pollen, 8%-12% of white sugar, 8%-12% of soybean meal with the particle size being more than 100 meshes, 8%-12% of water and 6%-8% of an additive.

The present invention provides, among other things, therapeutic compositions and methods that can effectively treat, slow or prevent mild cognitive impairment (MCI) or Alzheimer's disease (AD), in particular, based on therapeutically effective amount of nifedipine, oxidized or nitroso nifedipine derivatives, thyroxine (T4), triiodothyronine (T3) and combinations thereof.

The invention relates to a feed for artificially breeding lygus lucorum. The feed comprises fresh egg, yolk powder, lecithin, sucrose, yeast powder, sorbic acid and the like which serve as main components. The artificial feed is suitable for artificially breeding a large quantity of adults and nymphs of the lygus lucorum, the bred lygus lucorum has high survival rate and quick growth and development, the average egg laying amount of single female lygus lucorum is high, the feed has long quality guarantee period, the frequency of changing the feed is greatly reduced, time and labor are saved, and the cost of the feed is reduced. The feed has the characteristics of simplicity and strong practicability, and is easy to operate.

The invention discloses a dragon blood extract. Based on 3-methoxy resveratrol and loureirin B, according to weight percentage, the content of total phenol is more than 50 percent, the content of loureirin A is between 0.5 and 4.0 percent, the content of the loureirin B is between 0.4 and 2.0 percent, the content of resveratrol is between 0.1 and 2.0 percent, the content of pterostilbene is between 0.3 and 4.0 percent, and the content of the 3-methoxy resveratrol is between 0.1 and 2.5 percent. Besides, the invention also discloses a method for preparing the dragon blood extract, a method for controlling the quality, and application of a pharmaceutical composition containing the dragon blood extract. The extraction process route of the dragon blood is simple and is suitable for industrial mass production; besides, the dragon's blood extract has better nerve cell protection function, and can serve as a protective agent for nerve cells.

The invention relates to a pre-stimulating stem cell as well as a preparation method and application thereof. The preparation method comprises the following steps of selecting non-target stem cells asauxiliary cells; inducing the auxiliary cells for pyroptosis; obtaining pyroptosis cells, secreta of pyroptosis cells and / or extracts of the pyroptosis cells for culturing stem cells. The preparationmethod provided by the invention can be used for obtaining the stem cells prestimulated by the secreta of the pyroptosis cells; the stem cells can adapt to the natural inflammatory environment; the restoration capability of the stem cells on the damage region can be improved; the method belongs to new breakthrough in the seed material pretreatment in the tissue engineering field; meanwhile, a feasible scheme is provided for pre-stimulating stem cells and solving the problem of clinic disease treatment.

The invention belongs to the field of biomedicine and relates to synergistic antitumor drug, in particular to application of antitumor drug like DNA-PK (DNA-dependent protein kinase, DNA-PK) inhibitors and oncolytic viruses in preparing antitumor drug. It is found for the first time that the antitumor drug like the DNA-PK inhibitor with various targets can be used for preparing oncolytic virus antitumor synergists. The invention further relates to a drug composition containing the antitumor drug and the oncolytic viruses, drug sets comprising the antitumor drug and the oncolytic viruses and application of the antitumor drug and the oncolytic viruses in treating tumor, especially for tumor insensitive to the oncolytic viruses.

The invention discloses a dendrobium huoshanense special-purpose planting matrix, comprising a matrix A, a matrix B, and a matrix C which are arranged in an overlaying manner from bottom to top in sequence. According to weight part ratio, the matrix A contains 10-20 parts of dry sorghum stalks or 10-20 parts of dry sugarcane leaves, the matrix B is a mixture of 10-15 parts of silkworm excrement, 10-20 parts of mature ethyl alcohol biogas residue, etc., and the matrix C is a mixture of 10-25 parts of modified charcoal, 15-45 parts of rotten wood, 2-5 parts of a trichoderma spp agent. The manufacturing method for the planting matrix comprises: manufacturing the modified charcoal, manufacturing the matrixes A, B, and C, and overlaying to form the planting matrix. The manufacturing method is simple and easy to understand, and the manufactured planting matrix overcomes problems that a matrix is rotted and does not ventilate and does not retain water after long time use. The matrix is low in cost, complete in nutrition, and is beneficial for growth of the dendrobium huoshanense, and promotes stems of the dendrobium huoshanense to grow thicker, and roots to be more developed.

The invention relates to an ex-situ conservation method for scleratinia and is characterized in that after the whole polyparium is excavated from origins, small corals with the diameter less than 25cm are fixed on a transplanting board by chemotec with the curing time of 30 to 60 minutes and then is placed into a fostering box full of seawater for fostering; the fostering box is fixed on a ship and is moved to the migration destination; large corals with the diameter more than 25cm is placed into a net box in the water for fostering and the transplanting board and the large corals are placed to the bottom of the sea for fixing after the ship arrives at the migration destination. The invention adopts a fostering method in the migration of the corals, leads the scleratinia not to reduce survival rate or be dead due to the environment without water for a long time and leads the survival rate of the scleratinia to be more than 95 percent, thus being an effective ex-situ conservation method for the scleratinia.

The invention belongs to the field of aquaculture and relates to a method for preventing and controlling prawn communicable diseases by Epinephelus coioids. The method comprises the steps of: releasing young prawns in high-salinity seawater, wherein the releasing amount is 80,000-10,0000 fish per mu (mu refers to a unit of area); when the prawn is cultivated to 0.3-0.7 gram, releasing the Epinephelus coioids into the seawater, wherein the weight of each Epinephelus coioids is 0.10-0.15 kg, and the releasing amount of the Epinephelus coioids is 15-20 fish per mu. Large amount of experiments prove that: the Epinephelus coioids about 0.10-0.15 kg in weight can eat ill and dead prawns in a culture pond, the probability of eating healthy prawns is very little due to the habit of the healthy prawns. According to the characteristic, the problem that the survival rate of the bred prawns is low because the healthy prawns are eaten is solved, and simultaneously, the prawn communicable diseases are effectively prevented and controlled.